Ethyl 2-cyanopropionate supplier

Name
Ethyl 2-cyanopropanoate
EINECS 216-393-9
CAS No. 1572-99-2
Article Data41
CAS DataBase
Density 1.019 g/cm³
Solubility
Melting Point
Formula C₆H₉NO₂
Boiling Point 194.452 °C at 760 mmHg
Molecular Weight 127.143
Flash Point 78.871 °C
Transport Information
Appearance
Safety 23-36/37/39
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols
Synonyms Propionicacid, 2-cyano-, ethyl ester (6CI,7CI,8CI);2-Cyanopropanoic acid ethyl ester;Ethyl 2-cyanopropanoate;Ethyl 2-cyanopropionate;Ethyl a-cyanopropionate;NSC 68508;
PSA 50.09000
LogP 0.70918

Synthetic route

: 109-06-8
α-picoline

Co2 (CO)8: Co2 (CO)8

: 107-13-1
acrylonitrile

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
In ethanol	95%

...Expand

: 7085-85-0
ethyl 2-cyanoacrylate

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
With trifluoroacetic acid at 0℃;	85%
With trifluoroacetic acid at 0℃; Mechanism;	85%
With hydrogen; hydrotalcite-supported palladium nanoparticles; palladium In toluene at 60℃; under 760 Torr; for 1h;

: 105-56-6
ethyl 2-cyanoacetate

: 74-88-4
methyl iodide

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
Stage #1: ethyl 2-cyanoacetate With sodium hydride In tetrahydrofuran; paraffin oil at 0℃; for 0.25h; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran; paraffin oil at 0 - 20℃; for 3h; Inert atmosphere;	83%
Stage #1: ethyl 2-cyanoacetate With potassium carbonate In acetonitrile at 20℃; for 0.25h; Stage #2: methyl iodide In acetonitrile at 20℃; for 6h;	41%
With potassium hydroxide In ethanol at 0℃; for 4h;

: 68897-45-0
N,N,N',N',N'',N''-Hexamethylguanidiniumcyanid

: 535-11-5, 41978-69-2
Ethyl 2-bromopropionate

A: 1572-99-2
ethyl 2-cyanopropionate

B: 6926-43-8
1,1,2,2,3,3-Hexamethylguanidiniumbromid

Conditions

Conditions	Yield
In dichloromethane at 40℃; for 18h;	A 73% B n/a

...Expand

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 107-13-1
acrylonitrile

: 122-57-6
1-Phenylbut-1-en-3-one

A: 10137-67-4
ethyl 3-cyanopropionate

B: 30378-23-5
2,4-dicyano-2-methylbutanoic acid ethyl ester

C: 115906-97-3
2-cyano-5-oxo-3-phenyl-2-methylhexanoic acid ethyl ester

D: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
With pyridine; dicobalt octacarbonyl at 110℃; under 75005.9 Torr; Further byproducts given;	A n/a B 59% C 10% D n/a

...Expand

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 107-13-1
acrylonitrile

: 140-88-5
ethyl acrylate

A: 10137-67-4
ethyl 3-cyanopropionate

B: 30378-23-5
2,4-dicyano-2-methylbutanoic acid ethyl ester

C: 91341-03-6
2-cyano-2-methyl-1,5-pentanedioic acid bis(ethyl ester)

D: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
With pyridine; dicobalt octacarbonyl at 110℃; under 75005.9 Torr; Further byproducts given;	A n/a B 44% C 5% D n/a

...Expand

: 773837-37-9
sodium cyanide

: 535-11-5, 41978-69-2
Ethyl 2-bromopropionate

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
In water; N,N-dimethyl-formamide at 23℃; for 12h;	30%

: 632-07-5
2-cyanopropanoic acid

: 64-17-5
ethanol

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
With sulfuric acid

: 64-17-5
ethanol

: 151-50-8
potassium cyanide

: 535-11-5, 41978-69-2
Ethyl 2-bromopropionate

A: 54677-60-0
diethyl 2,3-dimethyl-2-cyanosuccinate

B: 1572-99-2
ethyl 2-cyanopropionate

...Expand

: 541-41-3
chloroformic acid ethyl ester

: 107-12-0
propiononitrile

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
With diethyl ether; sodium

: 18852-51-2
sodium cyanoacetic acid ethyl ester

: 77-78-1
dimethyl sulfate

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
With ethanol

: 18852-51-2
sodium cyanoacetic acid ethyl ester

: 77-78-1
dimethyl sulfate

A: 1572-98-1
2-cyano-2-methyl-propionic acid ethyl ester

B: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
With benzene

...Expand

: 151-50-8
potassium cyanide

: 535-11-5, 41978-69-2
Ethyl 2-bromopropionate

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
With ethanol
With ethanol at 100℃; im geschlossenen Rohr;

: 18852-51-2
sodium cyanoacetic acid ethyl ester

: 74-88-4
methyl iodide

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
With diethyl ether
analog reagiert mit Aethyljodid und mit Allyljodid;

: 18852-51-2
sodium cyanoacetic acid ethyl ester

: 74-88-4
methyl iodide

A: 1572-98-1
2-cyano-2-methyl-propionic acid ethyl ester

B: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
With diethyl ether

...Expand

: 74-83-9
methyl bromide

: 105-56-6
ethyl 2-cyanoacetate

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
(i) NaOEt, EtOH, (ii) /BRN= 1209223/; Multistep reaction;
Stage #1: ethyl 2-cyanoacetate With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: methyl bromide In tetrahydrofuran at 0℃; for 8h; Inert atmosphere;

: 13435-20-6
tetraethylammoniumcyanide

: 535-11-5, 41978-69-2
Ethyl 2-bromopropionate

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
In dichloromethane

: 617-35-6
2-oxo-propionic acid ethyl ester

: 7677-24-9
trimethylsilyl cyanide

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
In tetrahydrofuran for 8h; Heating;

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 107-13-1
acrylonitrile

A: 10137-67-4
ethyl 3-cyanopropionate

B: 30378-23-5
2,4-dicyano-2-methylbutanoic acid ethyl ester

C: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
With pyridine; dicobalt octacarbonyl In toluene at 110℃; under 75005.9 - 90007.2 Torr; for 6h;	A 6.0 % Chromat. B 75 % Chromat. C 17.7 % Chromat.

...Expand

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 535-11-5, 41978-69-2
Ethyl 2-bromopropionate

A: 54677-60-0
diethyl 2,3-dimethyl-2-cyanosuccinate

B: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium hydroxide In acetonitrile Yield given. Yields of byproduct given;
With tetra(n-butyl)ammonium hydroxide Yield given. Yields of byproduct given;

...Expand

: 18852-51-2
sodium cyanoacetic acid ethyl ester

: 77-78-1
dimethyl sulfate

A: 1572-99-2
ethyl 2-cyanopropionate

B α-cyano-isobutyric acid ethyl ester: α-cyano-isobutyric acid ethyl ester

Conditions

Conditions	Yield
With benzene

...Expand

: 74-88-4
methyl iodide

sodium cyanoacetic acid nitrile: sodium cyanoacetic acid nitrile

A: 1572-98-1
2-cyano-2-methyl-propionic acid ethyl ester

B: 1572-99-2
ethyl 2-cyanopropionate

...Expand

: 50-00-0
formaldehyd

: 105-56-6
ethyl 2-cyanoacetate

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
Stage #1: formaldehyd; ethyl 2-cyanoacetate; hydrotalcite; palladium In water; N,N-dimethyl-formamide at 80℃; for 3h; Stage #2: With hydrogen; hydrotalcite; palladium In water; N,N-dimethyl-formamide at 60℃; under 760 Torr; for 1h;	91 % Chromat.

: 105-56-6
ethyl 2-cyanoacetate

ammonia: ammonia

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrotalcite-supported palladium nanoparticles / dimethylformamide / 3 h / 80 °C 2: hydrogen / hydrotalcite-supported palladium nanoparticles / toluene / 1 h / 60 °C / 760 Torr View Scheme

: 105-56-6
ethyl 2-cyanoacetate

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diethyl ether; sodium 2: analog reagiert mit Aethyljodid und mit Allyljodid View Scheme

: 110-89-4
piperidine

: 50-00-0
formaldehyd

: 105-56-6
ethyl 2-cyanoacetate

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
With acetic acid; palladium on charcoal catalyst In water

...Expand

: 110-89-4
piperidine

: 50-00-0
formaldehyd

: cyano ethylacetate

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
With hydroquinone; palladium on charcoal catalyst In acetic acid; toluene

...Expand

: 84-65-1
9,10-phenanthrenequinone

: 105-56-6
ethyl 2-cyanoacetate

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
With zinc diacetate; paraformaldehyde; palladium In water; acetic acid

: 2417-90-5
bromopropionitrile

: 105-53-3
diethyl malonate

: 1572-99-2
ethyl 2-cyanopropionate

Conditions

Conditions	Yield
Stage #1: diethyl malonate With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.166667h; Stage #2: bromopropionitrile In tetrahydrofuran; mineral oil at 20℃; for 24h;

: 1572-99-2
ethyl 2-cyanopropionate

: 107-13-1
acrylonitrile

: 30378-23-5
2,4-dicyano-2-methylbutanoic acid ethyl ester

Conditions

Conditions	Yield
With triethylamine In chloroform at 20℃; for 8h; Michael Addition; enantioselective reaction;	99%
With [2,6-bis(4',4'-dimethyl-2'-oxazolinyl)phenyl](acetonitrile)nickel(II) tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 4.5h; Michael addition;	95%
With 3-(diethylamino)propyltrimethoxysilane supported on silica-alumina In toluene at 60℃; for 24h; Michael reaction;	95%

: 1572-99-2
ethyl 2-cyanopropionate

: 292638-85-8
acrylic acid methyl ester

: ethyl 2-cyano-2-methyl-4-(methoxycarbonyl)butanedioate

Conditions

Conditions	Yield
With dihydridotetrakis(triphenylphosphine)ruthenium In tetrahydrofuran for 24h; Ambient temperature;	99%
Ru(+)Cp(NCC(Me)HCO2Et)(-)*(PPh3)2 In tetrahydrofuran at 25℃; for 5h; Addition; Michael reaction;	99%

: 1572-99-2
ethyl 2-cyanopropionate

: 78-94-4
methyl vinyl ketone

: ethyl 2-cyano-2-methyl-5-oxohexanoate

Conditions

Conditions	Yield
With [2,6-bis(4',4'-dimethyl-2'-oxazolinyl)phenyl](acetonitrile)nickel(II) tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 4.5h; Michael addition;	99%
With BF4(1-)*C34H40N5Ni(1+); N-ethyl-N,N-diisopropylamine In toluene at 20℃; for 5h; Michael addition; Inert atmosphere;	99%
With triethylamine In chloroform at 20℃; for 8h; Reagent/catalyst; Solvent; Michael Addition; enantioselective reaction;	99%

: 924-44-7
glyoxylic acid ethyl ester

: 1572-99-2
ethyl 2-cyanopropionate

: diethyl 2-cyano-3-hydroxy-2-methylsuccinate

Conditions

Conditions	Yield
With triphenylphosphine; acetylacetonatodicarbonylrhodium(l) In tetrahydrofuran at 20℃; for 1h;	99%

: 1572-99-2
ethyl 2-cyanopropionate

: 632-07-5
2-cyanopropanoic acid

Conditions

Conditions	Yield
With lithium hydroxide In tetrahydrofuran; methanol; water for 1h;	98%
With lithium hydroxide; water In methanol at 20℃; for 36h;	89%
With water; potassium hydroxide In methanol at 0 - 40℃; for 2h;	85%

: 1572-99-2
ethyl 2-cyanopropionate

: 71565-78-1
2-cyanopropionamide

Conditions

Conditions	Yield
With ammonia In ethanol at 20℃; for 15h;	98%
With ammonia; water

: 1572-99-2
ethyl 2-cyanopropionate

: 26526-81-8
ethyl 2-bromo-2-cyano-propionate

Conditions

Conditions	Yield
With bromine; sodium acetate; acetic acid at 20℃; for 3h;	98%
With bromine; sodium acetate; acetic acid at 20 - 30℃; for 1h;
With bromine; sodium acetate; acetic acid at 20℃; for 3h; Inert atmosphere;

: 50-00-0
formaldehyd

: 1572-99-2
ethyl 2-cyanopropionate

: cyano(hydroxymethyl)methylacetic acid ethyl ester

Conditions

Conditions	Yield
With triphenylphosphine; acetylacetonatodicarbonylrhodium(l) In tetrahydrofuran; water at 20℃; for 1h;	97%
With triethylamine In acetonitrile at 50℃;	80.9%
With potassium carbonate In ethanol at 20℃; for 2.5h;	59%
With potassium carbonate In ethanol for 18h;	48%
With potassium carbonate In ethanol at 25℃; for 12h;	16 g

: 1572-99-2
ethyl 2-cyanopropionate

: 106-96-7
propargyl bromide

: 1093658-82-2
ethyl 2-cyano-2-methylpent-4-ynoate

Conditions

Conditions	Yield
Stage #1: ethyl 2-cyanopropionate With potassium carbonate In tetrahydrofuran at 20℃; for 0.5h; Stage #2: propargyl bromide In tetrahydrofuran for 24h; Reflux;	96.4%

conc. aqueous ammonia: conc. aqueous ammonia

: 64-17-5
ethanol

: 1572-99-2
ethyl 2-cyanopropionate

: 71565-78-1
2-cyanopropionamide

Conditions

Conditions	Yield
	96%

...Expand

: 1572-99-2
ethyl 2-cyanopropionate

: 4-phenyl-1-butylidenecyclopropane

: ethyl 2-cyano-2-methyl-4-methylene-8-phenyloctanoate

Conditions

Conditions	Yield
tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 100℃;	95%
tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 100℃; Addition; ring cleavage;	95%

: 2449-05-0
dibenzyl azodicarboxylate

: 1572-99-2
ethyl 2-cyanopropionate

: C22H23N3O6

Conditions

Conditions	Yield
Stage #1: ethyl 2-cyanopropionate With C45H40N4O5 In tetrahydrofuran at -78℃; for 0.25h; Michael Addition; Stage #2: dibenzyl azodicarboxylate In tetrahydrofuran for 3h; Michael Addition; enantioselective reaction;	95%

: 1572-99-2
ethyl 2-cyanopropionate

: 98-80-6
phenylboronic acid

: 93-55-0
1-phenyl-propan-1-one

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; water; palladium diacetate; 2-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine at 60℃; for 5h;	95%

: 64-17-5
ethanol

: 1572-99-2
ethyl 2-cyanopropionate

: 31522-04-0
3-ethoxy-3-imino-2-methylpropionate ethyl hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether at 0℃; for 120h;	94%
With hydrogenchloride In diethyl ether at 0℃; for 72h;	92%
With hydrogenchloride at 0℃; for 4.5h;
With hydrogenchloride In toluene at 0 - 20℃; for 24.6667h;	14.01 g

: 1572-99-2
ethyl 2-cyanopropionate

: 74-95-3
1,1-dibromomethane

: 109539-54-0
ethyl 3-bromo-2-cyano-2-methylpropanoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 20h;	94%
With sodium hydride In N,N-dimethyl-formamide; benzene for 2h; Ambient temperature;	68%

: 1572-99-2
ethyl 2-cyanopropionate

: 140-88-5
ethyl acrylate

: 91341-03-6
2-cyano-2-methyl-1,5-pentanedioic acid bis(ethyl ester)

Conditions

Conditions	Yield
With 3-(diethylamino)propyltrimethoxysilane supported on silica-alumina In toluene at 90℃; for 24h; Michael reaction;	94%

: (1,5-cyclooctadiene)(1,3,5-cyclooctatriene)ruthenium

: 1572-99-2
ethyl 2-cyanopropionate

: 1486-28-8
diphenyl(methyl)phosphine

: RuH(P(CH3)(C6H5)2)4(NCC(CH3)COOC2H5)*C6H6

Conditions

Conditions	Yield
In tetrahydrofuran (N2); addn. of NCCH(CH3)CO2C2H5 to Ru complex and P(CH3)(C6H5)2 in THF, stirring (55°C, 30 h); pptn. by addn. of hexane, washing (hexane; Et2O); elem. anal.;	93%

...Expand

: 1572-99-2
ethyl 2-cyanopropionate

: 1266802-94-1
potassium 2-cyanopropanoate

Conditions

Conditions	Yield
With potassium tert-butylate In ethanol; water at 60℃; for 0.5h; Schlenk technique; Inert atmosphere;	93%
With potassium tert-butylate In ethanol; water Inert atmosphere; Heating;	92%
With potassium tert-butylate; water In ethanol
With potassium tert-butylate; water In ethanol at 20℃; Inert atmosphere;

: 1070687-43-2
N-(bis(4-fluorophenyl)methyl)-4-methylbenzenesulfonamide

: 1572-99-2
ethyl 2-cyanopropionate

: ethyl 2-cyano-3,3-bis(4-fluorophenyl)-2-methylpropanoate

Conditions

Conditions	Yield
With aluminum (III) chloride In chloroform at 80℃; for 12h; Sealed tube;	93%

: 1572-99-2
ethyl 2-cyanopropionate

: 72796-37-3
1,1,5-Trimethoxy-4-oxo-1,4-dihydronaphthalene

: 72796-45-3
Ethyl 2-(1,1,5-Trimethoxy-4-oxo-1,2,3,4-tetrahydro-2-naphthyl)-2-cyanopropionate

Conditions

Conditions	Yield
With sodium ethanolate In ethanol Ambient temperature;	92%

: 66003-76-7
Diphenyliodonium triflate

: 1572-99-2
ethyl 2-cyanopropionate

: 98459-41-7, 15601-34-0
cyano-methyl-phenyl-acetic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: ethyl 2-cyanopropionate With potassium tert-butylate In dichloromethane at 0℃; for 0.0833333h; Schlenk technique; Inert atmosphere; Stage #2: Diphenyliodonium triflate In dichloromethane at 0℃; for 0.333333h; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere;	92%

: 592-76-7
1-Heptene

: 1572-99-2
ethyl 2-cyanopropionate

: ethyl (E)-2-cyano-2-methylnon-4-enoate

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); 2,5-di-tert-butyl-p-benzoquinone; O,O'-(1,1'-biphenyl-2,2'-diyl)-N,N'-diisopropylphosphoramidite In 1,4-dioxane at 50℃; for 24h; Reagent/catalyst; Schlenk technique; Inert atmosphere;	92%

: 92-66-0
4-bromo-1,1'-biphenyl

: 1572-99-2
ethyl 2-cyanopropionate

: 54321-43-6
2-([1,1'-biphenyl]-4-yl)propanenitrile

Conditions

Conditions	Yield
Stage #1: 4-bromo-1,1'-biphenyl; ethyl 2-cyanopropionate With C22H17N3O2; copper(I) bromide; sodium t-butanolate In isopropyl alcohol at 60℃; for 24h; Schlenk technique; Inert atmosphere; Stage #2: With water; sodium hydroxide In isopropyl alcohol at 60℃; for 4h; Schlenk technique; Inert atmosphere; Cooling;	92%

: 13191-29-2
thienyl vinyl ketone

: 1572-99-2
ethyl 2-cyanopropionate

: (R)-ethyl 2-cyano-2-methyl-5-oxo-5-(thiophen-2-yl)pentanoate

Conditions

Conditions	Yield
With 4 A molecular sieve; 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea In toluene at -60℃; for 96h; Michael addition;	91%

: 1572-99-2
ethyl 2-cyanopropionate

: 58109-40-3
diphenyliodonium hexafluorophosphate

: 98459-41-7, 15601-34-0
cyano-methyl-phenyl-acetic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: ethyl 2-cyanopropionate With potassium tert-butylate In dichloromethane at 0℃; for 0.0833333h; Schlenk technique; Inert atmosphere; Stage #2: diphenyliodonium hexafluorophosphate In dichloromethane at 0℃; for 0.333333h; Schlenk technique; Inert atmosphere;	91%

: 1629-58-9
4-penten-3-one

: 1572-99-2
ethyl 2-cyanopropionate

: ethyl 2-cyano-2-methyl-5-oxoheptanoate

Conditions

Conditions	Yield
With C54H82N6NiO3 In chloroform at 20℃; for 8h; Reagent/catalyst; Michael Addition; Schlenk technique;	91%

: 53915-69-8
allenyltributylstannane

: 1572-99-2
ethyl 2-cyanopropionate

: 2,5-Dicyano-2,5-dimethyl-3-methylene-hexanedioic acid diethyl ester

Conditions

Conditions	Yield
With 1,4-di(diphenylphosphino)-butane; tris(dibenzylideneacetone)dipalladium(0) chloroform complex In tetrahydrofuran for 48h; Heating;	90%

: 1572-99-2
ethyl 2-cyanopropionate

: 1-trimethylsilanylvinylacetylene

: 2-Cyano-2-methyl-4-trimethylsilanyl-hexa-4,5-dienoic acid ethyl ester

Conditions

Conditions	Yield
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene In tetrahydrofuran at 65℃; for 43h;	90%
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene In tetrahydrofuran at 65℃; for 43h;	90%

Ethyl 2-cyanopropionate Chemical Properties

Molecular Structure:

Molecular Formula: C₆H₉NO₂
Molecular Weight: 127.1412
IUPAC Name: Ethyl 2-cyanopropanoate
Synonyms of Ethyl 2-cyanopropionate (CAS NO.1572-99-2): AI3-05609 ; EINECS 216-393-9 ; Propanoic acid, 2-cyano-, ethyl ester
CAS NO: 1572-99-2
Index of Refraction: 1.418
Molar Refractivity: 31.49 cm³
Molar Volume: 124.8 cm³
Surface Tension: 33.9 dyne/cm
Density: 1.018 g/cm³
Flash Point: 78.9 °C
Enthalpy of Vaporization: 43.06 kJ/mol
Boiling Point: 194.5 °C at 760 mmHg
Vapour Pressure of Ethyl 2-cyanopropionate (CAS NO.1572-99-2): 0.441 mmHg at 25°C

Ethyl 2-cyanopropionate Safety Profile

Risk Statements of Ethyl 2-cyanopropionate (CAS NO.1572-99-2): 20/21/22-36/37/38
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 23-36/37/39
S23: Do not breathe vapour.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 3276

Product Name

Ethyl 2-cyanopropanoate

Synthetic route

Ethyl 2-cyanopropionate Chemical Properties

Ethyl 2-cyanopropionate Safety Profile

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