Bromoform supplier | CasNO.75-25-2

Name
Bromoform
EINECS 200-854-6
CAS No. 75-25-2
Article Data209
CAS DataBase
Density 2.997 g/cm³
Solubility 3.2 g/L at 30 °C in water
Melting Point 8 °C
Formula CHBr₃
Boiling Point 149.2 °C at 760 mmHg
Molecular Weight 252.731
Flash Point 44 °C
Transport Information UN 2515 6.1/PG 3
Appearance colourless to yellow liquid
Safety 28-45-61-28A-36/37-16-7
Risk Codes 23-36/38-51/53-22-39/23/24/25-23/24/25-11
Molecular Structure
Hazard Symbols T, N, F
Synonyms Methenyl tribromide;NSC 8019;Tribromomethane;Tribromomethane;Methyl tribromide;Tribrommethan;NCI-C55130;CCRIS 98;
PSA 0.00000
LogP 2.45470

Synthetic route

: 941-98-0
1'-naphthacetophenone

A: 75-25-2
Bromoform

B: 2459-24-7
methyl 1-naphthoate

C: 149-73-5
trimethyl orthoformate

Conditions

Conditions	Yield
With methanol; sodium bromide at 30℃; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	A n/a B 88% C n/a

...Expand

: 100-06-1
1-(4-methoxyphenyl)ethanone

A: 75-25-2
Bromoform

B: 121-98-2
methyl 4-methoxybenzoate

C: 149-73-5
trimethyl orthoformate

Conditions

Conditions	Yield
With methanol; sodium bromide at 30℃; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	A n/a B 85% C n/a

...Expand

: 281-23-2
adamantane

: 75-05-8
acetonitrile

A: 768-90-1
1-Adamantyl bromide

B: 75-25-2
Bromoform

C: 23074-42-2
1-adamantanecarbonitrile

Conditions

Conditions	Yield
With carbon tetrabromide; molybdenum hexacarbonyl at 140 - 160℃; for 6h; Reactivity; Mechanism; Reagent/catalyst;	A 15% B n/a C 85%

...Expand

: 558-13-4
carbon tetrabromide

A: 594-73-0
hexabromoethane

B: 75-25-2
Bromoform

Conditions

Conditions	Yield
With 2+ In water; acetonitrile at 20℃; Mechanism; Rate constant; Product distribution;	A 4% B 84%
With Co(II)W12O407-; sodium perchlorate In water; acetonitrile at 20℃; for 2h; Rate constant; Product distribution; pH 7; reaction in MeCN/D2O; reaction between CBr4 and the heteropoly blues Co(II)W12O407- and Co(II)W12O408-, kinetic and product stidy, effect of inert salts,;	A 1 % Spectr. B 77 % Spectr.

: 122-00-9
para-methylacetophenone

A: 99-75-2
4-methyl-benzoic acid methyl ester

B: 75-25-2
Bromoform

C: 149-73-5
trimethyl orthoformate

Conditions

Conditions	Yield
With methanol; sodium bromide at 30℃; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	A 83% B n/a C n/a

...Expand

: 98-86-2
acetophenone

A: 93-58-3
benzoic acid methyl ester

B: 75-25-2
Bromoform

C: 149-73-5
trimethyl orthoformate

Conditions

Conditions	Yield
With methanol; sodium bromide at 30℃; for 4h; Product distribution; Mechanism; electrolysis (Pt-anode, Cu-Zn (60:40) cathode, 220 mA/cm2 constant current); other electrolyte, other electrolyte-to-substrate ratio, other material of electrodes;	A 74% B n/a C 15%
With methanol; sodium bromide at 30℃; for 4h; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	A 74% B n/a C n/a

...Expand

: 592-41-6
1-hexene

: 558-13-4
carbon tetrabromide

A: 75-25-2
Bromoform

B: 3740-44-1
1,1,1,3-tetrabromoheptane

C: 90278-16-3
1,1,3-tribromoheptane

D: 5,7,7,9-tetrabromotridecane

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile) at 80℃; for 4h; Product distribution; further reagent, further conditions;	A 3.7% B 70% C 10.1% D 9.1%
With 2,2'-azobis(isobutyronitrile) at 80℃; for 4h;	A 3.7% B 70% C 10.1% D 9.1%

...Expand

: 29949-72-2
di(tert-butyl)(n-butyl)phosphine

A: 75-25-2
Bromoform

B: 81193-50-2
butyl-di-t-butylchlorophosphonium bromide

Conditions

Conditions	Yield
With carbon tetrabromide; hydrogen chloride In diethyl ether 1) -120 deg C to -50 deg C 2) 0 deg C, Et2O;	A 70% B 70%

: 563-80-4
3-methyl-butan-2-one

A: 75-25-2
Bromoform

B: 547-63-7
Methyl isobutyrate

C: 149-73-5
trimethyl orthoformate

Conditions

Conditions	Yield
With methanol; sodium bromide at 30℃; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	A n/a B 67% C n/a

...Expand

: 106053-65-0
4,5-Dimethoxy-2-(2-phenylethyl)acetophenon

A: 75-25-2
Bromoform

B: 106053-67-2
2-Brom-4,5-dimethoxybibenzyl

C: 106053-50-3
4,5-Dimethoxy-2-(2-phenylethyl)benzoesaeure

Conditions

Conditions	Yield
With sodium hydroxide; bromine In 1,4-dioxane for 1h; Ambient temperature;	A n/a B 2% C 65%
With sodium hydroxide; bromine In 1,4-dioxane for 1h; Ambient temperature;	A n/a B 2% C 65%

...Expand

: 111-13-7
hexyl-methyl-ketone

A: 75-25-2
Bromoform

B: 19841-72-6
2,2-dimethoxy-3-octanol

C: 106-73-0
methyl heptanoate

D: 149-73-5
trimethyl orthoformate

Conditions

Conditions	Yield
With methanol; sodium bromide at 30℃; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	A n/a B 29% C 62% D n/a
With methanol; sodium bromide at 30℃; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	A n/a B 29% C 62% D n/a

...Expand

: 122-57-6
1-Phenylbut-1-en-3-one

A: 75-25-2
Bromoform

B: 103-26-4
methyl cinnamate

C: 149-73-5
trimethyl orthoformate

Conditions

Conditions	Yield
With methanol; sodium bromide at 30℃; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	A n/a B 61% C n/a

...Expand

: 34557-54-5
methane

A: 74-83-9
methyl bromide

B: 75-25-2
Bromoform

C: 558-13-4
carbon tetrabromide

D: 74-95-3
1,2-dibromomethane

Conditions

Conditions	Yield
With bromine at 500℃; Product distribution; Further Variations:; Temperatures; Bromination;	A 17.4% B 0.48% C 2.5% D 5%

...Expand

: 56-23-5
tetrachloromethane

: 108565-60-2
N-(2,2,2-tribromo-1-hydroxy-ethyl)-butyramide

A: 541-35-5
butanamide

B: 75-25-2
Bromoform

...Expand

: 56-23-5
tetrachloromethane

: N-(2,2,2-tribromo-1-hydroxy-ethyl)-octanamide

A: 75-25-2
Bromoform

B: 629-01-6
n-octanamide

...Expand

: 115-17-3
bromal

: 75-25-2
Bromoform

Conditions

Conditions	Yield
With potassium carbonate

: 493-72-1
5-phenyl-cyclohexane-1,3-dione

A: 75-25-2
Bromoform

B: 4165-96-2
3-phenylglutaric acid

Conditions

Conditions	Yield
With sodium hypobromide

: 74-96-4
ethyl bromide

: 67-66-3
chloroform

: 75-25-2
Bromoform

Conditions

Conditions	Yield
With aluminium trichloride

: 72997-31-0
HacacBr

: furan-2,3,5(4H)-trione pyridine (1:1)

A: 75-25-2
Bromoform

B: 64-19-7
acetic acid

C: 67-64-1
acetone

...Expand

: 34557-54-5
methane

A: 75-25-2
Bromoform

B: 74-95-3
1,2-dibromomethane

Conditions

Conditions	Yield
With bromine at 400℃;

: 64-17-5
ethanol

: 558-13-4
carbon tetrabromide

A: 74-96-4
ethyl bromide

B: 75-25-2
Bromoform

C: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
at 150℃;

...Expand

: 64-17-5
ethanol

: 75-96-7
tribromoacetic acid

: 75-25-2
Bromoform

: 64-17-5
ethanol

: 75-25-2
Bromoform

Conditions

Conditions	Yield
With calcium bromide
With calcium bromide Electrolysis;
With potassium bromide Electrolysis;
With potassium bromide Electrolysis;
With calcium bromide Electrolysis;

: 617-48-1
malic acid

: 75-25-2
Bromoform

Conditions

Conditions	Yield
With bromine

: 67-66-3
chloroform

: 75-25-2
Bromoform

Conditions

Conditions	Yield
With aluminum tri-bromide
With aluminum tri-bromide
With aluminum tri-bromide; hydrogen bromide

: 558-13-4
carbon tetrabromide

: 18351-42-3
dimethyl phenylphosphonite

: 75-25-2
Bromoform

: 558-13-4
carbon tetrabromide

: 75-25-2
Bromoform

Conditions

Conditions	Yield
With alkaline arsenite
With alkaline sulfite
With phenylhydrazine

: 5340-45-4
3,4,4-trimethyl-2-pentanone

A: 75-25-2
Bromoform

B: 19910-29-3
2,3,3-trimethylbutanoic acid

Conditions

Conditions	Yield
With sodium hypobromide

: 107-38-0
arsonoacetic acid

A: 75-25-2
Bromoform

B: 75-96-7
tribromoacetic acid

Conditions

Conditions	Yield
With bromine

: 88982-70-1
tribromoacetyl-urea

A: 108-19-0
BIURET

B: 75-25-2
Bromoform

Conditions

Conditions	Yield
With ammonia; water

: 67-56-1
methanol

: 75-25-2
Bromoform

: 149-73-5
trimethyl orthoformate

Conditions

Conditions	Yield
With sodium at 30℃; for 4h;	100%

: 1195-32-0
1-methyl-4-isopropenylbenzene

: 75-25-2
Bromoform

: 87959-45-3
1-(2,2-dibromo-1-methylcyclopropyl)-4-methylbenzene

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In dichloromethane; water at 40 - 45℃; for 22h; Inert atmosphere;	100%
With sodium hydroxide In dichloromethane at 40℃;	73%
With potassium tert-butylate In hexane at 0℃; for 2h;	50%

: 75-25-2
Bromoform

: 83466-54-0, 93602-74-5, 79073-99-7
Bis(2,4,6-tri-tert-butylphenyl)diphosphen

: 111888-02-9
1,2-bis(2,4,6-tri-tert-butylphenyl)3,3-dibromo diphosphirane

Conditions

Conditions	Yield
With potassium hydroxide In hexane at 15℃; for 2h; sonication;	100%
With n-butyllithium In diethyl ether at 0℃;
With potassium tert-butylate CBr4 + n-BuLi is also possible;

: 75-25-2
Bromoform

: 149-73-5
trimethyl orthoformate

Conditions

Conditions	Yield
With methanol; sodium at 30℃; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	100%
With methanol; sodium at 30℃; for 4h; Product distribution; electrolysis (Pt-anode, Cu-Zn (60:40) cathode, 220 mA/cm2 constant current); reaction with NaBr/CH3OH;	100%

: 123-19-3
4-heptanone

: 75-25-2
Bromoform

: 258504-48-2
4-(Tribromomethyl)heptan-4-ol

Conditions

Conditions	Yield
Stage #1: Bromoform With lithium diisopropyl amide In tetrahydrofuran; hexane at -100℃; for 0.166667h; Metallation; Stage #2: 4-heptanone With boron trifluoride diethyl etherate In tetrahydrofuran; diethyl ether; hexane at -90℃; for 4h; Addition;	100%

: 502-49-8
cycloactanone

: 75-25-2
Bromoform

: 258504-47-1
1-(Tribromomethyl)cyclooctan-1-ol

Conditions

Conditions	Yield
Stage #1: Bromoform With lithium diisopropyl amide In tetrahydrofuran; hexane at -100℃; for 0.166667h; Metallation; Stage #2: cycloactanone With boron trifluoride diethyl etherate In tetrahydrofuran; diethyl ether; hexane at -90℃; for 4h; Addition;	100%

: 75-25-2
Bromoform

: 93-55-0
1-phenyl-propan-1-one

: 258504-50-6
1,1,1-Tribromo-2-phenylbutan-2-ol

Conditions

Conditions	Yield
Stage #1: Bromoform With lithium diisopropyl amide In tetrahydrofuran; hexane at -100℃; for 0.166667h; Metallation; Stage #2: 1-phenyl-propan-1-one With boron trifluoride diethyl etherate In tetrahydrofuran; diethyl ether; hexane at -90℃; for 4h; Addition;	100%

: 75-25-2
Bromoform

: (1S,5R,7S,9R,13S)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-13-methyl-tricyclo[7.4.1.01,5]tetradec-10-en-14-one

: C23H38Br2O2Si

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In diethyl ether at 25℃; for 1h;	100%

: 75-25-2
Bromoform

: 105160-08-5
(η5:η5-C10H8)W2(CO)6H2

: 158790-07-9
(η5:η5-C10H8)W2(CO)6Br2

Conditions

Conditions	Yield
In diethyl ether under Ar; addn. CHBr3/ether to soln. W-complex/ether, soln. kept 2 h (crystn.); solvent decanted, solid washed (ether), dried (vac.), elem. anal.;	100%

: 75-25-2
Bromoform

: 1055313-43-3
C26H56O5Si3

: ((2R,3R,6S)-2-((t-butyldimethylsilyloxy)methyl)-6-(2,2-dibromocyclopropoxy)tetrahydro-2H-pyran-3,4-diyl)bis(oxy)bis(t-butyldimethylsilane)

Conditions

Conditions	Yield
With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;	100%

: 67-56-1
methanol

: 75-25-2
Bromoform

: 179056-82-7
4-(5-methyl-1,3,4-oxadiazol-2-yl)benzaldehyde

: 1333472-39-1
2-methoxy-2-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)acetic acid

Conditions

Conditions	Yield
Stage #1: methanol; Bromoform; 4-(5-methyl-1,3,4-oxadiazol-2-yl)benzaldehyde With potassium hydroxide In 1,4-dioxane at 20℃; Cooling with ice; Stage #2: With hydrogenchloride In water pH=1;	100%

...Expand

: 75-25-2
Bromoform

: 1746-23-2
4-tert-Butylstyrene

: 1-(tert-Butyl)-4-(2,2-dibromocyclopropyl)-benzene

Conditions

Conditions	Yield
With benzyltriethylammonium bromide; sodium hydroxide In water at 0 - 20℃; for 2h;	100%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 0 - 60℃;	80%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 50 - 60℃; for 2h; Inert atmosphere;
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 50 - 60℃; Inert atmosphere;
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃;

: 156042-18-1, 81741-00-6, 145842-96-2
trans-(η(5)-pentamethylcyclopentadienyl)(dicarbonyl)(dihydrido)rhenium

: 75-25-2
Bromoform

: trans-(η(5)-pentamethylcyclopentadienyl)(dibromo)(dicarbonyl)rhenium

Conditions

Conditions	Yield
Heating; Schlenk technique;	100%

: 75-25-2
Bromoform

: (η5:η5-4,4',5,5'-tetra-tert-butylfulvalene)[Ir(CO)2]2

: 71-43-2
benzene

A: (η5:η5-4,4',5,5'-tetratert-butylfulvalene)[Ir(CO)(Ph)(Br)][Ir(CO)(Br)2]

B: (η5:η5-4,4',5,5'-tetratert-butylfulvalene)[Ir(CO)(Ph)(Br)]2

Conditions

Conditions	Yield
Stage #1: (η5:η5-4,4',5,5'-tetra-tert-butylfulvalene)[Ir(CO)2]2; benzene for 8h; Irradiation; Inert atmosphere; Stage #2: Bromoform at 50℃; for 12h;	A 100% B 100%

...Expand

: 75-25-2
Bromoform

: 2039-93-2
1-ethylstyrene

: 66444-06-2
2,2-dibromo-1-ethyl-1-phenylcyclopropane

Conditions

Conditions	Yield
With cetyltrimethylammonim bromide; sodium hydroxide In dichloromethane; water at 5℃;	99%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃; Inert atmosphere;	80%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃; Inert atmosphere;	80%

: 75-25-2
Bromoform

: 62322-46-7
3-(1-methoxy-1-methylethoxy)prop-1-ene

: 259194-62-2
1,1-Dibromo-2-[(1-methoxy-1-methylethoxy)methyl]cyclopropan

Conditions

Conditions	Yield
With cetyltrimethylammonim bromide; triethylamine In dichloromethane at 20℃; for 48h; cyclocondensation;	99%

: 75-25-2
Bromoform

: 63922-74-7
(E)-1-(Trimethylsilyl)-2-nonene

: trans-1,1-dibromo-2-hexyl-3-(trimethylsilylmethyl)cyclopropane

Conditions

Conditions	Yield
With potassium tert-butylate In hexane at 0 - 20℃;	99%

: 75-25-2
Bromoform

: 40595-34-4
(E)-trimethyl(3-phenylallyl)silane

: trans-1,1-dibromo-2-phenyl-3-(trimethylsilylmethyl)cyclopropane

Conditions

Conditions	Yield
With potassium tert-butylate In hexane at 0 - 20℃;	99%

: 75-25-2
Bromoform

: 15870-10-7
2-methylhept-1-ene

: 197661-72-6
1,1-dibromo-2-methyl-2-pentyl-cyclopropane

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In dichloromethane; water at 40 - 45℃; for 22h; Inert atmosphere;	99%
With sodium hydroxide; tetrabutylammomium bromide In water at 55℃; for 1h;

: 75-25-2
Bromoform

: 1712-70-5
1-chloro-4-(1-methylethenyl)-benzene

: 1064000-89-0
1-chloro-4-(2,2-dibromo-1-methylcyclopropyl)benzene

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃; Inert atmosphere;	99%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃; Inert atmosphere;	99%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In dichloromethane; water at 40 - 45℃; for 22h; Inert atmosphere;	93%

: 928-95-0
(E)-2-Hexen-1-ol

: 75-25-2
Bromoform

: C7H12Br2O

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In water	99%

: 75-25-2
Bromoform

: 611-15-4
1-methyl-2-vinyl-benzene

: 132608-14-1
1-(2,2-dibromocyclopropyl)-2-methylbenzene

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃; Inert atmosphere;	99%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 50 - 60℃; for 2h;	41%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 50 - 60℃; for 2h; Inert atmosphere;

: 75-25-2
Bromoform

: 175164-50-8
4-(tert-butyldiphenylsilyloxy)hepta-1,6-diene

: C22H26Br2OSi

Conditions

Conditions	Yield
Stage #1: 4-(tert-butyldiphenylsilyloxy)hepta-1,6-diene With Grubbs catalyst first generation In dichloromethane at 20℃; for 0.333333h; Inert atmosphere; Stage #2: Bromoform With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In dichloromethane for 6h; Inert atmosphere; Sonication;	99%

: 75-25-2
Bromoform

: 57204-39-4
4-(vinyl-β,β-d2)-1,1'-biphenyl

: 4-(2,2-dibromocyclopropyl-3,3-d2)-1,1'-biphenyl

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃; Inert atmosphere;	99%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃; Inert atmosphere;	99%

: 563-79-1
2,3-Dimethyl-2-butene

: 75-25-2
Bromoform

: 22715-57-7
2,2,3,3-tetramethyl-1,1-dibromocyclopropane

Conditions

Conditions	Yield
With potassium tert-butylate In n-heptane at -9 - 20℃; for 4h;	98%
With potassium tert-butylate In pentane	95%
With potassium tert-butylate In n-heptane at -10 - 20℃; Inert atmosphere; Industrial scale;	76%

: 75-25-2
Bromoform

: 115-11-7
isobutene

: 32264-50-9
1,1-dibromo-2,2-dimethylcyclopropane

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In ethanol; dichloromethane for 5h;	98%
With potassium tert-butylate In tert-butyl alcohol; pentane at 0℃; for 14h;	93%
With potassium tert-butylate at -25℃;	91%

: 75-25-2
Bromoform

: 513-81-5
2,3-dimethyl-buta-1,3-diene

: 62405-61-2
2,2,2',2'-tetrabromo-1,1'-dimethyl-1,1'-bicyclopropyl

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane for 1.5h; ultrasound treatment;	98%
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride 1.) 30 min, 0 deg C, 2.) 2 d, r.t.;	63%
With sodium hydroxide	35%
With potassium tert-butylate In pentane

: 75-25-2
Bromoform

: 38898-42-9
3-methylenetetracyclo<3.2.0.02,7,04,6>heptane

: 81787-72-6
2,2-Dibromspiro2,7.04,6>heptan>

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride at 40℃; for 4h;	98%
With potassium tert-butylate In hexane at 0℃; for 0.75h;	72%

: 75-25-2
Bromoform

: 3446-89-7
4-(Methylthio)benzaldehyde

: 109086-16-0
2-hydroxy-2-(4-methylthiophenyl)ethanoic acid

Conditions

Conditions	Yield
With sodium hydroxide; lithium bromide In 1,4-dioxane	98%
With potassium hydroxide; lithium bromide In 1,4-dioxane; water 1.) 0 deg C, 18 h, 2.) 23 deg C, 24 h;	7.6 g

: 75-25-2
Bromoform

: 502-42-1
cycloheptanone

: 20920-03-0
1-hydroxycycloheptanecarboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide for 1h; Ambient temperature;	98%

Bromoform Consensus Reports

Reported in EPA TSCA Inventory. Community Right-To-Know List.

Bromoform Standards and Recommendations

OSHA PEL: TWA 0.5 ppm (skin)
ACGIH TLV: TWA 0.5 ppm (skin); Animal Carcinogen
DFG MAK: Confirmed Animal Carcinogen with Unknown Relevance to Humans
DOT Classification: 6.1; Label: KEEP AWAY FROM FOOD

Bromoform Analytical Methods

For occupational chemical analysis use NIOSH: Hydrocarbons, Halogenated, 1003.

Bromoform Specification

The Bromoform with CAS registry number of 75-25-2 is also known as Methane, tribromo-. The IUPAC name and product name are the same. It belongs to product categories of Pharmaceutical Intermediates; Organics; Heterocyclic Compounds; Analytical Chemistry; Solvents for HPLC & Spectrophotometry; Solvents for Spectrophotometry; Standard Solution of Volatile Organic Compounds for Water & Soil Analysis; Standard Solutions (VOC); 600 Series Wastewater Methods; A-BAlphabetic; Alpha Sort; B; BI - BZChemical Class; BromoEPA; Halogenated; Method 601; Volatiles/ Semivolatiles. Its EINECS registry number is 200-854-6. In addition, the formula is CHBr₃ and the molecular weight is 252.73.

Physical properties about Bromoform are: (1)ACD/LogP: 2.29; (2)ACD/LogD (pH 5.5): 2.29; (3)ACD/LogD (pH 7.4): 2.29; (4)ACD/BCF (pH 5.5): 32.39; (5)ACD/BCF (pH 7.4): 32.39; (6)ACD/KOC (pH 5.5): 419.56; (7)ACD/KOC (pH 7.4): 419.56; (8)Index of Refraction: 1.619; (9)Molar Refractivity: 29.83 cm³; (10)Molar Volume: 84.9 cm³; (11)Surface Tension: 49.8 dyne/cm; (12)Density: 2.974 g/cm³; (13)Flash Point: 44 °C; (14)Enthalpy of Vaporization: 39.66 kJ/mol; (15)Boiling Point: 149.2 °C at 760 mmHg; (16)Vapour Pressure: 5.17 mmHg at 25 °C.

Preparation of Bromoform: it is prepared by reaction of acetone with sodium hypobromite under alkaline conditions. Then product is derived after decomposition, distillation, washing, filtration and drying.

Uses of Bromoform: it is used to produce 1,1-dibromo-2-phenyl-cyclopropane by reaction with vinylbenzene. The reaction occurs with reagent potassium tert-butoxide and solvent pentane at ambient temperature for 10 hours. The yield is about 65%. This cehmical is also can be used as dye intermediate, disinfectant, analgesic, anesthetic, refrigerant, mineral agent, precipitating agent, solvent and liquid component of blast-resistant.

Bromoform is used to produce 1,1-dibromo-2-phenyl-cyclopropane by reaction with vinylbenzene.

When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes and skin. It's toxic to aquatic organisms and may cause long-term adverse effects in the aquatic environment. What's more, it has danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed. During using it, wear suitable protective clothing and gloves. Avoid release to the environment. In case of accident or if you feel unwell seek medical advice immediately. After using it, keep container tightly closed and away from sources of ignition. After contact with skin, wash immediately.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C(Br)(Br)Br
2. InChI: InChI=1S/CHBr3/c2-1(3)4/h1H
3. InChIKey: DIKBFYAXUHHXCS-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	LDLo	oral	143mg/kg (143mg/kg)		"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 141, 1969.
mammal (species unspecified)	LC50	inhalation	12100mg/m³ (12100mg/m³)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(4), Pg. 55, 1974.
mouse	LD50	intraperitoneal	1274mg/kg (1274mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 20(12), Pg. 52, 1976.
mouse	LD50	oral	1072mg/kg (1072mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	National Toxicology Program Technical Report Series. Vol. NTP-TR-350, Pg. 1989,
mouse	LD50	subcutaneous	1820mg/kg (1820mg/kg)		Toxicology and Applied Pharmacology. Vol. 4, Pg. 354, 1962.
rabbit	LDLo	subcutaneous	410mg/kg (410mg/kg)		Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 28, Pg. 201, 1891.
rat	LCLo	inhalation	45gm/m³/4H (45000mg/m³)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 28, 1982.
rat	LD50	intraperitoneal	414mg/kg (414mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ANTIPSYCHOTIC BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Toxicology Letters. Vol. 15, Pg. 251, 1983.
rat	LD50	oral	933mg/kg (933mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	National Toxicology Program Technical Report Series. Vol. NTP-TR-350, Pg. 1989,

Product Name

Bromoform

Synthetic route

Bromoform Consensus Reports

Bromoform Standards and Recommendations

Bromoform Analytical Methods

Bromoform Specification

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