Cyclobutanemethanol supplier

Name
Cyclobutanemethanol
EINECS 224-575-4
CAS No. 4415-82-1
Article Data46
CAS DataBase
Density 0.961 g/cm³
Solubility Immiscible with water
Melting Point 68.5 °C
Formula C₅H₁₀O
Boiling Point 143.499 °C at 760 mmHg
Molecular Weight 86.1338
Flash Point 40 °C
Transport Information UN 1987 3/PG 3
Appearance Clear colourless liquid
Safety 16
Risk Codes 10
Molecular Structure
Hazard Symbols R10:;
Synonyms (Hydroxymethyl)cyclobutane;Cyclobutylcarbinol;Cyclobutylmethyl alcohol;
PSA 20.23000
LogP 0.77880

Synthetic route

: C8H18OSi

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
With methanol; 1,3-disulfonic acid imidazolium hydrogen sulfate at 20℃; for 0.0666667h; Green chemistry;	98%

: 3721-95-7
Cyclobutanecarboxylic acid

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether for 1.5h; Ambient temperature;	96%
With lithium aluminium tetrahydride In diethyl ether	72%
With lithium aluminium tetrahydride; diethyl ether

: 14924-53-9
ethyl cyclobutylcarboxylate

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether 1) rt, 24 h, 2) reflux, 1.5 h;	53%
With ethanol; sodium
Stage #1: ethyl cyclobutylcarboxylate With diethoxymethylane; zinc diacetate In toluene at 100℃; for 24h; Inert atmosphere; Stage #2: With methanol; potassium hydroxide chemoselective reaction;	65 %Chromat.

: 64-17-5
ethanol

: 3779-29-1
diethyl cyclobutane-1,1-dicarboxylate

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
With sodium; toluene

: 3779-29-1
diethyl cyclobutane-1,1-dicarboxylate

A: 4415-73-0
[1-(hydroxymethyl)cyclobutyl]methanol

B: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
With ethanol; sodium
With ethanol; sodium Erwaermen des Reaktionsgemisches auf 130-140grad;

: 89182-08-1
(1-cyclobutenyl)methyl alcohol

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
With methanol; platinum Hydrogenation;

: 5006-22-4
Cyclobutanecarbonyl chloride

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
With diethyl ether; sodium
With lithium aluminium tetrahydride In diethyl ether for 2h; Heating; Yield given;

: 1120-56-5
methylidenecyclobutane

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
(i) B2H6, THF, (ii) H2O2; Multistep reaction;

: 2987-17-9
cyclobutylaldehyde

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
With sodium hydroxide at 80℃; for 42h;

: 15963-49-2
3-(hydroxymethyl)cyclobutene

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
With hydrogen; platinum(IV) oxide In methanol

: 21746-87-2
5-bromo-1,2-epoxypentane

A: 96-41-3
Cyclopentanol

B: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
With tributylphosphine; copper In tetrahydrofuran Product distribution; other reagent and solvent;
With tributylphosphine; copper In tetrahydrofuran Yield given. Yields of byproduct given;
With copper(l) iodide; lithium dihydronaphthylide radical; triphenylphosphine In tetrahydrofuran 1) -45 deg C, 5 min, -23 deg C, 3 h, r.t.; Yield given. Yields of byproduct given;

: 1120-56-5
methylidenecyclobutane

A: 111-29-5
1 ,5-pentanediol

B: 4415-82-1
cyclobutanemethanol

: trans-2-methylcyclobutanol

Conditions

Conditions	Yield
With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide 1.) THF, a) RT, 1.5 h, b) 110 deg C, 96 h, 2.) THF, water, 50 deg C to 60 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide 1.) THF, a) RT, 1.5 h, b) 110 deg C, 96 h, 2.) THF, water, 50 deg C to 60 deg C 1 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 51108-24-8
cyclobutyl brosylate

A: 4415-82-1
cyclobutanemethanol

B: 138-36-3
p-bromobenzene sulfonic acid

Conditions

Conditions	Yield
With sodium methylate In ethanol; water at 45℃; Rate constant;
With sodium acetate In formic acid; acetic acid at 45℃; Rate constant;

: 99700-68-2
2-(3-Iodo-propyl)-oxirane

A: 96-41-3
Cyclopentanol

B: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
With tert.-butyl lithium 1.) Et2O, pentane, -78 deg C, 5 min; 2.) warming; Yield given. Multistep reaction. Yields of byproduct given;
With tert.-butyl lithium In diethyl ether; pentane at -78℃; Product distribution; Effect of various additives or warming.;

: 60-29-7
diethyl ether

: 5006-22-4
Cyclobutanecarbonyl chloride

sodium: sodium

: 4415-82-1
cyclobutanemethanol

...Expand

hydrochloride of aminomethyl-cyclobutane: hydrochloride of aminomethyl-cyclobutane

A: 96-41-3
Cyclopentanol

B: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
With silver(I) nitrite

: 64-17-5
ethanol

: 3779-29-1
diethyl cyclobutane-1,1-dicarboxylate

sodium: sodium

A: 4415-73-0
[1-(hydroxymethyl)cyclobutyl]methanol

B: 4415-82-1
cyclobutanemethanol

...Expand

: 7664-93-9
sulfuric acid

: cyclobutylmethyl-cyclobutylmethylen-amine

A: 38834-90-1
cyclobutylmethyl cyclobutanecarboxylate

B: 4415-82-1
cyclobutanemethanol

...Expand

: 5454-82-0
cyclobutylmethylamine hydrochloride

AgNO2: AgNO2

A: 1120-56-5
methylidenecyclobutane

B: 96-41-3
Cyclopentanol

C: 4415-82-1
cyclobutanemethanol

D: 142-29-0
cyclopentene

Conditions

Conditions	Yield
man erhitzt die Loesung des erhaltenen Nitrils;

...Expand

: 40628-41-9
methyl cyclobut-1-enecarboxylate

A: 4415-82-1
cyclobutanemethanol

B: 89182-08-1
(1-cyclobutenyl)methyl alcohol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether at 25℃; for 0.25h; Reduction; Title compound not separated from byproducts.;

: 23519-90-6
1-cyclobutenecarboxylic acid

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 100 percent / diethyl ether / 0.5 h / 0 °C 2: lithium aluminum hydride / diethyl ether / 0.25 h / 25 °C View Scheme
Multi-step reaction with 2 steps 1: 81 percent / diethyl ether / 48 h / 20 °C 2: lithium aluminum hydride / diethyl ether / 0.25 h / 25 °C View Scheme

: 3779-29-1
diethyl cyclobutane-1,1-dicarboxylate

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) KOH / 1.) EtOH, H2O; 2.) reflux 2: thionyl chloride 3: lithium aluminum hydride / diethyl ether / 2 h / Heating View Scheme

: 81469-29-6
1-chloro-1-(hydroxymethyl)cyclobutane

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol. KOH-solution 2: platinum; methanol / Hydrogenation View Scheme

: 35207-71-7
3-chlorocyclobutane-1-carboxylic acid

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: (i) Et2O, (ii) LiAlH4 2: KOtBu / dimethylsulfoxide 3: H2 / PtO2 / methanol View Scheme

: 51816-01-4
cyclobutane-1,1-dicarboxylic acid dichloride

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: SO2Cl2, (PhCO)2O2 / 3 h / Heating 2: H2O 3: 12 h / 180 °C 4: (i) Et2O, (ii) LiAlH4 5: KOtBu / dimethylsulfoxide 6: H2 / PtO2 / methanol View Scheme

: 5445-51-2
cyclobutane-1,1'-dicarboxylic acid

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: SOCl2 / 3 h / Heating 2: SO2Cl2, (PhCO)2O2 / 3 h / Heating 3: H2O 4: 12 h / 180 °C 5: (i) Et2O, (ii) LiAlH4 6: KOtBu / dimethylsulfoxide 7: H2 / PtO2 / methanol View Scheme

: 89639-43-0
3-chloro-1,1-cyclobutanedicarboxylic acid

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 12 h / 180 °C 2: (i) Et2O, (ii) LiAlH4 3: KOtBu / dimethylsulfoxide 4: H2 / PtO2 / methanol View Scheme

: 89582-02-5
3-Chlor-1,1-cyclobutandicarbonsaeure-dichlorid

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: H2O 2: 12 h / 180 °C 3: (i) Et2O, (ii) LiAlH4 4: KOtBu / dimethylsulfoxide 5: H2 / PtO2 / methanol View Scheme

: 15963-47-0
3-chlorocyclobutanemethanol

: 4415-82-1
cyclobutanemethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: KOtBu / dimethylsulfoxide 2: H2 / PtO2 / methanol View Scheme

: 4415-82-1
cyclobutanemethanol

: 124-63-0
methanesulfonyl chloride

: 63659-30-3
cyclobutylmethyl methanesulfonate

Conditions

Conditions	Yield
With triethylamine In chloroform at 20℃; for 2h;	100%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 3h;	66%
With triethylamine In dichloromethane at -10℃; for 0.333333h;

: 4415-82-1
cyclobutanemethanol

: 2987-17-9
cyclobutylaldehyde

Conditions

Conditions	Yield
With pyridinium chlorochromate In dichloromethane for 1h; Ambient temperature;	99%
Stage #1: cyclobutanemethanol With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide In dichloromethane; water at -5℃; for 0.333333h; Stage #2: With sodium hypochlorite In dichloromethane; water at -5 - 0℃; for 0.5h; Stage #3: With potassium dihydrogenphosphate In dichloromethane; water at 20℃; for 0.5h;	70.4%
Stage #1: cyclobutanemethanol With oxalyl dichloride; dimethyl sulfoxide In dichloromethane at -78℃; for 1h; Stage #2: With triethylamine In dichloromethane at -78℃;	63%

: 3095-95-2
diethylphosphonoacetic acid

: 4415-82-1
cyclobutanemethanol

: cyclobutylmethyl 2-(diethoxyphosphoryl)acetate

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;	99%

: 4415-82-1
cyclobutanemethanol

: 545-06-2
trichloroacetonitrile

: cyclobutylmethyl 2,2,2-trichloroacetimidate

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane	99%

: 876-27-7
4-chlorophenyl acetate

: 4415-82-1
cyclobutanemethanol

: 2158-14-7
4-acetamidobenzenesulfonyl azide

: cyclobutylmethyl 2-(4-chlorophenyl)-2-diazoacetate

Conditions

Conditions	Yield
Stage #1: 4-chlorophenyl acetate; cyclobutanemethanol With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane for 20h; Stage #2: 4-acetamidobenzenesulfonyl azide With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 0℃; for 16h;	99%

...Expand

: 25726-04-9
phenylglyoxylyl chloride

: 4415-82-1
cyclobutanemethanol

: cyclobutylmethyl 2-oxo-2-phenylacetate

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane at 0 - 20℃; Inert atmosphere;	98%

: 4415-82-1
cyclobutanemethanol

: 28144-70-9
anthranilic acid amide

: 2-cyclobutylquinazolin-4(3H)-one

Conditions

Conditions	Yield
With tert.-butylhydroperoxide In dimethyl sulfoxide at 25 - 35℃; for 40h; Irradiation; Green chemistry;	98%
With tert.-butylhydroperoxide at 110℃; for 12h;	74%

: 4415-82-1
cyclobutanemethanol

: 98-59-9
p-toluenesulfonyl chloride

: 13295-53-9
cyclobutylmethyl 4-methylbenzenesulfonate

Conditions

Conditions	Yield
With dmap In dichloromethane at 0 - 25℃;	97%
In pyridine at 0℃; for 24h;	92%
In pyridine at -15℃;	92%

: 4415-82-1
cyclobutanemethanol

: 16000-39-8
1-cyano-2-methoxynaphthalene

: 2-(cyclobutylmethoxy)-1-naphthonitrile

Conditions

Conditions	Yield
With potassium tert-butylate In 1,4-dioxane at 20℃; for 16h; Inert atmosphere; Sealed tube; Glovebox;	96%

: 4415-82-1
cyclobutanemethanol

: 99-23-0
puberulic acid

: C13H14O6

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 120℃; for 16h; Sealed tube;	95%

: 4415-82-1
cyclobutanemethanol

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: C8H18OSi

Conditions

Conditions	Yield
With 1,3-disulfonic acid imidazolium hydrogen sulfate In neat (no solvent) at 20℃; for 0.05h; Green chemistry;	94%

: 14080-23-0
2-cyanopyrimidine

: 4415-82-1
cyclobutanemethanol

: 2-(cyclobutylmethoxy)pyrimidine

Conditions

Conditions	Yield
With caesium carbonate In dimethyl sulfoxide at 80℃; for 5h;	94%

: 4415-82-1
cyclobutanemethanol

: C25H26ClN3O2

: C30H35N3O3

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran; mineral oil at 20 - 50℃; for 2.5h;	91%

: 57125-20-9
ditungsten hexa-tert-butoxide

: 4415-82-1
cyclobutanemethanol

: 120853-44-3
W4(OCH2-c-Bu)12(HOCH2-c-Bu)

Conditions

Conditions	Yield
In hexane byproducts: t-C4H9OH; under N2, adding cyclobutylmethanol dropwise to soln. of W2(O-t-Bu)6, room temp., stirring, 2 h; evapn. of volatile components in vac., dissolving in 1,2-dimethoxyethane, cooling to -20°C, 16 h, filtration at 0°C (2nd crop from filtrate); elem. anal.;	90.2%

: 6863-73-6
3-chloropyrazin-2-amine

: 4415-82-1
cyclobutanemethanol

: 3-(cyclobutylmethoxy)pyrazin-2-amine

Conditions

Conditions	Yield
Stage #1: cyclobutanemethanol With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: 3-chloropyrazin-2-amine In N,N-dimethyl-formamide at 100℃; for 20h;	89%

: 674-82-8
4-methyleneoxetan-2-one

: 4415-82-1
cyclobutanemethanol

: 103785-41-7
cyclobutylmethyl acetoacetate

Conditions

Conditions	Yield
With sodium hydride at 70 - 80℃; for 2h;	88%

: 4415-82-1
cyclobutanemethanol

: 474295-85-7
methyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-(4-hydroxyphenyl)propanoate

: methyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-[4-(cyclobutylmethoxy)phenyl]propanoate

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20 - 35℃; Mitsunobu Displacement; Inert atmosphere;	87%

: 4415-82-1
cyclobutanemethanol

: N-(3-((1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4,5-difluorophenyl)-5-chloro-2-pyrazinecarboxamide

: N-(3-((1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4,5-difluorophenyl)-5-(cyclobutylmethoxy)pyrazine-2-carboxamide

Conditions

Conditions	Yield
With caesium carbonate In tetrahydrofuran at 50℃; for 2h;	86%

: 4415-82-1
cyclobutanemethanol

: cyclobutylmethyl sulfamate

Conditions

Conditions	Yield
With formic acid; isocyanate de chlorosulfonyle; triethylamine In dichloromethane at 0 - 25℃; Schlenk technique; Inert atmosphere;	86%

: 944804-88-0
tert-butyl N-(4-bromo-1,3-thiazol-2-yl)carbamate

: 4415-82-1
cyclobutanemethanol

: tert-butyl (4-bromothiazol-2-yl)(cyclobutylmethyl)carbamate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 40℃; for 1.5h; Inert atmosphere;	85%

: 4415-82-1
cyclobutanemethanol

: 141-53-7
sodium formate

: 110-83-8
cyclohexene

: cyclobutylmethyl cyclohexanecarboxylate

Conditions

Conditions	Yield
With 2-Hydroxymethylpyridine; dodecacarbonyl-triangulo-triruthenium at 170℃; for 4h;	84%

...Expand

: 4415-82-1
cyclobutanemethanol

: 17763-67-6
Phenyl triflate

: 5407-98-7
1-cyclobutyl-1-phenyl-methanone

Conditions

Conditions	Yield
With 2,2,6,6-tetramethyl-piperidine; bis(1,5-cyclooctadiene)nickel (0); acetone; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In toluene at 130℃; for 20h; Inert atmosphere;	84%

: 4415-82-1
cyclobutanemethanol

sodium monochloroacetic acid: sodium monochloroacetic acid

: 848666-52-4
cyclobutylmethoxyacetic acid

Conditions

Conditions	Yield
Stage #1: cyclobutanemethanol With sodium hydride In tetrahydrofuran at -15 - 25℃; for 1h; Stage #2: sodium monochloroacetic acid In dimethyl sulfoxide at 20℃; for 20h; Stage #3: With hydrogenchloride In water	83%
Stage #1: cyclobutanemethanol With sodium hydride In tetrahydrofuran at -15 - 25℃; for 1h; pH=2; Stage #2: sodium monochloroacetic acid In tetrahydrofuran; dimethyl sulfoxide at 20℃; for 2h;	83%

: 4415-82-1
cyclobutanemethanol

: 91923-30-7
methyl cyclohexanethionocarboxylate

: O-(cyclobutylmethyl) cyclohexanecarbothioate

Conditions

Conditions	Yield
With sodium hydride at 75 - 80℃; for 0.5h;	83%

: 4415-82-1
cyclobutanemethanol

: C14H11FO2

: C19H20O3

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 60℃; for 12h; Inert atmosphere;	81.5%

: 4415-82-1
cyclobutanemethanol

: potassium cyclobutanecarboxylate

Conditions

Conditions	Yield
With C22H36IrNP(1+)*CF3O3S(1-); potassium hydroxide In toluene at 120℃; for 40h;	81%

: ethyl diazomethanesulfonate

: 4415-82-1
cyclobutanemethanol

: ((6-(3,3-bis(trifluoromethyl)-1λ3-benzo[d][1,2]iodaoxol-1(3H)-yl)hex-5-yn-1-yl)oxy)(tertbutyl)diphenylsilane

: ethyl 7-((tert-butyldiphenylsilyl)oxy)-1-(cyclobutylmethoxy)hept-2-yne-1-sulfonate

Conditions

Conditions	Yield
With tetrakis(actonitrile)copper(I) hexafluorophosphate In dichloromethane at 25℃; for 2h; Inert atmosphere; Sealed tube; Microwave irradiation;	81%

...Expand

: 4415-82-1
cyclobutanemethanol

: 613-94-5
benzoic acid hydrazide

: N′,N′-bis(cyclobutylmethyl)benzohydrazide

Conditions

Conditions	Yield
With t-butylnitrite; C24H20N2O4Ru; sodium t-butanolate In tert-butyl alcohol at 130℃; for 24h; Schlenk technique; Inert atmosphere;	81%

Cyclobutanemethanol Specification

The Cyclobutanemethanol, with the CAS registry number 4415-82-1, is also known as Hydroxymethylcyclobutane. It belongs to the product categories of API Intermediates; Cyclobutanes & Cyclobutenes; Simple 4-Membered Ring Compounds; Cycloalkanes; Alcohols; C2 to C6; Oxygen Compounds. Its EINECS registry number is 224-575-4. This chemical's molecular formula is C₅H₁₀O and molecular weight is 86.13. What's more, both its IUPAC name and systematic name are the same which is called Cyclobutylmethanol. When you are dealing with this chemical, you should be very careful. This chemical is flammable. Therefore, you should keep away from sources of ignition.

Physical properties about Cyclobutanemethanol are: (1)ACD/LogP: 0.737; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.74; (4)ACD/LogD (pH 7.4): 0.74; (5)ACD/BCF (pH 5.5): 2.14; (6)ACD/BCF (pH 7.4): 2.14; (7)ACD/KOC (pH 5.5): 60.00; (8)ACD/KOC (pH 7.4): 60.00; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 20.23 Å²; (13)Index of Refraction: 1.463; (14)Molar Refractivity: 24.676 cm³; (15)Molar Volume: 89.549 cm³; (16)Polarizability: 9.782×10^-24cm³; (17)Surface Tension: 37.253 dyne/cm; (18)Density: 0.962 g/cm³; (19)Flash Point: 40 °C; (20)Enthalpy of Vaporization: 44.341 kJ/mol; (21)Boiling Point: 143.499 °C at 760 mmHg; (22)Vapour Pressure: 2.137 mmHg at 25 °C.

Preparation of Cyclobutanemethanol: this chemical can be prepared by cyclobutanecarboxylic acid. This reaction needs reagent LiAlH₄ and solvent diethyl ether at ambient temperature. The reaction time is 1.5 hours. The yield is 96 %.

Cyclobutanemethanol can be prepared by cyclobutanecarboxylic acid.

Uses of Cyclobutanemethanol: (1) it is used as pharmaceutical intermediates; (2) it is used to produce other chemicals. For example, it can react with diketene to get cyclobutylmethyl acetoacetate. The reaction occurs with reagent NaH in oil at temperature of 70-80 °C. The reaction time is 2 hours. The yield is 88 %.

Cyclobutanemethano can react with diketene to get cyclobutylmethyl acetoacetate.

You can still convert the following datas into molecular structure:
(1) SMILES: OCC1CCC1
(2) InChI: InChI=1S/C5H10O/c6-4-5-2-1-3-5/h5-6H,1-4H2
(3) InChIKey: WPOPOPFNZYPKAV-UHFFFAOYSA-N

Product Name

Cyclobutanemethanol

Synthetic route

Cyclobutanemethanol Specification

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