Diethyl ether supplier | CasNO.60-29-7

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Name
Diethyl ether
EINECS 200-467-2
CAS No. 60-29-7
Article Data681
CAS DataBase
Density 0.734 g/cm³
Solubility 69 g/L (20 °C) in water
Melting Point -116 °C
Formula C₄H₁₀O
Boiling Point 33.177 °C at 760 mmHg
Molecular Weight 74.1228
Flash Point -45 °C
Transport Information UN 1155 3/PG 1
Appearance Colourless liquid
Safety 9-16-29-33-45-36/37
Risk Codes 12-19-22-66-67-39/23/24/25-23/24/25
Molecular Structure
Hazard Symbols F+, Xn, T
Synonyms Ether(6CI);Ethyl ether (8CI);1,1'-Oxybisethane;3-Oxapentane;Anaesthetic ether;Anesthesia ether;Anesthetic ether;Diethyl oxide;Ethoxyethane;Ethyl oxide;NSC 100036;Pronarcol;Sulfuric ether;Ethyl ether;Ethane, 1,1'-oxybis-;
PSA 9.23000
LogP 1.04280

Synthetic route

: 64-17-5
ethanol

: 60-29-7
diethyl ether

Conditions

Conditions	Yield
With reduced Sn/hydrotalcite catalyst at 250℃; under 25502.6 Torr; Catalytic behavior; Reagent/catalyst; Temperature; Pressure;	99%
With SA5 at 199.84℃; Catalytic behavior; Reagent/catalyst; Temperature; Inert atmosphere;	2.6%
With sulfuric acid at 130 - 140℃; Darstellung im grossen;

: 64-17-5
ethanol

A: 60-29-7
diethyl ether

B: 74-85-1
ethene

Conditions

Conditions	Yield
With alumina at 449.84℃; Catalytic behavior; Reagent/catalyst; Temperature; Inert atmosphere; Overall yield = 100 %;	A 0.1% B 98.9%
C2I2O2Rh(1-)*C8H20N(1+); tetraethylammonium iodide; hydrogen iodide In water at 110℃; Product distribution / selectivity; Inert atmosphere; Autoclave;	A 10% B 50%
1-methyl-3-(propyl-3-sulfonyl)imidazolium trifluoromethanesulfonate; CF3O3S(1-)CHF3O3SC7H13N2O3S(1+) at 240 - 260℃; for 4h; Product distribution / selectivity;	A n/a B 12%

: 945614-32-4
triethyloxonium tris(pentafluoroethyl)trifluorophosphate

: 65039-09-0
1-ethyl-3-methyl-1H-imidazol-3-ium chloride

A: 377739-43-0
1-ethyl-3-methyl-imidazolium tris(pentafluoroethyl)trifluorophosphate

B: 60-29-7
diethyl ether

C: 75-00-3
chloroethane

Conditions

Conditions	Yield
at 80℃; for 3h; Product distribution / selectivity;	A 98.9% B n/a C n/a

...Expand

: 945614-32-4
triethyloxonium tris(pentafluoroethyl)trifluorophosphate

: 30388-20-6
N,N,N',N',N'',N''-hexamethylguanidinium chloride

A: hexamethylguanidinium tris(pentafluoroethyl)trifluorophosphate

B: 60-29-7
diethyl ether

C: 75-00-3
chloroethane

Conditions

Conditions	Yield
at 80℃; for 3h;	A 98.9% B n/a C n/a

...Expand

: 945614-32-4
triethyloxonium tris(pentafluoroethyl)trifluorophosphate

: 155371-19-0
1-ethyl-3-methylimidazolium hexafluorophosphate

A: 377739-43-0
1-ethyl-3-methyl-imidazolium tris(pentafluoroethyl)trifluorophosphate

B: 60-29-7
diethyl ether

C: 353-36-6
1-fluoroethane

D: 7647-19-0, 874483-74-6
phosphorus pentafluoride

Conditions

Conditions	Yield
at 100℃; for 10h; Product distribution / selectivity;	A 98.7% B n/a C n/a D n/a

...Expand

: 945614-34-6
triethyloxonium bis(trifluoromethylsulfonyl)imide

: 59016-54-5
1-cyano-4-N,N-dimethylaminopyridinium bromide

A: 74-96-4
ethyl bromide

B: 60-29-7
diethyl ether

C: 945614-38-0
1-cyano-4-dimethylaminopyridinium bis(trifluoromethylsulfonyl)imide

Conditions

Conditions	Yield
at 60℃; for 5h;	A n/a B n/a C 98.2%

...Expand

: 945614-34-6
triethyloxonium bis(trifluoromethylsulfonyl)imide

: 65039-09-0
1-ethyl-3-methyl-1H-imidazol-3-ium chloride

A: 60-29-7
diethyl ether

B: 75-00-3
chloroethane

C: 174899-82-2
1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide

Conditions

Conditions	Yield
at 80℃; for 3h;	A n/a B n/a C 97.9%

...Expand

: 766-77-8
Dimethylphenylsilane

: 123-63-7
paracetaldehyde

A: 60-29-7
diethyl ether

B: 56-33-7
1,1,3,3-tetramethyl-1,3-diphenyldisiloxane

Conditions

Conditions	Yield
With (pentamethylcyclopentadienyl)Ge(II)+B(ArF)4- In dichloromethane-d2 at 50℃; Catalytic behavior; Reagent/catalyst;	A n/a B 97%

...Expand

: 141-78-6
ethyl acetate

A: 60-29-7
diethyl ether

B: 597-67-1
ethoxytriethylsilane

Conditions

Conditions	Yield
With triethylsilane; [CpW(CO)2(1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene)]B(C6F5)4 at 23℃; for 26h; Conversion of starting material;	A 5.9% B 96.3%

: bis(pentamethylcyclopentadienyl)ytterbium(diethyl ether)

: 3790-23-6
tetraethyldiphosphine disulfide

A: 115018-02-5
((CH3)5C5)2Yb(S2P(C2H5)2)

B: 60-29-7
diethyl ether

C: 3040-63-9
1,1,2,2-tetraethyldiphosphane

D: tetraethyldiphosphane monosulfide

Conditions

Conditions	Yield
In toluene stirring, 2 h, under N2; concn., cooling to -10°C; elem. anal.;	A 96% B n/a C n/a D n/a

...Expand

: 945614-32-4
triethyloxonium tris(pentafluoroethyl)trifluorophosphate

: 1-decyl-3-methylimidazol-3-ium chloride

A: 60-29-7
diethyl ether

B: 75-00-3
chloroethane

C: 916807-26-6
1-decyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate

Conditions

Conditions	Yield
at 80℃; for 3h;	A n/a B n/a C 96%

...Expand

: 776-76-1
methyldiphenylsilane

: 123-63-7
paracetaldehyde

A: 60-29-7
diethyl ether

B: 807-28-3
1,3-Dimethyl-1,1,3,3-tetraphenyldisiloxan

Conditions

Conditions	Yield
With (pentamethylcyclopentadienyl)Ge(II)+B(ArF)4- In dichloromethane-d2 at 50℃; Catalytic behavior;	A n/a B 96%

...Expand

: 945614-32-4
triethyloxonium tris(pentafluoroethyl)trifluorophosphate

: 76-83-5
trityl chloride

A: 60-29-7
diethyl ether

B: 75-00-3
chloroethane

C: tritylium tris(pentafluoroethyl)trifluorophosphate

Conditions

Conditions	Yield
at 80℃; for 10h;	A n/a B n/a C 93.6%

...Expand

: 945614-32-4
triethyloxonium tris(pentafluoroethyl)trifluorophosphate

: 59016-54-5
1-cyano-4-N,N-dimethylaminopyridinium bromide

A: 74-96-4
ethyl bromide

B: 60-29-7
diethyl ether

C: 945614-37-9
1-cyano-4-dimethylaminopyridinium tris(pentafluoroethyl)trifluorophosphate

Conditions

Conditions	Yield
at 60℃; for 5h;	A n/a B n/a C 93.2%

...Expand

: N-(n-hexyl)-N-methylpyrrolidinium chloride

: 945614-32-4
triethyloxonium tris(pentafluoroethyl)trifluorophosphate

A: 60-29-7
diethyl ether

B: 75-00-3
chloroethane

C: 945614-40-4
1-hexyl-1-methylpyrrolidinium tris(pentafluoroethyl)trifluorophosphate

Conditions

Conditions	Yield
at 80℃; for 3h;	A n/a B n/a C 93%

...Expand

: 105-58-8
Diethyl carbonate

A: 60-29-7
diethyl ether

B: 64-17-5
ethanol

Conditions

Conditions	Yield
With NaX faujasite at 180 - 240℃; for 6h;	A 93% B 5%

: 74-85-1
ethene

: 64-19-7
acetic acid

A: 60-29-7
diethyl ether

B: 64-17-5
ethanol

C: 141-78-6
ethyl acetate

Conditions

Conditions	Yield
Stage #1: acetic acid With water at 92.4℃; Stage #2: ethene; cesium nitrate; tungstophosphoric acid; water; mixture of, dried, tabletted at 92.4 - 194.4℃; under 6750.68 Torr; Product distribution / selectivity; Gas phase;	A 3.2% B 3.6% C 92.7%
With water; cesium nitrate; tungstophosphoric acid; water; mixture of, dried, tabletted at 92.4 - 165℃; under 6750.68 Torr; Product distribution / selectivity; Gas phase;	A 3% B 3.4% C 91.5%
With water; lithium nitrate; silica; tungstophosphoric acid; water; mixture of, heated at 150 C at 102.2 - 165℃; under 6750.68 Torr; Product distribution / selectivity; Gas phase;	A 2.2% B 5% C 90.1%
With water; lithium nitrate; silica; tungstosilicic acid; water; mixture of, heated at 150 C at 102.2 - 165℃; under 6750.68 Torr; Conversion of starting material; Gas phase;	A 4.7% B 7.6% C 87.7%

...Expand

: 74-85-1
ethene

: 79-10-7
acrylic acid

A: 60-29-7
diethyl ether

B: 64-17-5
ethanol

C: 140-88-5
ethyl acrylate

Conditions

Conditions	Yield
With water; cesium nitrate; tungstophosphoric acid; water; mixture of, dried, tabletted at 85.6 - 165℃; under 2250.23 Torr; Product distribution / selectivity; Gas phase;	A 3.5% B 4.3% C 91.8%

...Expand

: 64-17-5
ethanol

: 15148-19-3
1,3-bis(p-nitrophenyl)-2-thia-1,3-diazaallene

A: 60-29-7
diethyl ether

B: 623-81-4
diethyl sulphite

C: 100-01-6
4-nitro-aniline

Conditions

Conditions	Yield
With copper dichloride for 24h; Product distribution; Ambient temperature; other reagent;	A 93.6 % Chromat. B 70% C 91%

...Expand

: 945614-32-4
triethyloxonium tris(pentafluoroethyl)trifluorophosphate

: 143314-16-3
1-ethyl-3-methylimidazolium tetrafluoroborate

A: 377739-43-0
1-ethyl-3-methyl-imidazolium tris(pentafluoroethyl)trifluorophosphate

B: 60-29-7
diethyl ether

C: 353-36-6
1-fluoroethane

D: 7637-07-2
boron trifluoride

Conditions

Conditions	Yield
at 100℃; for 10h; Product distribution / selectivity;	A 90.3% B n/a C n/a D n/a

...Expand

: 60-29-7
diethyl ether

: 74415-68-2
hexafluoro-3-oxatricyclo<3.2.0.02,4>hept-6-ene

A: 353-36-6
1-fluoroethane

B: pentafluoro-2-ethoxycyclohexa-2,5-dienone

Conditions

Conditions	Yield
for 2160h; Ambient temperature;	A 100% B 75%
for 2160h; Yields of byproduct given;	A n/a B 21%

...Expand

: 60-29-7
diethyl ether

A: 353-36-6
1-fluoroethane

B: pentafluoro-2-ethoxycyclohexa-2,5-dienone

Conditions

Conditions	Yield
With hexafluoro-3-oxatricyclo<3.2.0.02,4>hept-6-ene for 2160h; Ambient temperature;	A 100% B 75%

: 60-29-7
diethyl ether

: 68602-57-3
trifluoroacetyl triflate

A: 383-63-1
ethyl trifluoroacetate,

B: 425-75-2
trifluoromethanesulfonic acid ethyl ester

Conditions

Conditions	Yield
at 0℃;	A 100% B 100%

...Expand

: 60-29-7
diethyl ether

: 2,3-bis(dimethylsilyl)-1,1,4,4-tetramethyl-1,4-disila-1,4-dihydronaphthalene

: [2,3-bis(dimethylsilyl)-1,1,4,4-tetramethyl-1,4-disila-1,4-dihydronaphthalenato]bis[(diethyl ether)lithium(I)]

Conditions

Conditions	Yield
With lithium at 20℃; for 20h; Reduction;	100%

: 60-29-7
diethyl ether

: 2,3,6,7-tetrakis(dimethylsilyl)-1,1,4,4,5,5,8,8-octamethyl-1,4,5,8-tetrasila-1,4,5,8-tetrahydroanthracene

: [2,3,6,7-tetrakis(dimethylsilyl)-1,1,4,4,5,5,8,8-octamethyl-1,4,5,8-tetrasila-1,4,5,8-tetrahydroanthracenato]tetrakis[(diethyl ether)lithium(I)]

Conditions

Conditions	Yield
With lithium at 20℃; for 20h; Reduction;	100%

: 60-29-7
diethyl ether

: 444-30-4
2-(trifluoromethyl)phenol

: 35335-16-1
1,4-bis(bromomethyl)-2,5-dibromobenzene

: 474330-25-1
1,4-dibromo-2,5-bis(2-trifluoromethylphenoxymethyl)benzene

Conditions

Conditions	Yield
With sodium hydroxide; potassium carbonate In dichloromethane; acetone	100%

...Expand

: 193902-67-9
4-[[[4-[4-(ethyloxycarbonyl)-1-piperazinyl]phenyl]amino]carbonyl]-1-t-butyloxycarbonyl-piperidine

: 60-29-7
diethyl ether

: 193902-68-0
4-[[[4-[4-(ethyloxycarbonyl)-1-piperazinyl]phenyl]amino]carbonyl]piperidine

Conditions

Conditions	Yield
In 1,4-dioxane; hydrogenchloride	100%

: 60-29-7
diethyl ether

: 108-95-2
phenol

: 4203-50-3
2-phenoxytetrahydropyran

Conditions

Conditions	Yield
With hydrogenchloride In 3,4-dihydro-2H-pyran	100%

: 79-37-8
oxalyl dichloride

: 60-29-7
diethyl ether

: 20017-67-8
3,3-diphenylpropan-1-ol

: 4279-81-6
3,3-diphenylpropanal

Conditions

Conditions	Yield
With dimethyl sulfoxide; triethylamine In dichloromethane	100%

...Expand

: 63606-55-3
2-(2-ethyl-benzofuran-3-yl)-propionic acid

: 60-29-7
diethyl ether

: 63606-56-4
2-(2-ethyl-benzofuran-3-yl)-propionamide

Conditions

Conditions	Yield
In thionyl chloride	100%

: 60-29-7
diethyl ether

: 609-72-3
N,N-dimethyl-o-toluidine

: 64308-58-3
2-(dimethylamino)benzyllithium

Conditions

Conditions	Yield
With n-butyllithium In hexane	100%
With n-butyllithium In hexane

: 60-29-7
diethyl ether

: 52341-13-6, 12264-20-9
trans-dichloro(ethylene)(2,4,6-trimethylpyridine)platinum

: 91068-18-7
trans-dichloro(diethyl ether)(2,4,6-trimethylpyridine)platinum(II)

Conditions

Conditions	Yield
In diethyl ether byproducts: ethylene; Irradiation (UV/VIS);	100%
In diethyl ether Irradiation (UV/VIS); the Pt-complex dissolved in Et2O was introduced into a muffshaped Schlenk tube surrounding a 125-W medium-pressure mercury lamp, Philips HPK 125, irradn. for 15 min at room temp., λ<310 nm was eliminated by Pyrex filter; the solvent was removed under reduced pressure at -30°C, the solid was recrystd. at -30°C in pentane-CH2Cl2;	95%

: 60-29-7
diethyl ether

: dimethylgallium tetrahydroborate

: 326903-59-7
(CH3)2GaBH4(CH3CH2)2O

Conditions

Conditions	Yield
In diethyl ether (high vac. line); condensing gallium complex in an ampoule with Et2O, warming to room temp. over a period of 30 min; fractionation, collection in a trap at -30°C;	100%

: 60-29-7
diethyl ether

: 293764-40-6
[(C5H4N)C(CH3)(CH2N(C6H2(CH3)3))2]Zr(CH3)2

: 917-54-4
methyllithium

: 486413-21-2
[C5H4NC(CH3)(CH2NC6H2(CH3)3)2]Zr(methyl)3[Li*diethyl ether]

Conditions

Conditions	Yield
In diethyl ether N2; addn. of methyllithium as 4.4 M ether soln. to ether suspn. of Zr complex at -30° C, stirring at room temp. for 10 min; filtration through Celite, drying the filtrate in vac.; elem. anal.;	100%

...Expand

: 60-29-7
diethyl ether

: bis[bis(pentamethylcyclopentadienyl)(μ-hydride)yttrium]

: 1076-43-3
benzene-d6

A: 165269-59-0
((CH3)5C5)2Y(OC2H5)

B: ((CH3)5C5)2Y(D)((C2H5)2O)

Conditions

Conditions	Yield
In diethyl ether; benzene-d6 byproducts: ethane; N2-atmosphere; room temp. (20 min);	A 100% B n/a

...Expand

: 60-29-7
diethyl ether

: 98720-39-9
[La(η5-C5(CH3)5)H]2

: 165269-60-3
((CH3)5C5)2La(OC2H5)(O(C2H5)2)

Conditions

Conditions	Yield
In benzene-d6 byproducts: ethane; N2-atmosphere; room temp. (10 min); evapn. (vac.);	100%

: 60-29-7
diethyl ether

: supersilylgallium dichloride, dimer

: supersilylgallium dichloride-diethyl ether (1/1)

Conditions

Conditions	Yield
In dichloromethane (inert conditions); removal of volatiles (vac.);	100%

: 16853-85-3
lithium aluminium tetrahydride

: 60-29-7
diethyl ether

: 13450-90-3
Gallium trichloride

: gallane etherate

Conditions

Conditions	Yield
In diethyl ether (N2), GaCl3 in Et2O added dropwise to soln. of LiAlH4 in Et2O at 0°C, stirred at 0°C for 2 h; stored overnight at -20°C, filtered cold, evapd. at -78°C;	100%

...Expand

: 60-29-7
diethyl ether

: C20H30O6

A: 1244773-04-3
(1S,3aR,5S,5'S,6R,6a'R)-2,2'-dimethyl-5'-(2-methyl-1,3-dioxolan-4-yl)dihydro-3a'H-3-oxaspiro[bicyclo[3.2.0.]heptane-6,6'-furo[2,3-d][1,3]dioxole]

B: 108-94-1
cyclohexanone

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate); benzene Inert atmosphere; Irradiation;	A 65% B 100%

...Expand

: 60-29-7
diethyl ether

: 1235436-62-0
bis(trimethylsilyl)-trifluoromethylsulfonium tetrakis(pentafluorophenyl)borate

: diethyl(trimethylsilyl)oxonium tetrakis(pentafluorophenyl)borate

Conditions

Conditions	Yield
react. bis(trimethylsilyl)-trifluoromethylsulfonium tetrakis(pentafluorophenyl)borate with Et2O;	100%

: 917-64-6
methyl magnesium iodide

: 119-61-9
benzophenone

: 60-29-7
diethyl ether

: C18H23IMgO2

Conditions

Conditions	Yield
at 20℃; for 12h;	100%

...Expand

: 917-64-6
methyl magnesium iodide

: 60-29-7
diethyl ether

: 98-86-2
acetophenone

: C13H21IMgO2

Conditions

Conditions	Yield
at 20℃; for 12h;	100%

...Expand

: 60-29-7
diethyl ether

: Cp*Ru(μ-SnC4Et4)2RuCp*

: 7439-93-2
lithium

: [Li(Et2O)]2[Cp*Ru(μ-SnC4Et4)2RuCp*]

Conditions

Conditions	Yield
at 20℃; for 1h; Inert atmosphere;	100%

...Expand

: 60-29-7
diethyl ether

: Ce(decafluorodiphenylamide)3

: 1445605-48-0
Ce(decafluorodiphenylamide)3(diethyl ether)2

Conditions

Conditions	Yield
for 0.5h; Inert atmosphere;	100%

: chloro(1,5-cyclooctadiene)rhodium(I) dimer

: 60-29-7
diethyl ether

: 1365891-80-0, 1365891-81-1
(R,Rb)-[1,1'-binaphthalene]-2,2'-diyl(2'-methoxy-[1,1'-binaphthalen]-2-yl)phosphonite

: 1436385-41-9
[RhCl((R,R)-C41H27O3P)(η4-cod)]*(C2H5)2O

Conditions

Conditions	Yield
In dichloromethane for 0.5h; Inert atmosphere; Schlenk technique;	100%

...Expand

: 60-29-7
diethyl ether

: bis(3,5-di-tert-butyl-2-phenol)amine trilithium salt

: 7721-01-9
tantalum pentachloride

: (bis(3,5-di-tert-butyl-2-phenol)amine-3H)TaCl2(Et2O)

Conditions

Conditions	Yield
In toluene Inert atmosphere; Glovebox;	100%

...Expand

: 110-91-8
morpholine

: 60-29-7
diethyl ether

: 100-74-3
N-ethylmorpholine;

Conditions

Conditions	Yield
With alumina at 270℃; under 760.051 Torr; Inert atmosphere; Gas phase; Green chemistry;	100%

: 60-29-7
diethyl ether

: Mo2[μ-κ2-PhB(N-2,6-iPr2C6H3)2]2

: [(tetrahydrofuran)2K18-C-6]2[Mo2{μ-κ2-PhB(2,6-iPr2C6H3)2}2]

: [(Et2O)K18-C-6][Mo2{μ-κ2-PhB(N-2,6-iPr2C6H3)2}2]

Conditions

Conditions	Yield
at -35 - 20℃; Inert atmosphere;	100%

...Expand

: 60-29-7
diethyl ether

: 106-93-4
ethylene dibromide

: 29858-07-9
magnesium bromide diethyl etherate

Conditions

Conditions	Yield
With magnesium Heating;	100%

Diethyl ether History

Alchemist Raymundus Lullus is credited with discovering the compound in 1275 AD, although there is no contemporary evidence of this.
Ethyl ether (CAS NO.60-29-7) was first synthesized in 1540 by Valerius Cordus, who called it "oil of sweet vitriol" (oleum dulcis vitrioli)—the name was because it was originally discovered by distilling a mixture of ethanol and sulfuric acid (then known as oil of vitriol)—and noted some of its medicinal properties. At about the same time, Theophrastus Bombastus von Hohenheim, better known as Paracelsus, discovered ether's analgesic properties. In 1730 ,August Siegmund Frobenius gave the name ether to the substance .

Diethyl ether Consensus Reports

IARC Cancer Review: Animal No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 93.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Diethyl ether Standards and Recommendations

OSHA PEL: TWA 400 ppm; STEL 500 ppm
ACGIH TLV: TWA 400 ppm; STEL 500 ppm
DFG MAK: 400 ppm (1200 mg/m³)
DOT Classification: 3; Label: Flammable Liquid

Diethyl ether Analytical Methods

For occupational chemical analysis use NIOSH: Ethyl Ether, 1610.

Diethyl ether Specification

The Ethyl ether with CAS registry number of 60-29-7 is also known as Diethyl ether. The IUPAC name is Ethoxyethane. It belongs to product categories of Refrigerants; Anhydrous Solvents; Synthetic Organic Chemistry; Chemistry. Its EINECS registry number is 200-467-2. In addition, the formula is C₄H₁₀O and the molecular weight is 74.12. This chemical is a colourless liquid and should be cool and dry place away from oxidizing agents.

Physical properties about Ethyl ether are: (1)ACD/LogP: 1.04; (2)ACD/LogD (pH 5.5): 1.041; (3)ACD/LogD (pH 7.4): 1.041; (4)ACD/BCF (pH 5.5): 3.638; (5)ACD/BCF (pH 7.4): 3.638; (6)ACD/KOC (pH 5.5): 87.722; (7)ACD/KOC (pH 7.4): 87.722; (8)#H bond acceptors: 1; (9)#Freely Rotating Bonds: 2; (10)Polar Surface Area: 9.23Å²; (11)Index of Refraction: 1.361; (12)Molar Refractivity: 22.326 cm³; (13)Molar Volume: 100.925 cm³; (14)Surface Tension: 19.09 dyne/cm; (15)Density: 0.734 g/cm³; (16)Enthalpy of Vaporization: 26.52 kJ/mol; (17)Boiling Point: 33.177 °C at 760 mmHg; (18)Vapour Pressure: 566.752 mmHg at 25 °C.

Preparation of Ethyl ether. Firstly, mix ethanol (95%) and concentrated sulfuric acid (98%) with ratio of 1:1 and heat the reaction mixture to 83 °C. Then pass into ethanol vapor and stir the mixture at 120-125 °C. After the reaction, gaseous product is washed through sodium hydroxide solution, saturated solution of sodium bisulfite and distilled water at atmospheric pressure. At last, product is obtained by collecting fraction of 33.5-34.5 °C.

Uses of Ethyl ether: it is important anesthetic in medicine. Besides, it is used as analytical reagent for nickel, potassium, magnesium and other analysis. What's more, it is used as solvent, cleaning agent and also used in medicine, electronic and other industries. For example, it is used to produce benzoic acid ethyl ester by reaction with benzoyl chloride. The reaction needs catalyst anhydrous cobalt(II) chloride and solvent acetonitrile at ambient temperature for 8 hours. The tield is about 49%.

The chemical is used to produce benzoic acid ethyl ester by reaction with benzoyl chloride.

When you are using this chemical, please be cautious about it. As a chemical, it is extremely flammable and may form explosive peroxides. What's more, it has danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed. Besides, its repeated exposure may cause skin dryness or cracking vapours may cause drowsiness and dizziness. During using it, wear suitable protective clothing and gloves and do not empty into drains. Keep container in a well-ventilated place and away from sources of ignition. In case of accident or if you feel unwell seek medical advice immediately. It is necessary to take precautionary measures against static discharges.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: CCOCC
2. InChI: InChI=1S/C4H10O/c1-3-5-4-2/h3-4H2,1-2H3
3. InChIKey: RTZKZFJDLAIYFH-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LCLo	inhalation	76000ppm (76000ppm)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1294, 1935.
frog	LDLo	subcutaneous	24gm/kg (24000mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935.
guinea pig	LDLo	intraperitoneal	2gm/kg (2000mg/kg)		American Industrial Hygiene Association Journal. Vol. 35, Pg. 21, 1974.
human	TCLo	inhalation	200ppm (200ppm)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION	Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 282, 1943.
man	LDLo	oral	260mg/kg (260mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse	LC50	inhalation	31000ppm/30M (31000ppm)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Experimental Animals. Jikken Dobutso Iho. Vol. 34, Pg. 379, 1985.
mouse	LD50	intraperitoneal	2420mg/kg (2420mg/kg)		Proceedings of the Western Pharmacology Society. Vol. 27, Pg. 511, 1984.
mouse	LD50	intravenous	996mg/kg (996mg/kg)		Journal of Pharmaceutical Sciences. Vol. 67, Pg. 566, 1978.
mouse	LDLo	subcutaneous	8mg/kg (8mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935.
rabbit	LCLo	inhalation	106000ppm (106000ppm)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1294, 1935.
rabbit	LD50	skin	> 20mL/kg (20mL/kg)		American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.
rat	LCLo	inhalation	32000ppm/4H (32000ppm)		American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.
rat	LD50	oral	1215mg/kg (1215mg/kg)		Toxicology and Applied Pharmacology. Vol. 19, Pg. 699, 1971.

Product Name

Diethyl ether

Synthetic route

Diethyl ether History

Diethyl ether Consensus Reports

Diethyl ether Standards and Recommendations

Diethyl ether Analytical Methods

Diethyl ether Specification

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