Enoxolone supplier | CasNO.471-53-4

Name
Enoxolone
EINECS 207-444-6
CAS No. 471-53-4
Article Data47
CAS DataBase
Density 1.14 g/cm³
Solubility Insoluble in water, but soluble in ethanol, chloroform, pyridine, acetic acid
Melting Point 292-295 °C(lit.)
Formula C₃₀H₄₆O₄
Boiling Point 588.3 °C at 760 mmHg
Molecular Weight 470.693
Flash Point 323.7 °C
Transport Information
Appearance white or greyish-white crystalline powder
Safety 22-24/25
Risk Codes 22-36
Molecular Structure
Hazard Symbols Xn
Synonyms Uralenic acid;(2S,4aR,6aS,6aS,6bR,8aS,10R,12aS,14bS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate;Biosone;Hidermart;Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,20β)-;Glycyrrhetic acid;3-Glycyrrhetinic acid;Glycyrrhetinate;10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid;β-Glycyrrhetinic Acid;Hidermart (TN);Glycyrrhetin;r-Glycyrrhetinic acid;Glycyrrhetinic acid;Glycyrrhetinic acid (JAN);(3β)-3-Hydroxy-11-oxoolean-12-en-30-oic acid;
PSA 74.60000
LogP 6.41260

Synthetic route

: 1405-86-3
glycyrrhizin

: 471-53-4
enoxolone

Conditions

Conditions	Yield
With methanol; thionyl chloride at 0 - 20℃; for 9h; Reagent/catalyst; Inert atmosphere;	90%
With hydrogenchloride; water In methanol at 90℃; for 20h;
With hydrogenchloride In water at 100℃; for 20h;
With sulfuric acid In methanol Reflux;	250 mg
With methanol; sulfuric acid at 90℃; for 24h;

: 83896-44-0, 103000-77-7, 119479-05-9, 142394-43-2, 1405-86-3
glycyrrizhin

: 471-53-4
enoxolone

Conditions

Conditions	Yield
With hydrogenchloride In water	85%
Multi-step reaction with 2 steps 1: 18.4 percent / CHCl3; dimethylformamide / 72 h / Ambient temperature 2: 68.3 percent / 20percent H2SO4 / dioxane / 4 h View Scheme
With hydrogenchloride In ethanol; water at 30 - 35℃; for 48h;	0.53%

: (3β,20β)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-D-glucopyranosiduronic acid

: 471-53-4
enoxolone

Conditions

Conditions	Yield
With hydrogenchloride In water; acetic acid at 100℃; for 1h;	72%
With hydrogenchloride; water In chloroform for 6h; Reflux;	13 mg

: 83896-44-0, 103000-77-7, 119479-05-9, 142394-43-2, 1405-86-3
glycyrrizhin

A: 6556-12-3, 489-91-8, 528-16-5, 552-12-5, 577-46-8, 643-33-4, 2240-07-5, 6294-16-2, 10133-02-5, 18402-78-3, 18968-14-4, 21179-08-8, 23018-83-9, 33599-45-0, 33599-46-1, 46171-67-9, 46171-69-1, 46172-26-3, 70021-34-0, 71031-08-8, 104195-06-4, 106499-29-0, 124817-72-7
D-glucuronic acid

B: 471-53-4
enoxolone

C: 6894-46-8, 14796-53-3, 17956-00-2, 76035-62-6, 564-16-9
11-deoxyglycyrrhetinic acid

Conditions

Conditions	Yield
With hydrogenchloride In water at 100℃; for 8h; Hydrolysis;	A n/a B 69.9% C 1.1%

...Expand

: 87918-97-6
6',6''-dibenzyl-18β-glycyrrhizin

: 471-53-4
enoxolone

Conditions

Conditions	Yield
With sulfuric acid In 1,4-dioxane for 4h;	68.3%

: β-glycyrrhizic acid monopotassium salt

: 471-53-4
enoxolone

Conditions

Conditions	Yield
With sulfuric acid In water at 100℃; for 8h; Hydrolysis;	68.3%

: 53956-04-0, 68083-53-4, 79165-06-3, 80287-34-9, 80658-20-4
Ammonium glycyrrhizate

: 471-53-4
enoxolone

Conditions

Conditions	Yield
at 40℃; for 3h; 15percent aq. solution of β-glucuronidase, acetate buffer 4.6;	48%
With β-glucuronidase In water at 40℃; for 3h; Rate constant; Kinetics; Product distribution; acetate buffer 4.6; other temp., other pH, other time;	48.08%

: 83896-44-0, 103000-77-7, 119479-05-9, 142394-43-2, 1405-86-3
glycyrrizhin

A: 6556-12-3, 489-91-8, 528-16-5, 552-12-5, 577-46-8, 643-33-4, 2240-07-5, 6294-16-2, 10133-02-5, 18402-78-3, 18968-14-4, 21179-08-8, 23018-83-9, 33599-45-0, 33599-46-1, 46171-67-9, 46171-69-1, 46172-26-3, 70021-34-0, 71031-08-8, 104195-06-4, 106499-29-0, 124817-72-7
D-glucuronic acid

B: 471-53-4
enoxolone

Conditions

Conditions	Yield
With β-glucuronidase In acetate buffer at 37℃; for 144h; pH=5.2; Hydrolysis; Enzymatic reaction;	A n/a B 45.9%

: 6894-46-8, 14796-53-3, 17956-00-2, 76035-62-6, 564-16-9
11-deoxyglycyrrhetinic acid

A: 3β-hydroxy-12-oxoolean-30-oic acid

B: 471-53-4
enoxolone

Conditions

Conditions	Yield
Stage #1: 11-deoxyglycyrrhetinic acid With ozone In methanol; dichloromethane at -60℃; Stage #2: With acetic acid; zinc In methanol; dichloromethane at 0℃; for 1h; Further stages.;	A 42% B n/a

: 10379-73-4, 10379-77-8, 18305-96-9, 6277-14-1
acetoxolone

: 471-53-4
enoxolone

Conditions

Conditions	Yield
With potassium hydroxide

: 67-56-1
methanol

: 121709-66-8
apioglycyrrhizin

A: 135414-74-3
methyl glucoside of D-glucurono-6,3-lactone

B: 471-53-4
enoxolone

C: 64481-62-5, 64481-63-6, 64481-64-7, 64481-65-8
methyl D-apiofuranoside

Conditions

Conditions	Yield
With hydrogenchloride the structure was confirmed;

...Expand

: 67-56-1
methanol

: 121687-83-0
araboglycyrrhizin

A: 135414-74-3
methyl glucoside of D-glucurono-6,3-lactone

B: 471-53-4
enoxolone

C: 449173-64-2
methyl α,β-L-arabinopyranoside

Conditions

Conditions	Yield
the structure was confirmed;

...Expand

: 1405-86-3
glycyrrhizin

A: 471-53-4
enoxolone

B: D-glucuronyl-β-1,2-D-glucuronic acid

Conditions

Conditions	Yield
With glycyrrhizinic acid hydrolase at 40℃; pH 5.0, acetate buffer;

: 34096-83-8
1-(18β-glycyrrhet-3-yl)-β-D-glucopyranuronic acid

: 471-53-4
enoxolone

Conditions

Conditions	Yield
With luminal contents in rat colon In phosphate buffer at 37℃; pH=7.4; Kinetics; Hydrolysis;

ammonium salt of/the/ glycyrrhizinic acid: ammonium salt of/the/ glycyrrhizinic acid

: 471-53-4
enoxolone

Conditions

Conditions	Yield
With sulfuric acid
With hydrogenchloride at 50℃;
With sulfuric acid at 130 - 155℃; unter Druck;

glycyrrhizinic acid: glycyrrhizinic acid

: 471-53-4
enoxolone

monoammonium salt of/the/ glycyrrhizinic acid: monoammonium salt of/the/ glycyrrhizinic acid

: 471-53-4
enoxolone

Conditions

Conditions	Yield
With sulfuric acid
With β-glucuronidase

potassium salt of/the/ glycyrrhizinic acid: potassium salt of/the/ glycyrrhizinic acid

: 471-53-4
enoxolone

Conditions

Conditions	Yield
With sulfuric acid
With hydrogenchloride at 50℃;
With sulfuric acid at 130 - 155℃; unter Druck;

: glycyrrhizic acid

: 471-53-4
enoxolone

Conditions

Conditions	Yield
With sulfuric acid In methanol Reflux;

: 1405-86-3
glycyrrhizin

A: 471-53-4
enoxolone

B: 34096-83-8
1-(18β-glycyrrhet-3-yl)-β-D-glucopyranuronic acid

Conditions

Conditions	Yield
With water at 100 - 140℃; under 52505.3 Torr; Kinetics; Thermodynamic data; Green chemistry;

: C38H49NO6

: 471-53-4
enoxolone

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; manganese; 2.9-dimethyl-1,10-phenanthroline; carbon dioxide In N,N-dimethyl-formamide at 20℃; under 2585.81 Torr; for 20h; Sealed tube; chemoselective reaction;

: 471-53-4
enoxolone

: 74-88-4
methyl iodide

: 1477-44-7, 5092-01-3, 7558-31-8, 10379-74-5, 10379-79-0, 21857-94-3, 118492-16-3
methyl glycyrrhetinate

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20℃; for 24h;	100%
With potassium carbonate In acetone at 20℃; for 12h;	95%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 10h;	94%

: 471-53-4
enoxolone

: 6738-17-6
O-benzyl-N,N'-dicyclohexylisourea

: 51984-75-9
benzyl (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylate

Conditions

Conditions	Yield
In chloroform for 5h; Heating;	99%

: 186581-53-3, 908094-01-9
diazomethane

: 471-53-4
enoxolone

: 1477-44-7, 5092-01-3, 7558-31-8, 10379-74-5, 10379-79-0, 21857-94-3, 118492-16-3
methyl glycyrrhetinate

Conditions

Conditions	Yield
In methanol; diethyl ether at 0℃;	99%
In tetrahydrofuran; diethyl ether for 0.833333h;	89.7%
In diethyl ether; dichloromethane	83%

: 471-53-4
enoxolone

: 18107-18-1
diazomethyl-trimethyl-silane

: 1477-44-7, 5092-01-3, 7558-31-8, 10379-74-5, 10379-79-0, 21857-94-3, 118492-16-3
methyl glycyrrhetinate

Conditions

Conditions	Yield
In methanol; diethyl ether at 0 - 20℃; for 2h;	99%
In diethyl ether at 20℃; for 1h;	98%
In methanol; hexane; toluene at 20℃; for 0.5h;	91%
In methanol; diethyl ether

: 471-53-4
enoxolone

: 124-63-0
methanesulfonyl chloride

: 1326599-59-0
(3β)-3-[(methylsulfonyl)oxy]-11-oxo-olean-12-en-30-oic acid

Conditions

Conditions	Yield
With pyridine at 20℃; for 70h;	99%
With triethylamine In dichloromethane at 4℃; for 3h;	65.7%

: 471-53-4
enoxolone

: 103-71-9
phenyl isocyanate

: 3-phenylcarbamoyl-18β-glycyrrhetinic acid

Conditions

Conditions	Yield
With triethylamine In toluene at 110℃; for 2h;	99%

: 471-53-4
enoxolone

: 108-24-7
acetic anhydride

: 10379-73-4, 10379-77-8, 18305-96-9, 6277-14-1
acetoxolone

Conditions

Conditions	Yield
With pyridine at 20℃; for 16h;	98%
With pyridine; dmap at 20℃; for 2h;	98.2%
for 1.5h; Reflux;	96.4%

: 471-53-4
enoxolone

: 6184-16-3, 7020-50-0, 146236-29-5
3,11-dioxoolean-12-en-30-oic acid

Conditions

Conditions	Yield
With chromium(VI) oxide; sulfuric acid In acetone at 0℃; for 1h;	98%
With Jones reagent In acetone at 0℃; for 1.5h;	96.25%
With Jones reagent In acetone at 0℃; for 2h;	96%

: 471-53-4
enoxolone

: S-(1-butyn-3-yl)-O-methyl xanthate

: 1477-44-7, 5092-01-3, 7558-31-8, 10379-74-5, 10379-79-0, 21857-94-3, 118492-16-3
Methyl ester of glycyrrhetic acid

Conditions

Conditions	Yield
In toluene Heating;	98%

: 471-53-4
enoxolone

: 870-63-3
prenyl bromide

: 18β-glycyrrhetinic acid 30-prenyl ester

Conditions

Conditions	Yield
With potassium carbonate In acetone at 50℃; for 4h;	98%

: 471-53-4
enoxolone

: 541-88-8
Chloroacetic anhydride

: 109278-66-2
(3β)‐(2‐chloroacetyloxy)‐11‐oxo‐olean‐12‐en‐30‐oic acid

Conditions

Conditions	Yield
In ethyl acetate at 130℃; for 1h;	98%

: 471-53-4
enoxolone

: 519-02-8, 641-39-4, 4702-09-4, 4979-18-4, 6783-60-4, 6838-36-4, 6882-68-4, 17801-36-4, 20078-88-0, 36284-98-7, 68421-43-2, 83148-91-8
Matrin

: C15H24N2O*C30H46O4

Conditions

Conditions	Yield
In ethanol at 50℃; Solvent; Temperature;	97.8%

: 471-53-4
enoxolone

: oxymatrine

: C30H46O4*C15H24N2O2

Conditions

Conditions	Yield
In ethanol at 50℃; Solvent; Temperature;	97.8%

: 471-53-4
enoxolone

: 572-09-8
2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

: C44H64O13

Conditions

Conditions	Yield
With Aliquat 336; potassium carbonate In dichloromethane; water for 48h; Ambient temperature;	97%

: 78239-72-2
3-bromo-4-fluoro-benzyl chloride

: 471-53-4
enoxolone

: 3-(3-bromo-4-fluoro-benzyloxy)-11-oxoolean-12-ene-29-oic acid

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20℃; for 8h; Inert atmosphere;	97%

: 471-53-4
enoxolone

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 3-(3-chloro-benzyloxy)-11-oxoolean-12-ene-29-oic acid

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20℃; for 8h; Inert atmosphere;	97%

: 471-53-4
enoxolone

: 25026-34-0
4-chlorophenacetyl chloride

: (3β)‐(2‐(4‐chlorophenyl)acetoxy)‐11‐oxo‐olean‐12‐en‐30‐oic acid

Conditions

Conditions	Yield
With triethylamine In ethyl acetate for 24h; Reflux;	97%

: 471-53-4
enoxolone

: 79-04-9
chloroacetyl chloride

: 109278-66-2
(3β)‐(2‐chloroacetyloxy)‐11‐oxo‐olean‐12‐en‐30‐oic acid

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran at 20℃; for 4h;	96.2%
Stage #1: enoxolone; chloroacetyl chloride With triethylamine In tetrahydrofuran at 25℃; for 12h; Stage #2: With hydrogenchloride In dichloromethane; water	45.3%

: 471-53-4
enoxolone

: 106-95-6
allyl bromide

: 31467-24-0
(3β,18β,20β)-3-hydroxy-11-oxoolean-12-en-29-oic acid allyl ester

Conditions

Conditions	Yield
With potassium carbonate In acetone at 50℃; for 4h;	96%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	84.2%
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 24.1667h;	69%

: 57260-73-8
N-BOC-1,2-diaminoethane

: 471-53-4
enoxolone

: 1334318-59-0
N-[2-(tert-butoxycarbonylamino)ethyl]glycyrrhetinamide

Conditions

Conditions	Yield
Stage #1: enoxolone With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere; Stage #2: N-BOC-1,2-diaminoethane In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;	96%
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 10h;	90%
Stage #1: enoxolone With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: N-BOC-1,2-diaminoethane In N,N-dimethyl-formamide at 0 - 20℃;	64%

: 471-53-4
enoxolone

: 2592-95-2
benzotriazol-1-ol

: 1612838-71-7
1H‐benzo[d][1,2,3]triazol‐1‐yl‐3β‐hydroxy‐11‐oxo‐olean‐12‐en‐30‐oate

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In acetonitrile for 0.333333h; Reflux;	95.8%
With hydrogenchloride In water for 3.5h; Reflux;	90%
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h;	27%
With piperazine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In acetonitrile at 20℃;

: 471-53-4
enoxolone

: 2592-95-2
benzotriazol-1-ol

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1612838-71-7
1H‐benzo[d][1,2,3]triazol‐1‐yl‐3β‐hydroxy‐11‐oxo‐olean‐12‐en‐30‐oate

Conditions

Conditions	Yield
Stage #1: enoxolone; benzotriazol-1-ol With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 0.333333h; Stage #2: 1-t-Butoxycarbonylpiperazine In dichloromethane for 24h; Reflux;	95.8%

...Expand

: 471-53-4
enoxolone

: 6894-46-8, 14796-53-3, 17956-00-2, 76035-62-6, 564-16-9
11-deoxyglycyrrhetinic acid

Conditions

Conditions	Yield
With hydrogenchloride; zinc amalgam In 1,4-dioxane; water for 5h; Clemmensen Reduction; Cooling;	95%
With hydrogenchloride; mercury dichloride; zinc In 1,4-dioxane; water	90%
With platinum(IV) oxide; hydrogen In acetic acid	87.6%

: 471-53-4
enoxolone

: 77397-93-4
11-hydroxymethyl-4,4,6a,6b,8a,11,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-eicosahydro-picene-3,14-diol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 60 - 70℃; for 4h;	95%
With sodium bis(2-methoxyethoxy)aluminium dihydride In tetrahydrofuran at 0 - 20℃;	63%
With sodium bis(2-methoxyethoxy)aluminium dihydride In tetrahydrofuran
With lithium aluminium tetrahydride In tetrahydrofuran at 60℃;

: 471-53-4
enoxolone

: (3β,18β,20β)-3,11-dihydroxyoleana-12-en-29-oic acid

Conditions

Conditions	Yield
With sodium tetrahydroborate; sodium hydroxide In tetrahydrofuran; water for 24h; Reflux;	95%
With sodium tetrahydroborate; sodium hydroxide In tetrahydrofuran; water for 4h; Reflux;	80%
With sodium hydroxide; sodium tetrahydroborate In tetrahydrofuran; water for 4h; Reduction; Heating;

: 471-53-4
enoxolone

: 459-46-1
4-Fluorobenzyl bromide

: 10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-eicosahydropicene-2-carboxylic acid 4-fluorobenzyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 3h;	95%

: 471-53-4
enoxolone

: 917-54-4
methyllithium

: 3β-hydroxy-11-methylene-18β-olean-12-en-30-oic acid

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran; diethyl ether at 20℃; for 1h;	95%

: 109-65-9
1-bromo-butane

: 471-53-4
enoxolone

: 1375691-79-4
butyl 3β-hydroxy-11-oxo-olean-12-en-30-oate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 3h;	95%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	85.8%

: 471-53-4
enoxolone

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 3-(4-chloro-benzyloxy)-11-oxoolean-12-ene-29-oic acid

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20℃; for 8h; Inert atmosphere;	95%

: 471-53-4
enoxolone

: 589-17-3
p-bromobenzyl chloride

: 3-(4-bromo-benzyloxy)-11-oxoolean-12-ene-29-oic acid

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20℃; for 8h; Inert atmosphere;	95%

Enoxolone Specification

The Enoxolone, with the CAS registry number 471-53-4, is also known as 18-beta-Glycyrrhetinic acid. It belongs to the product categories of Pentacyclic Triterpenes; Tri-Terpenoids; Miscellaneous; Biochemistry; Terpenes; Terpenes (Others); Natural Plant Extract; Cosmetic Ingredients & Chemicals; Chiral Reagents; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals. Its EINECS number is 207-444-6. This chemical's molecular formula is C₃₀H₄₆O₄ and molecular weight is 470.68. What's more, its systematic name is (3β)-3-hydroxy-11-oxoolean-12-en-30-oic acid. Its classification code is Anti-Inflammatory Agents. It can be used as edible flavoring and sauces. It should be sealed and stored in a cool, ventilated and dry place. Moreover, it should be protected from oxides. It is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice. It is used in flavoring and it masks the bitter taste of drugs like aloe and quinine. It is effective in the treatment of peptic ulcer and also has expectorant (antitussive) properties.

Physical properties of Enoxolone are: (1)ACD/LogP: 6.57; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 5.73; (4)ACD/LogD (pH 7.4): 3.93; (5)ACD/BCF (pH 5.5): 8289; (6)ACD/BCF (pH 7.4): 131.57; (7)ACD/KOC (pH 5.5): 12748.06; (8)ACD/KOC (pH 7.4): 202.35; (9)#H bond acceptors: 4; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 52.6 Å²; (13)Index of Refraction: 1.562; (14)Molar Refractivity: 133.69 cm³; (15)Molar Volume: 411.6 cm³; (16)Polarizability: 52.99×10^-24cm³; (17)Surface Tension: 47.7 dyne/cm; (18)Density: 1.14 g/cm³; (19)Flash Point: 323.7 °C; (20)Enthalpy of Vaporization: 100.81 kJ/mol; (21)Boiling Point: 588.3 °C at 760 mmHg; (22)Vapour Pressure: 2.71E-16 mmHg at 25°C.

Preparation: this chemical can be prepared by b-glycyrrhizic acid monopotassium salt at the temperature of 100 °C. This reaction will need reagent H₂SO₄ and solvent H₂O with the reaction time of 8 hours. The yield is about 68.3%.

Enoxolone can be prepared by b-glycyrrhizic acid monopotassium salt at the temperature of 100 °C

Uses of Enoxolone: it can be used to produce 3,11-dioxo-olean-12-en-30-oic acid at the temperature of 0 °C. It will need reagents CrO₃, H₂SO₄ and solvent acetone with the reaction time of 1 hour. The yield is about 98%.

Enoxolone can be used to produce 3,11-dioxo-olean-12-en-30-oic acid at the temperature of 0 °C

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful if swallowed and is irritating to eyes. You should not breathe dust. When using it, you must avoid contact with eyes.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)[C@]5(C)C[C@H]4/C3=C/C(=O)[C@H]1[C@](CC[C@@H]2[C@]1(C)CC[C@H](O)C2(C)C)(C)[C@]3(C)CC[C@@]4(C)CC5
(2)Std. InChI: InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,
(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1
(3)Std. InChIKey: MPDGHEJMBKOTSU-YKLVYJNSSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	308mg/kg (308mg/kg)	Drugs in Japan Vol. -, Pg. 319, 1990.
mouse	LD50	intravenous	56mg/kg (56mg/kg)	U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02067,
mouse	LD50	subcutaneous	518mg/kg (518mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 5, Pg. 98, 1963.

Product Name

Enoxolone

Synthetic route

Enoxolone Specification

Related Products

Hot Products