Cefotaxime sodium supplier | CasNO.64485-93-4

Name
Cefotaxime sodium
EINECS 264-915-9
CAS No. 64485-93-4
Article Data17
CAS DataBase
Density 1.8 g/cm³
Solubility Soluble in water.
Melting Point 162-163 °C
Formula C₁₆H₁₆N₅NaO₇S₂
Boiling Point
Molecular Weight 477.454
Flash Point
Transport Information
Appearance White to pale yellow crystalline powder
Safety 22-36/37
Risk Codes 42/43
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms cefotaxim sodium salt;Cefotaxime Sodium (Sterile);Cefotaxime free acid;RU 24662;Liquiritin;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;sodium [6R-[6α,7β(Z)]]-3-(acetoxymethyl)-7-[(2-aminothiazol-4-yl)(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;Sodium (6R,7R)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate 7(sup 2)-(Z)-(O-methyloxime), acetate (ester);Claforan (TN);Sodium 7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)cephalosporanate;Cefotaxime sodium (JP14/USP);HR 756;Claforan sodium;Cefotaxime sodium salt;sodium (6R,7R)-3-(acetyloxymethyl)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;63527-52-6;Cefotaxime Sodium. Sterile;Cefotaxima [INN-Spanish];Cefotaxime sodium [USAN:JAN];sodium (6R,7R)-3-(acetyloxymethyl)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;Sodium (6R-(6alpha,7beta(Z)))-3-(acetoxymethyl)-7-((2-aminothiazol-4-yl)(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate;Prestwick_823;RU 24756;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)-;(+)-Cefotaxime sodium salt;Sodium cefotaxime;Tolycar;(6S,7S)-3-(acetyloxymethyl)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, monosodium salt, (6R-(6alpha,7beta(Z)))-;Cefotaxime Sodium sterile;
PSA 229.88000
LogP -1.04720

Synthetic route

: 63527-52-6
cefotaxime

: 64485-93-4
cefotaxime sodium salt

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol Substitution;	95.4%
With sodium isooctanoate; sodium sulfite In water; acetone at 5 - 10℃; for 0.5h;	95%
With triethylamine; sodium 2-ethylhexanoic acid In methanol; ethyl acetate	88.7%

: 60846-21-1, 63527-52-6, 63527-53-7
cefotaxime

: 64485-93-4
cefotaxime sodium salt

Conditions

Conditions	Yield
With sodium acetate trihydrate In water; acetone

: 957-68-6
7-Aminocephalosporanic acid

: 64485-93-4
cefotaxime sodium salt

Conditions

Conditions	Yield
Stage #1: 7-Aminocephalosporanic acid In water; acetone at 10℃; for 10h; Large scale; Stage #2: With sodium hydroxide In water; acetone at 10 - 15℃; pH=9.5; Temperature; pH-value; Large scale;

: 91868-79-0
2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid

: 36923-17-8
(6R,7R)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

: 64485-93-4
cefotaxime sodium salt

Conditions

Conditions	Yield
Stage #1: 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid With dmap; dicyclohexyl-carbodiimide In ethanol at 20℃; for 0.5h; Stage #2: With 1-hydroxy-pyrrolidine-2,5-dione In ethanol at 20℃; for 0.5h; Stage #3: (6R,7R)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Further stages;	2.59 g

: 91868-79-0
2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid

: 64485-93-4
cefotaxime sodium salt

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2.5 h / 2 - 25 °C 2: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 1 h / -5 - 0 °C 3: sodium sulfite; sodium isooctanoate / water; acetone / 0.5 h / 5 - 10 °C View Scheme

: silver nitrate

: 64485-93-4
cefotaxime sodium salt

: C32H32Ag2N10O14S4

Conditions

Conditions	Yield
In methanol for 1h; Reflux;	77%

: 7732-18-5
water

: tin(ll) chloride

: 64485-93-4
cefotaxime sodium salt

: Sn(2+)*Cl(1-)*C16H16N5O7S2(1-)*H2O

Conditions

Conditions	Yield
at 20℃; for 6h;	72%

...Expand

: 4741-45-1
furane-2-monocarboxylic acid

: 64485-93-4
cefotaxime sodium salt

: 80370-57-6
ceftiofur

Conditions

Conditions	Yield
With methanesulfonic acid In acetonitrile at 20℃; for 3h;	25%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 64485-93-4
cefotaxime sodium salt

: C23H24N6O7S2

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water pH=4.5;	24%

: N-methyl-O-allylhydroxylamine hydrochloride

: 64485-93-4
cefotaxime sodium salt

: C20H24N6O7S2

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water pH=4.5;	24%

: 38945-21-0
O-allylhydroxylamine hydrochloride

: 64485-93-4
cefotaxime sodium salt

: C19H22N6O7S2

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water pH=4.5;	16%

: 71925-14-9
O-benzyl-N-methylhydroxylamine hydrochloride

: 64485-93-4
cefotaxime sodium salt

: C24H26N6O7S2

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water pH=4.5;	14%

: 64485-93-4
cefotaxime sodium salt

A: 104301-63-5
2-<<(2-amino-4-thiazolyl)((Z)-methoxyimino)acetyl>amino>acetoaldehyde

B: (Z)-4-Acetoxy-2-amino-3-mercaptomethyl-but-2-enoic acid

Conditions

Conditions	Yield
With sodium hydroxide at 95℃; for 0.416667h;

: 64485-93-4
cefotaxime sodium salt

: (E)-3-Acetoxymethyl-2-imino-4-(7-nitro-benzo[1,2,5]oxadiazol-4-ylsulfanyl)-but-3-enoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: aq. NaOH / 0.42 h / 95 °C 2.1: Na2B4O7*10H2O / H2O 2.2: H2O; acetone / 0.5 h / 25 °C View Scheme

: 101234-94-0
1-Cyclopropyl-4-thiopyridone

: 64485-93-4
cefotaxime sodium salt

: (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[(1-cyclopropylpyridinium-4-yl)thiomethyl]-ceph-3-em-4-carboxylate

Conditions

Conditions	Yield
With sodium iodide In water; acetone; acetonitrile

: 88-89-1
2,4,6-Trinitrophenol

: 64485-93-4
cefotaxime sodium salt

: C16H16N5O7S2(1-)*C6H3N3O7*Na(1+)

Conditions

Conditions	Yield
In methanol at 20℃; for 2h;

: 87-88-7
3,6-dichloro-2,5-dihydroxy-1,4-benzoquinone

: 64485-93-4
cefotaxime sodium salt

: C16H16N5O7S2(1-)*Na(1+)*C6H2Cl2O4

Conditions

Conditions	Yield
In methanol at 20℃; for 2h;

: 84-58-2
2,3-dicyano-5,6-dichloro-p-benzoquinone

: 64485-93-4
cefotaxime sodium salt

: C16H16N5O7S2(1-)*Na(1+)*C8Cl2N2O2

Conditions

Conditions	Yield
In methanol at 20℃; for 2h;

: 1518-16-7
7,7',8,8'-tetracyanoquinodimethane

: 64485-93-4
cefotaxime sodium salt

: C16H16N5O7S2(1-)*Na(1+)*C12H4N4

Conditions

Conditions	Yield
In methanol at 20℃; for 2h;

: 7758-99-8
copper(II) sulfate

: 64485-93-4
cefotaxime sodium salt

: Cu(2+)*C16H16N5O7S2(1-)*Na(1+)

Conditions

Conditions	Yield
In aq. acetate buffer at 60℃; for 0.666667h; pH=5.5; pH-value; Concentration; Temperature; Solvent;

: cadmium sulfate

: 64485-93-4
cefotaxime sodium salt

: Cd(2+)*C16H16N5O7S2(1-)*Na(1+)

Conditions

Conditions	Yield
In aq. buffer at 40℃; for 0.666667h; pH=11; pH-value; Concentration; Temperature; Solvent;

: 64485-93-4
cefotaxime sodium salt

: C16H16N5O7S2(1-)*Na(1+)*0.25H2O

Conditions

Conditions	Yield
With water In methanol	80.87 g

Cefotaxime sodium Chemical Properties

Empirical Formula: C₁₆H₁₇N₅O₇S₂
Molecular Weight: 455.4655
EINECS: 264-915-9
Index of Refraction: 1.778
Density: 1.8 g/cm³
Melting point: 162-163 °C(lit.)
Storage tempreture: 2-8 °C
Appearance: White to pale yellow crystalline powder
Structure of Cefotaxime sodium (CAS NO.64485-93-4):

IUPAC Name: Sodium (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Canonical SMILES: CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)[O-].[Na+]
Isomeric SMILES: CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OC)/C3=CSC(=N3)N)SC1)C(=O)[O-].[Na+]
InChI: InChI=1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1
InChIKey: AZZMGZXNTDTSME-JUZDKLSSSA-M
Product Category of Cefotaxime sodium (CAS NO.64485-93-4): API;Antibiotics for Research and Experimental Use;Biochemistry;Antibiotic Explorer;Heterocycles;Intermediates & Fine Chemicals;Sulfur & Selenium Compounds

Cefotaxime sodium Uses

Cefotaxime sodium (CAS NO.64485-93-4) can be used as antibiotic medicine for the treatment of respiratory, urinary, intestinal and biliary tract, skin and soft tissue, burns, and bone and joint infections and other diseases.

Cefotaxime sodium Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	intravenous	1800mg/kg/18D (1800mg/kg)	BLOOD: AGRANULOCYTOSIS	Drug Intelligence and Clinical Pharmacy. Vol. 17, Pg. 739, 1983.
dog	LD50	intramuscular	> 716mg/kg (716mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
dog	LD50	intravenous	> 1500mg/kg (1500mg/kg)		Journal of Antimicrobial Chemotherapy. Vol. 6(Suppl,
mouse	LD50	intraperitoneal	10gm/kg (10000mg/kg)		Drugs in Japan Vol. 6, Pg. APP-8, 1982.
mouse	LD50	intravenous	6845mg/kg (6845mg/kg)		Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. Vol. 35(5), Pg. 25, 1990.
mouse	LD50	oral	> 20gm/kg (20000mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ATAXIA	Chemotherapy Vol. 28(Suppl,
mouse	LD50	subcutaneous	12950mg/kg (12950mg/kg)		Drugs in Japan Vol. 6, Pg. APP-8, 1982.
rabbit	LD50	intravenous	1880mg/kg (1880mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ATAXIA	Chemotherapy Vol. 28(Suppl,
rat	LD50	intramuscular	> 2gm/kg (2000mg/kg)		Chemotherapy Vol. 28(Suppl,
rat	LD50	intraperitoneal	10gm/kg (10000mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ATAXIA	Chemotherapy Vol. 28(Suppl,
rat	LD50	intravenous	7gm/kg (7000mg/kg)		Drugs in Japan Vol. 6, Pg. APP-8, 1982.
rat	LD50	oral	> 20gm/kg (20000mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Chemotherapy Vol. 28(Suppl,
rat	LD50	subcutaneous	18400mg/kg (18400mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Chemotherapy Vol. 28(Suppl,

Cefotaxime sodium Safety Profile

Moderately toxic by intravenous and intramuscular routes. Mildly toxic by ingestion and intraperitoneal routes. Human systemic effects by intravenous route: agranulocytosis. An experimental teratogen. When heated to decomposition it emits toxic fumes of SO_x, NO_x and Na₂O.
Hazard Codes: Harmful Xn, Irritant Xi(Harmful)
Risk Statements:
R42/43 (May cause sensitization by inhalation and skin contact )
Safety Statements:
S22:Do not breathe dust
S36/37 :Wear suitable protective clothing and gloves
WGK Germany: 2

Cefotaxime sodium Specification

Cefotaxime sodium , its cas register number is 64485-93-4. It also can be called Claforan ; CTX ; and [6R-[6alpha,7beta(z)]]-3-[(Acetyloxy)methyl]-[[(2-amine-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid monosodium salt .

Product Name

Cefotaxime sodium

Synthetic route

Cefotaxime sodium Chemical Properties

Cefotaxime sodium Uses

Cefotaxime sodium Toxicity Data With Reference

Cefotaxime sodium Safety Profile

Cefotaxime sodium Specification

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