DL-Norvaline supplier | CasNO.760-78-1

Name
DL-Norvaline
EINECS 212-082-7
CAS No. 760-78-1
Article Data48
CAS DataBase
Density 1.067 g/cm³
Solubility water: 1 g/10 mL (18 °C)
Melting Point ≥300 °C (dec.)
Formula C₅H₁₁NO₂
Boiling Point 222.9 °C at 760 mmHg
Molecular Weight 117.148
Flash Point 88.6 °C
Transport Information
Appearance white to off-white crystals or crystalline powder
Safety 22-24/25-37/39-26
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms DL-alpha-Aminovaleric acid;(+-)-Norvaline;DL-2-Aminopentanoic acid;2-Aminovaleric acid;(2R)-2-azaniumylpentanoate;DL-.alpha.-Aminovaleric acid;Valeric acid, 2-amino-, DL-;Norvaline, DL-;.alpha.-DL-Aminopentanoic acid;(2S)-2-azaniumylpentanoate;DL-Norvaline 99% min。;alpha-DL-Aminopentanoic acid;
PSA 63.32000
LogP 0.89870

Synthetic route

: 56548-09-5
2-acetylamino-2-cyano-valeric acid ethyl ester

: 623-11-0
1-methyl-4-nitrosobenzene

: 760-78-1
2-aminopentanoic acid

: 56548-09-5
2-acetylamino-2-cyano-valeric acid ethyl ester

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With hydrogen bromide
With hydrogenchloride

: 74-90-8
hydrogen cyanide

: 40898-95-1
1-(-)-2-amino-1-butanol

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With hydrogenchloride

: 21486-54-4
2-hydroxyiminopentanoic acid

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With hydrogenchloride; palladium on activated charcoal under 7355.08 Torr; Hydrogenation;

: 6967-47-1
ethyl 2-cyanopentanoate

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With hydrazine hydrate Umsetzung des erhaltenen Hydrazids mit NaNO2 in wss.HCl, Erwaermen des gebildeten Azids mit Aethanol und Aether und Kochen des Reaktionsprodukts mit konz.wss.HCl;

: propyl-malonic acid monohydrazide

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite Kochen des entstandenen Azids in Tetrachlorkohlenstoff und Erhitzen des Reaktionsprodukts mit konz.wss.HCl auf 120grad;
Ueberfuehrung durch Propylmalonsaeure-monoazid;

: 82518-89-6
acetylamino-propyl-malonic acid diethyl ester

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With hydrogenchloride
With hydrogen bromide

: 64527-14-6
2-phenylhydrazono-valeric acid

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With hydrogenchloride; zinc

: 2-p-tolylhydrazono-valeric acid

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With hydrogenchloride; zinc

: 2-{[1-[5-((R)-2-Acetylamino-2-carboxy-ethylsulfanylmethyl)-3-hydroxy-2-methyl-pyridin-4-yl]-meth-(E)-ylidene]-amino}-pentanoic acid

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With water

: 1821-02-9
2-oxopentanoic acid

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With C52H74N6OS at 26℃; phosphate buffer, pH 9.3; amination of phenylpyruvic acid to phenylalanine and α-ketovaleric acid tp norvaline by using macrocyclic pyridoxamine derivative, compason with anination by using simple pyrodoxamine pyridoxamine-cyclodextrine derivative;
With α-transaminase

: 2-Benzyloxyamino-pent-4-enoic acid

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol

α-bromo-n-valeric acid: α-bromo-n-valeric acid

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With ammonia at 25℃; DL-norvaline;

(+-)-2-nitro-valeric acid: (+-)-2-nitro-valeric acid

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With palladium on activated charcoal; acetic acid Hydrogenation;

(+-)-2-propyl-acetoacetic acid ethyl ester: (+-)-2-propyl-acetoacetic acid ethyl ester

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With sodium hydroxide; bromine anschliessend mit fluessigem NH3 und Erhitzen des Reaktionsprodukts mit wss.HCl;

: 584-93-0
2-Bromovaleric acid

: 7664-41-7
ammonia

: 760-78-1
2-aminopentanoic acid

: 3209-39-0
2-amino-4-hydroxypentanoic acid

: 5329-51-1
D-gluco-heptulose phenylosazone

: 10034-85-2
hydrogen iodide

: 760-78-1
2-aminopentanoic acid

...Expand

α-bromo-n-valeric acid: α-bromo-n-valeric acid

ammonia: ammonia

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With water at 130℃;

α-bromo-n-valeric acid: α-bromo-n-valeric acid

ammonia: ammonia

ammonium carbonate: ammonium carbonate

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With water at 100℃; im Autoklaven;

...Expand

benzoylconiine: benzoylconiine

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With potassium permanganate

: 74-90-8
hydrogen cyanide

butyraldehyde-ammonia: butyraldehyde-ammonia

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
With hydrogenchloride ueber mehrere Stufen;

: 2280-42-4
2-amino-3-hydroxy-valeric acid

: 10034-85-2
hydrogen iodide

red phosphorus: red phosphorus

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
at 140 - 150℃;

...Expand

: 7647-01-0
hydrogenchloride

: 56548-09-5
2-acetylamino-2-cyano-valeric acid ethyl ester

: 760-78-1
2-aminopentanoic acid

: 56548-09-5
2-acetylamino-2-cyano-valeric acid ethyl ester

: 10035-10-6, 12258-64-9
hydrogen bromide

: 760-78-1
2-aminopentanoic acid

: 1821-02-9
2-oxopentanoic acid

diazonium salt of 8-ethyl-<6>quinolylamine: diazonium salt of 8-ethyl-<6>quinolylamine

: 760-78-1
2-aminopentanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Zn(OAc)2, NaOH / methanol / 30 °C 2: H2O View Scheme

: 300-84-5
hypotaurine

: 1821-02-9
2-oxopentanoic acid

A: 760-78-1
2-aminopentanoic acid

B: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
With 5,5'-dithiobis-(2-nitrobenzoic acid); pyridoxal 5'-phosphate; ω-amino acidpyruvate-transaminase from Caulobacter crescentus (UniProt ID Q9A3Q9) In aq. phosphate buffer; ethanol at 30℃; pH=7.5; Reagent/catalyst; Solvent; Enzymatic reaction;

...Expand

: 760-78-1
2-aminopentanoic acid

: 3282-30-2
pivaloyl chloride

: 1380547-40-9
(±)-2-pivalamidopentanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane; water at 0 - 20℃;	99%

: 85-44-9
phthalic anhydride

: 760-78-1
2-aminopentanoic acid

: 19506-88-8
N-phthalyl-(RS)-norvaline

Conditions

Conditions	Yield
With triethylamine In toluene Heating;	98%
at 160 - 180℃;
With triethylamine In toluene Reflux; Dean-Stark;
With triethylamine

: 760-78-1
2-aminopentanoic acid

: 1644308-41-7
((S)-N-(2-benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)pyrrolidine-2-carboxamide)

: 6018-89-9
nickel(II) acetate tetrahydrate

: C30H28Cl3N3NiO3

Conditions

Conditions	Yield
With potassium carbonate In methanol at 60℃; for 1.5h; Temperature; diastereoselective reaction;	98%

...Expand

: 760-78-1
2-aminopentanoic acid

: 407-25-0
trifluoroacetic anhydride

: 2357-40-6
4-propyl-2-(trifluoromethyl)oxazol-5(2H)-one

Conditions

Conditions	Yield
Reflux;	97%

: 760-78-1
2-aminopentanoic acid

: 1217-89-6
1-benzylisatin

: 21728-28-9
(2-oxo-1,2-dihydro-indol-3-ylidene)-acetic acid ethyl ester

: C31H31N3O4

Conditions

Conditions	Yield
In methanol at 30℃; for 12h; diastereoselective reaction;	96%

...Expand

: 760-78-1
2-aminopentanoic acid

: (S)-N-(2-benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)-2-methylpyrrolidine-2-carboxamide

: 373-02-4, 14998-37-9, 33025-09-1, 94044-50-5, 98268-31-6
nickel diacetate

: nickel(II)-(S)-N-(2-benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)-2-methylpyrrolidine-2-carboxamide/(S)-norvaline Schiff base complex

Conditions

Conditions	Yield
With potassium carbonate In methanol at 60℃; for 12h; diastereoselective reaction;	92%

...Expand

: 33331-97-4, 134309-95-8
3,4-epoxy-4-methyltetrahydropyran

: 760-78-1
2-aminopentanoic acid

: 129673-44-5
2-((3R,4R)-4-Hydroxy-4-methyl-tetrahydro-pyran-3-ylamino)-pentanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In water at 80℃; for 4h;	90%

: 760-78-1
2-aminopentanoic acid

: (R)-N-(2-benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)-2-methylpyrrolidin-2-carboxamide

: 373-02-4, 14998-37-9, 33025-09-1, 94044-50-5, 98268-31-6
nickel diacetate

: nickel(II)-(R)-N-(2-benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)-2-methylpyrrolidine-2-carboxamide/(R)-norvaline Schiff base complex

Conditions

Conditions	Yield
With potassium carbonate In methanol at 60℃; for 12h; diastereoselective reaction;	90%

...Expand

: 760-78-1
2-aminopentanoic acid

: 2-(4-(benzo[d]thiazol-2-yl)-2-methoxyphenoxy)-N’-(2-chloroacetyl)acetohydrazide

: 2-(2-(2-(2-(4-(benzo[d]thiazol-2-yl)-2-methoxyphenoxy)acetyl)hydrazinyl)-2-oxoethylamino)pentanoic acid

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 27h; Cooling with ice;	90%

: 760-78-1
2-aminopentanoic acid

: C20H24N2O2*ClH

: nickel dichloride

: C25H31N3NiO3

Conditions

Conditions	Yield
With sodium carbonate In methanol at 65℃; diastereoselective reaction;	89%

...Expand

: 760-78-1
2-aminopentanoic acid

: 93-97-0
benzoic acid anhydride

: 1896-62-4
(E)-benzalacetone

: 1242985-35-8
(R)-4-((R)-3-oxo-1-phenylbutyl)-2-phenyl-4-propyloxazol-5(4H)-one

Conditions

Conditions	Yield
With FBIP-OTf; sodium acetate; benzoic acid In tetrahydrofuran; toluene at 70℃; for 7h; Inert atmosphere; optical yield given as %ee; stereoselective reaction;	87%

...Expand

: 760-78-1
2-aminopentanoic acid

: 870-46-2
t-butoxycarbonylhydrazine

: 100856-48-2
3-Amino-5-propyl-imidazolidine-2,4-dione

Conditions

Conditions	Yield
In quinoline for 6h; Heating;	86%

: nickel(II) nitrate hexahydrate

: 760-78-1
2-aminopentanoic acid

: (S)-N-(2-benzoyl-4-chlorophenyl)-2-(1-(1-adamantyl)ethylamino)acetamide

: C32H38ClN3NiO3

Conditions

Conditions	Yield
With potassium carbonate In methanol for 2h; Reflux;	84%

...Expand

: 760-78-1
2-aminopentanoic acid

usual acetylating agent: usual acetylating agent

: 7682-15-7, 15891-50-6, 57357-56-9
N-acetylnorvaline

Conditions

Conditions	Yield
	81.7%

: 760-78-1
2-aminopentanoic acid

: 1387637-91-3
5-(2-bromophenyl)-3-phenyl-1H-pyrazole

: 1417340-83-0
2-phenyl-5-propylpyrazolo[1,5-c]quinazoline

Conditions

Conditions	Yield
Stage #1: 2-aminopentanoic acid; 5-(2-bromophenyl)-3-phenyl-1H-pyrazole With copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 12h; Green chemistry; Stage #2: With oxygen In N,N-dimethyl-formamide at 90℃; under 760.051 Torr; for 24h; Green chemistry;	81%

: 91-63-4
2-methylquinoline

: 760-78-1
2-aminopentanoic acid

: 1415734-90-5
1-propylimidazo[1,5-a]quinoline

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; iodine In N,N-dimethyl-formamide at 80℃; for 3h;	81%
With tert.-butylhydroperoxide; diphenyl-phosphinic acid; tetra-(n-butyl)ammonium iodide In dimethyl sulfoxide at 90℃; for 8h; Sealed tube;	59%
With ammonium iodide In dimethyl sulfoxide at 100℃; for 9h; Electrochemical reaction;	32%

: 50-00-0
formaldehyd

: 760-78-1
2-aminopentanoic acid

: 135636-66-7
butane-2,3-dione mono-oxime

: 126263-03-4
2-(4,5-Dimethyl-3-oxy-imidazol-1-yl)-pentanoic acid

Conditions

Conditions	Yield
In ethanol Heating;	80%

...Expand

: 760-78-1
2-aminopentanoic acid

: 501-53-1
benzyl chloroformate

: 21691-43-0
(R,S)-2-(N-benzyloxycarbonylamino)pentanoic acid

Conditions

Conditions	Yield
Stage #1: 2-aminopentanoic acid; benzyl chloroformate With sodium hydrogencarbonate In water at 0 - 20℃; for 24.75h; Inert atmosphere; Stage #2: With hydrogenchloride In water pH=1;	80%
With sodium hydroxide; sodium carbonate In water at 0 - 20℃;
Schotten-Baumann reaction;

: 760-78-1
2-aminopentanoic acid

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid

Conditions

Conditions	Yield
With sodium carbonate In acetone at 0 - 20℃;	79.4%

: 696-59-3
cis,trans-2,5-dimethoxytetrahydrofuran

: 760-78-1
2-aminopentanoic acid

: 70901-15-4
2-(1H-pyrrol-1-yl)pentanoic acid

Conditions

Conditions	Yield
Stage #1: 2-aminopentanoic acid With thionyl chloride In methanol Stage #2: cis,trans-2,5-dimethoxytetrahydrofuran With sodium acetate In acetic acid Stage #3: With potassium hydroxide In methanol	79%
With tartaric acid In water; 1,2-dichloro-ethane at 80℃; for 1h;	62%

: 760-78-1
2-aminopentanoic acid

: 79-04-9
chloroacetyl chloride

: 6940-47-2
N-Chloroacetyl norvaline

Conditions

Conditions	Yield
In acetonitrile for 1.5h; Heating;	77%
With sodium hydroxide
With ethyl acetate

: 703-80-0
3-acetylindole

: 760-78-1
2-aminopentanoic acid

: 3-(2-propyl-1,3-oxazol-5-yl)-1H-indole

Conditions

Conditions	Yield
With Oxone; iodine In dimethyl sulfoxide at 110℃; for 0.75h; Cooling with ice;	76%

: 760-78-1
2-aminopentanoic acid

: 98-86-2
acetophenone

: 128488-62-0
2-propyl-5-phenyloxazole

Conditions

Conditions	Yield
With iodine; 4-aminobenzene sulfonic acid In dimethyl sulfoxide at 100℃; for 5h;	75%
With oxone; iodine In dimethyl sulfoxide at 95℃;	20%

: 760-78-1
2-aminopentanoic acid

: 899694-59-8
2-(2-bromophenyl)-5-methyl-1H-indole

: 1430808-97-1
10-methyl-6-propylindolo[1,2-c]quinazoline

Conditions

Conditions	Yield
Stage #1: 2-aminopentanoic acid; 2-(2-bromophenyl)-5-methyl-1H-indole With copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 12h; Green chemistry; Stage #2: With oxygen In N,N-dimethyl-formamide at 90℃; under 760.051 Torr; for 24h; Green chemistry;	75%

: 128-53-0
N-Ethylmaleimide

: 760-78-1
2-aminopentanoic acid

: 100-52-7
benzaldehyde

: C30H33N3O4

B: C30H33N3O4

Conditions

Conditions	Yield
With acetic acid In ethanol at 90℃; for 6h; diastereoselective reaction;	A 75% B n/a

...Expand

: 760-78-1
2-aminopentanoic acid

: 98-88-4
benzoyl chloride

: 5632-87-1, 70050-92-9, 121470-62-0, 34337-10-5
N-benzoylnorvaline

Conditions

Conditions	Yield
With sodium hydroxide	74.5%
With sodium hydroxide In water; acetonitrile at 0 - 20℃;	62%
With sodium hydroxide In water; acetonitrile at 0 - 20℃;	62%

: 760-78-1
2-aminopentanoic acid

: 3930-83-4
o-iodobenzamide

: 4765-54-2
2-propyl-3H-quinazolin-4-one

Conditions

Conditions	Yield
With caesium carbonate In ethylene glycol; dimethyl sulfoxide at 120℃;	74%

: 91-02-1
phenyl(pyridin-2-yl)methanone

: 760-78-1
2-aminopentanoic acid

: 1-phenyl-3-propylimidazo[1,5-a]pyridine

Conditions

Conditions	Yield
With di-tert-butyl peroxide; iodine In toluene at 120℃; for 12h; Sealed tube;	73%
With di-tert-butyl peroxide; iodine; copper(II) bis(trifluoromethanesulfonate) In toluene at 120℃; for 10h; Sealed tube;	72%

: 760-78-1
2-aminopentanoic acid

: 64-86-8
colchicine

: 10-colchicidyl-DL-norvaline

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 60 - 70℃;	72%

: 760-78-1
2-aminopentanoic acid

: 94347-45-2
2-chloropentanoic acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In diethyl ether at 20℃; for 16h;	71%
With hydrogenchloride; nitric acid
With hydrogenchloride; sodium nitrite In water; toluene at 0 - 20℃; for 4h;

DL-Norvaline Chemical Properties

IUPAC Name: 2-Aminopentanoic acid
Empirical Formula: C₅H₁₁NO₂
Molecular Weight: 117.1463 g/mol
Index of Refraction: 1.463
Density: 1.067 g/cm³
Flash Point: 88.6 °C
Melting point: 300 °C
Storage tempreture: Store at RT.
Water solubility: 1 g/10 mL (18 °C)
Solubility: Soluble in water
Boiling Point: 222.9 °C at 760 mmHg
Vapour Pressure: 0.0366 mmHg at 25 °C
Appearance: White to off-white crystals or crystalline powder
Structure of DL-Norvaline (CAS NO.760-78-1):

Product Category of DL-Norvaline (CAS NO.760-78-1): Norvaline;Peptide

DL-Norvaline Uses

DL-Norvaline (CAS NO.760-78-1) can be used as a pharmaceutical intermediate.

DL-Norvaline Toxicity Data With Reference

DL-Norvaline (CAS NO.760-78-1) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65. And the toxicological properties have not been fully investigated.

DL-Norvaline Safety Profile

Hazard Codes: Harmful Xn
Risk Statements: 20/21/22-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-37/39-26
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.

DL-Norvaline Specification

DL-Norvaline ,its cas register number is 760-78-1. It also can be called DL-2-Aminovaleric acid ; (+/-)-2-Aminopentanoic acid ; and DL-2-Aminovaleric acid . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. And as soon as to get medical aid. Then you have the ingesting of the product : Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, DL-Norvaline (CAS NO.760-78-1) could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: nitrogen oxides, carbon monoxide, carbon dioxide.

Product Name

DL-Norvaline

Synthetic route

DL-Norvaline Chemical Properties

DL-Norvaline Uses

DL-Norvaline Toxicity Data With Reference

DL-Norvaline Safety Profile

DL-Norvaline Specification

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