Conditions | Yield |
---|---|
Stage #1: 1,2-dichloro-ethane; iminodiacetonitrile With calcium oxide In 5,5-dimethyl-1,3-cyclohexadiene at 105 - 115℃; for 9.5h; Large scale; Stage #2: With sodium hydroxide In water at 70 - 80℃; for 9h; Reagent/catalyst; Solvent; Temperature; Large scale; | 96.83% |
Diethyl iminodiacetate
1,2-dichloro-ethane
ethylenediaminetetraacetic acid
Conditions | Yield |
---|---|
Stage #1: Diethyl iminodiacetate; 1,2-dichloro-ethane With sodium hydroxide In toluene at 80 - 90℃; for 9.5h; Stage #2: With sodium hydroxide In water at 70 - 80℃; for 4.5h; Reflux; | 95.81% |
1-Bromo-2-chloroethane
iminodiacetonitrile
ethylenediaminetetraacetic acid
Conditions | Yield |
---|---|
Stage #1: 1-Bromo-2-chloroethane; iminodiacetonitrile With calcium oxide In 5,5-dimethyl-1,3-cyclohexadiene at 105 - 115℃; for 9h; Stage #2: With sodium hydroxide In water at 70 - 80℃; for 8.5h; | 95.47% |
Conditions | Yield |
---|---|
Stage #1: 1,2-dichloro-ethane; iminodiacetic acid With sodium hydrogencarbonate In toluene at 80 - 90℃; for 10.5h; Stage #2: With sodium hydroxide In water at 70 - 80℃; for 8.5h; Reflux; | 95.29% |
With 1,4-dioxane; alkali carbonate at 80 - 125℃; | |
With alkali carbonate; water at 80 - 125℃; |
2,2′-iminobis(acetamide)
1,2-dichloro-ethane
ethylenediaminetetraacetic acid
Conditions | Yield |
---|---|
Stage #1: 2,2′-iminobis(acetamide); 1,2-dichloro-ethane With calcium hydroxide In toluene at 80 - 90℃; for 11.5h; Stage #2: With sodium hydroxide In water at 70 - 80℃; for 3.5h; Reflux; | 95.29% |
formaldehyd
hydrogen cyanide
ethylenediamine
ethylenediaminetetraacetic acid
Conditions | Yield |
---|---|
With sodium hydroxide |
formaldehyd
sodium cyanide
ethylenediamine
ethylenediaminetetraacetic acid
Conditions | Yield |
---|---|
With sodium hydroxide at 60℃; |
sodium monochloroacetic acid
ethylenediamine
ethylenediaminetetraacetic acid
Conditions | Yield |
---|---|
With sodium carbonate at 90 - 95℃; | |
With sodium carbonate at 90 - 95℃; |
Conditions | Yield |
---|---|
With alkali carbonate; water at 80 - 125℃; | |
With 1,4-dioxane; alkali carbonate at 80 - 125℃; |
tetrachloromethane
formaldehyd
sodium cyanide
water
ethylenediamine
ethylenediaminetetraacetic acid
Conditions | Yield |
---|---|
at 10℃; | |
at 10℃; |
Conditions | Yield |
---|---|
at 80 - 120℃; |
Conditions | Yield |
---|---|
at 80 - 120℃; |
Conditions | Yield |
---|---|
in wss.-alkal.Loesung vom pH 9.5; |
Conditions | Yield |
---|---|
With sodium hydroxide In water pH=7.9; | |
With hydrogenchloride In water | |
With dihydrogen peroxide; acetic acid In water at 20℃; for 72h; | 5.2 mg |
tetramethyl ethylenediamine-N,N,N',N'-tetraacetate
ethylenediaminetetraacetic acid
Conditions | Yield |
---|---|
With water at 90℃; pH=~ 0.5; Product distribution / selectivity; |
ethanediyldiimino-tetra-acetic acid tetrapropyl ester
ethylenediaminetetraacetic acid
Conditions | Yield |
---|---|
With water at 90℃; pH=~ 0.5; Product distribution / selectivity; |
Conditions | Yield |
---|---|
With water; sodium hydroxide at 12℃; pH=4.06 - 9.82; Temperature; pH-value; Reflux; |
Conditions | Yield |
---|---|
With sodium hydroxide In water for 0.5h; Reflux; | 100% |
ethylenediaminetetraacetic acid
ethylenediaminetetraacetic dianhydride
Conditions | Yield |
---|---|
With pyridine; acetic anhydride at 80℃; for 24h; | 99% |
Stage #1: ethylenediaminetetraacetic acid With pyridine at 65℃; for 1h; Inert atmosphere; Stage #2: With acetic anhydride at 65℃; for 16h; | 97% |
With pyridine; acetic anhydride at 65℃; for 24h; | 94% |
ethylenediaminetetraacetic acid
ethanol
{[2-(bis-ethoxycarbonylmethyl-amino)-ethyl]-ethoxycarbonylmethyl-amino}-acetic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: ethylenediaminetetraacetic acid; ethanol With sulfuric acid at 90℃; for 17h; Inert atmosphere; Stage #2: With sodium hydrogencarbonate In water pH=9; | 98% |
With toluene-4-sulfonic acid for 4h; Reflux; Inert atmosphere; | 97% |
With thionyl chloride at 20℃; for 120h; | 80% |
With sulfuric acid for 6h; Heating; | 70% |
With sulfuric acid for 6h; Heating; | 70% |
2-(2,4-difluorophenyl)-3-(4-iodophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-buten-2-ol
ethylenediaminetetraacetic acid
trimethylsilylacetylene
Conditions | Yield |
---|---|
With copper(I) iodide; triethylamine In water | 98% |
ethylenediaminetetraacetic acid
Conditions | Yield |
---|---|
With NH3 In water addn. of ammonia to Ga-salt (pptn.), sepn., washing (H2O), mixing with soln. of EDTA, heating with stirring (pH = 1); filtration, crystn. on concn. (evapn., water bath), washing (acetone), drying (90°C); elem. anal.; | 98% |
Conditions | Yield |
---|---|
Stage #1: morpholine; ethylenediaminetetraacetic acid In water for 0.25h; Sonication; Green chemistry; Stage #2: gadolinium(III) oxide In water for 0.333333h; Sonication; Green chemistry; | 96% |
ethylenediaminetetraacetic acid
(2R)-2-aminobutan-1-ol
(+)-N,N,N',N'-tetrakis{[4-(R)-ethyloxazolin-2-yl]methyl}ethylenediamine
Conditions | Yield |
---|---|
Stage #1: ethylenediaminetetraacetic acid; (2R)-2-aminobutan-1-ol In toluene for 20h; Reflux; Stage #2: at 135℃; for 8h; | 95% |
ethylenediaminetetraacetic acid
N,N-dimethyl-formamide
Conditions | Yield |
---|---|
With triethylamine | 95% |
Conditions | Yield |
---|---|
With potassium acetate In dimethyl sulfoxide at 55℃; for 1.5h; | 94.58% |
Conditions | Yield |
---|---|
With dihydrogen peroxide In water byproducts: H2{Coaedtaq}*2H2O; heating of a suspension of CoCO3 and C10H16N2O8 in H2O under vivious stirring slowly to 75°C; oxidation with 30% aq. H2O2-soln. under pptn. of H2(Coaedtaq)*2H2O; addn. of BaCO3-powder; filtration; slow pouring of the filtrate in ethanol;; washing with ethanol for two times; drying for 24 h at 50°C;; | 94% |
With H2O2 In water byproducts: H2{Coaedtaq}*2H2O; heating of a suspension of CoCO3 and C10H16N2O8 in H2O under vivious stirring slowly to 75°C; oxidation with 30% aq. H2O2-soln. under pptn. of H2(Coaedtaq)*2H2O; addn. of BaCO3-powder; filtration; slow pouring of the filtrate in ethanol;; washing with ethanol for two times; drying for 24 h at 50°C;; | 94% |
ethylenediaminetetraacetic acid
(ethylenediaminetetraacetato)cobalt(II)(2-)
Conditions | Yield |
---|---|
In water for 0.5h; | 91.1% |
ethylenediaminetetraacetic acid
acetic anhydride
ethylenediaminetetraacetic dianhydride
Conditions | Yield |
---|---|
In pyridine at 65℃; for 24h; Inert atmosphere; | 91% |
With triethylamine In dimethyl sulfoxide at 55℃; for 1.5h; Reagent/catalyst; Reflux; | 75.17% |
Conditions | Yield |
---|---|
With K2CO3 In water Under inert atmosphere, neutralizing of H4edta soln. with K2CO3, addn. of VCl3 to the soln., stirring (15 min).; Evapn. of solvent, addn. of EtOH gives pale brown crystals, filtn., washing (EtOH, ether), elem. anal.; | 90% |
Conditions | Yield |
---|---|
In water byproducts: CO2; Cu:H4EDTA:adenine=1:1:2 molar ratio, Cu compd. and H4EDTA heated (15 min, <50°C, vac.) in water, stirred with heating at 60° for 30 min, cooled to room temp., slowly filtered, adenine added, stirred; filtered, slow evapd. at room temp. (1-2 wk), ppt. filtered, washed (cold water), air-dried; elem. anal.; | 90% |
Conditions | Yield |
---|---|
In water byproducts: CO2; Cu compd. and H4EDTA heated (15 min, <50°C, vac.) in water, stirred with heating at 60° for 30 min, cooled to room temp., slowly filtered, adenine added, stirred; filtered, slow evapd. at room temp. (1-2 wk), crysts. filtered, washed (cold water), air-dried; elem. anal.; | 90% |
Conditions | Yield |
---|---|
In water byproducts: HNO3, H2O; aq. soln. of tetraacetatic acid (1 equiv.) and hydrazine hydrate (4 equiv.) was added to aq. soln. of nitrate; filtered; kept at room temp. for 2-3 d; filtered; quickly washed (cold H2O, EtOH); dried in air; elem. anal.; | 90% |
Conditions | Yield |
---|---|
In water byproducts: HNO3, H2O; aq. soln. of tetraacetatic acid (1 equiv.) and hydrazine hydrate (4 equiv.) was added to aq. soln. of nitrate; filtered; kept at room temp. for 2-3 d; filtered; quickly washed (cold H2O, EtOH); dried in air; elem. anal.; | 90% |
Conditions | Yield |
---|---|
In water addn. aq. soln. of ethylenediaminetetraacetic acid (0.01 mol) and N2H4*H2O (0.04 mol) to aq. soln. of Dy(NO3)3*nH2O with stirring; kept at atm. pressure at room temp. for 30 min; filtered; allowed to stand at room temp. for 8-9 w for crystn.; crystalsfiltered off, washed (several times ice-cold distd. H2O), air-dried; el em. anal.; | 90% |
Conditions | Yield |
---|---|
In water addn. aq. soln. of ethylenediaminetetraacetic acid (0.01 mol) and N2H4*H2O (0.04 mol) to aq. soln. of Tb(NO3)3*nH2O with stirring; kept at atm. pressure at room temp. for 30 min; filtered; allowed to stand at room temp. for 8-9 w for crystn.; crystalsfiltered off, washed (several times ice-cold distd. H2O), air-dried; el em. anal.; | 90% |
Conditions | Yield |
---|---|
at 20℃; for 1h; pH=3; | 88.1% |
Conditions | Yield |
---|---|
In water at 90℃; for 1h; pH=7; Large scale; | 88.1% |
ethylenediaminetetraacetic acid
Conditions | Yield |
---|---|
With HCl In water RuO2*(3-4)H2O dissolved in concd. HCl by heating, evapd. to dryness, residue dissolved in H2O, org. compd. added, mixture heated until clear soln. appeared, soln. heated at 120°C for 5 h; cooling, washing (EtOH, acetone); elem. anal.; | 85% |
Conditions | Yield |
---|---|
In water addn. aq. soln. of ethylenediaminetetraacetic acid (0.01 mol) and N2H4*H2O (0.04 mol) to aq. soln. of Gd(NO3)3*nH2O with stirring; kept at atm. pressure at room temp. for 30 min; filtered; allowed to stand at room temp. for 8-9 w for crystn.; crystalsfiltered off, washed (several times ice-cold distd. H2O), air-dried; el em. anal.; TGA; | 85% |
ethylenediaminetetraacetic acid
Conditions | Yield |
---|---|
With ammonium hydroxide; sulfuric acid; dihydrogen peroxide In sulfuric acid; water Addn. of aq. ammonia to an aq. soln. of U-compound until a yellow ppt. ceases to appear, filtn., washing, treating with aq. H2SO4, filtn., cooling (ice-bath), addn. of H4edta with stirring, addn. of an excess of H2O2.; Filtn., washing (EtOH), drying in vac. over conc. H2SO4, elem. anal.; | 84% |
ethylenediaminetetraacetic acid
1-deoxy-1-(methylamino)-D-glucitol
gadolinium ethylenediamine tetraacetic acid meglumine salt
Conditions | Yield |
---|---|
Stage #1: ethylenediaminetetraacetic acid; 1-deoxy-1-(methylamino)-D-glucitol In water for 0.25h; Sonication; Green chemistry; Stage #2: gadolinium(III) oxide In water for 0.333333h; Sonication; Green chemistry; | 84% |
Edetic acid (CAS NO.60-00-4) was first described in 1935 by Ferdinand Munz, who prepared the compound from ethylenediamine and chloroacetic acid.
Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
The most sensitive method of detecting and measuring Edetic acid (CAS NO.60-00-4) in biological samples is selected-reaction-monitoring capillary-electrophoresis mass-spectrometry which has a detection limit of 7.3 ng/mL in human plasma and a quantitation limit of 15 ng/mL.This method works with sample volumes as small as ~7-8 nL.It has also been measured in non-alcoholic beverages using high performance liquid chromatography (HPLC) of 2.0 μg/mL.
The Ethylenediaminetetraacetic acid, with the CAS registry number 60-00-4,is also known as Edetic acid; EDTA; (Ethylenedinitrilo)tetraacetic acid; Edathamil. It belongs to the product categories of Amino Acids & Derivatives;Chelating Agents & Ligands. This chemical's molecular formula is C10H16N2O8 and molecular weight is 292.24.Its EINECS number is 200-449-4. What's more,Its systematic name is Ethylenediaminetetraacetic acid. It is a white crystals or powder which is stable,incompatible with copper,copper alloys,nickel,aluminium,strong oxidizing agents,strong bases.Ethylenediaminetetraacetic acid is slightly soluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. It is a chelating agent (CHELATING AGENTS) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.
Physical properties about Ethylenediaminetetraacetic acid are:
(1)ACD/LogP: -0.836; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -5.89; (4)ACD/LogD (pH 7.4): -6.32; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 10; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 11; (12)Index of Refraction: 1.58; (13)Molar Refractivity: 62.078 cm3; (14)Molar Volume: 186.612 cm3; (15)Surface Tension: 86.1630020141602 dyne/cm; (16)Density: 1.566 g/cm3; (17)Flash Point: 325.248 °C; (18)Enthalpy of Vaporization: 99.499 kJ/mol; (19)Boiling Point: 614.186 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES:C(CN(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O;
(2)Std. InChI:InChI=1S/C10H16N2O8/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);
(3)Std. InChIKey:KCXVZYZYPLLWCC-UHFFFAOYSA-N.
Safety Information of Ethylenediaminetetraacetic acid:
The Ethylenediaminetetraacetic acid is irritating to eyes, respiratory system and skin and harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Avoid release to the environment. Refer to special instructions / safety data sheets. When you use it ,wear suitable protective clothing, suitable gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
The toxicity data of Ethylenediaminetetraacetic acid are as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 250mg/kg (250mg/kg) | National Technical Information Service. Vol. AD691-490, | |
mouse | LD50 | intravenous | 28500ug/kg (28.5mg/kg) | Japanese Journal of Pharmacology. Vol. 63, Pg. 187, 1993. | |
mouse | LD50 | oral | 30mg/kg (30mg/kg) | Food and Chemical Toxicology. Vol. 29, Pg. 845, 1991. | |
rat | LD50 | intraperitoneal | 397mg/kg (397mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arhiv za Higijenu Rada i Toksikologiju. Archives of Industrial Hygiene and Toxicology. Vol. 13, Pg. 295, 1962. |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View