Conditions | Yield |
---|---|
With thionyl chloride at 100℃; for 5h; Substitution; | 100% |
With thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride In chloroform for 4h; Chlorination; Heating; | 85% |
With thionyl chloride at 75℃; for 2h; | 80% |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 77 percent / NaOH / H2O / 3 h / 110 - 120 °C 2: SOCl2 View Scheme | |
Multi-step reaction with 2 steps 1: 33percent aq. NaOH / 1 h / Heating 2: SOCl2 / CHCl3 / 6 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: aq. NaOH / 0.5 h / Heating 2: SOCl2 / benzene; ethyl acetate / 6 h / Heating View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: K2CO3; KI; PEG-600 / toluene / 1.5 h / 100 °C 1.2: 94 percent / HCl / H2O / 60 °C 2.1: 85 percent / SOCl2; benzyltriethylammonium chloride / CHCl3 / 4 h / Heating View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethyl acetate 2: thionyl chloride / 8 h / Heating View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaOH / H2O / Heating 2: SOCl2 / ethyl acetate; methanol / 7 h / Heating View Scheme |
A
2-hydroxyethyl 5-(2-chloro-4-trifluoromethyl phenoxy)-2-nitrobenzoate
B
2-(2,4-dichlorophenoxy)acetyl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane; ethylene glycol |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide 2: thionyl chloride / Reflux View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium hydroxide / methanol; water / 12 h / 50 °C 2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 12 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
With sodium hydroxide; PEG-600 In dichloromethane; water at 20℃; for 1h; Acylation; | 99% |
Conditions | Yield |
---|---|
With sodium hydroxide; PEG-600 In dichloromethane; water at 20℃; for 1h; Acylation; | 98% |
Conditions | Yield |
---|---|
With sodium hydroxide; PEG-600 In dichloromethane; water at 20℃; for 1h; Acylation; | 98% |
Conditions | Yield |
---|---|
With sodium hydroxide; PEG-600 In dichloromethane; water at 20℃; for 1h; Acylation; | 96% |
dimethyl (1-hydroxyethyl)phosphonate
2-(2,4-dichlorophenoxy)acetyl chloride
O,O-dimethyl α-(2,4-dichlorophenoxyacetoxy)ethylphosphonate
Conditions | Yield |
---|---|
With dmap; triethylamine In chloroform; toluene at -40 - -30℃; for 4h; Temperature; Solvent; Reagent/catalyst; Autoclave; Large scale; | 95.8% |
With organic base In chloroform at 20 - 40℃; for 5h; | 90.7% |
With pyridine In chloroform at 10 - 42℃; | 89% |
(Z)-2-chloro-N'-hydroxyethanimidamide
2-(2,4-dichlorophenoxy)acetyl chloride
O-(2,4-dichlorophenoxy)acetylchloroacetamidoxime
Conditions | Yield |
---|---|
With triethylamine In toluene | 95.1% |
2-(2,4-dichlorophenoxy)acetyl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 0.5h; | 94.6% |
2-(N,N-dimethylamino)ethanol
2-(2,4-dichlorophenoxy)acetyl chloride
(2,4-dichloro-phenoxy)-acetic acid-(2-dimethylamino-ethyl ester); hydrochloride
Conditions | Yield |
---|---|
In chloroform | 94% |
With chloroform | |
With benzene |
Conditions | Yield |
---|---|
With sodium hydroxide; PEG-600 In dichloromethane; water at 20℃; for 1h; Acylation; | 93% |
6-amino-4-methyl-2-(4-morpholinyl)quinoline
2-(2,4-dichlorophenoxy)acetyl chloride
Conditions | Yield |
---|---|
In dichloromethane for 3h; | 93% |
Conditions | Yield |
---|---|
With sodium hydroxide; PEG-600 In dichloromethane; water at 20℃; for 1h; Acylation; | 92% |
2-(2,4-dichlorophenoxy)acetyl chloride
2,4-dichlorophenoxyacetylhydrazine
Conditions | Yield |
---|---|
In tetrahydrofuran for 0.166667h; Time; Reagent/catalyst; Temperature; Microwave irradiation; | 92% |
3-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)propenone
2-(2,4-dichlorophenoxy)acetyl chloride
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0℃; for 12h; | 91.5% |
6-hydroxy-4'-methoxylaurone
2-(2,4-dichlorophenoxy)acetyl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 0.5h; | 91.2% |
2-(2,4-dichlorophenoxy)acetyl chloride
Conditions | Yield |
---|---|
In benzene for 0.5h; | 91% |
dimethyl α-hydroxy-α-(2-thienyl)methanephosphonate
2-(2,4-dichlorophenoxy)acetyl chloride
Conditions | Yield |
---|---|
In chloroform | 91% |
With organic base In chloroform at 20 - 40℃; for 5h; | 86.2% |
With pyridine In dichloromethane at 5℃; for 4h; | |
With pyridine In dichloromethane at 5℃; for 4h; |
4-hydroxy-3-ethoxybenzaldehyde
2-(2,4-dichlorophenoxy)acetyl chloride
C17H14Cl2O5
Conditions | Yield |
---|---|
With pyridine In benzene at 20 - 23℃; | 91% |
Conditions | Yield |
---|---|
With hydrogenchloride; magnesium chloride; triethylamine In acetonitrile | 91% |
6-hydroxy-4'-dimethylaminoaurone
2-(2,4-dichlorophenoxy)acetyl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 0.5h; | 90.8% |
2-benzylidene-6-hydroxybenzofuran-3(2H)-one
2-(2,4-dichlorophenoxy)acetyl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 0.5h; | 90.1% |
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
2-(2,4-dichlorophenoxy)acetyl chloride
(2,4-Dichloro-phenoxy)-acetic acid 6-hydroxymethyl-4-oxo-4H-pyran-3-yl ester
Conditions | Yield |
---|---|
With sodium hydroxide In water; acetone for 2h; Ambient temperature; | 90% |
1,7,7-trimethyl-bicyclo[2.2.1]heptane-2-one-oxime
2-(2,4-dichlorophenoxy)acetyl chloride
Conditions | Yield |
---|---|
With pyridine In benzene at 20 - 23℃; | 90% |
2-(2,4-dichlorophenoxy)acetyl chloride
Conditions | Yield |
---|---|
With sodium hydroxide In water; benzene | 90% |
2-(3,4-dimethoxybenzylidene)-6-hydroxybenzofuran-3(2H)-one
2-(2,4-dichlorophenoxy)acetyl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 0.5h; | 89.4% |
2-(2,4-dichlorophenoxy)acetyl chloride
5-Phenoxymethyl-3H-[1,3,4]oxadiazol-2-one
Conditions | Yield |
---|---|
for 0.5h; | 89% |
Diethyl-α-hydroxyethylphosphinoxid
2-(2,4-dichlorophenoxy)acetyl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 6h; | 89% |
2-(2,4-dichlorophenoxy)acetyl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; | 88.96% |
2-(2,4-dichlorophenoxy)acetyl chloride
O,O-dimethyl 1-[(2,4-dichlorophenoxy)acetoxy]-1-(pyridin-2-yl)methylphosphonate
Conditions | Yield |
---|---|
With triethylamine In chloroform at 0 - 40℃; | 88% |
With organic base In chloroform at 20 - 40℃; for 5h; | 82.5% |
dimethyl(furan-2-yl(hydroxy)methyl)phosphonate
2-(2,4-dichlorophenoxy)acetyl chloride
O,O-dimethyl (2,4-dichlorophenoxyacetoxy)(furan-2-yl)methylphosphonate
Conditions | Yield |
---|---|
In chloroform | 87% |
With organic base In chloroform at 20 - 40℃; for 5h; | 81.4% |
The Acetyl chloride,2-(2,4-dichlorophenoxy)- is an organic compound with the formula C8H5Cl3O2. The IUPAC name of this chemical is 2-(2,4-dichlorophenoxy)acetyl chloride. With the CAS registry number 774-74-3, it is also named as 2,4-Dichlorophenoxyacetyl chloride.
Physical properties about Acetyl chloride,2-(2,4-dichlorophenoxy)- are: (1)ACD/LogP: 3.32; (2)ACD/LogD (pH 5.5): 3.32; (3)ACD/LogD (pH 7.4): 3.32; (4)ACD/BCF (pH 5.5): 195.7; (5)ACD/BCF (pH 7.4): 195.7; (6)ACD/KOC (pH 5.5): 1520.29; (7)ACD/KOC (pH 7.4): 1520.29; (8)#H bond acceptors: 2; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 26.3 Å2; (11)Index of Refraction: 1.556; (12)Molar Refractivity: 52.23 cm3; (13)Molar Volume: 162.3 cm3; (14)Polarizability: 20.7×10-24cm3; (15)Surface Tension: 44.3 dyne/cm; (16)Density: 1.475 g/cm3; (17)Flash Point: 126.3 °C; (18)Enthalpy of Vaporization: 53.62 kJ/mol; (19)Boiling Point: 296.4 °C at 760 mmHg; (20)Vapour Pressure: 0.00144 mmHg at 25°C.
Preparation: this chemical can be prepared by (2,4-dichloro-phenoxy)-acetic acid. This reaction will need reagent SOCl2.
Uses of Acetyl chloride,2-(2,4-dichlorophenoxy)-: it can be used to produce N-(2-vinyloxyethyl)-2,4-dichlorophenoxyacetamide at temperature of 40 - 45 °C. It will need reagent Et3N and solvent benzene with reaction time of 30 min. The yield is about 62%.
You can still convert the following datas into molecular structure:
(1)SMILES: Clc1cc(Cl)ccc1OCC(Cl)=O
(2)InChI: InChI=1/C8H5Cl3O2/c9-5-1-2-7(6(10)3-5)13-4-8(11)12/h1-3H,4H2
(3)InChIKey: FUJSJWRORKKPAI-UHFFFAOYAT
(4)Std. InChI: InChI=1S/C8H5Cl3O2/c9-5-1-2-7(6(10)3-5)13-4-8(11)12/h1-3H,4H2
(5)Std. InChIKey: FUJSJWRORKKPAI-UHFFFAOYSA-N
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