5-Methyl furfural supplier

Name
5-Methyl furfural
EINECS 210-622-6
CAS No. 620-02-0
Article Data156
CAS DataBase
Density 1.099 g/cm³
Solubility Soluble in alcohol and water.
Melting Point 171 °C
Formula C₆H₆O₂
Boiling Point 187 °C at 760 mmHg
Molecular Weight 110.112
Flash Point 72.8 °C
Transport Information
Appearance Colorless to light yellow liquid
Safety 26-36-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 2-Furaldehyde,5-methyl- (6CI,8CI);2-Formyl-5-methylfuran;2-Formyl-5-methyltetrahydrofuran;2-Methyl-5-formylfuran;2-Methyl-5-furaldehyde;5-Methyl-2-furaldehyde;5-Methyl-2-furancarboxaldehyde;5-Methyl-2-furfural;5-Methyl-2-furfuraldehyde;5-Methyl-2-furfurylaldehyde;5-Methylfuran-2-al;5-Methylfuran-2-aldehyde;5-Methylfuran-2-carbaldehyde;5-Methylfurfural;5-Methylfurfuraldehyde;
PSA 30.21000
LogP 1.40050

Synthetic route

: 62202-47-5
(5-methylfuran-2-yl)methylene diacetate

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With [NO(1+)18-crown-6H(NO3)2(1-)]; silica gel In dichloromethane at 20℃; for 0.0833333h;	100%
With caro's acid; silica gel In dichloromethane for 0.0333333h; Heating;	100%
With aluminium trichloride In acetonitrile for 0.0833333h; Deacetylation; Heating;	99%

: 534-22-5
2-methylfuran

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With trichlorophosphate In 1,2-dichloro-ethane 1.) 0 deg C, 1 h, 2.) 0 deg C - 26 deg C;	99.6%
With bis(trichloromethyl) carbonate In dichloromethane at 20℃;	98.8%
With trichlorophosphate
Yield given. Multistep reaction;

: 1623-88-7
5-chloromethylfurfural

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With hydrogen In 1,2-dichloro-ethane at 70℃; under 8250.83 Torr; for 5h; pH=8.88; Reagent/catalyst; Temperature; Autoclave;	99%
With palladium 10% on activated carbon; hydrogen; N,N-dimethyl-formamide under 3361.55 Torr; for 1.21667h;	97%
With palladium 10% on activated carbon; hydrogen; N,N-dimethyl-formamide under 103.432 - 3361.55 Torr; for 1.21667h; Reagent/catalyst;	97%

: 39131-44-7
5-bromomethyl-furan-2-carbaldehyde

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With 5%-palladium/activated carbon; hydrogen In 1,2-dichloro-ethane at 50℃; under 8250.83 Torr; for 5h; pH=8.39; Reagent/catalyst; Autoclave;	98%
With hydrogenchloride; tin(ll) chloride

: 1899-24-7
5-bromo-2-furancarboxaldehyde

[3-(dimethylamino)propyl]dimethylindium: [3-(dimethylamino)propyl]dimethylindium

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
bis-triphenylphosphine-palladium(II) chloride In benzene at 80℃; for 12h;	97%

: 1899-24-7
5-bromo-2-furancarboxaldehyde

bis(μ-[2-(dimethylamino)ethanolato-N,O:O]tetramethyldiindium: bis(μ-[2-(dimethylamino)ethanolato-N,O:O]tetramethyldiindium

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
bis-triphenylphosphine-palladium(II) chloride In benzene at 80℃; for 24h;	95%

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 620-02-0
5-Methylfurfural

B: 1883-75-6
2,5-bis-(hydroxymethyl)furan

Conditions

Conditions	Yield
With hydrogen; 20Cu/Al2O3 In methanol at 130℃; under 22502.3 Torr; for 1h; Catalytic behavior; Solvent;	A 6.62% B 93.01%
With water; hydrogen at 160℃; under 30003 Torr; for 4h; Autoclave;
With hydrogen In ethanol at 100℃; under 37503.8 Torr; for 6h; Autoclave;

: 2-((5-methylfuran-2-yl)methylene)hydrazine-1-carboxamide

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With tetrachlorosilane; silica gel In hexane; water for 1h; Heating;	92%
With aluminium trichloride; 1-benzyl-4-aza-1-azoniabicyclo[2.2.2]octane dichromate at 20℃; for 0.0111111h;	90%
With zirconium hydrogen sulfate; silica gel In hexane at 20℃; for 0.2h;	90%

: 534-22-5
2-methylfuran

: 75-44-5
phosgene

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
Stage #1: 2-methylfuran; phosgene With N,N-dimethyl-formamide In toluene at 40 - 60℃; for 5 - 13h; Stage #2: With water In toluene at 40 - 45℃; Stage #3: With sodium hydroxide In water; toluene for 1h; pH=8.9; Product distribution / selectivity;	92%

: 3857-25-8
2-hydroxymethyl-5-methylfuran

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With oxygen; hydroquinone In tetrahydrofuran; aq. phosphate buffer at 20℃; for 12h; pH=4.5; Green chemistry;	91%
With butyltriphenylphosphonium dichromate In chloroform for 0.75h; Oxidation; Heating;	88%
With potassium dichromate; aluminium trichloride for 0.0666667h;	88%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium carbonate; N-Phenylglycine; copper(ll) bromide In water for 16h; Reflux; Schlenk technique;	82%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; dimethyl 3-methyl-9-oxo-7-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)-2,4-di(pyridin-2-yl)-3,7-diazabicyclo-[3.3.1]nonane-1,5-dicarboxylate; copper(I) bromide In water at 20℃; for 10h; Green chemistry;	76%

: 98-01-1
furfural

: 109-72-8, 29786-93-4
n-butyllithium

: 74-88-4
methyl iodide

A: 620-02-0
5-Methylfurfural

B: 70396-63-3, 14313-18-9
1-(5-methylfuran-2-yl)pentan-1-ol

Conditions

Conditions	Yield
With N,O-dimethylhydroxylamine*hydrochloride In tetrahydrofuran; hexane at -20℃; for 1h; Product distribution; Further Variations:; Reagents; Solvents; Temperatures; time;	A 90.7% B 1.1%

...Expand

: 1899-24-7
5-bromo-2-furancarboxaldehyde

[3-(dimethylamino)propyl]dimethylgallium: [3-(dimethylamino)propyl]dimethylgallium

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
bis-triphenylphosphine-palladium(II) chloride In benzene at 80℃; for 24h;	90%

: 5-methyl-2-furancarbaldehyde oxime

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With aluminium trichloride; 1-benzyl-4-aza-1-azoniabicyclo[2.2.2]octane dichromate at 20℃; for 0.00833333h;	89%
With 1-benzyl-4-aza-1-azoniabicyclo[2.2.2]octane dichromate In dichloromethane for 0.00833333h; Irradiation;	89%
With aluminium trichloride; benzyltriphenylphosphonium chlorochromate In acetonitrile for 0.833333h; Heating;	89%

: 102390-86-3
5-(2-furaldehyde)methyl formate

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With formic acid; 5%-palladium/activated carbon; ammonium formate at 80℃; for 1h;	89%

: 57784-53-9
5-methylfuran-2-carbaldehyde oxime

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With benzeneselenic anhydride In dichloromethane	83%

: 104208-14-2
2-(furan-2-yl)-1,3-dimethylimidazolidine

: 74-88-4
methyl iodide

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
Stage #1: 2-(furan-2-yl)-1,3-dimethylimidazolidine With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at -78℃; for 2h; Stage #2: methyl iodide at 20℃; for 12h; Stage #3: With hydrogenchloride In water	82%
With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid Yield given. Multistep reaction;

: 1899-24-7
5-bromo-2-furancarboxaldehyde

: 823-96-1
Trimethylboroxine

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With C70H40Cl2F68N2O6Pd2; tetrabutylammomium bromide; potassium carbonate In water at 140℃; for 0.266667h; Suzuki-Miyaura reaction; Microwave irradiation;	82%

: 1883-75-6
2,5-bis-(hydroxymethyl)furan

A: 625-86-5
2,5-dimethylfuran

B: 620-02-0
5-Methylfurfural

C: 823-82-5
2,5-diformylfurane

Conditions

Conditions	Yield
With iodine at 60℃; for 10h; Inert atmosphere; Sealed tube;	A 5% B 80% C 6%

...Expand

: 23029-68-7
2-dibutoxymethyl-5-methylfuran

A: 620-02-0
5-Methylfurfural

B: 126080-80-6
5-Methyl-furan-2-carboxylic acid butyl ester

Conditions

Conditions	Yield
With tin(IV) chloride In 1,2-dichloro-ethane at 0℃; for 0.25h;	A 22% B 78%

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 625-86-5
2,5-dimethylfuran

B: 620-02-0
5-Methylfurfural

C: 1883-75-6
2,5-bis-(hydroxymethyl)furan

D: C7H10O

E: 121709-55-5
2,2′-(1,2-ethanediyl)bis [5-methylfuran]

Conditions

Conditions	Yield
With hydrogen In tetrahydrofuran at 130℃; under 7500.75 Torr; for 24h; Pressure; Temperature; Reagent/catalyst; Time; Autoclave; High pressure;	A 76% B n/a C n/a D n/a E n/a

...Expand

: 534-22-5
2-methylfuran

: 3724-43-4, 149409-22-3
Vilsmeier reagent

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
Stage #1: 2-methylfuran; Vilsmeier reagent at 0℃; for 1h; Stage #2: With water; sodium carbonate at 0℃;	76%

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With formic acid In tetrahydrofuran at 220℃; under 3750.38 Torr; for 7.5h; Catalytic behavior; Mechanism; Reagent/catalyst; Temperature; Inert atmosphere; Autoclave; Green chemistry;	73%
With hydrogen iodide In benzene-d6; water at 100℃; under 15514.9 Torr; for 2.5h; Inert atmosphere;	47%
With hydrogenchloride; sodium iodide In diethyl ether; dichloromethane; water electrolysis, mercury pool cathode, -0.2 V;

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 625-86-5
2,5-dimethylfuran

B: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With hydrogen; Al(OH)(2,2'-bipyridine-5,5'-dicarboxylic acid)0.81(PdCl2)0.48(OTf)0.38 at 150℃; under 15001.5 Torr; for 24h;	A 71% B 29%
With awaruite; hydrogen at 160℃; under 7500.75 Torr; for 2h; Catalytic behavior; Time; chemoselective reaction;	A 15.7% B 19.8%
With hydrogenchloride; hydrogen In tetrahydrofuran at 60℃; under 760.051 Torr; for 6h; Reagent/catalyst; Schlenk technique;	A 8 %Chromat. B 7 %Chromat.

: 470-23-5
D-fructose

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With hydrogen iodide; hydrogen; palladium on activated charcoal In water; benzene at 90℃; under 15514.9 Torr; for 0.5h; Product distribution / selectivity;	69%
With palladium on activated charcoal; hydrogen iodide; hydrogen at 120℃; under 15514.9 Torr; for 0.5h;	68%
With rhodium(III) chloride trihydrate; hydrogen iodide In water; toluene at 80℃; under 15514.9 Torr; for 9h; Inert atmosphere;	100 %Chromat.
With phosphoric acid; hydrogen iodide In water; toluene at 90℃; for 3h;
Multi-step reaction with 2 steps 1: hydrogen bromide / 1,2-dichloro-ethane / 8 h / Reflux 2: 5%-palladium/activated carbon; formic acid; ammonium formate / 1 h / 80 °C View Scheme

: 23029-68-7
2-dibutoxymethyl-5-methylfuran

A: 620-02-0
5-Methylfurfural

B: 126080-79-3
2-butoxymethyl-5-methylfuran

C: 126080-80-6
5-Methyl-furan-2-carboxylic acid butyl ester

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In 1,2-dichloro-ethane at 0℃; for 0.25h;	A 8% B 65% C 13%

...Expand

: 634-74-2, 2438-80-4, 3615-37-0, 3615-41-6, 3713-31-3, 4348-84-9, 5158-61-2, 5624-55-5, 5652-45-9, 7420-19-1, 7658-08-4, 7658-09-5, 7658-10-8, 7724-73-4, 10485-94-6, 18546-02-6, 18546-05-9, 19479-17-5, 32738-74-2, 35867-45-9, 39665-53-7, 64364-07-4, 75247-25-5, 78684-66-9, 84985-25-1
D-rhamnose

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With Dowex 50Wx8-200 ion-exchange resin at 100℃; for 3h; Ionic liquid; Sealed tube;	63%
With Phenylalanine In water at 98℃; for 10h; Product distribution; formation of furfural derivatives in amino-carbonyl reaction; various pH (2 - 12);

: 57-48-7, 87-79-6, 87-81-0, 551-68-8, 3615-39-2, 3615-56-3, 6035-50-3, 7776-48-9, 16354-64-6, 17598-81-1, 17598-82-2, 23140-52-5, 30237-26-4, 65732-90-3, 73952-10-0, 73952-11-1, 139686-85-4
fructose

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With tungsten monocarbide; hydrogen iodide; hydrogen In water; toluene at 130℃; under 10343.2 Torr; for 1h; Catalytic behavior; Pressure; Reagent/catalyst;	63%

: 73-34-7
L-rhamnose

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With chromium dichloride; 4-methyl-2-pentanone; 1-butyl-3-methylimidazolium chloride at 100℃; Catalytic behavior; Reagent/catalyst; Temperature;	61%
With hydrogenchloride; C12H25C6H4SO3Na; cetyltrimethylammonium chloride 1.) 20 deg C, 2 h; 2.) carbon tetrachloride, 40-70 deg C; Yield given. Multistep reaction;

inulin: inulin

: 620-02-0
5-Methylfurfural

Conditions

Conditions	Yield
With hydrogen iodide; hydrogen; ruthenium trichloride In water; benzene at 75℃; under 15514.9 Torr; for 2h;	61%
With tungsten monocarbide; hydrogen iodide; hydrogen In water; toluene at 160℃; under 10343.2 Torr; for 1h;	30%
With rhodium(III) chloride hydrate; hydrogen iodide; hydrogen In water; benzene at 75℃; under 15514.9 Torr; for 2h; Autoclave;	61 %Spectr.

: 620-02-0
5-Methylfurfural

: 74-90-8
hydrogen cyanide

: 136521-57-8
(S)-(+)-2-hydroxy-2-(5-methyl-2-furyl)acetonitrile

Conditions

Conditions	Yield
With almond meal; citrate buffer pH 5.5 In ethyl acetate at 4℃;	100%
With almond meal In di-isopropyl ether at 15℃;	99%
With almond meal ((R)-oxynitrilase) In di-isopropyl ether at 4 - 30℃;	60%

: 620-02-0
5-Methylfurfural

: 104-94-9
4-methoxy-aniline

: 95124-23-5
N-(4-methoxyphenyl)-1-(5-methylfuran-2-yl)methanimine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In diethyl ether at 20℃; Molecular sieve; Inert atmosphere;	100%

: 620-02-0
5-Methylfurfural

: 61700-55-8
pipecolic acid hydrazide

: 3-(5-Methyl-furan-2-yl)-2-{[1-(5-methyl-furan-2-yl)-meth-(E)-ylidene]-amino}-hexahydro-imidazo[1,5-a]pyridin-1-one

Conditions

Conditions	Yield
In ethanol	100%

: 620-02-0
5-Methylfurfural

: 917-54-4
methyllithium

: 14003-15-7
2-(1-hydroxyethyl)-5-methylfuran

Conditions

Conditions	Yield
In tetrahydrofuran at -78℃;	100%

: 620-02-0
5-Methylfurfural

: 100-46-9
benzylamine

: 91608-35-4
Benzyl-[1-(5-methyl-furan-2-yl)-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
In ethanol at 20℃;	100%
In dichloromethane at 20℃; for 24h;
In benzene Heating;
With magnesium sulfate In dichloromethane at 20℃;
In ethanol at 100℃; for 0.0166667h; Concentration; Sealed tube; Microwave irradiation;

: 620-02-0
5-Methylfurfural

: 473731-98-5
C8H7F5O2

Conditions

Conditions	Yield
Stage #1: Pentafluoroethyl iodide With methyl lithium lithium bromide complex In diethyl ether at -78℃; for 0.25h; Stage #2: 5-Methylfurfural In diethyl ether at -78 - 45℃; for 2h; Stage #3: With ammonium chloride In diethyl ether; water at 20℃; for 1h;	100%

: 620-02-0
5-Methylfurfural

: 697748-22-4
1-methoxycarbonyl-2-t-butoxycarbonyl ethyl phosphorane

: 697748-19-9
E-3-methoxycarbonyl-4-(5-methylfur-2-yl)-but-3-enoic acid t-butyl ester

Conditions

Conditions	Yield
In toluene at 80℃; for 48h;	100%

: 620-02-0
5-Methylfurfural

: 927885-19-6
N-(4-aminomethylbenzyl)-N',N'-dipropylbutane-1,4-diamine

: 927885-35-6
{(4-dipropylaminobutyl)-[4-(5-methylfuran-2-ylmethylidene)aminomethylbenzyl]}-amine

Conditions

Conditions	Yield
With sodium sulfate In ethanol at 20℃; for 25h;	100%
With sodium sulfate In ethanol at 25℃; for 20h;	100%

: 620-02-0
5-Methylfurfural

: 9-Phenyl-1,2,3,4,5,6,7,8-octahydro-xanthenylium; perchlorate

: 1161226-52-3
C31H29O3(1+)*ClO4(1-)

Conditions

Conditions	Yield
With phosphorus pentoxide In isopropyl alcohol Reflux;	100%

: 620-02-0
5-Methylfurfural

: 354-64-3
Pentafluoroethyl iodide

: 473731-98-5
C8H7F5O2

Conditions

Conditions	Yield
Stage #1: Pentafluoroethyl iodide With methyllithium lithium bromide In diethyl ether at -78℃; for 0.25h; Stage #2: 5-Methylfurfural In diethyl ether at -45℃; for 2h;	100%
Stage #1: Pentafluoroethyl iodide With methyllithium lithium bromide In diethyl ether at -78℃; for 0.25h; Stage #2: 5-Methylfurfural In diethyl ether at -78 - -45℃; for 2h; Stage #3: With ammonium chloride In diethyl ether; water at 20℃; for 1h;	100%

: 620-02-0
5-Methylfurfural

: 693-04-9
butyl magnesium bromide

: 70396-63-3, 14313-18-9
1-(5-methylfuran-2-yl)pentan-1-ol

Conditions

Conditions	Yield
In diethyl ether at -10 - 10℃; Grignard reaction; Inert atmosphere;	100%

: 110-89-4
piperidine

: 620-02-0
5-Methylfurfural

: 1233407-67-4
1,1'-[(5-methylfuran-2-yl)methanediyl]dipiperidine

Conditions

Conditions	Yield
at 20℃; for 0.166667h; neat (no solvent);	100%

: 620-02-0
5-Methylfurfural

: 1201652-21-2
(E)-2-((5-methylfuran-2-yl)methyleneamino)-N-phenylbenzamide

Conditions

Conditions	Yield
	100%

: 620-02-0
5-Methylfurfural

: 39533-32-9
methyl 2-isocyano-2-phenylacetate

: 106-49-0
p-toluidine

: 1360806-67-2
C23H22N2O3

Conditions

Conditions	Yield
With sulphate sodium salt; silver(I) acetate In methanol at 20℃; for 20h; Inert atmosphere; optical yield given as %de;	100%

...Expand

: 620-02-0
5-Methylfurfural

: 1003-38-9
2,5-dimethyltetrahydrofuran

Conditions

Conditions	Yield
With rhodium(III) iodide; hydrogen iodide; hydrogen In water; toluene at 125℃; under 15514.9 Torr; for 12h;	100%
Multi-step reaction with 2 steps 1: hydrogen / butan-1-ol / 3 h / 199.84 °C / 22502.3 Torr / Autoclave 2: hydrogen / butan-1-ol / 3 h / 199.84 °C / 22502.3 Torr / Autoclave View Scheme
Multi-step reaction with 2 steps 1: hydrogen / butan-1-ol / 3 h / 199.84 °C / 22502.3 Torr / Autoclave 2: hydrogen / butan-1-ol / 3 h / 199.84 °C / 22502.3 Torr / Autoclave View Scheme

: 620-02-0
5-Methylfurfural

: 100-36-7
N,N-diethylethylenediamine

: N1,N1-diethyl-N2-((5-methylfuran-2-yl)methylene)ethane-1,2-diamine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; Inert atmosphere; Darkness;	100%

: 620-02-0
5-Methylfurfural

: 99-98-9
4-amino-N,N-dimethylaniline

: (E)-4-((5-methylfuran-2-ylmethylene)amino)-N,N-dimethylaniline

Conditions

Conditions	Yield
In diethyl ether at 20℃; Inert atmosphere; Molecular sieve; Darkness;	100%

: 620-02-0
5-Methylfurfural

: 864914-08-9
4-[(4-dipropylaminobutyl)amino]methylbenzonitrile

: 4-{[(4-dipropylaminobutyl)-(5-methylfuran-2-ylmethyl)amino]methyl}benzonitrile

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In ethanol at 0 - 20℃; for 19h;	99.5%
With sodium tris(acetoxy)borohydride In ethanol at 0 - 20℃; for 19h;	99.5%

: 620-02-0
5-Methylfurfural

: 920-39-8
isopropylmagnesium bromide

: 32869-73-1
2-methyl-1-(5-methylfuran-2-yl)propan-1-ol

Conditions

Conditions	Yield
In diethyl ether at -10 - 10℃; Grignard reaction; Inert atmosphere;	99%
With diethyl ether

: 534-22-5
2-methylfuran

: 620-02-0
5-Methylfurfural

: 86269-31-0
2,2',2''-methylidenetris(5-methylfuran)

Conditions

Conditions	Yield
With ion-exchange resin Lewatit SPC 108 (acid form) In 1,4-dioxane; water at 60℃; for 3h;	99%
gold(III) chloride In acetonitrile at 20℃; for 48h;	98%
With 1-methyl-3-(4-sulfobutyl)-1H-imidazol-3-ium hydrogensulfate In water at 65℃; for 2h; Green chemistry;	94%

: 620-02-0
5-Methylfurfural

: 78-94-4
methyl vinyl ketone

: 85660-09-9
(Methyl-5' furyl-2')-1 pentanedione-1,4

Conditions

Conditions	Yield
With acetate de sodium anhydre; iodure de dimethyl-3,4(hydroxyethyl-2)-5 thiazolium-1,3; triethylamine In ethanol Heating;	99%

: 620-02-0
5-Methylfurfural

: 1575-38-8
3,5-dibromo-1,2-phenylendiamine

: 4,6-Dibromo-2-(5-methyl-furan-2-yl)-1-(4-methyl-furan-2-ylmethyl)-1H-benzoimidazole

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water for 0.25h; Heating;	99%

: 620-02-0
5-Methylfurfural

A: 1917-15-3
5-methylfuran-2-carboxylic acid

B: 3857-25-8
2-hydroxymethyl-5-methylfuran

Conditions

Conditions	Yield
Stage #1: 5-Methylfurfural With potassium hydroxide for 0.0833333h; Cannizzaro Reaction; Milling; Inert atmosphere; Sealed tube; Green chemistry; Stage #2: With hydrogenchloride In water for 0.0833333h; Green chemistry;	A 99% B 99%
With sodium hydroxide In diethyl ether; water for 4h; Heating;	A 42% B 35%

: 620-02-0
5-Methylfurfural

: C15H15O(1+)*BF4(1-)

: BF4(1-)*C21H19O2(1+)

Conditions

Conditions	Yield
With phosphorus pentoxide In isopropyl alcohol; acetonitrile Heating;	99%

: 620-02-0
5-Methylfurfural

: 594-19-4
tert.-butyl lithium

: 1210782-06-1
2,2-dimethyl-1-(5-methylfuran-2 yl)propan-1-ol

Conditions

Conditions	Yield
In tetrahydrofuran at -10 - 10℃; Inert atmosphere;	99%

: 620-02-0
5-Methylfurfural

: 99968-74-8
amide of 5-methylfuran-2-carboxylic acid

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; caesium carbonate In water; dimethyl sulfoxide at 125℃; for 14h;	99%
Multi-step reaction with 2 steps 1: hydroxylamine hydrochloride; pyridine / methanol / 24 h / 20 °C 2: [RuCl2(η2-C6H6){P(NMe2)3}]; water / 1 h / 100 °C / Inert atmosphere; Sealed tube View Scheme

: 620-02-0
5-Methylfurfural

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 2,2,2-Trifluoro-1-(5-methyl-furan-2-yl)-ethanol

Conditions

Conditions	Yield
Stage #1: 5-Methylfurfural; (trifluoromethyl)trimethylsilane With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 4h; Stage #2: With tetrabutyl ammonium fluoride In N,N-dimethyl-formamide for 4h;	99%

5-Methyl furfural Chemical Properties

Molecular Structure of 5-Methyl furfural (CAS NO.620-02-0):

IUPAC Name: 5-Methylfuran-2-carbaldehyde
Canonical SMILES: CC1=CC=C(O1)C=O
InChI: InChI=1S/C6H6O2/c1-5-2-3-6(4-7)8-5/h2-4H,1H3
InChIKey: OUDFNZMQXZILJD-UHFFFAOYSA-N
Molecular Weight: 110.11064 [g/mol]
Molecular Formula: C₆H₆O₂
XLogP3: 0.7
EINECS: 210-622-6
Boiling Point: 187-189 °C(lit.)
Density: 1.107 g/mL at 25 °C(lit.)
Refractive index: n20/D 1.531
FEMA: 2702
Flash Point: 163 °F
Storage temp.: Refrigerator
Sensitive: Air Sensitive
Appearance: Colorless to light yellow liquid
Classification Code: Mutation data; Natural Product
Product Categories: Pharmaceutical Raw Materials; Aromatic Aldehydes & Derivatives (substituted); API intermediates; Furans; aldehyde Flavor

5-Methyl furfural Toxicity Data With Reference

1.	dnr-bcs 55 µg/disc	DFSCDX Developments in Food Science. 13 (1986),353.
2.	cyt-ham:ovr 37,700 µmol/L	CALEDQ Cancer Letters (Shannon, Ireland). 13 (1981),89.
3.	orl-rat LD50:2200 mg/kg	FCTOD7 Food and Chemical Toxicology. 20 (1982),751.

5-Methyl furfural Consensus Reports

Reported in EPA TSCA Inventory.

5-Methyl furfural Safety Profile

Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating vapors.
Safety Information of 5-Methyl furfural (CAS NO.620-02-0):
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S24/25:Avoid contact with skin and eyes.
WGK Germany: 2
RTECS: LT7032500

5-Methyl furfural Specification

5-Methyl furfural (CAS NO.620-02-0), its Synonyms are 2-Formyl-5-methylfuran ; 2-Furaldehyde, 5-methyl- ; 2-Furancarboxaldehyde, 5-methyl- ; 2-Methyl-5-formylfuran ; 5-Methyl-2-furaldehyde ; 5-Methyl-2-furancarboxaldehyde ; 5-Methyl-2-furfural ; 5-Methyl-2-furfuraldehyde ; 5-Methylfuran-2-al ; 5-Methylfuran-2-carbaldehyde ; 5-Methylfurfural ; 5-Methylfurfuraldehyde .

Product Name

5-Methyl furfural

Synthetic route

5-Methyl furfural Chemical Properties

5-Methyl furfural Toxicity Data With Reference

5-Methyl furfural Consensus Reports

5-Methyl furfural Safety Profile

5-Methyl furfural Specification

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