9-Fluorenylmethyl carbazate supplier

Name
FMOC-HYDRAZIDE HCL
EINECS 624-360-9
CAS No. 35661-51-9
Article Data18
CAS DataBase
Density 1.26 g/cm³
Solubility
Melting Point ~170 °C (dec.)
Formula C₁₅H₁₄N₂O₂
Boiling Point 485.8 °C at 760 mmHg
Molecular Weight 254.288
Flash Point 247.6 °C
Transport Information
Appearance
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 9-Fluorenylmethoxycarbonylhydrazine;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]hydrazine;
PSA 64.35000
LogP 3.49000

Synthetic route

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

Conditions

Conditions	Yield
With hydrazine In water; acetonitrile at 0 - 20℃; for 14h;	99%
With hydrazine hydrate In water; acetonitrile at 0 - 20℃; for 14h;	99%
With hydrazine In diethyl ether at 20℃; Cooling with ice;	99%

: 2432-99-7
11-aminoundecanoic acid

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

Conditions

Conditions	Yield
With sodium carbonate In 1,4-dioxane; water pH=9; Reflux;	86%

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

Conditions

Conditions	Yield
With hydrazine hydrate In water; acetonitrile at 20℃;	46%
With hydrazine hydrate In water; acetonitrile

: 24324-17-2
9-Fluorenylmethanol

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CH2Cl2 2: aq. N2H4 / diethyl ether View Scheme

: 936015-89-3
C20H22N2O4

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 0℃; for 1.5h;

aqueous hydrazine: aqueous hydrazine

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

Conditions

Conditions	Yield
In diethyl ether; acetonitrile

: 16937-99-8
N-Boc-D-Leu

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 919527-94-9
(2R)-2-[(tert-butoxy)carbonylamino]-N-[(fluoren-9-ylmethoxy)carbonylamino]-4-methylpentanamide

Conditions

Conditions	Yield
With 2,3,4-lutidine; 1-hydroxy-7-aza-benzotriazole; diisopropyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 3h; Product distribution / selectivity;	100%
Stage #1: N-Boc-D-Leu With 2,4,6-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; diisopropyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: N-(9-fluorenylmethyloxycarbonyl)hydrazine In N,N-dimethyl-formamide for 5h; Product distribution / selectivity;	100%

: 500-22-1
3-pyridinecarboxaldehyde

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 1158960-29-2
(E)-(9H-fluoren-9-yl)methyl 2-(pyridin-3-ylmethylene)hydrazinecarboxylate

Conditions

Conditions	Yield
at 20℃; for 1.5h; Neat (no solvent); Ball-milling;	100%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 100-52-7
benzaldehyde

: 1111765-75-3
(E)-(9H-fluoren-9-yl)methyl-2-benzylidene hydrazinecarboxylate

Conditions

Conditions	Yield
at 20℃; for 1h; Neat (no solvent); Ball-milling;	100%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 90-02-8
salicylaldehyde

: 1338091-82-9
(E)-(9H-fluoren-9-yl)methyl 2-(2-hydroxybenzylidene)hydrazinecarboxylate

Conditions

Conditions	Yield
at 20℃; for 1h; Neat (no solvent); Ball-milling;	100%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 123-72-8
butyraldehyde

: 1338091-81-8
(E)-(9H-fluoren-9-yl)methyl 2-butylidenehydrazinecarboxylate

Conditions

Conditions	Yield
at 20℃; for 2h; Neat (no solvent); Ball-milling;	100%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 78-84-2
isobutyraldehyde

: 1426577-90-3
C19H20N2O2

Conditions

Conditions	Yield
In dichloromethane at 20℃;	100%
In ethanol Reflux;
In dichloromethane for 16h;	4.12 g

: 4926-12-9
4-(4-fluorophenyl)dihydropyran-2,6(3H)-dione

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 348110-32-7
5-[N'-(9H-fluoren-9-ylmethoxycarbonyl)-hydrazino]-5-oxo-3-(4-fluoro)-phenylpentanoic acid

Conditions

Conditions	Yield
In tetrahydrofuran for 16h; Heating;	99%

: 1137-61-7
3-(4-bromo)-phenylglutaric acid anhydride

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 348110-34-9
5-[N'-(9H-fluoren-9-ylmethoxycarbonyl)-hydrazino]-5-oxo-3-(4-bromo)-phenylpentanoic acid

Conditions

Conditions	Yield
In tetrahydrofuran for 16h; Heating;	99%

: 4160-80-9
3-phenylglutaric acid anhydride

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 320727-73-9
5-[N'-(9H-fluoren-9-ylmethoxycarbonyl)-hydrazino]-5-oxo-3-phenylpentanoic acid

Conditions

Conditions	Yield
In tetrahydrofuran for 16h; Heating;	99%
In tetrahydrofuran for 16h; Heating / reflux;

: 53911-68-5
3-(4-chlorophenyl)glutaric anhydride

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 348110-33-8
5-[N'-(9H-fluoren-9-ylmethoxycarbonyl)-hydrazino]-5-oxo-3-(4-chloro)-phenylpentanoic acid

Conditions

Conditions	Yield
In tetrahydrofuran for 16h; Heating;	99%

: 57171-24-1
3-(4-methoxyphenyl)glutaric anhydride

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 348110-35-0
5-[N'-(9H-fluoren-9-ylmethoxycarbonyl)-hydrazino]-5-oxo-3-(4-methoxy)-phenylpentanoic acid

Conditions

Conditions	Yield
In tetrahydrofuran for 16h; Heating;	99%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 348110-29-2
3-(3,5-dichloro)-phenylglutaric acid anhydride

: 348110-36-1
5-[N'-(9H-fluoren-9-ylmethoxycarbonyl)-hydrazino]-5-oxo-3-(3,5-dichloro)-phenylpentanoic acid

Conditions

Conditions	Yield
In tetrahydrofuran for 16h; Heating;	99%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 348110-30-5
3-(4-biphenyl)-glutaric acid anhydride

: 348110-37-2
5-[N'-(9H-fluoren-9-ylmethoxycarbonyl)-hydrazino]-5-oxo-3-(4-biphenyl)-pentanoic acid

Conditions

Conditions	Yield
In tetrahydrofuran for 16h; Heating;	99%

: 872-85-5
pyridine-4-carbaldehyde

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 1158960-30-5
C21H17N3O2

Conditions

Conditions	Yield
In dichloromethane	99%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 66-77-3
1-naphthaldehyde

: 1158960-21-4
C26H20N2O2

Conditions

Conditions	Yield
In dichloromethane	99%
In ethanol Reflux;

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 40015-15-4
1,1-dimethoxy-2-methylsulfanyl-ethane

: 2-(methylthio)acetaldehyde N-(9-fluorenylmethyloxycarbonyl)hydrazone

Conditions

Conditions	Yield
With trifluoroacetic acid In ethanol; water Reflux;	99%
With trifluoroacetic acid In ethanol; water Reflux;

: 924-44-7
glyoxylic acid ethyl ester

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: (9H-fluoren-9-yl)methyl (E)-2-(2-ethoxy-2-oxoethylidene)hydrazine-1-carboxylate

Conditions

Conditions	Yield
In toluene at 20℃; for 16h; Inert atmosphere;	99%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 3218-36-8
4-Phenylbenzaldehyde

: 1158960-23-6
C28H22N2O2

Conditions

Conditions	Yield
In dichloromethane	98%
In ethanol Reflux;

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 947528-28-1
N'-((S)-2-tert-Butoxycarbonylamino-propionyl)-hydrazine carboxylic acid 9H-fluoren-9-ylmethyl ester

Conditions

Conditions	Yield
Stage #1: L-N-Boc-Ala With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.5h; Stage #2: N-(9-fluorenylmethyloxycarbonyl)hydrazine In dichloromethane at 20℃;	97%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 15186-48-8
2,3-isopropylidene-glyceraldehyde

: C21H22N2O4

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 12h; optical yield given as %ee; stereoselective reaction;	97%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 459-57-4
4-fluorobenzaldehyde

: 1158960-26-9
C22H17FN2O2

Conditions

Conditions	Yield
In dichloromethane	97%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 66-99-9
β-naphthaldehyde

: 1158960-22-5
C26H20N2O2

Conditions

Conditions	Yield
In dichloromethane	97%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 3403-25-6
tert-butyl (2R)-2-amino-3-phenyl-propanoate hydrochloride

: C29H31N3O5

Conditions

Conditions	Yield
Stage #1: N-(9-fluorenylmethyloxycarbonyl)hydrazine With di(succinimido) carbonate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; for 1h; Inert atmosphere; Stage #2: tert-butyl (2R)-2-amino-3-phenyl-propanoate hydrochloride With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	97%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 3392-10-7
tert-butoxycarbonyl-L-proline N-hydroxysuccinimide ester

: 947528-18-9
(S)-2-[N'-(9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
In dichloromethane at 20℃;	96%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 642-31-9
9-anthracene aldehyde

: 1158960-27-0
C30H22N2O2

Conditions

Conditions	Yield
In dichloromethane	96%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 2043-61-0
cyclohexanecarbaldehyde

: 1158960-25-8
C22H24N2O2

Conditions

Conditions	Yield
In dichloromethane	96%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 947527-93-7
N'-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-hydrazine carboxylic acid 9H-fluoren-9-ylmethyl ester

Conditions

Conditions	Yield
Stage #1: N-tert-butoxycarbonyl-L-phenylalanine With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.5h; Stage #2: N-(9-fluorenylmethyloxycarbonyl)hydrazine In dichloromethane at 20℃;	95%

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 947528-12-3
N'-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoyl)-hydrazine carboxylic acid 9H-fluoren-9-ylmethyl ester

Conditions

Conditions	Yield
Stage #1: N-tert-butoxycarbonyl-L-leucine With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.5h; Stage #2: N-(9-fluorenylmethyloxycarbonyl)hydrazine In dichloromethane at 20℃;	95%

: 119-61-9
benzophenone

: 35661-51-9
N-(9-fluorenylmethyloxycarbonyl)hydrazine

: 1158960-24-7
C28H22N2O2

Conditions

Conditions	Yield
In dichloromethane	95%

9-Fluorenylmethyl carbazate Chemical Properties

Molecular Structure of 9-Fluorenylmethyl carbazate (CAS No.35661-51-9):

Molecular Formula: C₁₅H₁₄N₂O₂
Molecular Weight: 254.2839
CAS No: 35661-51-9
H bond acceptors: 4
H bond donors: 3
Freely Rotating Bonds: 4
Polar Surface Area: 32.78 Å²
Index of Refraction: 1.632
Molar Refractivity: 72.02 cm³
Molar Volume: 201.8 cm³
Surface Tension: 56.1 dyne/cm
Density: 1.259 g/cm³
Flash Point: 247.6 °C
Enthalpy of Vaporization: 75.14 kJ/mol
Boiling Point: 485.8 °C at 760 mmHg
Vapour Pressure: 1.37E-09 mmHg at 25°C
IUPAC Name: 9H-Fluoren-9-ylmethyl N-aminocarbamate
InChI: InChI=1/C₁₅H₁₄N₂O₂/c16-17-15(18)19-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9,16H2,(H,17,18)
InChIKey: YGCGPEUVGHDMLO-UHFFFAOYAQ
Std. InChI: InChI=1S/C₁₅H₁₄N₂O₂/c16-17-15(18)19-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9,16H2,(H,17,18)
Std. InChIKey: YGCGPEUVGHDMLO-UHFFFAOYSA-N

9-Fluorenylmethyl carbazate Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
F: 3-10

9-Fluorenylmethyl carbazate Specification

9-Fluorenylmethyl carbazate (CAS No.35661-51-9), its synonyms are 9H-Fluoren-9-ylmethyl hydrazinecarboxylate ; Hydrazinecarboxylic acid, 9H-fluoren-9-ylmethyl ester ; Fmoc-hydrazide .

Product Name

FMOC-HYDRAZIDE HCL

Synthetic route

9-Fluorenylmethyl carbazate Chemical Properties

9-Fluorenylmethyl carbazate Safety Profile

9-Fluorenylmethyl carbazate Specification

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