Ethyl 4-chlorobutyrate supplier

Name
ETHYL 4-CHLOROBUTYRATE
EINECS 221-591-3
CAS No. 3153-36-4
Article Data33
CAS DataBase
Density 1.057 g/cm³
Solubility insoluble in water
Melting Point -70oC
Formula C₆H₁₁ClO₂
Boiling Point 186 °C at 760 mmHg
Molecular Weight 150.605
Flash Point 51.7 °C
Transport Information UN 1993
Appearance clear yellow to brownish liquid
Safety 26-36-37/39-16
Risk Codes 36/37/38-22-10
Molecular Structure
Hazard Symbols Xi, Xn
Synonyms Butyricacid, 4-chloro-, ethyl ester (6CI,7CI,8CI);4-Chlorobutyric acid ethyl ester;Ethyl 4-chlorobutanoate;Ethyl 4-chlorobutyrate;Ethyl g-chlorobutyrate;Ethyl w-chlorobutyrate;NSC 81215;Ethyl gamma-chlorobutyrate;
PSA 26.30000
LogP 1.56850

Synthetic route

: 96-48-0
4-butanolide

: 64-17-5
ethanol

: 3153-36-4
4-chloro-butyric acid ethyl ester

Conditions

Conditions	Yield
With thionyl chloride for 16h; Heating;	80%
With hydrogenchloride
With hydrogenchloride

: 1191-95-3
cyclobutanone

: 1801-77-0
oxovanadium(V) ethoxydichloride

: 3153-36-4
4-chloro-butyric acid ethyl ester

Conditions

Conditions	Yield
With lithium chloride In diethyl ether for 13h; Ambient temperature;	43%

: ethyl 4-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butanoate

: 3153-36-4
4-chloro-butyric acid ethyl ester

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate; 4-tert-Butylcatechol; 2-methoxybenzo[d][1,3,2]dioxaborole; trans-di-O-tert-butyl hyponitrite In methanol; dichloromethane; benzene at 70℃; for 16h; Inert atmosphere;	30%

: 123-91-1
1,4-dioxane

: 14077-66-8
4-ethoxy-butyryl chloride

: 3153-36-4
4-chloro-butyric acid ethyl ester

Conditions

Conditions	Yield
at 70℃; Geschwindigkeit der Umlagerung verschiedener Konz.;
at 100℃; Geschwindigkeit der Umlagerung verschiedener Konz.;

: 96-48-0
4-butanolide

: 64-17-5
ethanol

A: 3153-36-4
4-chloro-butyric acid ethyl ester

B: 4-(4-chloro-butyryloxy)-butyric acid ethyl ester

Conditions

Conditions	Yield
With hydrogenchloride

...Expand

: 628-20-6
4-Chlorobutyronitrile

: 64-17-5
ethanol

: 3153-36-4
4-chloro-butyric acid ethyl ester

Conditions

Conditions	Yield
With hydrogenchloride
With sulfuric acid
With hydrogenchloride
With hydrogenchloride In dichloromethane at 8℃;

: 64-17-5
ethanol

: 28341-54-0
4-(4-nitrophenoxy)butanoic acid

: 3153-36-4
4-chloro-butyric acid ethyl ester

Conditions

Conditions	Yield
With hydrogenchloride zuletzt bei Siedetemperatur;

: 14077-66-8
4-ethoxy-butyryl chloride

: 3153-36-4
4-chloro-butyric acid ethyl ester

Conditions

Conditions	Yield
at 100℃;
at 100℃;
at 50℃; Geschwindigkeit der Umlagerung;
at 100℃; Geschwindigkeit der Umlagerung;

: 10374-37-5
4-ethoxybutanoic acid

: 3153-36-4
4-chloro-butyric acid ethyl ester

Conditions

Conditions	Yield
With thionyl chloride
Multi-step reaction with 2 steps 1: hydrogen; SOCl2 2: 100 °C / Geschwindigkeit der Umlagerung View Scheme
Multi-step reaction with 2 steps 1: hydrogen; SOCl2 2: 100 °C View Scheme

: 105-54-4
butanoic acid ethyl ester

: 3153-36-4
4-chloro-butyric acid ethyl ester

Conditions

Conditions	Yield
With tetrachloromethane; sulfuryl dichloride; dibenzoyl peroxide

: 627-00-9
γ-chlorobutyric acid

: 64-17-5
ethanol

: 3153-36-4
4-chloro-butyric acid ethyl ester

Conditions

Conditions	Yield
With sulfuric acid
With thionyl chloride at 0℃; for 2h; Reflux;
With acetyl chloride at 20℃; for 24h; Inert atmosphere;

: 1191-95-3
cyclobutanone

: 1801-77-0
oxovanadium(V) ethoxydichloride

: 107-13-1
acrylonitrile

A: 3153-36-4
4-chloro-butyric acid ethyl ester

B: 132960-08-8
ethyl 6-chloro-6-cyanohexanoate

Conditions

Conditions	Yield
With copper dichloride 1.) dichloromethane, -75 deg C, 2.) a) -75 deg C, 2 h, b) room temperature, 14-19 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 1191-95-3
cyclobutanone

: 1801-77-0
oxovanadium(V) ethoxydichloride

: 80-62-6
methacrylic acid methyl ester

A: 3153-36-4
4-chloro-butyric acid ethyl ester

B: 132960-09-9
ethyl 6-chloro-6-(methoxycarbonyl)heptanoate

Conditions

Conditions	Yield
With copper dichloride 1.) dichloromethane, -75 deg C, 2.) a) -75 deg C, 2 h, b) room temperature, 14-19 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 1191-95-3
cyclobutanone

: 1801-77-0
oxovanadium(V) ethoxydichloride

: 126-98-7
methacrylonitrile

A: 3153-36-4
4-chloro-butyric acid ethyl ester

B: 132960-07-7
ethyl 6-chloro-6-cyanoheptanoate

Conditions

Conditions	Yield
With copper dichloride Product distribution; multistep reaction; other olefins, or LiCl, other halogen source, other cyclic carbonyl compound; oxidative ring-opening reaction;
With copper dichloride 1.) dichloromethane, -75 deg C, 2 h, 2.) a) -75 deg C, 2 h, b) room temperature, 17 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 64-17-5
ethanol

: 4635-59-0
4-Chlorobutanoyl chloride

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 56-23-5
tetrachloromethane

: 7791-25-5
sulfuryl dichloride

: 105-54-4
butanoic acid ethyl ester

: 94-36-0
dibenzoyl peroxide

A: 3153-36-4
4-chloro-butyric acid ethyl ester

B: 7425-45-8
ethyl 2-chlorobutyrate

C: 7425-48-1
3-chloro-butyric acid ethyl ester

...Expand

: 7719-09-7
thionyl chloride

: 10374-37-5
4-ethoxybutanoic acid

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 205995-80-8
5,11,17,23-tetra-tert-butyl-25,27-di(3-ethoxycarbonylpropoxy)-26,28-dihydroxycalix[4]arene

: 3153-36-4
4-chloro-butyric acid ethyl ester

Conditions

Conditions	Yield
With titanium(IV) chloride tetrahydrofuran In toluene for 24h; Inert atmosphere; Reflux;

: 302577-73-7
ethyl 3-(4,4,5,5,-tetramethyl-[1,3,2]dioxaborolan-2-yl)-propionate

: 3153-36-4
4-chloro-butyric acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: n-butyllithium / tetrahydrofuran; diethyl ether / 16 h / -100 - 20 °C / Inert atmosphere 2: trimethylsilyl trifluoromethanesulfonate; 4-tert-Butylcatechol; trans-di-O-tert-butyl hyponitrite; 2-methoxybenzo[d][1,3,2]dioxaborole / dichloromethane; benzene; methanol / 16 h / 70 °C / Inert atmosphere View Scheme

: 140-88-5
ethyl acrylate

: 3153-36-4
4-chloro-butyric acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: copper(II) carbonate; copper(II) hydroxide; triphenylphosphine / water / 0.5 h / 20 °C / Inert atmosphere 1.2: 16 h / 20 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran; diethyl ether / 16 h / -100 - 20 °C / Inert atmosphere 3.1: trimethylsilyl trifluoromethanesulfonate; 4-tert-Butylcatechol; trans-di-O-tert-butyl hyponitrite; 2-methoxybenzo[d][1,3,2]dioxaborole / dichloromethane; benzene; methanol / 16 h / 70 °C / Inert atmosphere View Scheme

Yield

Multi-step reaction with 3 steps
1.1: copper(II) carbonate; copper(II) hydroxide; triphenylphosphine / water / 0.5 h / 20 °C / Inert atmosphere
1.2: 16 h / 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; diethyl ether / 16 h / -100 - 20 °C / Inert atmosphere
3.1: trimethylsilyl trifluoromethanesulfonate; 4-tert-Butylcatechol; trans-di-O-tert-butyl hyponitrite; 2-methoxybenzo[d][1,3,2]dioxaborole / dichloromethane; benzene; methanol / 16 h / 70 °C / Inert atmosphere
View Scheme

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 6436-90-4
ethyl 2-(benzylamino)acetate

: 63876-32-4
4-[benzyl(ethoxycarbonylmethyl)amino]butyric acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In toluene for 8h; Solvent; Reflux; Large scale;	99.1%
With potassium carbonate In chloroform at 66 - 68℃; for 24h;

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 64214-66-0
N-Methyl-N-methoxy-4-chlorobutanamide

Conditions

Conditions	Yield
With trimethylaluminum In hexane; dichloromethane for 24h; Ambient temperature;	99%
Stage #1: N,O-dimethylhydroxylamine*hydrochloride With dimethyl aluminium chloride In hexane; dichloromethane at 0 - 20℃; for 1h; Stage #2: 4-chloro-butyric acid ethyl ester In dichloromethane for 1h;	82%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 57260-67-0
1-(3,4-dichloro)phenylpiperazine

: 1061701-06-1
ethyl 4-[4-(3,4-dichlorophenyl)piperazin-1-yl]butanoate

Conditions

Conditions	Yield
With cesium hydroxide; sodium iodide at 50℃; for 0.266667h; Microwave irradiation; Neat (no solvent); chemoselective reaction;	98%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 1013-25-8
1-(2,5-dimethylphenyl)piperazine

: 1061701-76-5
ethyl 4-[4-(2,5-dimethylphenyl)piperazin-1-yl]butanoate

Conditions

Conditions	Yield
With cesium hydroxide; sodium iodide at 50℃; for 0.266667h; Microwave irradiation; Neat (no solvent); chemoselective reaction;	97%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride

: 108786-32-9
ethyl 4-[4-(3-(trifluoromethyl)phenyl)piperazin-1-yl]butanoate

Conditions

Conditions	Yield
With cesium hydroxide; sodium iodide at 50℃; for 0.266667h; Microwave irradiation; Neat (no solvent); chemoselective reaction;	97%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 636-93-1
5-nitroguaiacol

: 1093798-74-3
ethyl 4-(2-methoxy-5-nitrophenoxy) butyrate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃;	96%
With potassium carbonate In N,N-dimethyl-formamide at 60℃;

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 621-23-8
1,2,3-trimethoxybenzene

: 1-(4-chlorobutyl)-2,4,6-trimethoxybenzene

Conditions

Conditions	Yield
With dimethylethylsilane; (μ3,η2,η3,η5-acenaphthylene)Ru3(CO)7 at 20℃; for 5h; Inert atmosphere; Neat (no solvent);	96%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 29781-80-4
octyl alpha-D-glucopyranoside

: Octyl 6-O-4-chlorobutanoyl-α-D-glucopyranoside

Conditions

Conditions	Yield
With zeolite CaA at 40℃; for 48h; SP 435 lipase;	95%
at 40℃; for 6h; Product distribution; lipase from Candida antarctica; other lipases, times; also in the presence of zeolite CaA;

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 51453-79-3
ethyl 4-azidobutyrate

Conditions

Conditions	Yield
With sodium azide; 15-crown-5 In acetonitrile for 12h; Heating;	95%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 130933-88-9
ethyl 4-<4-(4-fluorophenyl)-1-piperazinyl>butyrate

Conditions

Conditions	Yield
With cesium hydroxide; sodium iodide at 50℃; for 0.266667h; Microwave irradiation; Neat (no solvent); chemoselective reaction;	95%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 81-83-4
1,8-Naphthalimide

: 150705-10-5
ethyl 4-(1,3-dioxo-2,3-dihydro-1H-benzo[d,e]isoquinolin-2-yl)butanoate

Conditions

Conditions	Yield
With caesium carbonate; sodium iodide In N,N-dimethyl-formamide at 70℃; for 0.166667h; Microwave irradiation;	95%

: 623-03-0
4-Cyanochlorobenzene

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 131379-33-4
4-cyano-benzenebutanoic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: 4-chloro-butyric acid ethyl ester With tetrabutylammomium bromide; iodine; zinc In N,N-dimethyl acetamide at 80℃; for 12h; Stage #2: 4-Cyanochlorobenzene; bis(triphenylphosphine)nickel(II) chloride In N,N-dimethyl acetamide Further stages.;	94%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 109-86-4
2-methoxy-ethanol

: 2-methoxyethyl 4-chlorobutanoate

Conditions

Conditions	Yield
With titanium(IV) isopropylate In toluene at 20℃; Dean-Stark;	94%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 623-69-8
1,3-dimethyl glycerol ether

: 1,3-dimethoxypropan-2-yl 4-chlorobutanoate

Conditions

Conditions	Yield
With titanium(IV) isopropylate In toluene at 20℃; Dean-Stark;	94%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 66502-79-2
4-chloro-1-butanol-1,1-d2

Conditions

Conditions	Yield
With lithium aluminium deuteride In diethyl ether -15 deg C -> 15 deg C; 15 deg C , 30 min;	93%
With lithium aluminium deuteride In diethyl ether at -10℃;

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 7-methyl-3,3-diphenylindoline

: ethyl 4-(7-methyl-3,3-diphenylindolin-1-yl)butanoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 6h;	92%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 1186130-66-4
5-methoxy-2-(3-phenylisoxazol-5-yl)phenol

: 1186130-80-2
ethyl 4-(5-methoxy-2-(3-phenylisoxazol-5-yl)phenoxy)butanoate

Conditions

Conditions	Yield
With potassium carbonate In acetone Williamson type O-alkylation; Reflux;	90.5%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 1,4-bis(piperazin-1-yl)-2,3,5,6-tetrafluorobenzene

: 4-(4-{4-[4-(3-ethoxycarbonyl-propyl)-piperazin-1-yl]-2,3,5,6-tetrafluoro-phenyl}-piperazin-1-yl)-butyric acid ethyl ester

Conditions

Conditions	Yield
With triethylamine In dimethyl sulfoxide Heating;	90%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 496043-96-0
5,5'-dimethyl-2,2'-dipyridyl diselenide

: 1124321-70-5
ethyl 2-(5-methyl)pyridylselenobutanoate

Conditions

Conditions	Yield
Stage #1: 5,5'-dimethyl-2,2'-dipyridyl diselenide With sodium tetrahydroborate In ethanol Inert atmosphere; Stage #2: 4-chloro-butyric acid ethyl ester In ethanol at 10 - 20℃; for 0.25h; Inert atmosphere;	90%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 1666-13-3
diphenyl diselenide

: 25059-06-7
ethyl 4-(phenylselanyl)butanoate

Conditions

Conditions	Yield
Stage #1: diphenyl diselenide With sodium tetrahydroborate In ethanol for 0.166667h; Stage #2: 4-chloro-butyric acid ethyl ester In ethanol at 55 - 60℃; for 1.5h;	89%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 49823-14-5
1-(2-phenylethyl)-1H-imidazole

: 3-(4-ethoxy-4-oxobutyl)-1-phenethyl-1H-imidazol-3-ium chloride

Conditions

Conditions	Yield
In toluene at 80℃; for 0.333333h; Microwave irradiation; Green chemistry;	89%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 136918-14-4
phthalimide

: 10294-97-0
ethyl 4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)butanoate

Conditions

Conditions	Yield
With caesium carbonate; sodium iodide In N,N-dimethyl-formamide at 70℃; for 0.166667h; Microwave irradiation;	88%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 24572-14-3
bis(diphenylmethyl) diselenide

: 1124321-77-2
ethyl 2-(diphenyl)methylselenobutanoate

Conditions

Conditions	Yield
Stage #1: bis(diphenylmethyl) diselenide With sodium tetrahydroborate In ethanol Inert atmosphere; Stage #2: 4-chloro-butyric acid ethyl ester In ethanol at 15 - 20℃; for 0.416667h; Inert atmosphere;	87%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 2845-89-8
1-chloro-3-methoxy-benzene

: 57816-01-0
ethyl 4-(3'-methoxyphenyl)butyrate

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; pyridine-2,6-bis(N-cyanocarboxamidine); lithium chloride; zinc In 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Catalytic behavior; Reagent/catalyst; Inert atmosphere;	87%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 371930-42-6
3-hydroxy-1-isopropyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

: ethyl 4-{[4-cyano-1-(propan-2-yl)-5,6,7,8-tetrahydroisoquinolin-3-yl]oxy}butanoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 75 - 80℃; for 2h;	87%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 925-90-6
ethylmagnesium bromide

: 174790-32-0
1-(3-chloropropyl)cyclopropanol

Conditions

Conditions	Yield
Stage #1: 4-chloro-butyric acid ethyl ester; ethylmagnesium bromide With titanium(IV) isopropylate In diethyl ether at 20℃; for 0.5h; Stage #2: With sulfuric acid In diethyl ether	86%
Stage #1: 4-chloro-butyric acid ethyl ester; ethylmagnesium bromide With titanium(IV) isopropylate In diethyl ether at 20℃; Kulinkovich Hydroxycyclopropanation; Stage #2: With sulfuric acid In diethyl ether	86%
With titanium(IV) isopropylate In diethyl ether Ambient temperature;	85%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 59957-75-4
2,2'-dipyridyldiselenide

: 1124321-67-0
ethyl 2-pyridylselenobutanoate

Conditions

Conditions	Yield
Stage #1: 2,2'-dipyridyldiselenide With sodium tetrahydroborate In ethanol Inert atmosphere; Stage #2: 4-chloro-butyric acid ethyl ester In ethanol at 10 - 20℃; for 0.5h; Inert atmosphere;	86%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 17932-23-9
bis(2-naphthyl) diselenide

: 23763-12-4
ethyl 2-naphthylselenobutanoate

Conditions

Conditions	Yield
Stage #1: bis(2-naphthyl) diselenide With sodium tetrahydroborate In ethanol Inert atmosphere; Stage #2: 4-chloro-butyric acid ethyl ester In ethanol at 30 - 35℃; for 1.41667h; Inert atmosphere;	86%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 95-25-0
5-chloro-2-benzoxazolinone

: 659724-36-4
ethyl 4-(5-chloro-2(3H)-benzoxazolon-3-yl)butanoate

Conditions

Conditions	Yield
Stage #1: 5-chloro-2-benzoxazolinone With sodium ethanolate In ethanol Stage #2: 4-chloro-butyric acid ethyl ester In N,N-dimethyl-formamide at 80℃; for 8h;	85%

: 3153-36-4
4-chloro-butyric acid ethyl ester

: 459-46-1
4-Fluorobenzyl bromide

: 17403-09-7
3-(4-piperidinyl)-1H-indole

: 4-{4-[1-(4-fluoro-benzyl)-1H-indol-3-yl]-piperidin-1-yl}-butyric acid

Conditions

Conditions	Yield
	85%

...Expand

Ethyl 4-chlorobutyrate Specification

The IUPAC name of Ethyl 4-chlorobutyrate is Ethyl 4-chlorobutanoate. With the CAS registry number 3153-36-4, it is also named as Ethyl gamma-chlorobutyrate. The product's categories are Aromatic Esters; C6 to C7; Carbonyl Compounds; Esters. Besides, it is clear yellow to brownish liquid, which should be stored in a closed, cool and dry place. In addition, its molecular formula is C₆H₁₁ClO₂ and molecular weight is 150.60. This chemical is also insoluble in water.

The other characteristics of this product can be summarized as: (1)EINECS: 221-591-3; (2)ACD/LogP: 1.70; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): 1.7; (5)ACD/LogD (pH 7.4): 1.7; (6)ACD/BCF (pH 5.5): 11.44; (7)ACD/BCF (pH 7.4): 11.44; (8)ACD/KOC (pH 5.5): 199.2; (9)ACD/KOC (pH 7.4): 199.2; (10)H bond acceptors: 2; (11)H bond donors: 0; (12)Freely Rotating Bonds: 5; (13)Polar Surface Area: 26.3 Å²; (14)Index of Refraction: 1.425; (15)Molar Refractivity: 36.47 cm³; (16)Molar Volume: 142.4 cm³; (17)Polarizability: 14.45×10^-24cm³; (18)Surface Tension: 30.2 dyne/cm; (19)Density: 1.057 g/cm³; (20)Flash Point: 51.7 °C; (21)Enthalpy of Vaporization: 42.22 kJ/mol; (22)Boiling Point: 186 °C at 760 mmHg; (23)Vapour Pressure: 0.678 mmHg at 25 °C.

Preparation of Ethyl 4-chlorobutyrate: this chemical can be prepared by Dihydro-furan-2-one and Ethanol.

This reaction needs SOCl₂ by heating. The reaction time is 16 hours. The yield is 80 %.

Uses of Ethyl 4-chlorobutyrate: this chemical is used in organic synthesis. Moreover, it can be used for producting 4-Iodo-butyric acid ethyl ester.

This reaction needs NaI and Butan-2-one by heating. The reaction time is 18 hours.

When you are using this chemical, please be cautious about it as the following: Ethyl 4-chlorobutyrate is flammable and harmful if swallowed. Please keep away from sources of ignition. Furthermore, this product is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing, gloves and eye/face protection. And in case of contact with eyes, please rinse immediately with plenty of water and seek medical advice.

People can use the following data to convert to the molecule structure.
(1)SMILES:ClCCCC(=O)OCC
(2)InChI:InChI=1/C6H11ClO2/c1-2-9-6(8)4-3-5-7/h2-5H2,1H3
(3)InChIKey:OPXNFHAILOHHFO-UHFFFAOYAU
(4)Std. InChI:InChI=1S/C6H11ClO2/c1-2-9-6(8)4-3-5-7/h2-5H2,1H3
(5)Std. InChIKey:OPXNFHAILOHHFO-UHFFFAOYSA-N

Product Name

ETHYL 4-CHLOROBUTYRATE

Synthetic route

Ethyl 4-chlorobutyrate Specification

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