Cinchophen supplier | CasNO.132-60-5

Name
CINCHOPHEN
EINECS
CAS No. 132-60-5
Article Data87
CAS DataBase
Density 1.28g/cm³
Solubility Insoluble in water
Melting Point 214-215 °C(lit.)
Formula C16H11 N O2
Boiling Point 456.9°Cat760mmHg
Molecular Weight 249.269
Flash Point 230.1°C
Transport Information
Appearance
Safety A human poison by ingestion. An experimental poison by intraperitoneal and subcutaneous routes. Moderately toxic by an unspecified route. When heated to decomposition it emits toxic fumes of NO_x.
Risk Codes 22
Molecular Structure
Hazard Symbols
Synonyms Cinchoninicacid, 2-phenyl- (8CI); 2-Phenyl-4-quinolinecarboxylic acid; 2-Phenylcinchonicacid; 2-Phenylcinchoninic acid; 4-Carboxy-2-phenylquinoline; Aciphenochinoline;Aciphenochinolinium; Agotan; Alutyl; Alutyo; Aminophan; Artam; Artexin; Atigoa;Atocin; Atofan; Atophan; Cinchophen; Cinchophene; Cinchophenic acid; Cinconal;Cincophen; Cincosal; Ikterosan; Mylofanol; NSC 2617; NSC 70178; Phenophan;Phenoquin; Polyphlogin; Quinofen; Quinophan; Quinophen; Rhematan; Rheumatan;Rheumin; Rheumine; Tervalon; Tophol; Tophosan; Traubofan; Vantyl; Viophan
PSA 50.19000
LogP 3.60000

Synthetic route

: 5467-57-2
2-chloroquinoline-4-carboxylic acid

: 98-80-6
phenylboronic acid

: 132-60-5
cinchophen

Conditions

Conditions	Yield
With potassium carbonate In ethanol; water at 50℃; for 4h; Suzuki-Miyaura coupling reaction; Inert atmosphere;	96%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 140℃; for 0.5h; Suzuki-Miyaura Coupling; Inert atmosphere; Microwave irradiation;

: 91-56-5
indole-2,3-dione

: 98-86-2
acetophenone

: 132-60-5
cinchophen

Conditions

Conditions	Yield
With potassium hydroxide In ethanol; water for 0.208333h; microwave irradiation;	95%
Stage #1: indole-2,3-dione With cetyltrimethylammonium hydroxide In water at 20℃; for 0.166667h; Pfitzinger Quinoline Synthesis; Sonication; Green chemistry; Stage #2: acetophenone In water at 35℃; for 2.5h; Solvent; Reagent/catalyst; Temperature; Pfitzinger Quinoline Synthesis; Sonication; Green chemistry;	95%
With potassium hydroxide In ethanol at 50 - 60℃; for 14h;	90%

: 5467-57-2
2-chloroquinoline-4-carboxylic acid

: 960-16-7
tributylphenylstannane

: 132-60-5
cinchophen

Conditions

Conditions	Yield
With cesium fluoride In ethanol; water at 50℃; for 5h; Stille coupling; Inert atmosphere;	92%

: 88730-73-8
3-Hydroxy-3-(2-oxo-2-phenyl-ethyl)-1,3-dihydro-indol-2-one

: 132-60-5
cinchophen

Conditions

Conditions	Yield
With sulfuric acid In acetic acid for 5h; Heating;	90%
With potassium hydroxide; ethanol

: 100-52-7
benzaldehyde

: 127-17-3
2-oxo-propionic acid

: 62-53-3
aniline

: 132-60-5
cinchophen

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethanol for 0.05h; Reagent/catalyst; Solvent; Microwave irradiation; Green chemistry;	80%
With ytterbium perfluorooctanoate In water for 3h; Doebner reaction; Reflux;	72%
In ethanol for 3h; Reflux;	51%

...Expand

: 100-52-7
benzaldehyde

: 127-17-3
2-oxo-propionic acid

: 132-60-5
cinchophen

Conditions

Conditions	Yield
Stage #1: benzaldehyde; 2-oxo-propionic acid With acetic acid for 1h; Reflux; Stage #2: With aniline for 8h; Reflux;	62.2%

: 117839-38-0
2-phenyl-4-quinolinecarboxaldehyde

A: 29268-33-5
4-hydroxymethyl-2-phenylquinoline

B: 132-60-5
cinchophen

Conditions

Conditions	Yield
With potassium hydroxide; ethanol; water
With potassium hydroxide; ethanol; water

: 31541-36-3, 34880-79-0, 56680-29-6
3-(2-oxo-2-phenyl-ethylidene)-1,3-dihydro-indol-2-one

: 132-60-5
cinchophen

Conditions

Conditions	Yield
With hydrogenchloride; ethanol; water
With ethanol; water; potassium carbonate

: 960-53-2
1,5-diphenyltetrahydro-2,3-pyrroledione

: 100-52-7
benzaldehyde

: 132-60-5
cinchophen

Conditions

Conditions	Yield
With ethanol; acetic acid; aniline

: 70097-13-1
2-(4-nitrophenyl)quinoline-4-carboxylic acid

: 132-60-5
cinchophen

Conditions

Conditions	Yield
beim Nitrieren;

: 859068-53-4
N-[2-oxo-1-(2-oxo-indolin-3-yl)-2-phenyl-ethyl]-benzamide

: 132-60-5
cinchophen

Conditions

Conditions	Yield
With hydrogenchloride; ethanol

: 538-51-2
benzylidene phenylamine

: 127-17-3
2-oxo-propionic acid

: 132-60-5
cinchophen

Conditions

Conditions	Yield
With ethanol

: 64-17-5
ethanol

: 100-52-7
benzaldehyde

: 127-17-3
2-oxo-propionic acid

: 62-53-3
aniline

A: 132-60-5
cinchophen

B: 102704-29-0
1,5-diphenyl-3-phenylimino-pyrrolidin-2-one

...Expand

: 484-38-8
isatic acid

: 98-86-2
acetophenone

: 132-60-5
cinchophen

Conditions

Conditions	Yield
With potassium hydroxide

: 99686-93-8
2-(2-acetamidophenyl)-N,N-diethyl-2-oxoacetamide

: 98-86-2
acetophenone

: 132-60-5
cinchophen

Conditions

Conditions	Yield
With sodium hydroxide 1.) reflux, 1 h, 2.) reflux, 18 h; Yield given. Multistep reaction;

: N-[2-((3S,3aS,6aR)-5-Hydroxy-4,4-dimethyl-2-oxo-6a-phenyl-hexahydro-furo[2,3-b]furan-3-yl)-phenyl]-benzamide

A: 132-60-5
cinchophen

B: 78-84-2
isobutyraldehyde

C: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid Heating; decomposition;

...Expand

: N-[2-((3R,3aS,6aR)-5-Methoxy-4,4-dimethyl-2-oxo-6a-phenyl-hexahydro-furo[2,3-b]furan-3-yl)-phenyl]-acetamide

A: 132-60-5
cinchophen

B: 78-84-2
isobutyraldehyde

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid Heating; decomposition;

: N-[2-((3S,3aS,6aR)-5-Methoxy-4,4-dimethyl-2-oxo-6a-phenyl-hexahydro-furo[2,3-b]furan-3-yl)-phenyl]-acetamide

A: 132-60-5
cinchophen

B: 78-84-2
isobutyraldehyde

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid Heating; decomposition;

: N-[2-((3R,3aS,6aR)-5-Ethoxy-4,4-dimethyl-2-oxo-6a-phenyl-hexahydro-furo[2,3-b]furan-3-yl)-phenyl]-acetamide

A: 132-60-5
cinchophen

B: 78-84-2
isobutyraldehyde

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid Heating; decomposition;

: N-[2-((3S,3aS,6aR)-5-Ethoxy-4,4-dimethyl-2-oxo-6a-phenyl-hexahydro-furo[2,3-b]furan-3-yl)-phenyl]-acetamide

A: 132-60-5
cinchophen

B: 78-84-2
isobutyraldehyde

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid Heating; decomposition;

: N-[2-((3S,3aR,6aS)-5-Methoxy-4,4-dimethyl-2-oxo-6a-phenyl-hexahydro-furo[2,3-b]furan-3-yl)-phenyl]-benzamide

A: 132-60-5
cinchophen

B: 78-84-2
isobutyraldehyde

C: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid Heating; decomposition;

...Expand

: N-[2-((3R,3aR,6aS)-5-Methoxy-4,4-dimethyl-2-oxo-6a-phenyl-hexahydro-furo[2,3-b]furan-3-yl)-phenyl]-benzamide

A: 132-60-5
cinchophen

B: 78-84-2
isobutyraldehyde

C: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid Heating; decomposition;

...Expand

: N-[2-((3R,3aS,6aR)-5-Ethoxy-4,4-dimethyl-2-oxo-6a-phenyl-hexahydro-furo[2,3-b]furan-3-yl)-phenyl]-benzamide

A: 132-60-5
cinchophen

B: 78-84-2
isobutyraldehyde

C: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid Heating; decomposition;

...Expand

: N-[2-((3S,3aS,6aR)-5-Ethoxy-4,4-dimethyl-2-oxo-6a-phenyl-hexahydro-furo[2,3-b]furan-3-yl)-phenyl]-benzamide

A: 132-60-5
cinchophen

B: 78-84-2
isobutyraldehyde

C: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid Heating; decomposition;

...Expand

β-<2-phenyl-quinolyl-(4)>-trimethylene glycol: β-<2-phenyl-quinolyl-(4)>-trimethylene glycol

: 132-60-5
cinchophen

Conditions

Conditions	Yield
With chromium(III) oxide; sulfuric acid

2-phenyl-quinoline-carboxylic acid-(4)-amide: 2-phenyl-quinoline-carboxylic acid-(4)-amide

: 132-60-5
cinchophen

Conditions

Conditions	Yield
With sulfuric acid at 130℃;

: 7647-01-0
hydrogenchloride

: 859068-53-4
N-[2-oxo-1-(2-oxo-indolin-3-yl)-2-phenyl-ethyl]-benzamide

: 132-60-5
cinchophen

: 7647-01-0
hydrogenchloride

: 64-17-5
ethanol

: 31541-36-3, 34880-79-0, 56680-29-6
3-(2-oxo-2-phenyl-ethylidene)-1,3-dihydro-indol-2-one

: 7732-18-5
water

: 132-60-5
cinchophen

...Expand

: 64-17-5
ethanol

: 31541-36-3, 34880-79-0, 56680-29-6
3-(2-oxo-2-phenyl-ethylidene)-1,3-dihydro-indol-2-one

: 7732-18-5
water

potassium carbonate: potassium carbonate

: 132-60-5
cinchophen

...Expand

: 67-56-1
methanol

: 132-60-5
cinchophen

: 4546-48-9
methyl 2-phenylquinoline-4-carboxylate

Conditions

Conditions	Yield
With sulfuric acid Reflux;	100%
With dicyclohexyl-carbodiimide; dmap In dichloromethane at 0 - 20℃; for 13h;	99%
With thionyl chloride at 0℃; Reflux;	84.9%

: 132-60-5
cinchophen

: 71822-97-4
3-amino-2-methyl-6-bromoquinazolin-4(3H)-one

: 98832-98-5
2-Phenyl-quinoline-4-carboxylic acid (6-bromo-2-methyl-4-oxo-4H-quinazolin-3-yl)-amide

Conditions

Conditions	Yield
With triethylamine; trichlorophosphate In toluene for 0.75h; Product distribution; Heating; other aromatic acids, also with 3-amino-2-methyl-4(3H)-quinazolone, influence of Et3N;	99%
With triethylamine; trichlorophosphate In toluene for 0.75h; Heating;	99%

: 132-60-5
cinchophen

: 2-phenylquinoline-4-carbonyl fluoride

Conditions

Conditions	Yield
With tetramethylammonium trifluoromethanethiolate In dichloromethane at 25℃; for 2h;	96%
With dmap; trifluoromethyl trifluoromethanesulfonate In dichloromethane at 20℃; for 1h; Inert atmosphere; Schlenk technique;	95%
With tetramethylammonium trifluoromethanethiolate In dichloromethane at 20℃; for 1h;	89%

: 132-60-5
cinchophen

: 211183-97-0
3-(tert-butyldimethylsilyloxy)-17α-(3'-hydroxyprop-1'-ynyl)estradiol

: 959414-78-9
3-O-tert-butyldimethylsilyl-17α-hydroxypropargyl-β-estradiolyl 2-phenylquinoline-4-carboxylate

Conditions

Conditions	Yield
With dmap; N,N'-1,2-ethylenediylbis-(L-cysteine) diethyl ester dihydrochloride In dichloromethane at 0 - 20℃; for 2h;	95%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃;	95%

: 132-60-5
cinchophen

: 108-15-6
1-(dimethylamino)-2-propylamine

: N‐[1‐(dimethylamino)propan‐2‐yl]‐2‐phenylquinoline‐4‐carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	94.3%

: 64-17-5
ethanol

: 132-60-5
cinchophen

: 4420-46-6
ethyl 2-phenylquinoline-4-carboxylate

Conditions

Conditions	Yield
With sulfuric acid for 0.166667h; microwave irradiation;	94%
With sulfuric acid Reflux;	89%
With sulfuric acid Fischer-Speier Esterification; Reflux;	75%

: 132-60-5
cinchophen

: 2627-86-3
(S)-1-phenyl-ethylamine

: (+)-(S)-N-(α-methylbenzyl)-2-phenylquinoline-4-carboxamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;	94%

: 132-60-5
cinchophen

: 2627-86-3
(S)-1-phenyl-ethylamine

: (-)-(R)-N-(α-methylbenzyl)-2-phenylquinoline-4-carboxamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 3h;	94%

: 132-60-5
cinchophen

: 258857-73-7
2-hydroxyethyl 4-O-tert-butyldimethylsilyl-3-(N,N-dimethylamino)-2,3,6-trideoxy-α-D-arabinohexopyranoside

: 258857-75-9
2-Phenyl-quinoline-4-carboxylic acid 2-[(2S,4R,5S,6R)-5-(tert-butyl-dimethyl-silanyloxy)-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy]-ethyl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 4.5h; Esterification;	93%

: 132-60-5
cinchophen

: 108-00-9
N,N-dimethylethylenediamine

: 124340-46-1
N-[2-(dimethylamino)ethyl]-2-phenylquinoline-4-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	93%

: 959957-92-7
1-methyl-azetidin-3-amine

: 132-60-5
cinchophen

: N‐(1‐methylazetidin‐3‐yl)‐2‐phenylquinoline‐4‐carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	92.3%

: 132-60-5
cinchophen

: 62-53-3
aniline

: 110662-85-6
N,2-diphenylquinoline-4-carboxamide

Conditions

Conditions	Yield
Stage #1: cinchophen; aniline With benzotriazol-1-ol In N,N-dimethyl-formamide for 0.25h; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 4h; Reagent/catalyst; Solvent; Temperature;	90.1%
With trichlorophosphate for 8h; Reflux;	56%
With Tetraethyl pyrophosphate; toluene
With Tetraethyl pyrophosphate

: 132-60-5
cinchophen

: 258857-74-8
2-hydroxyethyl 4-O-tert-butyldimethylsilyl-3-(N,N-dimethylamino)-2,3,6-trideoxy-β-D-arabinohexopyranoside

: 258857-76-0
2-Phenyl-quinoline-4-carboxylic acid 2-[(2R,4R,5S,6R)-5-(tert-butyl-dimethyl-silanyloxy)-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy]-ethyl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 4.5h; Esterification;	90%

: 132-60-5
cinchophen

: 106-96-7
propargyl bromide

: prop-2-ynyl-2-phenylquinoline-4-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	90%

: 5739-10-6
N-[2-(aminoethyl)]imidazole

: 132-60-5
cinchophen

: N‐[2‐(1H‐imidazol‐1‐yl)ethyl]‐2‐phenylquinoline‐4‐carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	89.2%

: 132-60-5
cinchophen

: 99-98-9
4-amino-N,N-dimethylaniline

: 300852-09-9
N-(4-(dimethylamino)phenyl)-2-phenylquinoline-4-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	89%

: 578-66-5
8-amino quinoline

: 132-60-5
cinchophen

: 2-phenyl-N-(quinolin-8-yl)quinoline-4-carboxamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; Inert atmosphere;	88%

: 132-60-5
cinchophen

: 109-55-7
1-amino-3-(dimethylamino)propane

: N-[3-(dimethylamino)propyl]-2-phenylquinoline-4-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	87%

: 132-60-5
cinchophen

: 1086562-05-1
2-(2-amino-3-methoxyphenyl)-benzoxazole-4-carboxylic acid methyl ester

: 1086562-34-6
2-[3-methoxy-2-[(2-phenylquinoline-4-carbonyl)-amino]-phenyl]-benzoxazole-4-carboxylic acid methyl ester

Conditions

Conditions	Yield
Stage #1: cinchophen With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; Stage #2: 2-(2-amino-3-methoxyphenyl)-benzoxazole-4-carboxylic acid methyl ester With pyridine In dichloromethane	86%

: 132-60-5
cinchophen

: 95-54-5
1,2-diamino-benzene

: 42039-62-3
2-phenyl-4-(benzimidazol-2-yl)quinoline

Conditions

Conditions	Yield
With PPA at 210 - 270℃; for 0.0416667h; microwave irradiation;	85%
With PPA	70%

: 132-60-5
cinchophen

: 1198001-03-4
2'-(tert-butyl)-2'H-spiro[piperidine-4,5'-pyrano[3,2-c]pyrazole]-7'(6'H)-one

: 2’-(tert-butyl)-1-(2-phenylquinoline-4-carbonyl)-2'H-spiro[piperidine-4,5'-pyrano[3,2-c]pyrazol]-7'(6'H)-one

Conditions

Conditions	Yield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0 - 20℃; for 12.5h;	85%
With triethylamine; HATU In N,N-dimethyl-formamide at 20℃; for 12h;	85%

: 627-27-0
homoalylic alcohol

: 132-60-5
cinchophen

: C20H17NO2

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 25℃; for 48h;	84%

: 132-60-5
cinchophen

: 100-01-6
4-nitro-aniline

: 2-phenyl-N-(4-nitrophenyl)-quinoline-4-carboxamide

Conditions

Conditions	Yield
With trichlorophosphate for 8h; Reflux;	84%

: 17832-99-4
3-(hydroxymethyl)benzo[d]oxazol-2(3H)-one

: 132-60-5
cinchophen

: (2-oxobenzo[d]oxazol-3(2H)-yl)methyl-2-phenylquinoline-4-carboxylate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 5℃; for 2h;	84%

: 13036-81-2
1,3,5-tripropyl-1,3,5-triazinane

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 132-60-5
cinchophen

: C25H29N3O2

Conditions

Conditions	Yield
In 1,2-dichloro-ethane at 45℃; Ugi Condensation;	83%

...Expand

: 132-60-5
cinchophen

: 106-40-1
4-bromo-aniline

: 2-phenyl-N-(4-bromophenyl)-quinoline-4-carboxamide

Conditions

Conditions	Yield
With trichlorophosphate for 8h; Reflux;	82%

Cinchophen Chemical Properties

Empirical Formula: C₁₆H₁₁NO₂
Molecular Weight: 249.264 g/mol
EINECS: 205-067-1
Melting point: 214-215 °C(lit.)
Sensitive: Light sensitive
Index of Refraction: 1.682
Density: 1.28 g/cm³
Flash Point: 230.1 °C
Enthalpy of Vaporization: 75.55 kJ/mol
Boiling Point: 456.9 °C at 760 mmHg
Vapour Pressure: 3.84E-09 mmHg at 25 °C
Structure of Cinchophen (CAS NO.132-60-5):

IUPAC Name: 2-Phenylquinoline-4-carboxylic acid
Product Categories: API intermediates;Quinolinecarboxylic Acids

Cinchophen Uses

Cinchophen (CAS NO.132-60-5) has been used as antipyretic analgesic for acute and chronic arthritis, rheumatic pain, neuralgia, lumbago, gout, headache and so on.

Cinchophen Production

First, having the preparation of isatin to be its sodium salt, and generated by the open-loop, and then with the cyclization of acetophenone to get Sim sodium , or with acetic acid or hydrochloric acid can be derived Xin-fen .

Cinchophen Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	1250mg/kg (1250mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
human	LDLo	oral	214mg/kg (214mg/kg)		"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 177, 1969.
man	LDLo	unreported	74mg/kg (74mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse	LD50	intraperitoneal	200mg/kg (200mg/kg)		National Technical Information Service. Vol. AD691-490,
mouse	LD50	subcutaneous	350mg/kg (350mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 116, Pg. 154, 1958.
mouse	LDLo	oral	1500mg/kg (1500mg/kg)		"Narkoseversuche mit Hoheren Alkoholen und Stickstoffderivaten, Dissertation," Leube, F., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rabbit	LDLo	unreported	500mg/kg (500mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 365, 1942.
rat	LD50	intravenous	600mg/kg (600mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
rat	LDLo	oral	500mg/kg (500mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 90, Pg. 260, 1947.

Cinchophen (CAS NO.132-60-5) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65. And the toxicological properties have not been fully investigated. You can see actual entry in RTECS for complete information.

Cinchophen Safety Profile

A human poison by ingestion. An experimental poison by intraperitoneal and subcutaneous routes. Moderately toxic by an unspecified route. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes of Cinchophen (CAS NO.132-60-5): Harmful Xn
Risk Statements: 22
R22:Harmful if swallowed.
Safety Statements: 36/37/39-26
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.

Cinchophen Specification

Cinchophen ,its cas register number is 132-60-5. It also can be called Cinchoninic acid, 2-phenyl- ; and 4-Quinolinecarboxylic acid, 2-phenyl- . 1g of the product can be dissolved in about 400ml chloroform, 100ml ether, 120ml of ethanol, almost insoluble in water. It is hazardous,so the first aid measures and others should be known. Such as: When on the skin: first,should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly,Get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While ,it's Inhaled: Remove from exposure and move to fresh air immediately.Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : Wash mouth out with water,and get medical aid immediately.Notes to physician: Treat supportively and symptomatically.
In addition, Cinchophen (CAS NO.132-60-5) may discolor on exposure to light. It is not compatible with strong oxidizing agents, strong bases, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: nitrogen oxides, carbon monoxide, carbon dioxide.

Product Name

CINCHOPHEN

Synthetic route

Cinchophen Chemical Properties

Cinchophen Uses

Cinchophen Production

Cinchophen Toxicity Data With Reference

Cinchophen Safety Profile

Cinchophen Specification

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