6-Bromoindanone supplier | CasNO.14548-39-1

Name
6-Bromoindanone
EINECS 688-934-0
CAS No. 14548-39-1
Article Data36
CAS DataBase
Density 1.608 g/cm³
Solubility
Melting Point 111-115 ºC
Formula C₉H₇BrO
Boiling Point 291.6 ºC at 760 mmHg
Molecular Weight 211.058
Flash Point 111.6 ºC
Transport Information
Appearance White to yellow crystalline powder or needles
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 1-Indanone,6-bromo- (6CI,7CI,8CI);6-Bromo-1-indanone;6-Bromo-2,3-dihydro-1H-inden-1-one;
PSA 17.07000
LogP 2.57800

Synthetic route

: 1643-30-7
3-(4-bromophenyl)propionic acid

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In dichloromethane at 80℃; for 1h; Friedel-Crafts Acylation; High pressure; Inert atmosphere; Green chemistry;	100%
With chlorosulfonic acid at 0℃; for 1h; Friedel-Crafts reaction;	98%
With aluminum (III) chloride In dichloromethane for 3h; Reflux;	80%

: 62803-47-8
6-hydroxy-1-indanone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane	98%

: 55394-81-5
3-(4-bromophenyl)propanoyl chloride

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
With aluminium trichloride In carbon disulfide	91%
With aluminium trichloride In carbon disulfide for 3h; Heating / reflux;	47%
With aluminium trichloride In dichloromethane

: 1383443-48-8
C15H13BrN2O3

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In chloroform at 50℃; for 4h; Friedel Crafts acylation; Inert atmosphere;	88%

: 69975-65-1
6-aminoindan-1-one

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
Stage #1: 6-aminoindan-1-one With hydrogenchloride; sodium nitrite In water at 0℃; Stage #2: With copper(I) bromide In water at 0 - 20℃; for 2h;	71%

: 1643-30-7
3-(4-bromophenyl)propionic acid

A: 14548-39-1
6-bromoindan-1-one

B: 1610628-81-3
6-bromo-2-[3-(4-bromophenyl)-1-oxopropyl]-indan-1-one

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; trifluoroacetic acid In dichloromethane at 20℃; for 2h;	A 8% B 70%

: 1643-30-7
3-(4-bromophenyl)propionic acid

A: 14548-39-1
6-bromoindan-1-one

B: C18H14Br2O2

Conditions

Conditions	Yield
Stage #1: 3-(4-bromophenyl)propionic acid With trifluoroacetic anhydride In dichloromethane at 20℃; for 0.25h; Stage #2: With trifluorormethanesulfonic acid In dichloromethane at 20℃; for 2h;	A 8% B 70%
Stage #1: 3-(4-bromophenyl)propionic acid With trifluoroacetic anhydride In dichloromethane at 20℃; for 0.25h; Stage #2: With trifluorormethanesulfonic acid In dichloromethane at 20℃; for 2h;	A 62% B n/a

: 83-33-0
inden-1-one

A: 15115-60-3
4-bromo-2,3-dihydroinden-1-one

B: 14548-39-1
6-bromoindan-1-one

C: 34598-49-7
5-Bromo-1-indanone

D: 103515-98-6
4,7-dibromo-1-indanone

Conditions

Conditions	Yield
With aluminium trichloride; bromine at 110℃; for 0.5h; Further byproducts given;	A 47% B 21% C 3% D 2%

...Expand

: 83-33-0
inden-1-one

A: 15115-60-3
4-bromo-2,3-dihydroinden-1-one

B: 14548-39-1
6-bromoindan-1-one

C: 34598-49-7
5-Bromo-1-indanone

D: 4,6-dibromo-1-indanone

Conditions

Conditions	Yield
With aluminium trichloride; bromine at 110℃; for 0.5h; Further byproducts given;	A 47% B 21% C 3% D 1%

...Expand

: 33065-61-1
6-bromo-1H-indene

A: 14548-39-1
6-bromoindan-1-one

B: (+)-(1S)-6-bromoinden-1-ol

Conditions

Conditions	Yield
With Pseudomonas putida UV4 for 7h;	A 28% B 16%

: 83-33-0
inden-1-one

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
Stage #1: inden-1-one With aluminum (III) chloride for 0.216667h; Stage #2: With bromine at 0 - 80℃; for 0.25h;	19%
Multi-step reaction with 3 steps 1.1: potassium nitrate; sulfuric acid / 1.5 h / 0 - 5 °C 2.1: iron; ammonium chloride / water; ethanol / 80 °C 3.1: sodium nitrite; hydrogenchloride / water / 0 °C 3.2: 2 h / 0 - 20 °C View Scheme

: 75476-78-7
5-bromo-1H-indene

A: 14548-39-1
6-bromoindan-1-one

B: 5-bromo-1,2-dihydroxyindane

Conditions

Conditions	Yield
With Pseudomonas putida UV4 for 7h;	A 4% B n/a

: 1643-30-7
3-(4-bromophenyl)propionic acid

A: 14548-39-1
6-bromoindan-1-one

B: 3-(4-bromo-3-sulfo-phenyl)-propionic acid

Conditions

Conditions	Yield
With sulfuric acid

: 83-33-0
inden-1-one

A: 15115-60-3
4-bromo-2,3-dihydroinden-1-one

B: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
With aluminium trichloride; bromine 1.) 10 min, 2.) 80 deg C, 5 min; Yield given. Multistep reaction. Yields of byproduct given;
With hydrogenchloride; bromine; aluminium trichloride In tetrahydrofuran; hexane; water

: 1643-30-7
3-(4-bromophenyl)propionic acid

: 7664-93-9
sulfuric acid

: 14548-39-1
6-bromoindan-1-one

p-bromo-hydrocinnamic acid: p-bromo-hydrocinnamic acid

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
With sulfuric acid at 145℃; man giesst auf Eis;

: 198494-75-6
5-(4-bromo-benzyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: H2O / acetonitrile / 0.5 h / 120 °C / microwave irradiation 2: 98 percent / chlorosulfonic acid / 1 h / 0 °C View Scheme

: 1122-91-4
4-bromo-benzaldehyde

LiPh2InH2: LiPh2InH2

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 63 percent / triethylammonium formate 2: H2O / acetonitrile / 0.5 h / 120 °C / microwave irradiation 3: 98 percent / chlorosulfonic acid / 1 h / 0 °C View Scheme

: 1200-07-3, 5676-63-1, 17916-60-8
trans-4-bromocinnamic acid

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: H2 / Pd/C / methanol 2: (COCl)2 / CH2Cl2 3: aluminum trichloride / CH2Cl2 View Scheme

: 1122-91-4
4-bromo-benzaldehyde

(S)-(Fmoc-amino)-(4-fluoro-phenyl)-acetic acid on Wang resin: (S)-(Fmoc-amino)-(4-fluoro-phenyl)-acetic acid on Wang resin

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: piperidine / pyridine 2: H2 / Pd/C / methanol 3: (COCl)2 / CH2Cl2 4: aluminum trichloride / CH2Cl2 View Scheme

: 34598-49-7
5-Bromo-1-indanone

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 90 percent / sodium borohydride / methanol / 2 h / 20 °C 2: 92 percent / p-TsOH / benzene / 2 h / Heating 3: 28 percent / Pseudomonas putida UV4 / 7 h View Scheme

: 34598-50-0
5-bromo-1-indanol

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 92 percent / p-TsOH / benzene / 2 h / Heating 2: 28 percent / Pseudomonas putida UV4 / 7 h View Scheme

: 75476-86-7
6-Bromo-2,3-dihydro-1H-inden-1-ol

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 87 percent / p-TsOH / benzene / 2 h / Heating 2: 4 percent / Pseudomonas putida UV4 / 7 h View Scheme

: 70146-78-0
diethyl 2-(4-bromobenzyl)malonate

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: aq. KOH / 4.5 h / Heating 2: aq. H2SO4 / 18 h / Heating 3: (COCl)2; DMF / 18 h / 20 °C 4: AlCl3 / CH2Cl2 / 3.5 h / Heating View Scheme
Multi-step reaction with 4 steps 1: 95 percent / KOH / acetic acid; H2O; tetrahydrofuran 2: 85 percent / 165 °C 3: thionyl chloride 4: 91 percent / AlCl3 / CS2 View Scheme

: 92013-18-8
2-[(4-bromophenyl)methyl]propanedioic acid

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aq. H2SO4 / 18 h / Heating 2: (COCl)2; DMF / 18 h / 20 °C 3: AlCl3 / CH2Cl2 / 3.5 h / Heating View Scheme
Multi-step reaction with 3 steps 1: 85 percent / 165 °C 2: thionyl chloride 3: 91 percent / AlCl3 / CS2 View Scheme

: 589-15-1
1-bromomethyl-4-bromobenzene

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: NaH / 1,2-dimethoxy-ethane / 2 h / 20 °C 1.2: 57 percent / 1,2-dimethoxy-ethane / 18 h / Heating 2.1: aq. KOH / 4.5 h / Heating 3.1: aq. H2SO4 / 18 h / Heating 4.1: (COCl)2; DMF / 18 h / 20 °C 5.1: AlCl3 / CH2Cl2 / 3.5 h / Heating View Scheme
Multi-step reaction with 5 steps 1: 74 percent / NaOEt / Heating 2: 95 percent / KOH / acetic acid; H2O; tetrahydrofuran 3: 85 percent / 165 °C 4: thionyl chloride 5: 91 percent / AlCl3 / CS2 View Scheme
Multi-step reaction with 2 steps 1: trifluoroacetic acid; lithium diisopropyl amide / tetrahydrofuran 2: hydrogenchloride; thionyl chloride / aluminium trichloride / dichloromethane View Scheme

: 3650-78-0, 71205-17-9, 84878-00-2
methyl 4-bromocinnamate

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen; palladium 10% on activated carbon / methanol 2: trifluorormethanesulfonic acid / 25 °C / Cooling with ice View Scheme

: 75567-84-9
methyl 3-(4-bromopehynl)propanoate

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid at 25℃; Cooling with ice;

: 24623-24-3
6-nitroindan-1-one

: 14548-39-1
6-bromoindan-1-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: iron; ammonium chloride / water; ethanol / 80 °C 2.1: sodium nitrite; hydrogenchloride / water / 0 °C 2.2: 2 h / 0 - 20 °C View Scheme

: 14548-39-1
6-bromoindan-1-one

: 75476-86-7
6-Bromo-2,3-dihydro-1H-inden-1-ol

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol at 10 - 20℃; for 3h;	100%
With sodium borohydrid In methanol	99%
With methanol; sodium tetrahydroborate at 20℃; for 2h; Temperature; Concentration; Inert atmosphere;	99%

: 14548-39-1
6-bromoindan-1-one

: 1073-69-4
N-4-chlorophenylhydrazine

: N-(6-Bromo-indan-1-ylidene)-N'-(4-chloro-phenyl)-hydrazine

Conditions

Conditions	Yield
With acetic acid In ethanol for 0.5h; Heating / reflux;	100%

: 14548-39-1
6-bromoindan-1-one

: 98-80-6
phenylboronic acid

: 170497-64-0
6-phenyl-1-indanone

Conditions

Conditions	Yield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; benzene Suzuki coupling; Heating;	99%

: 14548-39-1
6-bromoindan-1-one

: 544-97-8
dimethyl zinc(II)

: 67159-88-0
6-bromo-1,1-dimethyl-2,3-dihydro-1H-indene

Conditions

Conditions	Yield
Stage #1: dimethyl zinc(II) With titanium tetrachloride In dichloromethane; toluene at -30 - 20℃; for 0.5h; Inert atmosphere; Stage #2: 6-bromoindan-1-one In dichloromethane; toluene at -10℃; for 4h;	99%
Stage #1: dimethyl zinc(II) With titanium(III) chloride In dichloromethane; toluene at 40℃; for 0.333333h; Stage #2: 6-bromoindan-1-one In dichloromethane; toluene at 20℃; for 18h;	94%
Stage #1: dimethyl zinc(II) With titanium tetrachloride In dichloromethane; toluene at 40℃; for 0.333333h; Stage #2: 6-bromoindan-1-one In dichloromethane; toluene at 20℃; for 18h;	94%

: 3144-09-0
methanesulfonamide

: 14548-39-1
6-bromoindan-1-one

: C10H11NO3S

Conditions

Conditions	Yield
With bis(η3-allyl-μ-chloropalladium(II)); potassium carbonate; tert-butyl XPhos In 1,4-dioxane at 80℃; for 3h; Inert atmosphere; Schlenk technique;	98%

: 14548-39-1
6-bromoindan-1-one

: potassium isopropenyltrifluoroborane

: C12H12O

Conditions

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate In 1,4-dioxane; water at 90℃; for 5h; Inert atmosphere; Sealed tube;	97%

: 14548-39-1
6-bromoindan-1-one

: 73183-34-3
bis(pinacol)diborane

: 915402-06-1
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1 H-inden-1-one

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In toluene at 90℃; for 12h; Inert atmosphere;	96%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In toluene at 90℃; for 12h; Inert atmosphere;	96%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In N,N-dimethyl-formamide at 100℃; for 1h; Microwave irradiation;	95%

: 14548-39-1
6-bromoindan-1-one

: 1779-49-3
Methyltriphenylphosphonium bromide

: 6-bromo-1-methylenyl-2,3-dihydro-1H-indene

Conditions

Conditions	Yield
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Stage #2: 6-bromoindan-1-one In tetrahydrofuran at 20℃; Inert atmosphere;	96%
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.583333h; Stage #2: 6-bromoindan-1-one In tetrahydrofuran at 20℃; for 1h; Stage #3: With water In tetrahydrofuran	93.4%
Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran; hexanes at 0℃; for 1h; Stage #2: 6-bromoindan-1-one In tetrahydrofuran; hexanes	62%
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran for 1h; Inert atmosphere; Cooling with ice; Stage #2: 6-bromoindan-1-one In tetrahydrofuran for 0.5h; Cooling with ice;	60%

: 14548-39-1
6-bromoindan-1-one

: 107-21-1
ethylene glycol

: 866848-94-4
6‘-bromo-2‘,3‘-dihydrospiro[[1,3]dioxolane-2,1‘-indene]

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene at 115℃; for 48h; Dean-Stark; Inert atmosphere;	95%
With toluene-4-sulfonic acid In benzene at 115℃; for 48h; Dean-Stark; Inert atmosphere;	95%
With toluene-4-sulfonic acid In benzene Heating;
With toluene-4-sulfonic acid In benzene for 24h; Heating / reflux;
With toluene-4-sulfonic acid In toluene at 125℃;	10.5 g

: 14548-39-1
6-bromoindan-1-one

: 74-88-4
methyl iodide

: 6-bromo-2,2-dimethyl-2,3-dihydro-1H-inden-1-one

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran; mineral oil at 23℃; for 16h; Inert atmosphere;	95%
Stage #1: 6-bromoindan-1-one; methyl iodide In tetrahydrofuran for 0.25h; Stage #2: With sodium hydride In tetrahydrofuran; water for 2.5h;	84%
Stage #1: 6-bromoindan-1-one; methyl iodide In tetrahydrofuran at 20℃; for 0.25h; Stage #2: With sodium hydride In tetrahydrofuran for 2h;	78.6%

: 14548-39-1
6-bromoindan-1-one

: 94839-07-3
3,4-(methylenedioxy)-benzeneboronic acid

: 6-benzo[1,3]dioxo-5-ylindan-1-one

Conditions

Conditions	Yield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; benzene Suzuki coupling; Heating;	94%

: 14548-39-1
6-bromoindan-1-one

: 67159-88-0
6-bromo-1,1-dimethyl-2,3-dihydro-1H-indene

Conditions

Conditions	Yield
Stage #1: With dimethyl zinc(II); titanium tetrachloride In dichloromethane; toluene at -40℃; for 0.333333h; Stage #2: 6-bromoindan-1-one In dichloromethane; toluene at -40 - 20℃; for 18h;	94%

: 14548-39-1
6-bromoindan-1-one

: 6-bromo-2,3-dihydro-1H-inden-1-one oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; potassium hydroxide In methanol; water for 3h; Reflux;	94%
With hydroxylamine hydrochloride In methanol for 1h; Heating;
With pyridine; hydroxylamine hydrochloride In ethanol at 20℃; for 2h;

: 14548-39-1
6-bromoindan-1-one

: 1039750-63-4
(S,E)-N-(1-(4-bromophenyl)ethylidene)-2-methylpropane-2-sulfinamide

: 1616493-88-9
C21H23Br2NO2S

Conditions

Conditions	Yield
Stage #1: 6-bromoindan-1-one With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.666667h; Inert atmosphere; Sealed tube; Stage #2: (S,E)-N-(1-(4-bromophenyl)ethylidene)-2-methylpropane-2-sulfinamide In tetrahydrofuran at -78℃; for 24h; Inert atmosphere; Sealed tube; diastereoselective reaction;	94%

: 14548-39-1
6-bromoindan-1-one

: 5122-94-1
4-biphenylboronic acid

: 6-biphenyl-4-ylindan-1-one

Conditions

Conditions	Yield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; benzene Suzuki coupling; Heating;	93%

: (SS)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide

: 14548-39-1
6-bromoindan-1-one

: 1556948-49-2
(S)-N-((S)-1-((S)-6-bromo-1-oxo-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroethyl)-2-methylpropane-2-sulfinamide

Conditions

Conditions	Yield
Stage #1: 6-bromoindan-1-one With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.666667h; Inert atmosphere; Stage #2: (SS)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide In tetrahydrofuran at -78℃; for 4h; Inert atmosphere; diastereoselective reaction;	93%

: 14548-39-1
6-bromoindan-1-one

: trans-2-(trifluoromethyl)cyclopropylboronic acid MIDA ester

: trans-6-(2-(trifluoromethyl)cyclopropyl)-2,3-dihydro-1H-inden-1-one

Conditions

Conditions	Yield
With potassium carbonate; ruphos; palladium diacetate In water; toluene at 100℃; Suzuki Coupling; Inert atmosphere; Sealed vial;	90%

: 14548-39-1
6-bromoindan-1-one

: trans-2-(trifluoromethyl)cyclopropylboronic diester of N-methyliminodiacetic acid

: trans-6-(2-(trifluoromethyl)cyclopropyl)-2,3-dihydro-1H-inden-1-one

Conditions

Conditions	Yield
With water; palladium diacetate; potassium carbonate; ruphos In toluene at 100℃; for 6h; Suzuki Coupling; Inert atmosphere;	90%

: 6165-68-0
thiophene boronic acid

: 14548-39-1
6-bromoindan-1-one

: 6-thiophen-2-ylindan-1-one

Conditions

Conditions	Yield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; benzene Suzuki coupling; Heating;	89%

: 14548-39-1
6-bromoindan-1-one

: 824-94-2
p-methoxybenzyl chloride

: 6-bromo-1-((4-methoxybenzyl)oxy)-2,3-dihydro-1H-indene

Conditions

Conditions	Yield
Stage #1: 6-bromoindan-1-one With sodium hydride In N,N-dimethyl-formamide at 4 - 23℃; for 1h; Stage #2: p-methoxybenzyl chloride In N,N-dimethyl-formamide at 10 - 23℃; for 14h;	87%

: 14548-39-1
6-bromoindan-1-one

: 74-89-5
methylamine

: 371251-07-9
6-bromo-N-methyl-2,3-dihydro-1H-inden-1-amine

Conditions

Conditions	Yield
Stage #1: 6-bromoindan-1-one; methylamine In methanol at 20℃; for 3.5h; Stage #2: With sodium tetrahydroborate In methanol at 20℃;	87%
Stage #1: 6-bromoindan-1-one; methylamine In methanol at 20℃; for 3.5h; Stage #2: With methanol; sodium tetrahydroborate at 20℃;

: 14548-39-1
6-bromoindan-1-one

: 33906-30-8, 52356-01-1
2-hydrazinobenzoic acid hydrochloride

: o-[(2,3-dihydro-6-bromoinden-3-ylidene)hydrazino]-benzoic acid

Conditions

Conditions	Yield
In ethanol; water at 20℃; for 1h;	86%

: 14548-39-1
6-bromoindan-1-one

: 124-40-3
dimethyl amine

: 371249-89-7
6-bromo-2,3-dihydro-N,N-dimethyl-1H-inden-1-amine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 120℃; for 0.0833333h; Microwave irradiation;	85%
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 120℃; for 0.0833333h; Product distribution / selectivity; Inert atmosphere; Microwave irradiation;	85%
Stage #1: 6-bromoindan-1-one; dimethyl amine In 1,2-dichloro-ethane Sealed tube; Stage #2: With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 120℃; for 0.0833333h; Product distribution / selectivity; Inert atmosphere; Microwave irradiation;	85%

: 14548-39-1
6-bromoindan-1-one

: 3,8,13-tribromo-10,15-dihydro-5H-diindeno[1,2-a:1',2'-c]fluorene

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; propionic acid In 1,2-dichloro-benzene at 105℃; for 16h;	84%
With toluene-4-sulfonic acid; propionic acid In 1,2-dichloro-benzene at 105℃; for 16h;	84%
With PPA at 120℃; for 12h;	24%

: 14548-39-1
6-bromoindan-1-one

: 844891-04-9
1,3,5-trimethylpyrazole-4-boronic acid pinacol ester

: 1096520-73-8
6-(1,3,5-Trimethyl-1 H-pyrazol-4-yl)-indan-1-one

Conditions

Conditions	Yield
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 100℃; for 3h;	84%

6-Bromoindanone Chemical Properties

Molecular Structure of 1H-Inden-1-one,6-bromo-2,3-dihydro- (CAS NO.14548-39-1):

IUPAC Name: 6-bromo-2,3-dihydroinden-1-one
Empirical Formula: C₉H₇BrO
Molecular Weight: 211.0553
H bond acceptors: 1
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 17.07 Å²
Index of Refraction: 1.622
Molar Refractivity: 46.24 cm³
Molar Volume: 131.2 cm³
Surface Tension: 49.9 dyne/cm
Density: 1.608 g/cm³
Flash Point: 111.6 °C
Enthalpy of Vaporization: 53.1 kJ/mol
Boiling Point: 291.6 °C at 760 mmHg
Vapour Pressure: 0.00193 mmHg at 25°C
InChI
InChI=1/C9H7BrO/c10-7-3-1-6-2-4-9(11)8(6)5-7/h1,3,5H,2,4H2
Smiles
c12C(CCc1ccc(c2)Br)=O
Melting point: 111-115 °C(lit.)
Product Categories: Benzocycles; pharmacetical; Pharmaceutical intermediate; C9; Carbonyl Compounds; Ketones

6-Bromoindanone Safety Profile

WGK Germany: 3

6-Bromoindanone Specification

1H-Inden-1-one,6-bromo-2,3-dihydro- , with CAS number of 14548-39-1, can be called 6-Bromo-2,3-dihydroinden-1-one ; 6-bromo-1-indanone ; 6-bromo-indan-1-one ; 6-bromo indanone ; 6-Bromo-1-indanone,98% ; 6-Brom-2,3-dihydro-1H-inden-1-on .It is a white to yellow crystalline powder or needles.

Product Name

6-Bromoindanone

Synthetic route

6-Bromoindanone Chemical Properties

6-Bromoindanone Safety Profile

6-Bromoindanone Specification

Related Products

Hot Products