Ethyl mercaptoacetate supplier

Name
ETHYL THIOGLYCOLATE
EINECS 210-800-3
CAS No. 623-51-8
Article Data30
CAS DataBase
Density 1.072 g/cm³
Solubility Not miscible or difficult to mix in water.
Melting Point -80 °C
Formula C₄H₈O₂S
Boiling Point 157.8 °C at 760 mmHg
Molecular Weight 120.172
Flash Point 47.8 °C
Transport Information UN 1992 3/PG 3
Appearance colourless liquid
Safety 26-36/37/39-45
Risk Codes 10-25-36/38
Molecular Structure
Hazard Symbols T
Synonyms Ethyl mercaptoacetate;Ethyl thioglycolate;Ethyl a-mercaptoacetate;Ethylthiomethyl acetate;Mercaptoacetic acid ethylester;NSC 8834;Sulfanylacetic acid ethyl ester;Thioglycolic acid ethyl ester;Ethyl 2-mercaptoacetate;Ethoxycarbonylmethanethiol;2-Mercaptoacetic acid ethyl ester;Aceticacid, mercapto-, ethyl ester (7CI,8CI,9CI);
PSA 65.10000
LogP 0.47930

Synthetic route

: 64-17-5
ethanol

: 68-11-1
mercaptoacetic acid

: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In chloroform esterified azeotropically;	72%
With LEWATIT K2621 In toluene for 72h; Heating;	58%
With magnesium sulfate; toluene-4-sulfonic acid for 16h; Inert atmosphere; Reflux;	36%

: 5349-28-0
thiocyanato-acetic acid ethyl ester

: 27032-03-7
1-(ethoxycarbonylmethyl)pyridinium chloride

A: 17281-70-8
pyridinium cyanoi(ethoxycarbonyl)methylide

B: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With potassium carbonate In chloroform Ambient temperature;	A 63% B n/a

...Expand

: 5349-28-0
thiocyanato-acetic acid ethyl ester

: 42508-60-1
1-(2-oxopropyl)pyridinium chloride

A: 37026-10-1
Cyano-acetyl-pyridinium-methylid

B: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With potassium carbonate In chloroform Ambient temperature;	A 58% B n/a

...Expand

: 5349-28-0
thiocyanato-acetic acid ethyl ester

: 129170-15-6
1-ethoxycarbonylmethyl-4-methylpyridinium chloride

A: 84802-40-4
C11H12N2O2

B: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With potassium carbonate In chloroform Ambient temperature;	A 53% B n/a

...Expand

: 5349-28-0
thiocyanato-acetic acid ethyl ester

: 129170-16-7
1-Ethoxycarbonylmethyl-3,5-dimethyl-pyridinium; chloride

A: 84802-41-5
C12H14N2O2

B: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With potassium carbonate In chloroform Ambient temperature;	A 51% B n/a

...Expand

: 5349-28-0
thiocyanato-acetic acid ethyl ester

: 20517-71-9
1-(2-oxo-2-phenylethyl)pyridin-1-ium chloride

A: 50737-38-7, 17281-69-5
1-(1-cyano-2-oxo-2-phenyl-ethyl)-pyridinium betaine

B: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With potassium carbonate In chloroform Ambient temperature;	A 45% B n/a

...Expand

: 5349-28-0
thiocyanato-acetic acid ethyl ester

: 129170-17-8
1-acetonyl-3,5-dimethylpyridinium chloride

A: 623-51-8
ethyl 2-sulfanylacetate

B: C11H12N2O

Conditions

Conditions	Yield
With potassium carbonate In chloroform Ambient temperature;	A n/a B 42%

...Expand

: 5349-28-0
thiocyanato-acetic acid ethyl ester

: 115260-53-2
1-acetonyl-4-methylpyridinium chloride

A: 623-51-8
ethyl 2-sulfanylacetate

B: C10H10N2O

Conditions

Conditions	Yield
With potassium carbonate In chloroform Ambient temperature;	A n/a B 40%

...Expand

: 5349-28-0
thiocyanato-acetic acid ethyl ester

: 105757-72-0
1-[2-oxo-2-(phenyl)ethyl]-4-methylpyridinium chloride

A: 623-51-8
ethyl 2-sulfanylacetate

B: C15H12N2O

Conditions

Conditions	Yield
With potassium carbonate In chloroform Ambient temperature;	A n/a B 37%

...Expand

: 5349-28-0
thiocyanato-acetic acid ethyl ester

: 1-phenacyl-3,5-dimethylpyridinium chloride

A: 623-51-8
ethyl 2-sulfanylacetate

B: C16H14N2O

Conditions

Conditions	Yield
With potassium carbonate In chloroform Ambient temperature;	A n/a B 28%

...Expand

: 5349-28-0
thiocyanato-acetic acid ethyl ester

: 120616-12-8
1-(cyanomethyl)-3,5-dimethylpyridinium chloride

A: 26960-15-6
3,5-dimethylpyridinium dicyanomethylide

B: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With potassium carbonate In chloroform Ambient temperature;	A 18% B n/a

...Expand

: 5349-28-0
thiocyanato-acetic acid ethyl ester

: 1-(cyanomethyl)-4-methylpyridinium chloride

A: 3189-57-9
4-methylpyridinium dicyanomethylide

B: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With potassium carbonate In chloroform Ambient temperature;	A 15% B n/a

...Expand

: 5349-28-0
thiocyanato-acetic acid ethyl ester

: 17281-59-3
2-pyridin-1-ium-1-ylacetonitrile chloride

A: 27032-01-5
pyridinium 1-dicyanomethylide

B: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With potassium carbonate In chloroform Ambient temperature;	A 7% B n/a

...Expand

: 5349-28-0
thiocyanato-acetic acid ethyl ester

: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With phosphoric acid beim Destillieren;

: 1665-65-2
diethyl 2,2'-disulfanediyldiacetate

: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With ethanol; 6-methyl-2,4-dinitrophenol durch Oxydations-Reduktionsfermente im Sonnenlicht bei pH 7.2;

: hydroxy-sulfanediyldi-acetic acid diethyl ester

A: 924-44-7
glyoxylic acid ethyl ester

B: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
zerfaellt in der Waerme;

: 61713-25-5
4,4-diethyl-3,5-dithia-heptanedioic acid diethyl ester

A: (1-ethyl-propenylmercapto)-acetic acid ethyl ester

B: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
Destillation im Vakuum;
Destillation im Vakuum;

: 860540-06-3
4,4-dipropyl-3,5-dithia-heptanedioic acid diethyl ester

A: (1-propyl-but-1-enylmercapto)-acetic acid ethyl ester

B: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
Destillation im Vakuum;

: 860541-76-0
4,4-dibutyl-3,5-dithia-heptanedioic acid diethyl ester

A: (1-butyl-pent-1-enylmercapto)-acetic acid ethyl ester

B: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
Destillation im Vakuum;

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 105-36-2
ethyl bromoacetate

: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With pyridine; phosphorous (V) sulfide anschliessend Behandeln mit Wasser;

: 68-11-1
mercaptoacetic acid

: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
Veresterung;

: 105-39-5
chloroacetic acid ethyl ester

: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With ethanol; potassium hydrosulfide
With hydrosulfide exchange resin (from Amberlite IRA-400); triethylamine hydrochloride In methanol for 1h; Ambient temperature;	97 % Chromat.

: 115-08-2
thiocarboxamide

: 105-36-2
ethyl bromoacetate

: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With ethanol

: 84257-71-6
1-(ethoxycarbonylmethylthio)-4-methylphthalazine

A: 5004-48-8
1-methyl-3,4-dihydro-4-oxophthalazine

B: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With hydrogenchloride

: C16H15O4S3(1-)

A: 25331-82-2
dibenzo<1,2>dithiin 5,5-dioxide

B: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
In 1,4-dioxane; water at 25℃; Rate constant; var. pH;

: 82408-32-0
(1-Hydroxy-2-oxo-2-phenyl-ethylsulfanyl)-acetic acid ethyl ester

A: 1075-06-5
2,2-dihydroxy-1-phenyl-ethanone

B: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In water; acetonitrile at 30℃; Equilibrium constant;

: 5349-28-0
thiocyanato-acetic acid ethyl ester

: 86119-84-8, 7664-38-2
phosphoric acid

: 7732-18-5
water

: 623-51-8
ethyl 2-sulfanylacetate

...Expand

: 78594-34-0
2-(acetylthio)acetate ethyl ester

: 623-51-8
ethyl 2-sulfanylacetate

Conditions

Conditions	Yield
With water

: C90H36O10S5

A: 1665-65-2
diethyl 2,2'-disulfanediyldiacetate

B: 623-51-8
ethyl 2-sulfanylacetate

C: 741268-81-5, 741268-84-8, 133227-82-4, 133320-10-2, 133320-11-3, 133869-47-3, 134054-62-9, 134932-61-9, 149820-05-3, 149820-06-4, 157903-26-9, 175779-21-2, 115383-22-7, 958017-68-0, 958017-71-5, 958017-74-8, 958017-77-1, 958017-80-6, 140630-87-1, 140694-21-9, 151716-50-6, 157008-89-4, 220062-79-3, 220062-83-9
[5,6]fullerene-C70

Conditions

Conditions	Yield
at 50℃; Temperature;

...Expand

: 6602-54-6
2-chloro-3-pyridinecarbonitrile

: 623-51-8
ethyl 2-sulfanylacetate

: 52505-46-1
ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate

Conditions

Conditions	Yield
Stage #1: ethyl 2-sulfanylacetate With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 0.25h; Stage #2: 2-chloro-3-pyridinecarbonitrile In dimethyl sulfoxide; mineral oil at 20℃; for 3h;	100%
With sodium carbonate In ethanol at 90℃; for 2.5h;	94%
With sodium carbonate In ethanol for 4.5h; Heating / reflux;	93.2%

: 115975-33-2
N,N-Dimethyl-2,4-bis(trifluoroacetyl)-1-naphthylamine

: 623-51-8
ethyl 2-sulfanylacetate

: 140666-92-8
2-ethoxycarbonyl-5-trifluoroacetyl-3-trifluoromethylnaphtho<1,2-b>thiophene

Conditions

Conditions	Yield
In acetonitrile for 2h; Heating;	100%

: 930-96-1
3-bromo-2-thiophenecarboxaldehyde

: 623-51-8
ethyl 2-sulfanylacetate

: 201004-08-2
ethyl thieno[3,2,-b]thiophene-2-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60 - 70℃;	100%
With potassium carbonate In N,N-dimethyl-formamide at 25 - 30℃; Inert atmosphere; Large scale;	97.9%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 72h;	91%

: 117-80-6
2,3-Dichloro-1,4-naphthoquinone

: 623-51-8
ethyl 2-sulfanylacetate

: 916250-47-0
ethyl 2-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-ylthio)acetate

Conditions

Conditions	Yield
With water at 50℃; for 2h;	100%
In water at 50℃; for 2h;	100%
In ethanol at 80 - 90℃;	97%

: 1009334-65-9
4-chloro-3-cyano-5-fluoropyridine

: 623-51-8
ethyl 2-sulfanylacetate

: 1008523-97-4
3-amino-7-fluoro-thieno[3,2-c]pyridine-2-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 40℃; for 1h;	100%

: 17417-09-3
2-fluoro-5-nitrobenzonitrile

: 623-51-8
ethyl 2-sulfanylacetate

: 27697-60-5
ethyl (3-amino-5-nitrobenzothiophen)-2-carboxylate

Conditions

Conditions	Yield
With triethylamine In dimethyl sulfoxide	100%
Stage #1: ethyl 2-sulfanylacetate With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 0.333333h; Stage #2: 2-fluoro-5-nitrobenzonitrile In dimethyl sulfoxide; mineral oil at 20℃; for 3h;	93%
With triethylamine In dimethyl sulfoxide at 20℃; for 3h;	90%

: 3518-87-4
1-benzoyl-4-oxo-piperidine-3-carboxylic acid methyl ester

: 623-51-8
ethyl 2-sulfanylacetate

A: 64281-03-4
1-benzoyl-4-ethoxycarbonylmethylsulfanyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester

B: 64281-02-3
5-benzoyl-3-hydroxy-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-2-carboxylic acid ethyl ester

Conditions

Conditions	Yield
In ethanol	A n/a B 100%

...Expand

: 623-51-8
ethyl 2-sulfanylacetate

: 178876-82-9
6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester

: 443956-13-6
methyl 3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carboxylate

Conditions

Conditions	Yield
Stage #1: ethyl 2-sulfanylacetate With sodium hydride In N,N-dimethyl-formamide at 0℃; for 1h; Stage #2: 6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester In N,N-dimethyl-formamide at 20℃;	100%
Stage #1: ethyl 2-sulfanylacetate With sodium hydride In N,N-dimethyl-formamide at 0℃; for 1h; Stage #2: 6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester In N,N-dimethyl-formamide at 20℃; for 16h;
Stage #1: ethyl 2-sulfanylacetate With sodium hydride In DMF (N,N-dimethyl-formamide) at 0℃; for 1h; Stage #2: 6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;

: 18269-47-1
allyldimethylethoxysilane

: 623-51-8
ethyl 2-sulfanylacetate

: 1024594-59-9
[3-(ethoxydimethylsilanyl)propylsulfanyl]acetic acid ethyl ester

Conditions

Conditions	Yield
at 100℃; for 16h; Inert atmosphere;	100%

: 1351238-40-8
3-bromo-6-(furan-2-yl)pyrazine-2-carbonitrile

: 623-51-8
ethyl 2-sulfanylacetate

: 1351238-41-9
ethyl 7-amino-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxylate

Conditions

Conditions	Yield
With sodium carbonate In ethanol at 20 - 50℃; for 3h;	100%
With sodium carbonate In ethanol at 20 - 50℃; for 3h;	10%

: 10135-00-9
3-bromobenzo[b]thiophene-2-carbaldehyde

: 623-51-8
ethyl 2-sulfanylacetate

: 35616-45-6
ethyl thieno[3,2-b][1]benzothiophene 2-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 50h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 72h;	92%
With potassium carbonate In N,N-dimethyl-formamide
With potassium carbonate In N,N-dimethyl-formamide

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 623-51-8
ethyl 2-sulfanylacetate

: 204863-51-4
4-ethoxycarbonylmethylsulfanyl-3-nitrobenzoic acid

Conditions

Conditions	Yield
With sodium acetate In water at 90℃; for 24h; Inert atmosphere;	100%

: 1397833-51-0
(2-amino-3-methylphenyl) (benzotriazole-1-yl)methanone

: 623-51-8
ethyl 2-sulfanylacetate

: 1476066-75-7
ethyl 2-(2-amino-3-methylbenzoylthio)acetate

Conditions

Conditions	Yield
With dmap In dichloromethane at 20℃;	100%

: (R)-4-(5-bromo-2-fluoro-phenyl)-3-(2,4-dimethoxy-benzyl)-4-methyl-[1,2,3]oxathiazolidine 2,2-dioxide

: 623-51-8
ethyl 2-sulfanylacetate

: (R)-ethyl 2-(2-(5-bromo-2-fluorophenyl)-2-(2,4-dimethoxybenzylamino)propylthio)acetate

Conditions

Conditions	Yield
With N,N,N',N'-tetramethylguanidine In N,N-dimethyl-formamide at 23℃; for 16h;	100%

: 1542437-92-2
3-bromo-5-(4-methoxyphenyl)thiophene-2-carbaldehyde

: 623-51-8
ethyl 2-sulfanylacetate

: 5-(4-methoxyphenyl)thieno[3,2-b]thiophene-2-ethylcarboxylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 50h;	100%

: 1309598-16-0
3-bromo-5-(4-(trifluoromethyl)phenyl)thiophene-2-carbaldehyde

: 623-51-8
ethyl 2-sulfanylacetate

: 5-(4-(trifluoromethyl)phenyl)thieno[3,2-b]thiophene-2-ethyl-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 50h;	100%

: 623-51-8
ethyl 2-sulfanylacetate

: 2-fluoro-3-(trifluoromethyl)benzonitrile

: ethyl 3-amino-5-(trifluoromethoxy)benzo[b]thiophene-2-carboxylate

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide at 0 - 20℃;	100%
With potassium tert-butylate In N,N-dimethyl-formamide at 0 - 20℃; for 1.5h;	100%

: 623-51-8
ethyl 2-sulfanylacetate

: 159730-72-0
2-bromo-4-methyl-5-nitrobenzaldehyde

: 159730-73-1
ethyl 6-methyl-5-nitrobenzo[b]thiophene-2-carboxylate

Conditions

Conditions	Yield
With sodium In ethanol for 3h; Inert atmosphere; Reflux;	99.8%
With sodium ethanolate 1.) EtOH, 5 deg C, 20 min, 2.) EtOH, reflux, 3 h; Yield given. Multistep reaction;

: 623-51-8
ethyl 2-sulfanylacetate

: 10191-60-3
dimethyl N-cyanodithioiminocarbonate

: 39736-29-3
ethyl 4-amino-2-(methylthio)thiazol-5-carboxylate

Conditions

Conditions	Yield
With diisopropylamine In N,N-dimethyl-formamide at 100℃; for 5h;	99%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 100℃;	89%
With triethylamine In N,N-dimethyl-formamide
With triethylamine In N,N-dimethyl-formamide at 100℃; for 2h;

: 286-20-4
cyclohexane-1,2-epoxide

: 623-51-8
ethyl 2-sulfanylacetate

: 82622-17-1
trans-2-hydroxycyclohexyl(carboethoxy)methyl sulfide

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 25h; Heating;	99%

: 110657-96-0
2-((R)-oxiran-2-ylmethoxy)tetrahydro-2H-pyran

: 623-51-8
ethyl 2-sulfanylacetate

: 106851-44-9
[(R)-2-Hydroxy-3-(tetrahydro-pyran-2-yloxy)-propylsulfanyl]-acetic acid ethyl ester

Conditions

Conditions	Yield
sodium ethanolate In ethanol at 22℃;	99%

: 623-51-8
ethyl 2-sulfanylacetate

: 70-11-1
α-bromoacetophenone

: 66560-19-8
ethyl 2-((2-oxo-2-phenylethyl)thio)acetate

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran at 20℃; Inert atmosphere;	99%
With sodium hydroxide In methanol for 4h;	60%
With sodium carbonate In ethanol at 20℃;

: 5147-80-8
[Bis(methylthio)methylene]malononitrile

: 623-51-8
ethyl 2-sulfanylacetate

: 116170-90-2
3-amino-4-cyano-5-(methylthio)thiophene-2-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With triethylamine In methanol for 2h; Reflux;	99%
With triethylamine In methanol for 2h; Reflux;	99%
With triethylamine In ethanol at 0 - 20℃; for 12h;	72.6%

: 211678-96-5
3-chloroisonicotinic acid ethyl ester

: 623-51-8
ethyl 2-sulfanylacetate

: 1008523-91-8
ethyl 3-hydroxythieno [2,3-c]pyridine-2-carboxylate

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 5 - 20℃; for 18.67h;	99%
In N,N-dimethyl-formamide; mineral oil at 20℃; for 3.25h; Cooling with ice;	70%

: 133116-83-3
2-fluoro-6-(trifluoromethyl)benzonitrile

: 623-51-8
ethyl 2-sulfanylacetate

: ethyl 3-amino-4-(trifluoromethyl)benzo[b]thiophene-2-carboxylate

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide at 0 - 20℃;	99%
With potassium tert-butylate In N,N-dimethyl-formamide at 0 - 20℃; for 1.5h;	99%

: 623-51-8
ethyl 2-sulfanylacetate

: N-(benzyloxy)formimidoyl chloride

: ethyl 2-((((benzyloxy)imino)methyl)thio)acetate

Conditions

Conditions	Yield
Stage #1: ethyl 2-sulfanylacetate With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.333333h; Inert atmosphere; Stage #2: N-(benzyloxy)formimidoyl chloride In tetrahydrofuran at 20℃; for 5h; Inert atmosphere;	99%

: 1-methyl-3-(1-adamantyloxycarbonylimino)indolin-2-one

: 623-51-8
ethyl 2-sulfanylacetate

: ethyl 2-[1-methyl-3-(1-adamantyloxylcarbonylamino)indolin-2-one-3-ylthio]acetate

Conditions

Conditions	Yield
With Trimethylsilanol; (S)-N-(2-pyridinesulfonyl)-(6-methoxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methanamine In toluene at -80℃; for 8h; Inert atmosphere; enantioselective reaction;	99%

: 1-benzyl-3-(1-adamantoxycarbonylimino)indolin-2-one

: 623-51-8
ethyl 2-sulfanylacetate

: ethyl 2-[1-benzyl-3-(1-adamantyloxylcarbonylamino)indolin-2-one-3-ylthio]acetate

Conditions

Conditions	Yield
With Trimethylsilanol; (S)-N-(2-pyridinesulfonyl)-(6-methoxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methanamine In toluene at -80℃; for 8h; Inert atmosphere; enantioselective reaction;	99%

: 5-fluoro-1-methyl-3-(1-adamantoxycarbonylimino)indolin-2-one

: 623-51-8
ethyl 2-sulfanylacetate

: ethyl 2-[1-methyl-3-(1-adamantyloxycarbonylamino)-5-fluoroindolin-2-one-3-ylthio]acetate

Conditions

Conditions	Yield
With Trimethylsilanol; (S)-N-(2-pyridinesulfonyl)-(6-methoxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methanamine In toluene at -80℃; for 8h; Inert atmosphere; enantioselective reaction;	99%

: 6-bromo-1-methyl-3-(1-adamantoxycarbonylimino)indolin-2-one

: 623-51-8
ethyl 2-sulfanylacetate

: ethyl 2-[1-methyl-3-(1-adamantyloxycarbonylamino)-6-bromoindolin-2-one-3-ylthio]acetate

Conditions

Conditions	Yield
With Trimethylsilanol; (S)-N-(2-pyridinesulfonyl)-(6-methoxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methanamine In toluene at -80℃; for 8h; Inert atmosphere; enantioselective reaction;	99%

Ethyl mercaptoacetate Specification

The Acetic acid,2-mercapto-, ethyl ester, with the CAS registry number 623-51-8, is also known as Thioglycolic acid ethyl ester. Its EINECS number is 210-800-3. This chemical's molecular formula is C₄H₈O₂S and molecular weight is 120.17. What's more, its systematic name is ethyl sulfanylacetate. It is air sensitive. It should be sealed and stored in a cool and dry place. Moreover, it should be protected from oxides, static electricity and fire. It is used as a reagent to determinate iron content.

Physical properties of Acetic acid,2-mercapto-, ethyl ester are: (1)ACD/LogP: 1.18; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.18; (4)ACD/LogD (pH 7.4): 1.14; (5)ACD/BCF (pH 5.5): 4.66; (6)ACD/BCF (pH 7.4): 4.21; (7)ACD/KOC (pH 5.5): 104.72; (8)ACD/KOC (pH 7.4): 94.67; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 51.6 Å²; (13)Index of Refraction: 1.452; (14)Molar Refractivity: 30.25 cm³; (15)Molar Volume: 112 cm³; (16)Polarizability: 11.99×10^-24cm³; (17)Surface Tension: 32.6 dyne/cm; (18)Density: 1.072 g/cm³; (19)Flash Point: 47.8 °C; (20)Enthalpy of Vaporization: 39.45 kJ/mol; (21)Boiling Point: 157.8 °C at 760 mmHg; (22)Vapour Pressure: 2.7 mmHg at 25°C.

Preparation: this chemical can be prepared by thioglycollicacid and ethanol by heating. This reaction will need solvent sulfuric acid with the reflux time of 24 hours. The product is gained by collecting the cut fraction of the temperature of 155-158 °C at atmospheric fractionation.

Uses of Acetic acid,2-mercapto-, ethyl ester: it can be used to produce (2-cyano-ethylsulfanyl)-acetic acid ethyl ester at the ambient temperature. It will need reagent sodium ethoxide with the reaction time of 14 hours. The yield is about 90%.

Acetic acid,2-mercapto-, ethyl ester can be used to produce (2-cyano-ethylsulfanyl)-acetic acid ethyl ester at the ambient temperature

When you are using this chemical, please be cautious about it as the following:
This chemical is flammable, so you should keep it away from sources of ignition - No smoking. It is toxic if swallowed. It is irritating to eyes and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, you must seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)InChI: InChI=1S/C4H8O2S/c1-2-6-4(5)3-7/h7H,2-3H2,1H3
(2)InChIKey: PVBRSNZAOAJRKO-UHFFFAOYSA-N
(3)Canonical SMILES: CCOC(=O)CS

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	100mg/kg (100mg/kg)	National Technical Information Service. Vol. AD277-689.
rat	LD50	intraperitoneal	176mg/kg (176mg/kg)	Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. Vol. 20, Pg. 575, 1974.
rat	LD50	oral	178mg/kg (178mg/kg)	Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. Vol. 20, Pg. 575, 1974.

Product Name

ETHYL THIOGLYCOLATE

Synthetic route

Ethyl mercaptoacetate Specification

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