Dimethylsulfamoyl chloride supplier

Name
Dimethylsulfamoyl chloride
EINECS 236-412-4
CAS No. 13360-57-1
Article Data27
CAS DataBase
Density 1.418 g/cm³
Solubility decomposes in water
Melting Point -13 °C
Formula C₂H₆ClNO₂S
Boiling Point 186.7 °C at 760 mmHg
Molecular Weight 143.594
Flash Point 94.4 °C
Transport Information UN 3390 6.1/PG 1
Appearance clear colorless to slightly yellow liquid
Safety 53-45
Risk Codes 45-21/22-26-34
Molecular Structure
Hazard Symbols T+
Synonyms Sulfamoylchloride, dimethyl- (6CI,7CI,8CI,9CI);Dimethylamidosulfonyl chloride;Dimethylaminosulfonyl chloride;Dimethylsulphamoylchloride;N,N-Dimethylamidosulfonyl chloride;N,N-Dimethylaminosulfonylchloride;N,N-Dimethylsulfamoyl chloride;N,N-Dimethylsulfamyl chloride;NSC93875;
PSA 45.76000
LogP 1.11240

Synthetic route

N,N-dimethylammonium chloride: N,N-dimethylammonium chloride

: 13360-57-1
dimethylamino sulfonyl chloride

: 1585-74-6
dimethylchloroamine

: 13360-57-1
dimethylamino sulfonyl chloride

Conditions

Conditions	Yield
With sulfur dioxide In tetrachloromethane 1.) 0 deg C, 1.5 h, 2.) up to r.t., overnight;	70%

: 124-40-3
dimethyl amine

: 13360-57-1
dimethylamino sulfonyl chloride

Conditions

Conditions	Yield
With sulfuryl dichloride
With sulfuryl dichloride; triethylamine In 1,4-dioxane; chloroform at 0 - 20℃;

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 13360-57-1
dimethylamino sulfonyl chloride

Conditions

Conditions	Yield
With chlorosulphuric acid
With sulfur trioxide

: 89168-09-2
Carbamidsaeure-methylester-N-sulfonsaeure-dimethylamid

: 13360-57-1
dimethylamino sulfonyl chloride

Conditions

Conditions	Yield
With phosphorus pentachloride

: 29777-18-2
C5H15N2O2S(1+)*Cl(1-)

: 13360-57-1
dimethylamino sulfonyl chloride

Conditions

Conditions	Yield
at 60℃;

: C2H6NO2S(1-)*Na(1+)

: 13360-57-1
dimethylamino sulfonyl chloride

Conditions

Conditions	Yield
With chlorine In tetrachloromethane

: 41955-27-5
C2H6NO3S(1-)*Na(1+)

: 13360-57-1
dimethylamino sulfonyl chloride

Conditions

Conditions	Yield
With trichlorophosphate In 1,2-dichloro-ethane at 80℃; for 18h;

antimony (V) pentachloride: antimony (V) pentachloride

: 506-59-2
N,N-dimethylammonium chloride

: 13360-57-1
dimethylamino sulfonyl chloride

Conditions

Conditions	Yield
With sulfuryl dichloride In acetonitrile	44.2 g (87%)
With sulfuryl dichloride In acetonitrile	44.2 g (87%)
With sulfuryl dichloride In acetonitrile	44.2 g (87%)

: 22086-53-9
dipropylchloroborane

: 3768-63-6
tetramethylsulfamide

A: 13113-78-5
(dimethylamino)di-n-propylborane

B: 13360-57-1
dimethylamino sulfonyl chloride

...Expand

: 1730-69-4
dibutylchloroborane

: 3768-63-6
tetramethylsulfamide

: 13360-57-1
dimethylamino sulfonyl chloride

: 177-11-7
4,4-ethylenedioxy-piperidine

: 13360-57-1
dimethylamino sulfonyl chloride

: 877796-41-3
N,N-dimethyl-1,4-dioxa-8-azaspiro[4.5]decane-8-sulfonamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 1h;	100%

: 13360-57-1
dimethylamino sulfonyl chloride

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 253176-45-3
(S)-6'-chloro-N-((R)-hept-6-en-3-ylsulfonyl)-5-((2-((S)-1-hydroxyallyl)-2-methylcyclobutyl)methyl)-3',4,4',5-tetrahydro-2H,2’H-spiro[benzo[b][1,4]oxazepine-3,1’-naphthalene]-7-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h; Inert atmosphere;	100%
With triethylamine In dichloromethane at 20℃; for 12h;	92%
With triethylamine at 0 - 20℃; for 4h; Inert atmosphere;	89%

: 13360-57-1
dimethylamino sulfonyl chloride

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 98961-97-8
piperazine-1-sulfonic acid dimethylamide

Conditions

Conditions	Yield
Stage #1: dimethylamino sulfonyl chloride; 1-t-Butoxycarbonylpiperazine With triethylamine In tetrahydrofuran at 0℃; for 1h; Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 48h; Stage #3: With sodium hydroxide In dichloromethane; water	100%

: 857252-49-4
N,N-diethyl-4-[7-hydroxy-6-methoxy-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]benzamide

: 13360-57-1
dimethylamino sulfonyl chloride

: 857252-50-7
1-{4-[(diethylamino)carbonyl]phenyl}-6-methoxy-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinolin-7-yl dimethylsulfamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 22h;	100%

: 13360-57-1
dimethylamino sulfonyl chloride

: 148016-92-6
(2S,4S)-2-aminomethyl-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine

(2S,4S)-1-p-methoxybenzyloxycarbonyl-2-N,N-dimethylsulfamoylaminomethyl-4-tritylthiopyrrolidine: (2S,4S)-1-p-methoxybenzyloxycarbonyl-2-N,N-dimethylsulfamoylaminomethyl-4-tritylthiopyrrolidine

Conditions

Conditions	Yield
With triethylamine In dichloromethane	100%

: 367-12-4
2-fluorophenol

: 13360-57-1
dimethylamino sulfonyl chloride

: 1201594-21-9
C8H10FNO3S

Conditions

Conditions	Yield
Stage #1: 2-fluorophenol With sodium hydride In 1,2-dimethoxyethane; mineral oil at 0 - 23℃; for 0.166667h; Stage #2: dimethylamino sulfonyl chloride In 1,2-dimethoxyethane at 23℃; for 11h;	100%

: 611-20-1
salicylonitrile

: 13360-57-1
dimethylamino sulfonyl chloride

: 1263387-24-1
C9H10N2O3S

Conditions

Conditions	Yield
Stage #1: salicylonitrile With sodium hydride In 1,2-dimethoxyethane; mineral oil at 0℃; for 0.166667h; Stage #2: dimethylamino sulfonyl chloride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃; for 11h;	100%

: 1288963-67-6
4-(3-(4-methoxyphenyl)-1H-indol-2-yl)-3,5-dimethylisoxazole

: 13360-57-1
dimethylamino sulfonyl chloride

: 1288963-72-3
2-(3,5-dimethylisoxazol-4-yl)-3-(4-methoxyphenyl)-N,N-dimethyl-1H-indole-1-sulfonamide

Conditions

Conditions	Yield
Stage #1: 4-(3-(4-methoxyphenyl)-1H-indol-2-yl)-3,5-dimethylisoxazole With sodium hydride In n-heptane; N,N-dimethyl-formamide at 0 - 20℃; for 0.5h; Inert atmosphere; Stage #2: dimethylamino sulfonyl chloride In n-heptane; N,N-dimethyl-formamide at 0 - 20℃; for 2h;	100%
Stage #1: 4-(3-(4-methoxyphenyl)-1H-indol-2-yl)-3,5-dimethylisoxazole With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h; Inert atmosphere; Stage #2: dimethylamino sulfonyl chloride In N,N-dimethyl-formamide at 0 - 20℃; for 2h; Stage #3: With water In N,N-dimethyl-formamide	100%

: 1343453-37-1
2-(3-amino-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid ethyl ester

: 13360-57-1
dimethylamino sulfonyl chloride

: 1343454-35-2
ethyl 2-(3-(N,N-dimethylsulfamoylamino)phenyl)-3,3-dimethyl-1,2,3,4-tetrahydroquinoline-6-carboxylate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 25℃; for 16h;	100%
With pyridine In dichloromethane at 0 - 25℃; for 16h;

: 4421-08-3
3-methoxy-4-hydroxybenzonitrile

: 13360-57-1
dimethylamino sulfonyl chloride

: 1432739-31-5
4-cyano-2-methoxyphenyl N,N-dimethylsulfamate

Conditions

Conditions	Yield
Stage #1: 3-methoxy-4-hydroxybenzonitrile With dmap; triethylamine In dichloromethane at 20℃; for 0.166667h; Stage #2: dimethylamino sulfonyl chloride In dichloromethane at 20℃; for 16h;	100%

: 106-48-9
4-chloro-phenol

: 13360-57-1
dimethylamino sulfonyl chloride

: 1135-05-3
4-chlorophenyl N,N-dimethylsulfamate

Conditions

Conditions	Yield
Stage #1: 4-chloro-phenol With sodium hydride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃; for 0.166667h; Stage #2: dimethylamino sulfonyl chloride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃; for 16h;	100%
Stage #1: 4-chloro-phenol With sodium hydride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃; for 10h; Stage #2: dimethylamino sulfonyl chloride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃;	83%

: 2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

: 13360-57-1
dimethylamino sulfonyl chloride

: 2,4-dichloro-N,N-dimethyl-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-sulfonamide

Conditions

Conditions	Yield
Stage #1: 2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride With triethylamine In dichloromethane Stage #2: dimethylamino sulfonyl chloride In dichloromethane	100%

: 288-13-1
NH-pyrazole

: 13360-57-1
dimethylamino sulfonyl chloride

: 133228-21-4
N,N-dimethyl-1H-pyrazole-1-sulfonamide

Conditions

Conditions	Yield
Stage #1: NH-pyrazole With sodium hydride In tetrahydrofuran at 20℃; for 1h; Stage #2: dimethylamino sulfonyl chloride In tetrahydrofuran for 1.5h;	99%
Stage #1: NH-pyrazole With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.5h; Inert atmosphere; Stage #2: dimethylamino sulfonyl chloride In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.5h; Inert atmosphere;	99%
With sodium hydride In tetrahydrofuran; mineral oil for 1.33333h; Inert atmosphere;	91%

: 100-66-3
methoxybenzene

: 13360-57-1
dimethylamino sulfonyl chloride

: 59907-37-8
N,N-dimethyl-4-methoxybenzenesulfonamide

Conditions

Conditions	Yield
indium(III) triflate In 1,2-dichloro-ethane at 100℃; for 24h;	99%

: 123-08-0
4-hydroxy-benzaldehyde

: 13360-57-1
dimethylamino sulfonyl chloride

4-formylphenyl N,N-dimethylsulfamate: 4-formylphenyl N,N-dimethylsulfamate

Conditions

Conditions	Yield
With N,N-dimethyl-cyclohexanamine at 90 - 95℃; for 3h;	99%
With N-ethyl-N,N-diisopropylamine at 90℃; for 2.5h;

4-Fluorophenol: 4-Fluorophenol

: 13360-57-1
dimethylamino sulfonyl chloride

: 1259092-05-1
4-fluorophenyl N,N-dimethylsulfamate

Conditions

Conditions	Yield
Stage #1: 4-Fluorophenol With sodium hydride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃; for 0.166667h; Stage #2: dimethylamino sulfonyl chloride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃; for 16h;	99%
Stage #1: 4-Fluorophenol With sodium hydride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃; for 0.25h; Inert atmosphere; Stage #2: dimethylamino sulfonyl chloride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃; Inert atmosphere;	91%
With sodium hydride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃; for 11h; Inert atmosphere;
Stage #1: 4-Fluorophenol With sodium hydride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃; for 0.166667h; Stage #2: dimethylamino sulfonyl chloride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃; for 12h;

: 37622-90-5
4-ethoxycarbonylpyrazole

: 13360-57-1
dimethylamino sulfonyl chloride

: ethyl 1-(N,N-dimethylsulfamoyl)-1H-pyrazole-4-carboxylate

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In acetonitrile for 1h; Inert atmosphere;	99%
Stage #1: 4-ethoxycarbonylpyrazole With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.333333h; Inert atmosphere; Stage #2: dimethylamino sulfonyl chloride In tetrahydrofuran; mineral oil at 25℃; for 22h; Inert atmosphere;	91%

: 1202657-29-1
methyl 3-(acetylamino)-1H-pyrazole-5-carboxylate

: 13360-57-1
dimethylamino sulfonyl chloride

: C9H14N4O5S

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In acetonitrile at 0 - 20℃; for 18h;	99%

: C17H19NO4

: 13360-57-1
dimethylamino sulfonyl chloride

: C23H34N4O10S3

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 10h;	98.2%

: 74-89-5
methylamine

: 13360-57-1
dimethylamino sulfonyl chloride

: 76820-42-3
N,N,N′-trimethylsulfamide

Conditions

Conditions	Yield
In tetrahydrofuran	98%
With potassium carbonate In tetrahydrofuran; dichloromethane at 0 - 25℃; for 2h;	97%
In water; benzene at 50℃; for 5h;	87%
With toluene

: 13360-57-1
dimethylamino sulfonyl chloride

: 3984-14-3
N,N-dimethylsulfamide

Conditions

Conditions	Yield
With ammonia In methanol at 60℃; for 16h; Sealed tube;	98%
With ammonium hydroxide at 0℃; for 3h;	94%
With ammonium hydroxide at 0℃; ice-bath;	76%

: 288-32-4
1H-imidazole

: 13360-57-1
dimethylamino sulfonyl chloride

: 78162-58-0
N,N-dimethyl-1H-imidazole-1-sulfonamide

Conditions

Conditions	Yield
With triethylamine In toluene at 20℃; for 8h;	98%
With triethylamine In benzene for 16h; Ambient temperature;	95%
With triethylamine In diethyl ether at 20℃; for 16h;	94.75%

: 17073-95-9
1,6-anhydro-3,4-O-isopropylidene-β-D-galactopyranose

: 13360-57-1
dimethylamino sulfonyl chloride

: 98815-77-1
1,6-anhydro-2-O-(N,N-dimethylsulfamoyl)-3,4-O-isopropylidene-β-D-talopyranose

Conditions

Conditions	Yield
With 1H-imidazole; sodium hydride In tetrahydrofuran for 2h; Heating;	98%

: 90-15-3
α-naphthol

: 13360-57-1
dimethylamino sulfonyl chloride

: 1144-13-4
naphthalen-1-yl N,N-dimethylsulfamate

Conditions

Conditions	Yield
With sodium hydride In 1,2-dimethoxyethane at 23℃; for 17h; Inert atmosphere;	98%
Stage #1: α-naphthol With sodium hydride In 1,2-dimethoxyethane; mineral oil at 0 - 23℃; for 0.166667h; Stage #2: dimethylamino sulfonyl chloride In 1,2-dimethoxyethane; mineral oil at 23℃; for 11h;	95%
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In benzene at 50℃; for 6h;	94%

: 670-91-7
4(5)-(4-tolyl)-1H-imidazole

: 13360-57-1
dimethylamino sulfonyl chloride

: 1-(dimethylsulfamoyl)-5-p-tolylimidazole

Conditions

Conditions	Yield
With potassium carbonate In ethyl acetate at 77℃; for 6h; Temperature;	98%

: C17H20N6

: 13360-57-1
dimethylamino sulfonyl chloride

: C21H30N8O4S2

Conditions

Conditions	Yield
Stage #1: C17H20N6 With sodium hydroxide In N,N-dimethyl-formamide for 0.5h; Cooling; Stage #2: dimethylamino sulfonyl chloride In N,N-dimethyl-formamide at 220℃; for 4h; Autoclave;	97.6%

: 71759-89-2
4-iodoimidazole

: 13360-57-1
dimethylamino sulfonyl chloride

: 135773-25-0
4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide

Conditions

Conditions	Yield
Stage #1: 4-iodoimidazole; dimethylamino sulfonyl chloride With sodium hydroxide In tetrahydrofuran at 8 - 20℃; Stage #2: In n-heptane at 70℃; for 4h;	97.3%
With triethylamine In acetonitrile at 20℃; for 2h;	80%
With triethylamine In dichloromethane for 60h; Heating;	60%
With triethylamine In dichloromethane at 20℃; for 26h; Inert atmosphere;	58%

: 78-83-1
2-methyl-propan-1-ol

: 13360-57-1
dimethylamino sulfonyl chloride

: 66950-72-9
isobutyl N,N-dimethylsulfamate

Conditions

Conditions	Yield
With sodium hydride In 1,2-dimethoxyethane	97%

: (+/-)-(1S*,6S*,8R*,9R*,10S*,11S*)-2,2-Dimethoxy-10,11-epoxy-6-methyl-12-oxatricyclo<6.3.1.01,6>dodecan-9-ol

: 13360-57-1
dimethylamino sulfonyl chloride

: C16H27NO7S

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran 1.) r.t., 5 min, 2.) r.t., 1 h;	97%

: 13360-57-1
dimethylamino sulfonyl chloride

: 195820-65-6
3,4-bis(trimethylsilyl)-1H-pyrrole

: 278167-17-2
N-N-dimethyl 3,4-bis(trimethylsilyl)-1H-pyrrole-1-sulfonamide

Conditions

Conditions	Yield
Stage #1: 3,4-bis(trimethylsilyl)-1H-pyrrole With sodium hydride In N,N-dimethyl-formamide at 0℃; for 2h; Metallation; Stage #2: dimethylamino sulfonyl chloride In N,N-dimethyl-formamide at 0 - 20℃; for 2h; Substitution; Further stages.;	97%

Dimethylsulfamoyl chloride Chemical Properties

IUPAC Name: N,N-Dimethylsulfamoyl chloride
Empirical Formula: C₂H₆ClNO₂S
Molecular Weight: 143.5925
EINECS: 236-412-4
Freely Rotating Bonds: 1
Polar Surface Area: 45.76 Å²
Index of Refraction: 1.481
Molar Refractivity: 28.82 cm³
Molar Volume: 101.2 cm³
Polarizability: 11.42 ×10^-24cm³
Surface Tension: 42.8 dyne/cm
Density: 1.418 g/cm³
Flash Point: 94.4 °C
Enthalpy of Vaporization: 42.3 kJ/mol
Boiling Point: 186.7 °C at 760 mmHg
Vapour Pressure: 0.653 mmHg at 25°C
The Cas Register Number of Sulfamoyl chloride,N,N-dimethyl- is 13360-57-1.The chemical synonyms of Sulfamoyl chloride,N,N-dimethyl- (CAS NO.13360-57-1) are Dimethylsulphamoyl chloride .The molecular structure of Sulfamoyl chloride,N,N-dimethyl- (CAS NO.13360-57-1) is
.

Dimethylsulfamoyl chloride Uses

Sulfamoyl chloride,N,N-dimethyl- (CAS NO.13360-57-1) is used as organic intermediate.

Dimethylsulfamoyl chloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LC	inhalation	> 300mg/m³/10M (300mg/m³)		National Defense Research Committee, Office of Scientific Research and Development, Progress Report.Vol. NDCrc-132, Pg. Nov, 1942.
mouse	LD50	oral	900mg/kg (900mg/kg)		Chemical Abstracts. Vol. 85, Pg. 117680t, 1976.

Dimethylsulfamoyl chloride Safety Profile

Hazard Codes: Very T+
Risk Statements: 45-21/22-26-34
R45: May cause cancer.
R21/22: Harmful in contact with skin and if swallowed.
R26: Very toxic by inhalation.
R34: Causes burns.
Safety Statements: 53-45
S53: Avoid exposure - obtain special instructions before use.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3390 6.1/PG 1
WGK Germany: 3
RTECS: WO7185500
F: 10
HazardClass: 6.1(a)
PackingGroup: III
HS Code: 29299000

Product Name

Dimethylsulfamoyl chloride

Synthetic route

Dimethylsulfamoyl chloride Chemical Properties

Dimethylsulfamoyl chloride Uses

Dimethylsulfamoyl chloride Toxicity Data With Reference

Dimethylsulfamoyl chloride Safety Profile

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