Conditions | Yield |
---|---|
With trichlorosilane; N-ethyl-N,N-diisopropylamine In acetonitrile at 15℃; for 30h; | 100% |
With trichlorosilane; N-ethyl-N,N-diisopropylamine In acetonitrile at 0 - 20℃; for 18h; Inert atmosphere; | 90% |
With ethanol; nickel Hydrogenation; | |
With methanol; nickel Hydrogenation; | |
With hydrogen; palladium on activated charcoal In ethanol under 2280 Torr; |
Conditions | Yield |
---|---|
Stage #1: formaldehyd; Nitroethane With triethanolamine In water at 50℃; for 105h; Stage #2: With Fe/Ni; hydrogen at 70℃; under 22502.3 Torr; for 4h; Reagent/catalyst; Temperature; Pressure; | 82.6% |
Conditions | Yield |
---|---|
Stage #1: hydroxy-2-propanone With ammonia In water at 0 - 20℃; for 1 - 1.5h; Stage #2: With hydrogen; nickel In water at 85℃; under 57647.8 Torr; Product distribution / selectivity; | 71.5% |
Stage #1: hydroxy-2-propanone With ammonia at 20℃; for 1h; Stage #2: With hydrogen; nickel at 85℃; under 57647.8 Torr; Product distribution / selectivity; | 33.4% |
Stage #1: hydroxy-2-propanone With ammonia In water at 20℃; for 1.5h; Stage #2: With hydrogen; Nickel Raney 5886 In water at 85℃; under 23252.3 Torr; for 0.166667 - 0.333333h; Product distribution / selectivity; | |
Stage #1: hydroxy-2-propanone With ammonia In water at 20℃; for 1.5h; Stage #2: With hydrogen; nickel oxide on kieselguhr In water at 85℃; under 25877.6 - 113786 Torr; Product distribution / selectivity; | |
With (S)-1-phenyl-ethylamine; pyridoxal 5'-phosphate; pQR1108 In aq. phosphate buffer; dimethyl sulfoxide at 30℃; for 18h; pH=8; Enzymatic reaction; |
Conditions | Yield |
---|---|
With sodium tetrahydroborate; iodine In tetrahydrofuran for 15h; Heating; | 60% |
With dimethylsulfide borane complex; boron trifluoride diethyl etherate In tetrahydrofuran for 2.5h; Heating; | |
Stage #1: rac-Ala-OH With lithium aluminium tetrahydride In tetrahydrofuran for 12h; Reflux; Stage #2: With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃; |
ethyl pyruvate oxime
2-Amino-1-propanol
Conditions | Yield |
---|---|
With sodium tetrahydroborate; iodine In tetrahydrofuran for 4h; Heating; | 60% |
AlaOEt
2-Amino-1-propanol
Conditions | Yield |
---|---|
With ethanol; nickel at 50 - 100℃; Hydrogenation; |
Conditions | Yield |
---|---|
With ethanol; sodium |
Conditions | Yield |
---|---|
With ethanol; sodium |
Conditions | Yield |
---|---|
With sodium amalgam; acetic acid |
Conditions | Yield |
---|---|
With alkaline aqueous sodium hypobromite |
hydroxy-2-propanone
A
2,5-dimethoxy-2,5-dimethyl-1,4-dioxane
B
2-Amino-1-propanol
Conditions | Yield |
---|---|
With methanol; ammonia; water; nickel at 90℃; under 11032.6 Torr; Hydrogenation; |
2-amino-2-[1,3]dithiolan-2-yl-ethanol
2-Amino-1-propanol
Conditions | Yield |
---|---|
With nickel |
methyl 2-aminopropanoate monohydrochloride
2-Amino-1-propanol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride |
propylamine
A
2-Amino-1-propanol
B
(RS)-isoserine
C
glycine
D
propan-1-ol-3-amine
E
3-amino propanoic acid
Conditions | Yield |
---|---|
In water at 10 - 20℃; Product distribution; pH=2.7 and pH=12.0, various reaction times, contact glow discharge electrolysis; |
propylamine
A
2-Amino-1-propanol
B
(RS)-isoserine
C
glycine
D
3-amino propanoic acid
Conditions | Yield |
---|---|
In water at 10 - 20℃; contact glow discharge electrolysis; Yield given. Further byproducts given. Yields of byproduct given; | |
In water at 10 - 20℃; contact glow discharge electrolysis, pH=2.7; Yield given. Further byproducts given. Yields of byproduct given; | |
In water at 10 - 20℃; contact glow discharge electrolysis, pH=2.7; Yield given. Further byproducts given; |
N-chloro-2-aminopropan-1-ol
2-Amino-1-propanol
Conditions | Yield |
---|---|
With disodium hydrogenphosphate; sodium dihydrogenphosphate; sodium perchlorate; sodium iodide Thermodynamic data; Kinetics; Rate constant; Ea, ΔH, ΔS, influence of pH on the rate constant, reaction mechanism; |
2-Amino-1-propanol
Conditions | Yield |
---|---|
With hydrogen S, Ram, L. D. Spicer Synth. Commun. 1987, 17, 415.; |
ammonia
hydroxy-2-propanone
A
2,5-dimethoxy-2,5-dimethyl-1,4-dioxane
B
2-Amino-1-propanol
Conditions | Yield |
---|---|
und anschliessenden Hydrierung an Raney-Nickel bei 80grad/15 at; |
tetrahydrofuran
N-(N-benzoyl-glycyl)-alanine ethyl ester
A
2-Amino-1-propanol
B
ethanolamine
Conditions | Yield |
---|---|
Stage #1: hydroxy-2-propanone With ammonia In water at 20℃; for 1.5h; Stage #2: With hydrogen; nickel In water at 85℃; under 113786 Torr; Product distribution / selectivity; | |
With ammonia; hydrogen; Nickel Raney 5886 at 85℃; under 23252.3 Torr; Product distribution / selectivity; |
Conditions | Yield |
---|---|
With trifluoroacetic acid polystyrene ((aminomethyl)polystyrene); Product distribution / selectivity; |
glycerol
A
piperazine
B
propylamine
C
2-Amino-1-propanol
D
N-(1-aminomethyl-2-hydroxyethyl)amine
E
(RS)-2-methylpiperazine
F
ethylamine
G
isopropylamine
H
1,2-diaminopropan
I
3-amino-2-propanol
J
methylamine
Conditions | Yield |
---|---|
With ammonia; hydrogen; catalyst obtained by prereduction from precursor whose catalytically active composition before the reduction with hydrogen comprised 13% by weight of Cu, calculated as CuO, 28% by weight of NI, calculated as NiO, 28% by weight of Co, calculated as CoO and 31% by weight of Zr, calculated as ZrO2 In water at 250℃; under 37503.8 - 225023 Torr; Product distribution / selectivity; Autoclave; |
glycerol
A
2-Amino-1-propanol
B
N-(1-aminomethyl-2-hydroxyethyl)amine
C
1,2,3-triaminopropane
D
(RS)-2-methylpiperazine
E
1,2-diaminopropan
F
2,6-dimethylpiperazine
G
2,5-dimethylpiperazine
Conditions | Yield |
---|---|
With ammonia; hydrogen; catalyst precursor whose active composition comprised 13% by weight of Cu, calculated as CuO, 28% by weight of Ni, calculated as NiO, 28% by weight of Co, calculated as CoO and 31% by weight of Zr, calculated as ZrO2 In water at 180℃; under 150015 Torr; for 53h; Product distribution / selectivity; |
glycerol
A
2-Amino-1-propanol
B
N-(1-aminomethyl-2-hydroxyethyl)amine
C
1,2,3-triaminopropane
D
2-aminomethyl-6-methylpiperazine
E
2,5-bis(aminomethyl)piperazine
F
2-aminomethylpiperazine
G
2-aminomethyl-5-methylpiperazine
H
(RS)-2-methylpiperazine
I
1,2-diaminopropan
J
2,6-dimethylpiperazine
K
2,5-dimethylpiperazine
Conditions | Yield |
---|---|
With ammonia; hydrogen; catalyst precursor whose active composition comprised 50% by weight of Ni, calculated as NiO, 18% by weight of Cu, calculated as CuO, 2% by weight of Mo, calculated as MoO3, and 30% by weight or Zr, calculated as ZrO2 In water at 192℃; under 150015 Torr; for 1076h; Product distribution / selectivity; |
glycerol
A
propan-1-ol
B
2-Amino-1-propanol
C
3-amino-2-propanol
D
isopropyl alcohol
Conditions | Yield |
---|---|
With ammonia; hydrogen In water at 20℃; under 37503.8 Torr; for 24h; |
2-Amino-1-propanol
N-methyl-N-tert-butyldimethylsilyl-1,1,1-trifluoroacetamide
(tert-Butyl-dimethyl-silanyl)-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-amine
Conditions | Yield |
---|---|
With tert-butyldimethylsilyl chloride In acetonitrile for 0.0833333h; Ambient temperature; other silylating agent; | 100% |
phthalic anhydride
2-Amino-1-propanol
2-(2-hydroxy-1-methylethyl)-1H-isoindole-1,3(2H)-dione
Conditions | Yield |
---|---|
With triethylamine In toluene Reflux; | 100% |
In toluene | 100% |
With triethylamine In toluene for 3h; Condensation; Heating; | 95% |
Conditions | Yield |
---|---|
In acetonitrile | 100% |
Conditions | Yield |
---|---|
In methanol at 20℃; for 1h; | 100% |
2-Amino-1-propanol
2-fluoro-4-[4-(4-fluorophenyl)-1-(2-methoxyethyl)-2-(methylsulfanyl)-1H-imidazol-5-yl]pyridine
Conditions | Yield |
---|---|
at 155℃; for 19h; | 100% |
In ethyl acetate at 155℃; for 19h; | 99.7% |
2-Amino-1-propanol
tert-butyldimethylsilyl chloride
1-(tert-butyldimethylsilyloxy)propan-2-amine
Conditions | Yield |
---|---|
With 1H-imidazole In dichloromethane at 20℃; for 4h; | 100% |
2-Amino-1-propanol
3-nitro-benzeneacetic acid
N-(1-hydroxypropan-2-yl)-2-(3-nitrophenyl)acetamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 16h; | 100% |
Conditions | Yield |
---|---|
With sodium ethanolate at 125℃; for 5h; | 99% |
With potassium carbonate at 130℃; for 3h; | 73% |
With sodium methylate for 4h; | |
With sodium methylate | |
With sodium methylate In methanol at 20℃; Heating / reflux; |
Conditions | Yield |
---|---|
In acetonitrile | 99% |
2-Amino-1-propanol
methyl [6-(3-fluoro-4-methoxybenzyl)-1,2,4,7-tetrahydro-3H-indolo[2,3-c][1,7]naphthyridin-3-yl]acetate
2-[6-(3-fluoro-4-methoxybenzyl)-1,2,4,7-tetrahydro-3H-indolo[2,3-c][1,7]naphthyridin-3-yl]-N-(2-hydroxy-1-methylethyl)acetamide
Conditions | Yield |
---|---|
at 100℃; for 18h; | 99% |
2-Amino-1-propanol
cis-5-tert-butoxycarbonyltetrahydro-3aH-furo[3,4-c]pyrrole-1,3-dione
C14H22N2O5
Conditions | Yield |
---|---|
In toluene at 170℃; for 0.233333h; Microwave irradiation; | 99% |
Conditions | Yield |
---|---|
at 50℃; for 3h; | 98% |
2-Amino-1-propanol
phenyl isothiocyanate
1-(1-hydroxypropan-2-yl)-3-phenylthiourea
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 0.5h; Alkylation; | 98% |
In tetrahydrofuran at 20℃; |
Conditions | Yield |
---|---|
Stage #1: 2-Amino-1-propanol; 2-fluorobenzonitrile With potassium tert-butylate In tetrahydrofuran at 0 - 25℃; Stage #2: With hydrogenchloride In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane | 97% |
2-Amino-1-propanol
di-tert-butyl dicarbonate
tert-butyl (1-hydroxypropan-2-yl)carbamate
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 14h; | 96% |
In dichloromethane at 20℃; for 1h; | 93% |
With triethylamine In dichloromethane at 20℃; for 0.5h; Cooling with ice; | 90.7% |
Conditions | Yield |
---|---|
With oxygen; potassium iodide; palladium(II) iodide In 1,2-dimethoxyethane at 100℃; under 15201 Torr; for 15h; | 96% |
With oxygen; sodium iodide; salen-Co(II) complex In 1,4-dioxane at 120℃; under 45004.5 Torr; for 2h; | 96% |
With oxygen; potassium iodide; palladium(II) iodide at 100℃; under 15001.5 Torr; for 24h; Autoclave; | 94% |
2-Amino-1-propanol
3-chloro-4-fluorobenzonitrile
3-chloro-4-(2-hydroxy-1-methyl-ethylamino)-benzonitrile
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 60℃; for 2h; | 96% |
In dimethyl sulfoxide at 60℃; for 2h; | 96% |
Conditions | Yield |
---|---|
With 3 A molecular sieve for 8h; Ambient temperature; | 95% |
Conditions | Yield |
---|---|
With dentritic zwitterionic imidazolium ionic liquid immobilized on mesoporous silica nanoparticles at 70℃; for 8h; Autoclave; | 95% |
With nanoparticulated CeO2 In ethanol at 160℃; under 5250.53 Torr; for 8h; Sealed reactor; |
Conditions | Yield |
---|---|
With sodium carbonate In water for 2h; Ambient temperature; | 94% |
With diethyl ether |
2-Amino-1-propanol
(fluorenylmethoxy)carbonyl chloride
(2-hydroxy-1-methylethyl)carbamic acid 9H-fluoren-9-yl methyl ester
Conditions | Yield |
---|---|
In diethyl ether at 20℃; for 2h; | 94% |
Conditions | Yield |
---|---|
With nitromethane for 0.0833333h; Microwave irradiation; | 94% |
2-Amino-1-propanol
ethyl 3-(2,6-dichloro-5-fluoro-3-pyridyl)-2--3-oxopropionate
(+/-)-ethyl 3-(2,6-dichloro-5-fluoro-3-pyridyl)-2-(4-methyloxazolidin-2-ylidene)-3-oxopropionate
Conditions | Yield |
---|---|
In toluene for 2.5h; Heating; | 93% |
Conditions | Yield |
---|---|
In benzene at 80℃; for 4h; | 93% |
2-Amino-1-propanol
n-hexadecanoyl chloride
(S)-2-methyl-2-(N-palmitoylamino)ethanol
Conditions | Yield |
---|---|
With triethylamine In chloroform; water | 93% |
2-Amino-1-propanol
p-toluenesulfonyl chloride
(+/-)-N-<2-hydroxy-1-methylethyl>-p-toluolsulfonamid
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 93% |
With triethylamine In dichloromethane at 0 - 20℃; for 18h; | 84% |
With triethylamine In dichloromethane at 20℃; |
2-Amino-1-propanol
2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid
2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid (2-hydroxy-1-methylethyl)amide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 7h; | 93% |
Conditions | Yield |
---|---|
With triethylamine In methanol Reflux; | 93% |
2-Amino-1-propanol
5-bromo-1,3-difluoro-2-nitro-benzene
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1h; | 93% |
The DL-Alaninol, with the CAS registry number 6168-72-5, is also known as 1-Propanol, 2-amino-. Its EINECS registry number is 220-388-7. This chemical's molecular formula is C3H9NO and molecular weight is 75.10966. Its IUPAC name is called 2-aminopropan-1-ol. This chemical is clear colorless to light yellow viscous liquid. The product should be sealed and stored in cool and dry place. It can be used in organic synthesis and also can be used as emulsifier.
Physical properties of DL-Alaninol: (1)ACD/LogP: -0.96; (2)ACD/LogD (pH 5.5): -4.05; (3)ACD/LogD (pH 7.4): -3.47; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 3; (11)Index of Refraction: 1.439; (12)Molar Refractivity: 20.97 cm3; (13)Molar Volume: 79.6 cm3; (14)Surface Tension: 35.7 dyne/cm; (15)Density: 0.943 g/cm3; (16)Flash Point: 83.9 °C; (17)Enthalpy of Vaporization: 47.83 kJ/mol; (18)Boiling Point: 174.5 °C at 760 mmHg; (19)Vapour Pressure: 0.373 mmHg at 25°C.
Uses of DL-Alaninol: it can be used to produce 2-Aminopropylhydrogensulfat. This reaction will need reagent H2SO4.
When you are using this chemical, please be cautious about it as the following:
This chemical may destroy living tissue on contact and may cause burns. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(CO)N
(2)InChI: InChI=1S/C3H9NO/c1-3(4)2-5/h3,5H,2,4H2,1H3
(3)InChIKey: BKMMTJMQCTUHRP-UHFFFAOYSA-N
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