Product Name

  • Name

    Ethylenediaminetetraacetic acid disodium salt

  • EINECS 205-358-3
  • CAS No. 139-33-3
  • Article Data13
  • CAS DataBase
  • Density 1.01 g/mL at 25 °C
  • Solubility water: clear, colorless
  • Melting Point 248 °C (dec.)(lit.)
  • Formula C10H14N2Na2O8
  • Boiling Point >100°C
  • Molecular Weight 336.209
  • Flash Point 325.2oC
  • Transport Information
  • Appearance white crystalline solid
  • Safety 26-36-37/39
  • Risk Codes 36/38-36/37/38-22
  • Molecular Structure Molecular Structure of 139-33-3 (Ethylenediaminetetraacetic acid disodium salt)
  • Hazard Symbols HarmfulXn
  • Synonyms Mavacid ED 4;Metaquest B;Perma Kleer Di Crystals;Sequestrene Na2;TW 204;Triplex III;Versene disodium salt;Versonol 120;Chelaplex III;Chelaton III;Clewat N;Complexon III;Disodium(ethylenedinitrilo)tetraacetate;Disodium EDTA;Disodium ethylenediamine-N,N,N',N'-tetraacetate;Disodiumversene;Dissolvine Na2;Dissolvine Na2S;
  • PSA 161.34000
  • LogP -4.74060

Synthetic route

4,5-Di-O-isopropylidene-D-erythro-2,3-hexodiuro-2,6-pyranose

4,5-Di-O-isopropylidene-D-erythro-2,3-hexodiuro-2,6-pyranose

Oxone

Oxone

(E)-1,2-diphenyl-ethene
103-30-0

(E)-1,2-diphenyl-ethene

edetate disodium
139-33-3

edetate disodium

(R,R)-trans-stilbene epoxide
1439-07-2

(R,R)-trans-stilbene epoxide

Conditions
ConditionsYield
With sodium hydrogencarbonate; triethylamine; tetra(n-butyl)ammonium hydrogen sulfate In hexane; acetonitrile95.2%
With sodium hydrogencarbonate; triethylamine; tetra(n-butyl)ammonium hydrogen sulfate In hexane; acetonitrile95.2%
...Expand
N-<3-<(mercaptocetyl)amino>benzoyl>glycine
67852-72-6

N-<3-<(mercaptocetyl)amino>benzoyl>glycine

edetate disodium
139-33-3

edetate disodium

N-[3-(Mercaptoacetylamino)benzoyl]-glycine Potassium Salt Hydrate

N-[3-(Mercaptoacetylamino)benzoyl]-glycine Potassium Salt Hydrate

Conditions
ConditionsYield
With potassium hydroxide In tetrahydrofuran; water93%
With potassium hydroxide In tetrahydrofuran; water93%
edetate disodium
139-33-3

edetate disodium

Ethylenediaminetetra-acetic acid N,N'-dioxide
3055-19-4

Ethylenediaminetetra-acetic acid N,N'-dioxide

Conditions
ConditionsYield
With sodium hydroxide; 3-chloro-benzenecarboperoxoic acid Ambient temperature;80%
N-<3-<(mercaptocetyl)amino>benzoyl>glycine
67852-72-6

N-<3-<(mercaptocetyl)amino>benzoyl>glycine

edetate disodium
139-33-3

edetate disodium

N-[3-(mercaptoacetylamino)benzoyl]glycine ammonium salt

N-[3-(mercaptoacetylamino)benzoyl]glycine ammonium salt

Conditions
ConditionsYield
With ammonium hydroxide In tetrahydrofuran79.3%
With ammonium hydroxide In tetrahydrofuran79.3%
CuCO3.Cu(OH)2.H2O

CuCO3.Cu(OH)2.H2O

piperazine-2-carboxylic acid dihydrochloride
3022-15-9, 126330-90-3, 133525-05-0, 135841-26-8

piperazine-2-carboxylic acid dihydrochloride

edetate disodium
139-33-3

edetate disodium

4-nitrobenzyl chloroformate
4457-32-3

4-nitrobenzyl chloroformate

piperazine-1,3-dicarboxylic acid 1-(4-nitrobenzyl)ester
623565-10-6

piperazine-1,3-dicarboxylic acid 1-(4-nitrobenzyl)ester

Conditions
ConditionsYield
With hydrogenchloride; sodium hydrogencarbonate In 1,4-dioxane; water77%
...Expand
Tetrahydrothiopyran-4-one
1072-72-6

Tetrahydrothiopyran-4-one

edetate disodium
139-33-3

edetate disodium

1,1-dioxotetrahydrothiopyran-4-one
17396-35-9

1,1-dioxotetrahydrothiopyran-4-one

Conditions
ConditionsYield
With oxone; sodium hydrogencarbonate In acetonitrile73%
sodium tungstate (VI) dihydrate
10213-10-2

sodium tungstate (VI) dihydrate

phosphoric acid
86119-84-8, 7664-38-2

phosphoric acid

copper(II) acetate monohydrate
6046-93-1

copper(II) acetate monohydrate

edetate disodium
139-33-3

edetate disodium

4Na(1+)*OH(1-)*2Cu(2+)*(CH2N(CH2CO2)2)2(4-)*PW12O40(3-)*17H2O=Na4(OH)(Cu2(CH2N(CH2CO2)2)2)PW12O40*17H2O

4Na(1+)*OH(1-)*2Cu(2+)*(CH2N(CH2CO2)2)2(4-)*PW12O40(3-)*17H2O=Na4(OH)(Cu2(CH2N(CH2CO2)2)2)PW12O40*17H2O

Conditions
ConditionsYield
In hydrogenchloride; water; sodium chloride Na2WO4*2H2O dissolved in H2O, heated to 90°C for 10 min, H3PO4 dissolved in aq. HCl and Cu(CH3CO2)2*H2O dissolved in satd. NaCl soln. added, pH adjusted to 3.33, kept at 90°C for 1 h, Na-salt added, stirred for 1 h, cooled to room temp.; filtered, filtrate retained in room temp. for 16 d; elem. anal.;54%
...Expand
sodium tungstate (VI) dihydrate
10213-10-2

sodium tungstate (VI) dihydrate

sodium metasilicate nonahydrate

sodium metasilicate nonahydrate

copper(II) acetate monohydrate
6046-93-1

copper(II) acetate monohydrate

edetate disodium
139-33-3

edetate disodium

4Na(1+)*2Cu(2+)*(CH2N(CH2CO2)2)2(4-)*SiW12O40(4-)*19H2O=Na4(Cu2(CH2N(CH2CO2)2)2)SiW12O40*19H2O

4Na(1+)*2Cu(2+)*(CH2N(CH2CO2)2)2(4-)*SiW12O40(4-)*19H2O=Na4(Cu2(CH2N(CH2CO2)2)2)SiW12O40*19H2O

Conditions
ConditionsYield
In hydrogenchloride; water; sodium chloride Na2WO4*2H2O dissolved in H2O, heated to 90°C for 10 min, Na2SiO3 dissolved in aq. HCl and Cu(CH3CO2)2*H2O dissolved in satd. NaCl soln. added, pH adjusted to 3.33, kept at 90°C for 1 h, Na-salt added, stirred for 1 h, cooled to room temp.; filtered, filtrate retained in room temp. for 16 d; elem. anal.;50%
...Expand
potassium pentachloronitrosylruthenate(III)

potassium pentachloronitrosylruthenate(III)

water
7732-18-5

water

edetate disodium
139-33-3

edetate disodium

Ru(H2edta)(NO)Cl*1.5H2O

Ru(H2edta)(NO)Cl*1.5H2O

Conditions
ConditionsYield
In hydrogenchloride Na2EDTA was suspended in aq. HCl, heated to reflux, soln. of Ru-complex in aq. HCl was added, heated to reflux for 18 h; filtered, solvent was removed in vacuo, dissolved in water, passed through Dowex column, collected, solvent was removed in vacuo, dried in vacuoat room temp.; elem. anal.;43.8%
...Expand
paraquat dichloride
1910-42-5

paraquat dichloride

edetate disodium
139-33-3

edetate disodium

methyl viologen cation radical
26985-31-9

methyl viologen cation radical

Conditions
ConditionsYield
With dinitrogen monoxide In water Rate constant; Irradiation; variation of MV2+ concentration, pH, mode and dose of γ-irradiation; reactivity of EDTA radicals toward methylviologen;
edetate disodium
139-33-3

edetate disodium

ethylenediamine-N,N,N'-triacetic acid
688-57-3

ethylenediamine-N,N,N'-triacetic acid

Conditions
ConditionsYield
With sodium hydroxide; ammonium ferric sulfate; oxygen In water for 168h; Heating;
edetate disodium
139-33-3

edetate disodium

C10H12N2O10(4-)*4Na(1+)

C10H12N2O10(4-)*4Na(1+)

Conditions
ConditionsYield
With sodium hydroxide; dihydrogen peroxide In water at 60℃; for 4h; pH 9;
edetate disodium
139-33-3

edetate disodium

A

formaldehyd
50-00-0

formaldehyd

B

formic acid
64-18-6

formic acid

C

CO2

CO2

Conditions
ConditionsYield
With perchloric acid; peroxomonophosphoric acid In water at 45℃; Kinetics; Thermodynamic data; LiClO4, Cu(II), Fe(II) and phosphate, other temperature, E(activ);
...Expand
edetate disodium
139-33-3

edetate disodium

A

carbon dioxide
124-38-9

carbon dioxide

B

sodium carbonate
497-19-8

sodium carbonate

C

NaNO3

NaNO3

Conditions
ConditionsYield
With ozone at 20℃; Mechanism; Rate constant; Thermodynamic data; variation in pH, acidity of solution, and temperature; activation energy;
...Expand
edetate disodium
139-33-3

edetate disodium

NO, CO2, H2O

NO, CO2, H2O

Conditions
ConditionsYield
With oxygen; platinum In gas at 900℃; Product distribution;
edetate disodium
139-33-3

edetate disodium

Cu(II)*EDTA
135179-45-2

Cu(II)*EDTA

Conditions
ConditionsYield
With copper(II) carbonate In water
edetate disodium
139-33-3

edetate disodium

iron(II) sulfate

iron(II) sulfate

ferrous ethylenediamine tetraacetate
21393-59-9

ferrous ethylenediamine tetraacetate

Conditions
ConditionsYield
With tartaric acid; sodium hydroxide In water
In water at 20℃; Heating / reflux;
4-hydroxy[1]benzopyran-2-one
1076-38-6

4-hydroxy[1]benzopyran-2-one

edetate disodium
139-33-3

edetate disodium

2-(benzo[d]isoxazol-3-yl)acetic acid
4865-84-3

2-(benzo[d]isoxazol-3-yl)acetic acid

Conditions
ConditionsYield
Stage #1: 4-hydroxy[1]benzopyran-2-one; edetate disodium With sodium hydroxide; hydroxylamine sulfate In water; 1,2-dichloro-ethane at 84 - 86℃; for 4h;
Stage #2: With sulfuric acid In water pH=1 - 2; Product distribution / selectivity;
5-chloro-1,1,3,3-tetrafluoro-1,3-dihydroisobenzofuran-6-yl-hydrazine

5-chloro-1,1,3,3-tetrafluoro-1,3-dihydroisobenzofuran-6-yl-hydrazine

edetate disodium
139-33-3

edetate disodium

2-Chloroacrylonitrile
920-37-6

2-Chloroacrylonitrile

5-amino-1-(6-chloro-1,1,3,3-tetrafluoro-1,3-dihydroisobenzofuran-5-yl)pyrazole

5-amino-1-(6-chloro-1,1,3,3-tetrafluoro-1,3-dihydroisobenzofuran-5-yl)pyrazole

Conditions
ConditionsYield
With sulfuric acid; sodium carbonate In methanol; water
...Expand
concentrated aqueous sodium chloride

concentrated aqueous sodium chloride

2,3,6-trichloro-4-trifluoromethyl-phenyl-hydrazine
86399-01-1

2,3,6-trichloro-4-trifluoromethyl-phenyl-hydrazine

edetate disodium
139-33-3

edetate disodium

2-Chloroacrylonitrile
920-37-6

2-Chloroacrylonitrile

5-amino-1-(2,3,6-trichloro-4-trifluoro-methyl-phenyl)-pyrazole
104924-77-8

5-amino-1-(2,3,6-trichloro-4-trifluoro-methyl-phenyl)-pyrazole

Conditions
ConditionsYield
With sulfuric acid; sodium carbonate In methanol; dichloromethane; water
...Expand
N-<3-<(mercaptocetyl)amino>benzoyl>glycine
67852-72-6

N-<3-<(mercaptocetyl)amino>benzoyl>glycine

edetate disodium
139-33-3

edetate disodium

N-<3-<(mercaptocetyl)amino>benzoyl>glycine ethylenediamine bissalt
67852-77-1

N-<3-<(mercaptocetyl)amino>benzoyl>glycine ethylenediamine bissalt

Conditions
ConditionsYield
With ethylenediamine In tetrahydrofuran; water
With ethylenediamine In tetrahydrofuran; water
lead(II) sulfide

lead(II) sulfide

edetate disodium
139-33-3

edetate disodium

A

Pb(2+)*2H(1+)*(O2CCH2)2NC2H4N(CH2CO2)2(4-)=Pb((O2CCH2)(HO2CCH2)NC2H4N(CH2CO2H)(CH2CO2))

Pb(2+)*2H(1+)*(O2CCH2)2NC2H4N(CH2CO2)2(4-)=Pb((O2CCH2)(HO2CCH2)NC2H4N(CH2CO2H)(CH2CO2))

B

Sulfate
14808-79-8

Sulfate

Conditions
ConditionsYield
With dihydrogen peroxide In water byproducts: H2O; PbS dissolved in aq. soln. contg. H2O2 and Trilon B; incomplete dissolution;
...Expand
edetate disodium
139-33-3

edetate disodium

vanadium(II) chloride

vanadium(II) chloride

{Vaedt}(2-)

{Vaedt}(2-)

Conditions
ConditionsYield
With sodium hydroxide In water neutralisation of a VCl2-soln. containing Na2H2C2H4(N(CH2COO)2)2-soln. in presence of HCl, NaCl or KCl with NaOH-soln. at glass electrode, equilibrium constants given;;

Ethylenediaminetetraacetic acid disodium salt Chemical Properties

Molecule structure of Ethylenediaminetetraacetic acid disodium salt (CAS NO.139-33-3):

IUPAC Name: Disodium 2-[carboxymethyl-[2-[carboxymethyl-(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate 
Molecular Weight: 336.2063 g/mol
Molecular Formula: C10H14N2Na2O8 
Melting Point: 248 °C (dec.)(lit.)
Flash Point: 325.2 °C
Enthalpy of Vaporization: 99.5 kJ/mol
Boiling Point: 614.2 °C at 760 mmHg
Vapour Pressure: 1.15E-16 mmHg at 25 °C 
Storage Temp.: 2-8 °C
Water Solubility: clear, colorless
H-Bond Donor: 2
H-Bond Acceptor: 10
Rotatable Bond Count: 9
Exact Mass: 336.054555
MonoIsotopic Mass: 336.054555
Topological Polar Surface Area: 161
Heavy Atom Count: 22
Canonical SMILES: C(CN(CC(=O)O)CC(=O)[O-])N(CC(=O)O)CC(=O)[O-].[Na+].[Na+]
InChI: InChI=1S/C10H16N2O8.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;/q;2*+1/p-2
InChIKey: ZGTMUACCHSMWAC-UHFFFAOYSA-L
EINECS: 205-358-3
Product Categories: INORGANIC & ORGANIC CHEMICALS

Ethylenediaminetetraacetic acid disodium salt Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 260mg/kg (260mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 52, Pg. 126S, 1956.
mouse LD50 intravenous 56mg/kg (56mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03781,
mouse LD50 oral 2050mg/kg (2050mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 52, Pg. 126S, 1956.
rabbit LD50 intravenous 47mg/kg (47mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 52, Pg. 113, 1956.
rabbit LD50 oral 2300mg/kg (2300mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 52, Pg. 113, 1956.
rat LD50 oral 2gm/kg (2000mg/kg)   Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 27, Pg. 465, 1968.

Ethylenediaminetetraacetic acid disodium salt Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Ethylenediaminetetraacetic acid disodium salt Safety Profile

Hazard Codes: HarmfulXn
Risk Statements: 36/38-36/37/38-22 
R36/38:Irritating to eyes and skin. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R22:Harmful if swallowed.
Safety Statements: 26-36-37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS: AH4410000
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Mutation data reported. The calcium disodium salt of EDTA is used as a chelating agent in treating lead poisoning. When heated to decomposition it emits toxic fumes of NOx and Na2O.

Ethylenediaminetetraacetic acid disodium salt Specification

 Ethylenediaminetetraacetic acid disodium salt (CAS NO.139-33-3) is also named as (Ethylenedinitrilo)-tetraacetic acid disodium salt ; Edta disodium ; AI3-18049 ; CBC 50152966 ; CCRIS 3658 ; Cheladrate ; Chelaplex III ; Chelaton 3 ; Chelaton III ; Chelest 200 ; Chelest B ; Clewat N ; Complexon III ; DR-16133 ; Dinatrium ethylendiamintetraacetat ; Dinatrium ethylendiamintetraacetat [Czech] ; Diso-Tate ; Disodium (ethylenedinitrilo)tetraacetate ; Disodium (ethylenedinitrilo)tetraacetic acid ; Disodium EDTA ; Disodium diacid ethylenediaminetetraacetate ; Disodium dihydrogen ethylenediaminetetraacetate ; Disodium dihydrogen(ethylenedinitrilo)tetraacetate ; Disodium edathamil ; Disodium edetate ; Disodium edta, anhydrous ; Disodium ethylenediamine-N,N,N',N'-tetraacetate ; Disodium ethylenediaminetetraacetate ; Disodium ethylenediaminetetraacetic acid ; Disodium salt of EDTA ; Disodium sequestrene ; Ethylenediaminetetraacetate, disodium salt ; F 1 (VAN) ; F 1 (complexon) ; Kiresuto B ; N,N'-1,2-Ethanediylbis(N-(carboxymethyl)glycine) disodium salt ; NSC 2760 ; Perma kleer 50 crystals disodium salt ; Versene NA ; Versene Na2 ; Versonol 120 ; Zonon D . Ethylenediaminetetraacetic acid disodium salt (CAS NO.139-33-3) is white crystalline solid.

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