Androsta-1,4-diene-3,17-dione supplier

Name
Androsta-1,4-diene-3,17-dione
EINECS 212-977-2
CAS No. 897-06-3
Article Data93
CAS DataBase
Density 1.14 g/cm³
Solubility 430mg/L at 20℃
Melting Point 138-139 °C(lit.)
Formula C₁₉H₂₄O₂
Boiling Point 434.2 °C at 760 mmHg
Molecular Weight 284.398
Flash Point 162.1 °C
Transport Information
Appearance White crystalline powder
Safety 26-36
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms 1,4-Androstadiendione;(+)-Androsta-1,4-diene-3,17-dione;1-Dehydroandrostenedione;Androsta-1,4-dien-3,17-dione;Androstadienedione;Androstane-1,4-diene-3,17-dione;Boldione;NSC 49080;D1,4-Androstadiene-3,17-dione;
PSA 34.14000
LogP 3.86340

Synthetic route

: 2-phenylseleno-4-androstene-3,17-dione

: 897-06-3
Androsta-1,4-diene-3,17-dione

Conditions

Conditions	Yield
With dihydrogen peroxide In dichloromethane for 4h;	90%

: 2α-phenylseleno-4-androstene-3,17-dione

: 897-06-3
Androsta-1,4-diene-3,17-dione

Conditions

Conditions	Yield
With dihydrogen peroxide In dichloromethane	90%

: 846-46-8
androstanedione

A: 897-06-3
Androsta-1,4-diene-3,17-dione

B: 571-40-4
5α-androst-1-ene-3,17-dione

Conditions

Conditions	Yield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In fluorobenzene; dimethyl sulfoxide at 70℃; for 24h;	A 4% B 84%
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In fluorobenzene; dimethyl sulfoxide at 70℃; for 24h; Dehydrogenation;	A 4% B 84%

: 63-05-8
Androstenedione

: 897-06-3
Androsta-1,4-diene-3,17-dione

Conditions

Conditions	Yield
With iodoxybenzene; benzeneseleninic anhydride In benzene for 12h; Heating;	72%
With diphenyl diselenide; iodosylbenzene In benzene for 12h; Heating;	72%
With periodic acid

: 57334-04-0
3-thioxo-androst-1,4-dien-17-on

: 897-06-3
Androsta-1,4-diene-3,17-dione

Conditions

Conditions	Yield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane for 8h; Ambient temperature;	72%

: 846-46-8
androstanedione

: 897-06-3
Androsta-1,4-diene-3,17-dione

Conditions

Conditions	Yield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In fluorobenzene; dimethyl sulfoxide at 85℃; for 48h;	72%
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In fluorobenzene; dimethyl sulfoxide at 85℃; for 48h; Dehydrogenation;	72%
Multi-step reaction with 2 steps 1: HBr; acetic acid; bromine / anschliessend Erwaermen auf 50grad View Scheme
Multi-step reaction with 2 steps 1: 3-ketosteroid Δ4-(5α)-dehydrogenase / Enzymatic reaction 2: 3-ketosteroid Δ1-dehydrogenase / Enzymatic reaction View Scheme

: 57-88-5
cholesterol

A: 63-05-8
Androstenedione

B: 897-06-3
Androsta-1,4-diene-3,17-dione

C: 40736-33-2
(20S)-20-hydroxymethylpregn-4-en-3-one

D: 80981-37-9
24-norchol-4-ene-3,22-dione

E: 80981-38-0
24-norchola-1,4-diene-3,22-dione

F: 35525-27-0
(20S)-20-(hydroxymethyl)pregna-1,4-dien-3-one

Conditions

Conditions	Yield
Product distribution; degradation by the Mycobacterium mutant CCM 3528;	A n/a B 0.20 g C n/a D 0.36 g E 1.21 g F 71%

...Expand

: 846-48-0
1-dehydrotestosterone

: 897-06-3
Androsta-1,4-diene-3,17-dione

Conditions

Conditions	Yield
for 336h; Rhodotorula mucilaginosa;	54%

: 57-83-0
Progesterone

A: 58-22-0
testosterone

B: 63-05-8
Androstenedione

C: 897-06-3
Androsta-1,4-diene-3,17-dione

D: 4416-57-3
testololactone

Conditions

Conditions	Yield
With Fusarium dimerum In water at 30℃; for 36h; pH=7; Product distribution; Further Variations:; Reagents; pH-values; var. times;	A 17.4% B 52.6% C 12.4% D 6.2%

...Expand

: 57-88-5
cholesterol

A: 58-22-0
testosterone

B: 63-05-8
Androstenedione

C: 897-06-3
Androsta-1,4-diene-3,17-dione

D: 846-48-0
1-dehydrotestosterone

E: 79694-52-3
2-[(8S,9S,10R,13S,14S)-10,13-Dimethyl-3-oxo-3,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-cyclopenta[a]phenanthren-(17Z)-ylidene]-propionic acid methyl ester

F: 71658-22-5
22-hydroxy-23,24-bisnor-1,4-choladien-3-one

Conditions

Conditions	Yield
With Mycobacterium sp. CCM 3529 Product distribution;	A 0.01 g B 0.03 g C 51% D 0.06 g E n/a F 0.38 g

...Expand

: 83-46-5
β-sitosterol

A: 897-06-3
Androsta-1,4-diene-3,17-dione

B: 3614-61-7, 5327-60-6, 66512-12-7, 96686-97-4, 14508-05-5
23,24-Bisnorchola-1,4-dien-3-one-22-carboxylic acid

Conditions

Conditions	Yield
With 8-quinolinol In water; N,N-dimethyl-formamide for 96h; Myc. lacticola 114;	A 5% B 47%

: 83-46-5
β-sitosterol

A: 63-05-8
Androstenedione

B: 897-06-3
Androsta-1,4-diene-3,17-dione

C: 3614-61-7, 5327-60-6, 66512-12-7, 96686-97-4, 14508-05-5
23,24-Bisnorchola-1,4-dien-3-one-22-carboxylic acid

D: 1058-61-3
stigmast-4-en-3-one

Conditions

Conditions	Yield
With 8-quinolinol In water; N,N-dimethyl-formamide at 27℃; for 72h; Product distribution; Myc. mucosum 3-AP, pH = 7.2 - 7.7; other strains of bacteria, other pH, other temperatures, other inhibitors, other time, different age of bacteria culture, different concentration of substrate;	A 0% B 12% C 44.1% D 22%

...Expand

: 83-46-5
β-sitosterol

A: 897-06-3
Androsta-1,4-diene-3,17-dione

B: 3614-61-7, 5327-60-6, 66512-12-7, 96686-97-4, 14508-05-5
23,24-Bisnorchola-1,4-dien-3-one-22-carboxylic acid

C: 1058-61-3
stigmast-4-en-3-one

Conditions

Conditions	Yield
With 8-quinolinol In water; N,N-dimethyl-formamide for 72h; Myc. mucosum 3-AP;	A 12% B 44.1% C 22%

...Expand

: 53-43-0
dehydroepiandrosterone

A: 633-34-1
androst-4,6-diene-3,17-dione

B: 571-36-8
5-androstenedione

C: 897-06-3
Androsta-1,4-diene-3,17-dione

Conditions

Conditions	Yield
With 2,2'-bipyridylchromium peroxide In benzene for 3h; Product distribution; Heating; effect of various chromium(VI) based oxidants;	A 40% B 10% C 8%
With 2,2'-bipyridylchromium peroxide In benzene for 3h; Heating;	A 40% B 10% C 8%

...Expand

: 83-46-5
β-sitosterol

A: 63-05-8
Androstenedione

B: 897-06-3
Androsta-1,4-diene-3,17-dione

Conditions

Conditions	Yield
With [2,2]bipyridinyl In water; N,N-dimethyl-formamide for 72h; Myc. flavum var. methanicum B5;	A 4% B 35%

: 481-29-8
Epiandrosterone

A: 58-22-0
testosterone

B: 25848-75-3
3β,11α-dihydroxy-5α-androstan-17-one

C: 25848-68-4
3beta-7alpha-Dihydroxy-5alpha-androstane-17-one

D: 25848-69-5
3beta-7beta-Dihydroxy-5alpha-androstane-17-one

E: 2260-01-7
1α,3β-dihydroxy-5α-androstan-17-one

F: 897-06-3
Androsta-1,4-diene-3,17-dione

G: 846-48-0
1-dehydrotestosterone

H: 62-99-7, 2944-87-8, 34096-63-4, 34442-08-5, 145772-79-8
6β-hydroxytestosterone

I: 571-40-4
5α-androst-1-ene-3,17-dione

J: 63-00-3
6β-hydroxy-4-androstene-3,17-dione

Conditions

Conditions	Yield
With malt extract; disodium hydrogenphosphate; calcium(II) chloride dihydrate; magnesium(II) chloride hexahydrate; strontium (III) chloride hexahydrate; potassium chloride; boric acid; sodium hydrogencarbonate; sodium sulfate; sodium chloride; potassium bromide; potassium hydroxide In water; N,N-dimethyl-formamide at 32℃; for 168h; pH=8; Enzymatic reaction;	A 2% B 2% C 2% D 3% E 5% F 5% G 3% H 2% I 2% J 32%

...Expand

: Dithiocarbonic acid O-((8S,9S,10R,11R,13S,14S,17S)-17-acetyl-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-11-yl) ester S-methyl ester

A: 897-06-3
Androsta-1,4-diene-3,17-dione

B: 83568-64-3
1-{(1S,3aS,4R,7aS)-4-[2-(5-Hydroxy-2-methyl-phenyl)-ethyl]-7a-methyl-2,3,3a,4,7,7a-hexahydro-1H-inden-1-yl}-ethanone

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In toluene for 40h; Heating;	A 25% B 25%

: 57-88-5
cholesterol

A: 63-05-8
Androstenedione

B: 601-57-0
Cholest-4-en-3-one

C: 897-06-3
Androsta-1,4-diene-3,17-dione

Conditions

Conditions	Yield
With [2,2]bipyridinyl; Moraxella sp at 28℃; for 72h;	A 23% B n/a C 7%

...Expand

: 57-88-5
cholesterol

A: 63-05-8
Androstenedione

B: 897-06-3
Androsta-1,4-diene-3,17-dione

Conditions

Conditions	Yield
With [2,2]bipyridinyl; Moraxella sp at 28℃; for 72h;	A 23% B 7%

: 57334-04-0
3-thioxo-androst-1,4-dien-17-on

A: 897-06-3
Androsta-1,4-diene-3,17-dione

B: 167956-32-3
1-Mercapto-4-methylestra-1,3,5(10)-trien-17-on

Conditions

Conditions	Yield
With hydrogen bromide for 240h; Ambient temperature;	A 5% B 10%

: 110-86-1
pyridine

: 42453-26-9
5α-androstan-2α,4α-dibromo-3,17-dione

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 108-75-8
2,4,6-trimethyl-pyridine

: 42453-26-9
5α-androstan-2α,4α-dibromo-3,17-dione

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 57-83-0, 851-22-9, 2000-66-0, 2755-10-4, 3562-13-8, 3795-19-5, 5750-05-0, 14546-13-5, 36027-73-3, 36027-74-4, 55122-80-0, 56271-98-8, 59952-90-8, 73889-98-2, 137940-28-4
progesterone

: 897-06-3
Androsta-1,4-diene-3,17-dione

Conditions

Conditions	Yield
With fusarium solani

: 521-17-5, 1963-03-7, 4593-57-1, 4593-58-2, 14504-94-0, 16895-59-3, 47122-33-8, 64162-67-0, 75767-22-5, 139973-51-6, 151284-19-4
5-androstenediol

: 897-06-3
Androsta-1,4-diene-3,17-dione

Conditions

Conditions	Yield
With corynebacterium simplex

: 20998-18-9
1α,3β-dihydroxy-androst-5-en-17-one

: 897-06-3
Androsta-1,4-diene-3,17-dione

Conditions

Conditions	Yield
With cyclohexanone; aluminum isopropoxide; toluene

: 846-48-0
1-dehydrotestosterone

: 108-94-1
cyclohexanone

: 897-06-3
Androsta-1,4-diene-3,17-dione

Conditions

Conditions	Yield
With aluminum isopropoxide; toluene

: 1229-12-5
androstane-3,17-dione

A: 63-05-8
Androstenedione

B: 897-06-3
Androsta-1,4-diene-3,17-dione

C: 571-39-1
5β-Androst-1-ene-3,17-dione

Conditions

Conditions	Yield
With Phenylselenyl chloride; dihydrogen peroxide Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 846-46-8
androstanedione

A: 63-05-8
Androstenedione

B: 897-06-3
Androsta-1,4-diene-3,17-dione

C: 571-40-4
5α-androst-1-ene-3,17-dione

Conditions

Conditions	Yield
With Phenylselenyl chloride; dihydrogen peroxide Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 5779-62-4, 83-46-5, 83-47-6, 19044-06-5, 31793-83-6, 125636-84-2, 130062-49-6
β-sitosterol

A: 897-06-3
Androsta-1,4-diene-3,17-dione

B: 71154-85-3
23,24-Bisnorchola-1,4-dien-3-on-22-oic acid

Conditions

Conditions	Yield
With 8-quinolinol; Myc. mucosum 3-AP In N,N-dimethyl-formamide for 72h; Product distribution; other mycobacteria, various media for cultivation of mycobacteria;

: 138430-08-7
bis-(3α,17β-dihydroxyandrost-5-en-1α-yl) disulphide

: 897-06-3
Androsta-1,4-diene-3,17-dione

Conditions

Conditions	Yield
Yield given. Multistep reaction;

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 4α,5α-Epoxy-1-androstene-3,17-dione

Conditions

Conditions	Yield
With C16H16F6FeN4O6S2; dihydrogen peroxide; acetic acid In acetonitrile at 20℃; for 0.166667h; stereoselective reaction;	100%

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 17α-cyano-17β-hydroxyandrost-1,4-dien-3-one

Conditions

Conditions	Yield
With sodium carbonate In water at 20 - 50℃; Temperature; Solvent; Reagent/catalyst;	98.6%
With sodium carbonate In water at 20 - 45℃; Solvent; Reagent/catalyst;	98.6%

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 143613-55-2, 143679-02-1
(E)-(8R,9S,10R,13S,14S,8'R,9'S,10'R,13'S,14'S)-10,13,10',13'-Tetramethyl-7,8,9,10,11,12,13,14,15,16,7',8',9',10',11',12',13',14',15',16'-icosahydro-6H,6'H-[3,3']bi[cyclopenta[a]phenanthrenylidene]-17,17'-dione

Conditions

Conditions	Yield
With zinc In tetrahydrofuran for 10h; Heating; other substrates;	97%
With zinc In tetrahydrofuran for 10h; Heating;	97%
With titanium; chloro-trimethyl-silane In 1,2-dimethoxyethane for 1h; Heating;	84%

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 57334-04-0
3-thioxo-androst-1,4-dien-17-on

Conditions

Conditions	Yield
With Lawessons reagent In tetrahydrofuran for 1h; Ambient temperature;	96%
With Lawessons reagent In tetrahydrofuran for 1h; Ambient temperature; various steroides;	96%
With tetraphosphorus decasulfide

: 897-06-3
Androsta-1,4-diene-3,17-dione

: Androsta-1,4-dien-3,17-dion-17-hydrazon

Conditions

Conditions	Yield
With sodium acetate; hydrazinium sulfate In ethanol for 72h; Ambient temperature;	95%

: 74-83-9
methyl bromide

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 72-63-9
metandienone

Conditions

Conditions	Yield
Stage #1: methyl bromide With magnesium In tetrahydrofuran at 40 - 45℃; Stage #2: Androsta-1,4-diene-3,17-dione In toluene at 50 - 55℃;	94.6%
Stage #1: methyl bromide With magnesium In tetrahydrofuran at 40 - 45℃; Stage #2: Androsta-1,4-diene-3,17-dione In toluene at 50 - 55℃;	94.6%
Stage #1: methyl bromide With magnesium In tetrahydrofuran at 40 - 45℃; Stage #2: Androsta-1,4-diene-3,17-dione In toluene at 50 - 55℃; Stage #3: With hydrogenchloride In water at 50 - 55℃; pH=2 - 3;	93.8%

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 75-24-1
trimethylaluminum

A: 51503-64-1
5β-methylandrost-1-ene-3,17-dione

B: 4136-62-3
1α-methyl-androst-4-ene-3,17-dione

Conditions

Conditions	Yield
With chloro-trimethyl-silane; copper(I) bromide In tetrahydrofuran; toluene for 2h; Ambient temperature;	A 2.6% B 93%

...Expand

: 74-87-3
methylene chloride

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 72-63-9
metandienone

Conditions

Conditions	Yield
Stage #1: methylene chloride With magnesium In tetrahydrofuran at 30 - 35℃; Stage #2: Androsta-1,4-diene-3,17-dione In tetrahydrofuran at 50 - 55℃;	92.5%
Stage #1: methylene chloride With magnesium In tetrahydrofuran at 30 - 35℃; Stage #2: Androsta-1,4-diene-3,17-dione In tetrahydrofuran at 50 - 55℃;	92.5%
Stage #1: methylene chloride With magnesium In tetrahydrofuran at 30 - 35℃; Stage #2: Androsta-1,4-diene-3,17-dione In tetrahydrofuran at 50 - 55℃; Stage #3: With hydrogenchloride In water at 50 - 55℃; pH=2 - 3;	92.5%

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 645-96-5
Benzeneselenol

: (1S,8S,9S,10R,13S,14S)-10,13-dimethyl-1-(phenylselanyl)-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]-phenanthrene-3,17(2H,6H)-dione

Conditions

Conditions	Yield
With γ-cyclodextrin; sodium hydride In water; acetone at 20℃; for 6h;	92%

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 74-88-4
methyl iodide

: 72-63-9
metandienone

Conditions

Conditions	Yield
Stage #1: methyl iodide With magnesium In diethyl ether at 30 - 35℃; Stage #2: Androsta-1,4-diene-3,17-dione In benzene at 50 - 55℃;	90.8%
Stage #1: methyl iodide With magnesium In diethyl ether at 30 - 35℃; Stage #2: Androsta-1,4-diene-3,17-dione In benzene at 50 - 55℃;	90.8%
Stage #1: methyl iodide With magnesium In diethyl ether at 30 - 35℃; Stage #2: Androsta-1,4-diene-3,17-dione In benzene at 50 - 55℃; Stage #3: With hydrogenchloride In water at 50 - 55℃; pH=2 - 3;	90.8%

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 79037-28-8
[1α,2α-2H2]androst-4-ene-3,17-dione

Conditions

Conditions	Yield
With water-d2; Wilkinson's catalyst In benzene-d6 at 20℃; for 1h;	90.2%

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 97-93-8
triethylaluminum

A: 148928-50-1
1α-ethylandrost-4-ene-3,17-dione

B: 5β-ethylandrost-1-ene-3,17-dione

Conditions

Conditions	Yield
With chloro-trimethyl-silane; copper(I) bromide In tetrahydrofuran; toluene for 2h; Ambient temperature;	A 90% B n/a

...Expand

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 16α,16β-dideuterium-1,4-androstenedione

Conditions

Conditions	Yield
With water-d2; potassium carbonate In tetrahydrofuran for 24h; Reflux;	90%

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 75-24-1
trimethylaluminum

: 4136-62-3
1α-methyl-androst-4-ene-3,17-dione

Conditions

Conditions	Yield
With chloro-trimethyl-silane; copper(I) bromide In tetrahydrofuran for 2h; Ambient temperature;	89%
copper(I) bromide In 1,4-dioxane; water; toluene
copper(I) bromide In 1,4-dioxane; water; toluene
With chloro-trimethyl-silane; copper(I) bromide In tetrahydrofuran; water; toluene

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 97-93-8
triethylaluminum

: 148928-50-1
1α-ethylandrost-4-ene-3,17-dione

Conditions

Conditions	Yield
With chloro-trimethyl-silane; copper(I) bromide In tetrahydrofuran; water; toluene	89%
With chloro-trimethyl-silane; copper(I) bromide In tetrahydrofuran for 1h; Ambient temperature;	87%
copper(I) bromide In 1,4-dioxane; hexane; water	85%
copper(I) bromide In 1,4-dioxane; hexane; water	85%

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 507-09-5
thioacetic acid

: 111611-76-8
S-((1S,8S,9S,10R,13S,14S)-10,13-dmethyl-3,17-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta-[a]phenanthren-1-yl) ethanethioate

Conditions

Conditions	Yield
In tetrahydrofuran; methanol; water at 20℃; for 12h; Inert atmosphere;	89%

: 358-23-6
trifluoromethylsulfonic anhydride

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 95667-41-7
androsten-3,5-dienyl-17-one 3-triflate

Conditions

Conditions	Yield
With 2,6-di-tert-butyl-4-methylpyridine In dichloromethane for 4h; Ambient temperature;	88%

: 67-62-9
O-Methylhydroxylamin

: 897-06-3
Androsta-1,4-diene-3,17-dione

: Androsta-1,4-dien-3,17-dion-17-(O-methyloxim)

Conditions

Conditions	Yield
With sodium acetate In ethanol for 120h; Ambient temperature;	85%

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 63-05-8
Androstenedione

Conditions

Conditions	Yield
With sodium hydroxide; iron pentacarbonyl In methanol; water at 50 - 60℃; for 16h;	85%
With thallium(III) nitrate trihydrate In diethylene glycol dimethyl ether for 24h; Ambient temperature;	29%
With hydrogen; silica gel; copper In toluene at 60℃; under 760 Torr; for 5h;

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 968-93-4
testolactone

Conditions

Conditions	Yield
With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; Baeyer-Villiger Ketone Oxidation;	85%
With Fusarium oxysporum SC1301 In dimethyl sulfoxide at 30℃; for 15h;	82%

: 897-06-3
Androsta-1,4-diene-3,17-dione

: (10R,13S)-17-(hydroxyimino)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium acetate In ethanol; water for 6h; Inert atmosphere; Reflux;	84.4%
With hydroxylamine hydrochloride; sodium hydroxide In ethanol; water for 1.5h; Reflux;

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 21749-63-3
2-(methylamino)benzenethiol

: 3'-Methylspiro-17-on

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In chloroform 1) RT, 2h, 2) 50 deg C, 32 h;	84%

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 930-69-8
sodium thiophenolate

: 108-98-5
thiophenol

: (1S,8S,9S,10R,13S,14S)-10,13-Dimethyl-1-(phenylthio)-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]-phenanthrene-3,17(2H,6H)-dione

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 48h; Inert atmosphere;	83%

...Expand

: 897-06-3
Androsta-1,4-diene-3,17-dione

A: 97455-05-5
1β,2β-Epoxy-4-androstene-3,17-dione

B: 4α,5α-Epoxy-1-androstene-3,17-dione

C: 4β,5β-Epoxy-1-androstene-3,17-dione

D: 1α,2α-Epoxy-4-androstene-3,17-dione

Conditions

Conditions	Yield
With 3,3-dimethyldioxirane In dichloromethane; acetone at 20℃; for 28h; Title compound not separated from byproducts;	A 1.2 % Spectr. B 12 % Spectr. C 81% D 5.8 % Spectr.
With 3,3-dimethyldioxirane In dichloromethane; acetone at 20℃; for 28h;	A 1.2 % Spectr. B 12 % Spectr. C 81% D 5.8 % Spectr.

...Expand

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 74087-85-7
3,3-dimethyldioxirane

: 4β,5β-Epoxy-1-androstene-3,17-dione

Conditions

Conditions	Yield
In acetone at 23℃; Kinetics;	81%

: 1199-01-5
2-phenylazlactone

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 106193-55-9
3-<5-Oxo-2-phenyl-1,3-oxazol-4(5H)-yliden>-1,4-androstadien-17-on

Conditions

Conditions	Yield
With pyridine; titanium tetrachloride In tetrahydrofuran; tetrachloromethane 1.) 0-5 deg C, 20 min.; 2.) 2 h, room temp.;	80%

: 897-06-3
Androsta-1,4-diene-3,17-dione

: 563-41-7
semicarbazide hydrochloride

: Androsta-1,4-dien-3,17-dion-17-semicarbazon

Conditions

Conditions	Yield
With sodium acetate In ethanol for 120h; Ambient temperature;	80%

Androsta-1,4-diene-3,17-dione Chemical Properties

IUPAC Name: (8R,9S,10R,13S,14S)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione
Synonyms of Androsta-1,4-diene-3,17-dione (CAS NO.897-06-3): Boldione ; 1,4-Androstadiene-3,17-dione ; 1-Dehydroandrostenedione ; Androstadienedione ; EINECS 212-977-2 ; NSC 49080
CAS NO: 897-06-3
Classification Code: Hormone ; Reproductive Effect
Molecular Formula of Androsta-1,4-diene-3,17-dione (CAS NO.897-06-3): C₁₉H₂₄O₂
Molecular Weight: 284.3927
Molecular Structure:

Melting Point: 138-139 °C
Polar Surface Area: 34.14 Å²
Index of Refraction: 1.568
Molar Refractivity: 81.62 cm³
Molar Volume: 249.2 cm³
Surface Tension: 43.8 dyne/cm
Density of Androsta-1,4-diene-3,17-dione (CAS NO.897-06-3): 1.14 g/cm³
Flash Point: 162.1 °C
Enthalpy of Vaporization: 69.03 kJ/mol
Boiling Point: 434.2 °C at 760 mmHg
Vapour Pressure: 9.62E-08 mmHg at 25°C

Androsta-1,4-diene-3,17-dione Uses

Androsta-1,4-diene-3,17-dione (CAS NO.897-06-3) is used as boldenone related steroid; anabolic androgenic steroid.

Androsta-1,4-diene-3,17-dione Safety Profile

Hazard Codes: Harmful Xn
Risk Statements: 20/21/22-36/37/38
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: BV7988000

Product Name

Androsta-1,4-diene-3,17-dione

Synthetic route

Androsta-1,4-diene-3,17-dione Chemical Properties

Androsta-1,4-diene-3,17-dione Uses

Androsta-1,4-diene-3,17-dione Safety Profile

Related Products

Hot Products