Difluoromethane supplier

Name
Difluoromethane
EINECS 200-839-4
CAS No. 75-10-5
Article Data117
CAS DataBase
Density 0.929 g/cm³
Solubility Insoluble in water
Melting Point -136 °C(lit.)
Formula CH₂F₂
Boiling Point −51.6°C(lit.)
Molecular Weight 52.0237
Flash Point
Transport Information UN 3252
Appearance colorless odorless gas
Safety 9-16-33
Risk Codes 11
Molecular Structure
Hazard Symbols F
Synonyms Difluoromethane;Ecolo Ace 32;F 32;FC 32;Freon 32;Genetron 32;HFA 32;HFC 32;Methylenedifluoride;R 32;R 32 (refrigerant);
PSA 0.00000
LogP 0.88290

Synthetic route

: 811-97-2
1,1,1,2-tetrafluoroethane

A: 354-33-6
1,1,1,2,2-pentafluoroethane

B: 75-10-5
Difluoromethane

C: 75-46-7
trifluoromethan

D: 76-16-4
Hexafluoroethane

Conditions

Conditions	Yield
With fluorine at 200 - 250℃; Product distribution; Further Variations:; Reagents;	A 1.1% B 0.9% C 0.4% D 97.6%

...Expand

: 75-09-2
dichloromethane

A: 74-87-3
methylene chloride

B: 75-10-5
Difluoromethane

C: 593-70-4
R32

D: 75-46-7
trifluoromethan

Conditions

Conditions	Yield
With hydrogen fluoride; antimony(III) fluoride; antimony pentafluoride at 5 - 100℃; under 12504.7 Torr;	A n/a B 96.9% C 3.08% D n/a
antimony pentafluoride	A n/a B 96.4% C 3.56% D n/a

...Expand

: 75-61-6
dibromodifluoromethane

: 75-10-5
Difluoromethane

Conditions

Conditions	Yield
With ammonium persulfate; ammonium formate In N,N-dimethyl-formamide at 30 - 40℃;	90%

: 75-09-2
dichloromethane

: 7664-41-7
ammonia

A: 74-90-8
hydrogen cyanide

B: 75-10-5
Difluoromethane

C: 75-45-6
Chlorodifluoromethane

D: 124-38-9
carbon dioxide

E: 201230-82-2
carbon monoxide

Conditions

Conditions	Yield
nickel titanate In neat (no solvent) steady-state flow reaction over NiTO3*6H2O catalyst at 773 K, further by-product is CFH3 (yield 0.3 %);	A 81.8% B 0.1% C 0.6% D 10.4% E 6.8%
nickel titanate In neat (no solvent) steady-state flow reaction over NiTO3*6H2O catalyst at 823 K, further by-product is CFH3 (yield 0.4 %);	A 66.2% B 0.2% C 1.4% D 12.9% E 18.8%
With catalyst: Pt/C In neat (no solvent) steady-state flow reaction over Pt/C catalyst at 821 K, a further by-product is CFH3 (yield 0.2 %);	A 64.6% B 0.3% C 0.2% D 0.6% E 0.8%

...Expand

: 75-09-2
dichloromethane

A: 75-10-5
Difluoromethane

B: 593-70-4
R32

Conditions

Conditions	Yield
Stage #1: With hydrogen fluoride; chromia-alumina catalyst at 100 - 400℃; for 24h; Stage #2: dichloromethane With hydrogen fluoride at 250 - 275℃; Conversion of starting material;	A 79.6% B 7.79%
With (PPh3)2Pd(Ph)F; bis(triphenylphosphine)iminium chloride for 0.583333h;
With (PPh3)2Pd(Ph)F; bis(triphenylphosphine)iminium chloride for 0.583333h; Product distribution; other time;

: 1511-62-2
bromodifluoromethane

: 5122-94-1
4-biphenylboronic acid

A: 4-phenyl-α,α-difluorotoluene

B: 75-10-5
Difluoromethane

Conditions

Conditions	Yield
With dibromobis(triphenylphosphine)nickel(II); potassium carbonate In tetrahydrofuran at 80℃; for 17h; Schlenk technique; Inert atmosphere; Sealed tube;	A 63% B 16%

...Expand

: 1895-39-2
sodium chlorodifluoroacetate

: 75-10-5
Difluoromethane

Conditions

Conditions	Yield
With triphenylphosphine In N,N-dimethyl-formamide at 130℃;	60%

: 75-09-2
dichloromethane

: 7664-41-7
ammonia

A: 74-90-8
hydrogen cyanide

B: 593-53-3
Methyl fluoride

C: 75-10-5
Difluoromethane

D: 75-45-6
Chlorodifluoromethane

E: 124-38-9
carbon dioxide

Conditions

Conditions	Yield
With catalyst: Pt/C In neat (no solvent) steady-state flow reaction over Pt/C catalyst at 769 K;	A 53.4% B 0.3% C 0.5% D 7.6% E 0.5%

...Expand

: 74-97-5
chlorobromomethane

A: 75-10-5
Difluoromethane

B: 593-70-4
R32

Conditions

Conditions	Yield
With potassium fluoride In ethylene glycol at 140 - 150℃; for 5h;	A n/a B 33%

: 75-43-4
Dichlorofluoromethane

: 1188-14-3
Triethylgerman

A: 75-10-5
Difluoromethane

B: 75-09-2
dichloromethane

C: 75-46-7
trifluoromethan

D: 75-45-6
Chlorodifluoromethane

E: 994-28-5
triethylchlorogermane

Conditions

Conditions	Yield
With ACF. Et3GeH at 25℃; for 72h; Schlenk technique; Inert atmosphere;	A n/a B n/a C 22% D 16% E n/a

...Expand

: 373-91-1
hypofluorous acid trifluoromethyl ester

: 34557-54-5
methane

A: 75-73-0
carbon tetrafluoride

B: 75-10-5
Difluoromethane

C: 75-46-7
trifluoromethan

Conditions

Conditions	Yield
im UV-Licht;

...Expand

: 75-11-6
diiodomethane

: 75-10-5
Difluoromethane

Conditions

Conditions	Yield
With mercury(I) fluoride; iodine

: 34557-54-5
methane

: 75-10-5
Difluoromethane

Conditions

Conditions	Yield
With nitrogen; copper; fluorine

: 75-09-2
dichloromethane

: 75-10-5
Difluoromethane

Conditions

Conditions	Yield
With antimony(III) fluoride
With hydrogen fluoride; antimonypentachloride at 120 - 140℃;
With antimonypentachloride; antimony(III) fluoride at 120 - 140℃;

: 75-71-8
Dichlorodifluoromethane

: 75-10-5
Difluoromethane

Conditions

Conditions	Yield
With ammonium chloride; water; zinc
under 0.8 - 15.001 Torr; Mechanism; Irradiation;
With hydrogen; silica gel; gold; palladium at 180℃;

: 354-33-6
1,1,1,2,2-pentafluoroethane

A: 116-14-3
polytetrafluoroethylene

B: 75-10-5
Difluoromethane

C: 75-46-7
trifluoromethan

D: 359-35-3
1,1,2,2-tetrafluoroethane

E: 76-16-4
Hexafluoroethane

F: 359-11-5
1,1,2-trifluoroethylene

Conditions

Conditions	Yield
Product distribution; Irradiation; variation of laser pulse energy;

...Expand

: 75-09-2
dichloromethane

A: 75-10-5
Difluoromethane

B: 593-70-4
R32

C: 75-45-6
Chlorodifluoromethane

D: 75-43-4
Dichlorofluoromethane

E: 75-71-8
Dichlorodifluoromethane

F: 75-69-4
trichlorofluoromethane

Conditions

Conditions	Yield
With xenon difluoride for 48h; Ambient temperature; other halogenocarbons; var. reaction time;

...Expand

: 75-71-8
Dichlorodifluoromethane

A: 74-90-8
hydrogen cyanide

B: 593-53-3
Methyl fluoride

C: 75-10-5
Difluoromethane

D: 75-45-6
Chlorodifluoromethane

E: 124-38-9
carbon dioxide

F: 201230-82-2
carbon monoxide

Conditions

Conditions	Yield
With O3Ti(2-)*Ni(2+); ammonia at 499.9℃; Product distribution; other catalysts;

...Expand

: 353-59-3
halon-1211

A: 1511-62-2
bromodifluoromethane

B: 75-10-5
Difluoromethane

C: 373-52-4
bromofluoromethane

D: 75-09-2
dichloromethane

E: 75-45-6
Chlorodifluoromethane

F: 74-95-3
1,2-dibromomethane

Conditions

Conditions	Yield
With hydrogen In gas at 400 - 900℃; under 760 Torr; Rate constant; Product distribution; Mechanism; other reagents; Ea;

...Expand

: 72344-34-4
perfluoro-2-phosphapropene

A: 75-10-5
Difluoromethane

B: 75-46-7
trifluoromethan

Conditions

Conditions	Yield
With potassium hydroxide Product distribution; other reagent - KOH powder;
With water by NMR;
With H2O by NMR;

: 72344-34-4
perfluoro-2-phosphapropene

A: 75-10-5
Difluoromethane

B: 75-46-7
trifluoromethan

C: 4669-85-6
Difluormethyl-phosphonigsaeure-dimethylester

D: 1571-80-8
Difluormethyl-trifluormethyl-phosphinigsaeure-methylester

E: 121-45-9
phosphorous acid trimethyl ester

Conditions

Conditions	Yield
With methanol; sodium methylate Product distribution; further reagents: EtOH/NaOEt, MeOH/NaOEt (80:20), EtOH/NaOMe (70:30);

...Expand

: 10112-10-4
(difluoromethyl)silane

A: 75-10-5
Difluoromethane

B: 753-44-6
methyl fluorosilane

C: 420-34-8
methyldifluorosilane

D: 373-74-0
methyltrifluorosilane

Conditions

Conditions	Yield
at 210 - 220℃; for 7h; Title compound not separated from byproducts;	A 1 % Spectr. B 8 % Spectr. C 43 % Spectr. D 6 % Spectr.

...Expand

: 78948-09-1
acetyl hypofluorite

A: 74-84-0
ethane

B: 593-53-3
Methyl fluoride

C: 75-10-5
Difluoromethane

D: 1538-06-3
methyl fluoroformate

E: 124-38-9
carbon dioxide

Conditions

Conditions	Yield
Product distribution; decomposition in diff. vessels; with/without oxygen;

...Expand

: barium trifluoroacetyl acetonate

A: 75-73-0
carbon tetrafluoride

B: 34557-54-5
methane

C: 74-84-0
ethane

D: 75-10-5
Difluoromethane

E: 75-46-7
trifluoromethan

Conditions

Conditions	Yield
at 230.9℃; Rate constant; Kinetics; thermal decomposition; in the presence of oxygen; var. temperatures;

...Expand

: bis(hexafluoroacetylacetonato)barium

A: 116-14-3
polytetrafluoroethylene

B: 75-73-0
carbon tetrafluoride

C: 75-10-5
Difluoromethane

D: 75-46-7
trifluoromethan

E: 76-16-4
Hexafluoroethane

Conditions

Conditions	Yield
at 230.9℃; Rate constant; Kinetics; thermal decomposition; in the presence of oxygen; var. temperatures;

...Expand

: 34557-54-5
methane

A: 593-53-3
Methyl fluoride

B: 75-10-5
Difluoromethane

C: 75-46-7
trifluoromethan

Conditions

Conditions	Yield
With NF4(1+)*AsF6(1-); hydrogen fluoride under 25857.4 Torr; for 4h; Product distribution; Mechanism; Ambient temperature; other fluorination agents; var. reagents ratio;

...Expand

: 460-96-8
bis(trifluoromethyl)phosphine

A: 75-10-5
Difluoromethane

B: 75-46-7
trifluoromethan

C: 72344-34-4
perfluoro-2-phosphapropene

Conditions

Conditions	Yield
With potassium hydroxide at -196 - 25℃; Title compound not separated from byproducts;

...Expand

: 2314-97-8
iodotrifluoromethane

A: 2154-59-8
difluoro-methylene

B: 2264-21-3
trifluoromethyl radical

C: 75-10-5
Difluoromethane

Conditions

Conditions	Yield
With Ni(100) surface under 2E-10 Torr; temperature and coverage dependence investigated;

...Expand

: 34557-54-5
methane

A: 75-73-0
carbon tetrafluoride

B: 593-53-3
Methyl fluoride

C: 75-10-5
Difluoromethane

D: 75-46-7
trifluoromethan

Conditions

Conditions	Yield
With cobalt (III) fluoride at 95 - 325℃; Product distribution; Mechanism; in the presence 95percent helium;

...Expand

: 593-53-3
Methyl fluoride

: 75-10-5
Difluoromethane

Conditions

Conditions	Yield
With cobalt (III) fluoride at 95 - 325℃; Rate constant; Thermodynamic data; in the presence 95percent helium; E;

: 17455-13-9
18-crown-6 ether

: 75-10-5
Difluoromethane

: 2785-29-7
benzyl potassium

: 877-07-6
hexamethylborazine

: [K(18-crown-6)][B3N3Me6(CF2H)]

Conditions

Conditions	Yield
Stage #1: 18-crown-6 ether; benzyl potassium; hexamethylborazine In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: Difluoromethane In tetrahydrofuran at 20℃; for 0.25h;	95%

...Expand

: 116-14-3
polytetrafluoroethylene

: 75-10-5
Difluoromethane

: 677-56-5
1,1,1,2,2,3-hexafluoropropane

Conditions

Conditions	Yield
With antimony pentafluoride at 50 - 80℃; for 28h;	92%
catalyst of example 4 (prepared from AlCl3 and CFCl3) at 65 - 70℃; for 12h; Product distribution / selectivity;

: 116-15-4
perfluoropropylene

: 75-10-5
Difluoromethane

: 65781-19-3
2-Trifluoromethyl-1,1,1,2,3-pentafluoropropane

Conditions

Conditions	Yield
With antimony pentafluoride at 50℃; for 16h;	90%

: 116-15-4
perfluoropropylene

: 75-10-5
Difluoromethane

: 35230-11-6
1H,3H-octafluorobutane

Conditions

Conditions	Yield
at 280℃; for 96h;	85%

: 17455-13-9
18-crown-6 ether

: 75-10-5
Difluoromethane

: 67459-71-6
potassium diisopropyl amide

: 18903-54-3
octahydro-[1,2]azaborinino[1,2-a][1,2]azaborinine

: [K(18-crown-6)][octahydro-[1,2]azaborinino[1,2-a][1,2]azaborinine(CF2H)]

Conditions

Conditions	Yield
Stage #1: potassium diisopropyl amide; octahydro-[1,2]azaborinino[1,2-a][1,2]azaborinine In tetrahydrofuran at -80℃; for 0.0166667h; Stage #2: Difluoromethane In tetrahydrofuran for 0.166667h; Sealed tube; Stage #3: 18-crown-6 ether In tetrahydrofuran at 20℃; for 0.25h; Sealed tube;	78%
Stage #1: potassium diisopropyl amide; octahydro-[1,2]azaborinino[1,2-a][1,2]azaborinine In tetrahydrofuran at -80℃; for 0.0166667h; Stage #2: Difluoromethane In tetrahydrofuran for 0.166667h; Sealed tube; Stage #3: 18-crown-6 ether In tetrahydrofuran; pentane at 20℃; for 0.5h;	78%

...Expand

: 17455-13-9
18-crown-6 ether

: 75-10-5
Difluoromethane

: 1569906-00-8
1,2,3,4-tetrahydro-[1,2]azaborinino[1,2-a][1,2]azaborinine

: 2785-29-7
benzyl potassium

: [K(18-crown-6)][1,2,3,4-tetrahydro-[1,2]azaborinino[1,2-a][1,2]azaborinine(CF2H)]

Conditions

Conditions	Yield
Stage #1: 18-crown-6 ether; 1,2,3,4-tetrahydro-[1,2]azaborinino[1,2-a][1,2]azaborinine; benzyl potassium In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: Difluoromethane In tetrahydrofuran at 20℃; for 0.5h;	62%

...Expand

: 75-10-5
Difluoromethane

: 402-43-7
p-trifluoromethylphenyl bromide

: 2251-82-3
1-(difluoromethyl)-4-(trifluoromethyl)benzene

Conditions

Conditions	Yield
With 2,6-dimethylpyridine; tris-(trimethylsilyl)silane; [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate In 1,2-dimethoxyethane at 30℃; for 18h; Inert atmosphere; Irradiation;	50%

: 75-10-5
Difluoromethane

: 598-88-9
1,2-dichloro-1,2-difluoroethene

: 422-00-4
1,3-dichloro-1,1,2,2,3-pentafluoropropane

Conditions

Conditions	Yield
With antimony pentafluoride at 20℃; for 2h;	36%

: 17455-13-9
18-crown-6 ether

: 75-10-5
Difluoromethane

: 2785-29-7
benzyl potassium

: 18903-54-3
octahydro-[1,2]azaborinino[1,2-a][1,2]azaborinine

: [K(18-crown-6)][octahydro-[1,2]azaborinino[1,2-a][1,2]azaborinine(CF2H)]

Conditions

Conditions	Yield
Stage #1: 18-crown-6 ether; benzyl potassium; octahydro-[1,2]azaborinino[1,2-a][1,2]azaborinine In tetrahydrofuran at 0℃; for 0.25h; Stage #2: Difluoromethane In tetrahydrofuran for 0.166667h; Sealed tube;	34%
Stage #1: 18-crown-6 ether; benzyl potassium; octahydro-[1,2]azaborinino[1,2-a][1,2]azaborinine In tetrahydrofuran at 0℃; for 0.25h; Stage #2: Difluoromethane In pentane at 20℃; for 0.416667h; Sealed tube;	34%

...Expand

: 75-10-5
Difluoromethane

: 1511-62-2
bromodifluoromethane

Conditions

Conditions	Yield
With bromine at 500 - 600℃;
With bromine; chlorine at 250 - 350℃;

: 75-10-5
Difluoromethane

: 75-45-6
Chlorodifluoromethane

Conditions

Conditions	Yield
With chlorine

: 75-10-5
Difluoromethane

: 75-71-8
Dichlorodifluoromethane

Conditions

Conditions	Yield
With chlorine at 350℃;

: 75-10-5
Difluoromethane

: 75-61-6
dibromodifluoromethane

Conditions

Conditions	Yield
With bromine; chlorine at 350℃;
With bromine at 500℃;
With bromine; chlorine at 400 - 500℃;

: 75-10-5
Difluoromethane

: Sodium; (Z)-1-methoxy-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propen-1-olate

: 67654-61-9
3,3-Difluoro-2-methyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propionic acid methyl ester

Difluoromethane Specification

The CAS register number of Methylene difluoride is 52727-23-8. It also can be called as Methane, difluoro- and the IUPAC name about this chemical is difluoromethane. The molecular formula about this chemical is CH₂F₂and the molecular weight is 52.02. It belongs to the following product categories, such as Refrigerants; Refrigerant and so on. This chemical is a colorless odorless gas, it insoluble in water and it has a high thermal stability. Its vapors are heavier than air. Under prolonged exposure to fire or intense heat the containers may rupture violently and rocket. It contacts with the unconfined liquid can cause frostbite. This chemical can be used as a refrigerant. This chemical is a refrigerant that has zero ozone depletion potential. Methylene difluoride in an azeotropic mixture with pentafluoroethane is known as R-410A, a common replacement for various chlorofluorocarbons in new refrigerant systems.

Physical properties about Methylene difluoride are: (1)ACD/LogP: 0.30; (2)ACD/LogD (pH 5.5): 0.3; (3)ACD/LogD (pH 7.4): 0.3; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 34.85; (7)ACD/KOC (pH 7.4): 34.85; (8)Index of Refraction: 1.195; (9)Molar Refractivity: 7 cm³; (10)Molar Volume: 55.9 cm³; (11)Polarizability: 2.77x10^-24cm³; (12)Surface Tension: 6.9 dyne/cm; (13)Enthalpy of Vaporization: 18.9 kJ/mol; (14)Boiling Point: °C at 760 mmHg; (15)Vapour Pressure: 13200 mmHg at 25°C.

The reaction of gas fluorinated can get Methylene difluoride: CH₄+2F₂→CH₂F₂+2HF

Another method to produce this chemical is Difluoromethane fluorinated: CH₃F+F₂→CH₂F₂+HF

When you are using this chemical, please be cautious about it as the following:
This chemical is highly flammable. When you are using it, please keep away from sources of ignition and take precautionary measures against static discharges. If you want to store it, please keep container in a well-ventilated place.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C(F)F
(2)InChI: InChI=1S/CH2F2/c2-1-3/h1H2
(3)InChIKey: RWRIWBAIICGTTQ-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LC50	inhalation	1810gm/m³(1810000mg/m³)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Toksikologicheskii Vestnik. Vol. (1), Pg. 27, 1996.
rat	LC50	inhalation	1890gm/m³/4H (1890000mg/m³)		Toksikologicheskii Vestnik. Vol. (3), Pg. 25, 1996.

Product Name

Difluoromethane

Synthetic route

Difluoromethane Specification

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