Product Name

  • Name

    Diethyl succinate

  • EINECS 204-612-0
  • CAS No. 123-25-1
  • Article Data208
  • CAS DataBase
  • Density 1.039 g/cm3
  • Solubility
  • Melting Point -20 °C
  • Formula C8H14O4
  • Boiling Point 218.4 °C at 760 mmHg
  • Molecular Weight 174.197
  • Flash Point 99.5 °C
  • Transport Information
  • Appearance clear liquid
  • Safety 26-36-24/25-22
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 123-25-1 (Diethyl succinate)
  • Hazard Symbols IrritantXi
  • Synonyms Butanedioicacid, diethyl ester (9CI);Succinic acid, diethyl ester (6CI,8CI);Butandioicacid diethyl ester;Diethyl butanedioate;
  • PSA 52.60000
  • LogP 0.89280

Synthetic route

diethyl Fumarate
623-91-6

diethyl Fumarate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With hexacarbonyl molybdenum; phenylsilane In tetrahydrofuran for 4.5h; Heating;100%
With 1,2,2,3,4,4-hexamethylphosphetane 1-oxide; phenylsilane; water In toluene at 80℃; for 24h; Catalytic behavior; Solvent; Temperature; Reagent/catalyst; Schlenk technique; Inert atmosphere;99%
With acetic acid; zinc for 0.5h; Ambient temperature; sonication;98%
but-2-enedioic acid diethyl ester
1520-50-9

but-2-enedioic acid diethyl ester

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With 5% Pd/C; hydrogen In ethanol at 20℃; for 0.5h; chemoselective reaction;100%
With hydrogen In methanol at 24.84℃; under 760.051 Torr;
With silica gel supported sulfonic acid In acetonitrile at 20℃; Reagent/catalyst; Electrochemical reaction;75 %Spectr.
acetylenedicarboxylic acid diethyl ester
762-21-0

acetylenedicarboxylic acid diethyl ester

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethyl acetate at 80℃; under 2585.81 Torr; for 0.05h; microwave irradiation;99%
With magnesium chloride electrolysis: large surface area gold wire electrode; 150 W cm-2 ultrasound intensity; Yield given;
With water; zinc In tetrahydrofuran; methanol for 3h; Heating;100 % Spectr.
Diethyl maleate
141-05-9

Diethyl maleate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With acetic acid; zinc for 2h; Ambient temperature; sonication;98%
With Decaborane; palladium on activated charcoal In methanol at 25℃; for 0.3h; Reduction;98%
With 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-7-methylbenzo-[d]imidazole; [Zr(2,6-bis(5-methyl-3-phenyl-1H-pyrrol-2-yl)pyridine)2] In benzene-d6 for 8h; UV-irradiation;98%
ethanol
64-17-5

ethanol

succinic acid
110-15-6

succinic acid

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With alumina methanesulfonic acid at 80℃; for 0.133333h; Microwave irradiation;97%
With Fe(SO4)3 * xH2O In toluene for 3h; Heating;95%
With N-dodecanoyl-N-methyl-1-glucamine In water at 45℃; for 6h; Green chemistry;87%
Succinimide
123-56-8

Succinimide

ethanol
64-17-5

ethanol

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With chloro-trimethyl-silane at 40℃; for 5h;96%
With chloro-trimethyl-silane at 20 - 40℃; for 5h; Inert atmosphere;96%
1,2-bis(ethoxycarbonyl)vinyl toluene-p-sulfonate
144150-81-2

1,2-bis(ethoxycarbonyl)vinyl toluene-p-sulfonate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With sodium tetrahydroborate; nickel dichloride In methanol ice-cooling;92%
Diethyl maleate
141-05-9

Diethyl maleate

A

diethyl 2-n-butylsuccinate
24766-10-7

diethyl 2-n-butylsuccinate

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With aluminium trichloride; lithium di-n-butylcuprate In diethyl ether at -65 - -40℃; for 1h;A 1.8%
B 92%
With lithium di-n-butylcuprate In diethyl ether at -65 - -40℃; for 1h; Product distribution; in the presence of AlCl3 as well; other solvents;A 1%
B 57%
diethyl meso-2,3-dibromosuccinate
1114-31-4

diethyl meso-2,3-dibromosuccinate

A

diethyl Fumarate
623-91-6

diethyl Fumarate

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With sodium hydroxide; sodium tetrahydroborate; 1,2-di(thiophen-2-yl)ditelluride In ethanol; water at 5℃;A 90%
B n/a
ethanol
64-17-5

ethanol

C12H24O4Si
594815-54-0

C12H24O4Si

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
Stage #1: C12H24O4Si With oxalyl dichloride; N,N-dimethyl-formamide
Stage #2: ethanol With pyridine
83%
ethyl iodide
75-03-6

ethyl iodide

C12H24O4Si
594815-54-0

C12H24O4Si

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride83%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 0℃;
ethanol
64-17-5

ethanol

4-oxopentanoic acid ethyl ester
539-88-8

4-oxopentanoic acid ethyl ester

A

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
Stage #1: 4-oxopentanoic acid ethyl ester With acetic acid at 120℃; for 6h;
Stage #2: ethanol for 6h; Reflux;
A 8.7%
B 80%
succinic acid
110-15-6

succinic acid

(2,2-diethoxyvinylidene)triphenylphosphorane
21882-77-9, 53472-13-2

(2,2-diethoxyvinylidene)triphenylphosphorane

A

ethyl (triphenylphosphoranylidene)acetate
1099-45-2

ethyl (triphenylphosphoranylidene)acetate

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
In tetrahydrofuran for 3h; Ambient temperature;A n/a
B 76%
diethyl sulphite
623-81-4

diethyl sulphite

succinic acid
110-15-6

succinic acid

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
sulfuric acid In ethanol Heating;73%
With mineral acid
cyclohexenone
930-68-7

cyclohexenone

1-iodocyclohexane
626-62-0

1-iodocyclohexane

O,O'-bistributyltin benzopinacolate
153094-32-7

O,O'-bistributyltin benzopinacolate

diethyl Fumarate
623-91-6

diethyl Fumarate

A

3-(hydroxydiphenylmethyl)cyclohexan-1-one
21086-38-4

3-(hydroxydiphenylmethyl)cyclohexan-1-one

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
In benzene at 80℃; for 8h;A 45%
B 72%
diethylmalate
7554-12-3

diethylmalate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide; Trimethylacetic acid In tetrahydrofuran at 20 - 22℃; for 2h;71%
bromo(2-ethoxy-2-oxoethyl)zinc
5764-82-9

bromo(2-ethoxy-2-oxoethyl)zinc

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With N,N-diethyl-N-bromoamine In tetrahydrofuran; diethyl ether at 20 - 25℃; Reagent/catalyst; Cooling; Inert atmosphere;71%
(2R,3R)-diethyl 2,3-bis(3,5-bis(trifluoromethyl)benzoyloxy)-succinate

(2R,3R)-diethyl 2,3-bis(3,5-bis(trifluoromethyl)benzoyloxy)-succinate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N-ethyl-N,N-diisopropylamine In water; acetonitrile at 40℃; for 16h; Sealed tube; Schlenk technique; Inert atmosphere; Irradiation;69%
Diethyl maleate
141-05-9

Diethyl maleate

Bu2CuLi*AlCl3

Bu2CuLi*AlCl3

A

diethyl 2-n-butylsuccinate
24766-10-7

diethyl 2-n-butylsuccinate

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
In diethyl ether at -65 - -40℃; for 1h;A 9%
B 66%
Diethyl tartrate
408332-88-7

Diethyl tartrate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With phosphorus; hydrogen iodide In water; toluene at 80℃; for 1.5h; Inert atmosphere;65%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

O-tert-butyl O-ethyl ketene acetal
121745-78-6

O-tert-butyl O-ethyl ketene acetal

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With 2,4,6-trimethyl-pyridine; dilauryl peroxide In cyclohexane for 3h; Heating;64%
dimanganese decacarbonyl
10170-69-1

dimanganese decacarbonyl

ethyl bromoacetate
105-36-2

ethyl bromoacetate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
In chloroform-d1 Irradiation (UV/VIS); (N2 or Ar); 250-W sun lamp, 3 h; colorless solution is filtered, (1)H-NMR;64%
5-diazo-4-oxo-valeric acid ethyl ester
61844-36-8

5-diazo-4-oxo-valeric acid ethyl ester

phenyl copper
3220-49-3

phenyl copper

A

Ethyl 4-oxo-5-phenyl-pentanoate
20416-11-9

Ethyl 4-oxo-5-phenyl-pentanoate

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
for 1h; Ambient temperature;A 62%
B n/a
pyrrole
109-97-7

pyrrole

5-diazo-4-oxo-valeric acid ethyl ester
61844-36-8

5-diazo-4-oxo-valeric acid ethyl ester

A

ethyl 4-oxo-5-(2-pyrrolyl)-pentanoate
105886-77-9

ethyl 4-oxo-5-(2-pyrrolyl)-pentanoate

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With copper In benzene for 0.25h;A 61%
B n/a
diethyl acetylsuccinate
1115-30-6

diethyl acetylsuccinate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With 1,2-diamino-benzene at 140℃; for 4h;61%
1,3-cyclopentadione
3859-41-4

1,3-cyclopentadione

ethanol
64-17-5

ethanol

A

butanedioic acid, monoethyl ester
1070-34-4

butanedioic acid, monoethyl ester

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With potassium peroxomonosulfate at 20℃; for 18h;A 25%
B 61%
ethanol
64-17-5

ethanol

levulinic acid
123-76-2

levulinic acid

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With carbonic acid dimethyl ester at 180℃; under 10343.2 Torr; for 5h; Reagent/catalyst; Temperature; Inert atmosphere;60.2%
diethyl Fumarate
623-91-6

diethyl Fumarate

A

diethyl 2-acetylmethyl-1,4-butanedioate
1187-74-2

diethyl 2-acetylmethyl-1,4-butanedioate

B

3,7-Bis-ethoxycarbonyl-5-oxo-nonanedioic acid diethyl ester

3,7-Bis-ethoxycarbonyl-5-oxo-nonanedioic acid diethyl ester

C

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With sulfur dioxide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 80℃; for 1.25h;A 6.2%
B 10%
C 58%
N-ethyl-N,N-diisopropylamine
7087-68-5

N-ethyl-N,N-diisopropylamine

diethyl Fumarate
623-91-6

diethyl Fumarate

A

diethyl 2-acetylmethyl-1,4-butanedioate
1187-74-2

diethyl 2-acetylmethyl-1,4-butanedioate

B

3,7-Bis-ethoxycarbonyl-5-oxo-nonanedioic acid diethyl ester

3,7-Bis-ethoxycarbonyl-5-oxo-nonanedioic acid diethyl ester

C

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With sulfur dioxide In N,N-dimethyl acetamide at 80℃; for 3.5h;A 16%
B 14%
C 56%
Diethyl maleate
141-05-9

Diethyl maleate

A

diethyl Fumarate
623-91-6

diethyl Fumarate

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With sulfur dioxide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 80℃; for 2.5h;A 10%
B 55%
formic acid ethyl ester
109-94-4

formic acid ethyl ester

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

diethyl 2-formylbutanedioate
5472-38-8

diethyl 2-formylbutanedioate

Conditions
ConditionsYield
With sodium In diethyl ether at 40℃; for 5h;100%
With sodium In diethyl ether at 40℃; for 5h;100%
With sodium hydride In toluene at 20℃; for 16h; Reagent/catalyst;95.1%
succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Butane-1,4-diol
110-63-4

Butane-1,4-diol

Conditions
ConditionsYield
With C56H70Cl3N10Ru2(1+)*F6P(1-); potassium tert-butylate; hydrogen In tetrahydrofuran; dodecane at 70℃; under 37503.8 Torr; for 16h; Inert atmosphere; Glovebox; Autoclave;100%
With C30H34Cl2N2P2Ru; potassium methanolate; hydrogen In tetrahydrofuran at 100℃; under 38002.6 - 76005.1 Torr; for 15h; Glovebox; Autoclave;91%
With ethanol; sodium
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C10H10O4S

C10H10O4S

Conditions
ConditionsYield
Stage #1: thiophene-2-carbaldehyde; succinic acid diethyl ester With potassium tert-butylate In tert-butyl alcohol for 1.5h; Heating / reflux;
Stage #2: With hydrogenchloride; water In tert-butyl alcohol pH=2;
100%
3-methyl-1H-pyrazole-4-carbaldehyde
112758-40-4

3-methyl-1H-pyrazole-4-carbaldehyde

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

3-(ethoxycarbonyl)-4-(3-methyl-1H-pyrazol-4-yl)but-3-enoic acid
200264-80-8

3-(ethoxycarbonyl)-4-(3-methyl-1H-pyrazol-4-yl)but-3-enoic acid

Conditions
ConditionsYield
Stage #1: 3-methyl-1H-pyrazole-4-carbaldehyde; succinic acid diethyl ester With potassium tert-butylate; tert-butyl alcohol at 80℃; for 4h;
Stage #2: With hydrogenchloride In water pH=~ 2;
100%
3-ethyl-1H-pyrazole-4-carbaldehyde
154926-98-4

3-ethyl-1H-pyrazole-4-carbaldehyde

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C12H16N2O4

C12H16N2O4

Conditions
ConditionsYield
Stage #1: 3-ethyl-1H-pyrazole-4-carbaldehyde; succinic acid diethyl ester With potassium tert-butylate; tert-butyl alcohol at 80℃; for 3h;
Stage #2: With hydrogenchloride In water pH=~ 2;
100%
4-Benzoyl-7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran

4-Benzoyl-7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C24H26O6
1259401-36-9

C24H26O6

Conditions
ConditionsYield
Stage #1: 4-Benzoyl-7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran; succinic acid diethyl ester With potassium tert-butylate In tetrahydrofuran at 55℃; for 1h; Stobbe Condensation;
Stage #2: With hydrogenchloride In tetrahydrofuran; water
100%
C16H14F2N2O
1262589-95-6

C16H14F2N2O

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C22H22F2N2O4
1262590-20-4

C22H22F2N2O4

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 55℃; for 1h;100%
C15H14OS2
1263318-62-2

C15H14OS2

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C21H22O4S2
1263318-63-3

C21H22O4S2

Conditions
ConditionsYield
Stage #1: C15H14OS2; succinic acid diethyl ester With potassium tert-butylate In tetrahydrofuran at 55℃;
Stage #2: With hydrogenchloride In tetrahydrofuran; water
100%
C15H12O4

C15H12O4

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C21H20O7

C21H20O7

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 55℃; for 1h; Stobbe Condensation;100%
C25H25NO4
1395868-61-7

C25H25NO4

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C31H33NO7
1395872-59-9

C31H33NO7

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 55℃; for 1h;100%
C20H16OS

C20H16OS

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C26H24O4S

C26H24O4S

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 55℃; for 1h;100%
C16H16OS3

C16H16OS3

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C22H24O4S3

C22H24O4S3

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 55℃; for 1h;100%
C22H20O2S
1427470-15-2

C22H20O2S

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C28H28O5S
1427470-16-3

C28H28O5S

Conditions
ConditionsYield
Stage #1: C22H20O2S; succinic acid diethyl ester With potassium tert-butylate In tetrahydrofuran for 1h;
Stage #2: With hydrogenchloride In water
100%
bis(p-methylphenyl)-methanone
611-97-2

bis(p-methylphenyl)-methanone

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

2-Di-p-tolylmethylene-succinic acid 1-ethyl ester
95698-26-3

2-Di-p-tolylmethylene-succinic acid 1-ethyl ester

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 55℃; for 1h;100%
furfural
98-01-1

furfural

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

3-(ethoxycarbonyl)-4-(furan-2-yl)-3-butenoic acid

3-(ethoxycarbonyl)-4-(furan-2-yl)-3-butenoic acid

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol at 110℃; for 3h; Inert atmosphere;99%
With potassium tert-butylate In tert-butyl alcohol for 1.5h; Stobbe condensation; Heating;
succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

succinic acid dihydrazide
4146-43-4

succinic acid dihydrazide

Conditions
ConditionsYield
With hydrazine hydrate In methanol for 8h; Reflux;98%
With hydrazine hydrate In ethanol for 12h; Reflux;65%
With ethanol; hydrazine hydrate
succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

lithium di-enolate of diethyl succinate

lithium di-enolate of diethyl succinate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.25h;98%
3,4-dimethoxy-benzaldehyde
120-14-9

3,4-dimethoxy-benzaldehyde

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

2-(3,4-dimethoxybenzylidene)butanedioic acid monoethyl ester
126274-95-1

2-(3,4-dimethoxybenzylidene)butanedioic acid monoethyl ester

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol for 3h; Heating;98%
With potassium tert-butylate In tert-butyl alcohol at 50℃; for 5h;
3,4-dimethoxy-benzaldehyde
120-14-9

3,4-dimethoxy-benzaldehyde

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

(E)-4-(3,4-dimethoxyphenyl)-3-(ethoxycarbonyl)but-3-enoic acid
182572-57-2

(E)-4-(3,4-dimethoxyphenyl)-3-(ethoxycarbonyl)but-3-enoic acid

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 4h; Stobbe Condensation; Inert atmosphere; Reflux;98%
With sodium ethanolate Stobbe Condensation; Reflux;96%
With sodium t-butanolate In tert-butyl alcohol Reflux;56%
With potassium tert-butylate In butan-1-ol at 20℃; for 3h; Stobbe condensation;
3,4-dichlorobenzophenone
6284-79-3

3,4-dichlorobenzophenone

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

3-ethoxycarbonyl-4-(3,4-dichlorophenyl)-4-phenyl-(Z)-but-3-enoic acid

3-ethoxycarbonyl-4-(3,4-dichlorophenyl)-4-phenyl-(Z)-but-3-enoic acid

Conditions
ConditionsYield
Stage #1: 3,4-dichlorobenzophenone; succinic acid diethyl ester In tert-butyl alcohol at 25 - 30℃;
Stage #2: With sodium hydride In tert-butyl alcohol at 85 - 90℃; for 4h;
Stage #3: With hydrogenchloride; water In hexane; ethyl acetate
98%
3-methoxy-4-(phenylmethoxy)benzaldehyde
2426-87-1

3-methoxy-4-(phenylmethoxy)benzaldehyde

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C21H22O6

C21H22O6

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 4h; Stobbe Condensation; Inert atmosphere; Reflux;98%
With sodium ethanolate for 4h; Stobbe condensation; Reflux;
3,4-dibenzyloxybenzaldehyde
5447-02-9

3,4-dibenzyloxybenzaldehyde

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C27H26O6

C27H26O6

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 4h; Stobbe Condensation; Inert atmosphere; Reflux;98%
succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

(+/-)-trans-5-benzyloxy-1,3-dimethyl-1H-isochromane-6-carbaldehyde

(+/-)-trans-5-benzyloxy-1,3-dimethyl-1H-isochromane-6-carbaldehyde

2-[1-((1S,3S)-5-Benzyloxy-1,3-dimethyl-isochroman-6-yl)-meth-(E)-ylidene]-succinic acid diethyl ester

2-[1-((1S,3S)-5-Benzyloxy-1,3-dimethyl-isochroman-6-yl)-meth-(E)-ylidene]-succinic acid diethyl ester

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol for 4h; Stobbe condensation; Heating;97%
ethyl [3H]formate
90009-92-0

ethyl [3H]formate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

diethyl ([3H]formyl)succinate
1035845-94-3

diethyl ([3H]formyl)succinate

Conditions
ConditionsYield
With sodium ethanolate In toluene at 20℃;97%
3,5-dimethoxybenzaldehdye
7311-34-4

3,5-dimethoxybenzaldehdye

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

(E)-4-(3,5-dimethoxyphenyl)-3-(ethoxycarbonyl)but-3-enoic acid
607356-91-2

(E)-4-(3,5-dimethoxyphenyl)-3-(ethoxycarbonyl)but-3-enoic acid

Conditions
ConditionsYield
With ethanol; sodium hydride In toluene; mineral oil at 0 - 20℃; Inert atmosphere;97%

Diethyl succinate Chemical Properties

IUPAC Name: Diethyl butanedioate
Synonyms of Diethyl succinate (CAS NO.123-25-1): Butanedioic acid, diethyl ester ; Diethyl ethanedicarboxylate ; Diethylester kyseliny jantarove ; Ethyl succinate
CAS NO: 123-25-1
Molecular Formula: C8H14O4
Molecular Weight: 174.20
Molecular Structure:
EINECS: 204-612-0 
H bond acceptors: 4
H bond donors: 0
Freely Rotating Bonds: 7
Polar Surface Area: 52.6 Å2
Melting point: -20°C
Boiling Point: 218.4 °C at 760 mmHg 
Flash Point: 99.5 °C 
Index of Refraction: 1.422 
Molar Refractivity: 42.66 cm
Molar Volume: 167.5 cm3 
Surface Tension: 32.4 dyne/cm 
Density: 1.039 g/cm
Enthalpy of Vaporization: 45.48 kJ/mol 
Vapour Pressure: 0.126 mmHg at 25°C 
Appearance: clear liquid
Product Categories of Diethyl succinate (CAS NO.123-25-1): Pharmaceutical Intermediates;Organics;SuccinicSeries;Fatty Acid Esters (Plasticizer);Functional Materials;Plasticizer;ester Flavor;Alpha Sort;D;Volatiles/ Semivolatiles;Plasticizers;Polymer Additives;Polymer Science;Alphabetical Listings;C-D;Flavors and Fragrances

Diethyl succinate Uses

 Diethyl succinate (CAS NO.123-25-1) is used as a food flavoring agent, solvent, organic synthesis intermediates, gas chromatography stationary phase,and it is also used in the plastics industry.

Diethyl succinate Production

  Diethyl succinate (CAS NO.123-25-1) is derived from the esterification of Succinic acid with Ethanol.

Diethyl succinate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 oral 8530mg/kg (8530mg/kg)   AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.

Diethyl succinate Consensus Reports

Reported in EPA TSCA Inventory.

Diethyl succinate Safety Profile

Safety Information about Diethyl succinate (CAS NO.123-25-1):
Hazard Codes: IrritantXi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25-22 
S22: Do not breathe dust. 
S24/25: Avoid contact with skin and eyes. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36: Wear suitable protective clothing.
WGK Germany: 2
RTECS: WM7400000
HS Code: 29171990
Mildly toxic by ingestion. A skin and eye irritant. Combustible liquid. Reaction with ethyl trifluoroacetate + sodium hydride may cause a fire or explosion. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Diethyl succinate Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Combustible liquid.
Extinguishing Media: Use agent most appropriate to extinguish fire. 
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container.

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