Fmoc-L-alpha-Alanine supplier

Name
FMOC-Ala-OH
EINECS 252-660-6
CAS No. 35661-39-3
Article Data48
CAS DataBase
Density 282 g/cm³
Solubility Soluble in water.
Melting Point 147-153 °C(lit.)
Formula C₁₈H₁₇NO₄
Boiling Point 544.1 °C at 760 mmHg
Molecular Weight 311.337
Flash Point 282.9 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 24/25-36/37/39-27-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms (2S)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]propanoicacid;(9-Fluorenylmethoxycarbonyl)-L-alanine;(S)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]propionic acid;(S)-N-Fmoc-alanine;FMOC-Alanine;N-(9-Fluorenylmethoxycarbonyl)alanine;N-9-Fluorenylmethoxycarbonyl-L-alanine;NPC 14688;NSC 334296;Fmoc-Ala-OH;Fmoc-β-Ala-OH;
PSA 79.12000
LogP 3.20260

Synthetic route

: C32H27NO5

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With potassium phosphate; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; ascorbic acid In water; acetonitrile at 20℃; for 1h; Irradiation;	100%

: 56-41-7
L-alanin

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With sodium carbonate In 1,4-dioxane; water at 20℃; for 18h;	99%
With sodium carbonate In N,N-dimethyl-formamide for 0.166667h; Ambient temperature;	96%
With sodium carbonate In 1,4-dioxane; water at 20℃; for 18h;

: 56-41-7
L-alanin

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
In water at 110℃; for 0.0833333h; Microwave irradiation; Green chemistry; chemoselective reaction;	96%
In ethanol; water at 60℃; for 4h; chemoselective reaction;	86%

: 56-41-7
L-alanin

polymer-bound Fmoc-O-succinimide: polymer-bound Fmoc-O-succinimide

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20℃; for 24h;	95%

: 56-41-7
L-alanin

: 1370440-36-0
N-(((9H-fluoren-9-yl)methoxy)carbonyloxy)-2-oxo-2-(piperidin-1-yl)acetimidoyl cyanide

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; acetone	93.2%

: 56-41-7
L-alanin

: 88744-04-1
(9-fluorenyl)methyl pentafluorophenyl carbonate

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; acetone Ambient temperature;	93%

: 56-41-7
L-alanin

: 1370440-32-6
N-(((9H-fluoren-9-yl)methoxy)carbonyloxy)-2-(ethylamino)-2-oxoacetimidoyl cyanide

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; acetone	92.6%

: 56-41-7
L-alanin

: 99503-04-5
Carbonic acid 3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl ester 9H-fluoren-9-ylmethyl ester

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With tertiary amine In 1,4-dioxane; water for 3h;	91%

: 56-41-7
L-alanin

: Carbonic acid 1,3-dioxo-1,3-dihydro-isoindol-2-yl ester 9H-fluoren-9-ylmethyl ester

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃; for 2h;	91%

ether-petroleum ether: ether-petroleum ether

: 56-41-7
L-alanin

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
In 1,4-dioxane; sodium carbonate	90.2%

...Expand

: 56-41-7
L-alanin

: 102774-86-7
9-fluorenylmethyl N-succinimidyl carbonate

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With triethylamine In water; acetonitrile for 1h;	90%

: Fmoc-Ala-OTIPS

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With potassium fluoride In tetrahydrofuran; methanol at 22℃; for 2h;	86%

: Fmoc-Ala-OSEM

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With magnesium bromide ethyl etherate In dichloromethane at -20 - 22℃; for 3.5h;	84%

: 135248-89-4
Nα-fluoren-9-ylmethoxycarbonyl-L-cysteine

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; triethyl phosphite In aq. phosphate buffer; acetonitrile at 20℃; for 0.5h; pH=6.5; Irradiation;	84%

: 146346-88-5
methyl 2-(((9H-fluoren-9-yl)methoxy)carbonyl)aminopropanoate

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With trimethyltin hydroxide In 1,2-dichloro-ethane at 80℃; for 5h;	75%

: 146549-15-7
(2S)-N-<(fluoren-9-yl)methoxycarbonyl>alanine prop-2-enyl ester

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With water; chlortris(triphenylphosphine)rhodium In ethanol for 1h;	67%

: (S)-(4'-((4-((2-(((9H-fluoren-9-yl)methoxy)carbonylamino)propanoyloxy)methyl)phenoxy)methyl)biphenyl-4-yl)triphenylphosphonium perchlorate

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 0℃; for 1.5h;	61%

N-Fmoc-L-alanine linked to Wang-resin: N-Fmoc-L-alanine linked to Wang-resin

A: 56-41-7
L-alanin

B: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With bis(tri-n-butyltin)oxide In chloroform at 61℃; for 60h;	A 40% B 18%

: C21H25NO4Si

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With methanol In dichloromethane for 0.5h; Ambient temperature; Yield given;

: 233281-32-8
N-(9-fluorenylmethyloxycarbonyl)alanine 3,4,5-tris(octadecyloxy)benzyl ester

A: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

B: 955095-33-7
5-(bromomethyl)-1,2,3-tris(octadecyloxy)benzene

Conditions

Conditions	Yield
With hydrogen bromide In acetic acid

: 233281-32-8
N-(9-fluorenylmethyloxycarbonyl)alanine 3,4,5-tris(octadecyloxy)benzyl ester

A: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

B: 233281-31-7
(3,4,5-trioctadecyloxyphenyl)methan-1-ol

Conditions

Conditions	Yield
With hydrogenchloride In ethyl acetate at 20℃;

: N-Fmoc-L-alanine phenacyl ester

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With magnesium; acetic acid In methanol; N,N-dimethyl-formamide at 20℃; for 75h;

PEGA1900-resin-NH-(p-COC6H4CH2)-(S)-OCOCH(CH3)NHFmoc: PEGA1900-resin-NH-(p-COC6H4CH2)-(S)-OCOCH(CH3)NHFmoc

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With chymotrypsin In phosphate buffer for 16h; pH=8;

PEGA1900-resin-NH-(p-COCH2OC6H4CH2)-(S)-OCOCH(CH3)NHFmoc: PEGA1900-resin-NH-(p-COCH2OC6H4CH2)-(S)-OCOCH(CH3)NHFmoc

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions

Conditions	Yield
With chymotrypsin In phosphate buffer for 16h; pH=8;

: 910126-27-1
Fmoc-Ala-MFE

A: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

B: 70672-05-8
3-O-methylfluorescein

Conditions

Conditions	Yield
With ethylenediaminetetraacetic acid; DL-dithiothreitol; cathepsin B In phosphate buffer at 37℃; pH=6.7; Enzyme kinetics;

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 142061-92-5, 145434-41-9, 130858-92-3
N-(9-fluorenylmethoxycarbonyl)-L-alanyl fluoride

Conditions

Conditions	Yield
With pyridine; trifluoro-[1,3,5]triazine In dichloromethane at 20℃; for 15h;	100%
With trifluoro-[1,3,5]triazine; triethylamine In dichloromethane at -40℃; for 2h;	93%
With pyridine; trifluoro-[1,3,5]triazine In dichloromethane for 4h; Ambient temperature; or in MeCN;	85%

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 103321-50-2
9H-fluoren-9-ylmethyl [(1S)-2-chloro-1-methyl-oxoethyl]carbamate

Conditions

Conditions	Yield
With thionyl chloride In dichloromethane at 60℃; for 0.5h; Inert atmosphere;	100%
With thionyl chloride In dichloromethane for 0.5h; Reflux;	98%
With thionyl chloride In dichloromethane at 20℃; for 0.366667h; Sonication;	96%

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 161529-13-1
(S)-2-(N-fluorenylmethoxycarbonylamino)propanol

Conditions

Conditions	Yield
Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine With 4-methyl-morpholine In 1,2-dimethoxyethane at -15℃; for 1h; Stage #2: With sodium tetrahydroborate In 1,2-dimethoxyethane; water at -15℃; Further stages.;	100%
Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine With isobutyl chloroformate In 1,2-dimethoxyethane at -15℃; for 0.0166667h; Acylation; Stage #2: With sodium tetrahydroborate In 1,2-dimethoxyethane at -15℃; for 0.00833333h; Reduction;	91%
Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate at 0℃; for 0.166667h; Stage #2: With sodium tetrahydroborate In water; ethyl acetate at 0℃; for 0.416667h;	88%

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 92545-30-7
salvinorin B

: 2-O-{(S)-2-[N-(9-fluorenylmethoxycarbonyl)amino]propionyl}salvinorin B

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 22h;	100%
With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In dichloromethane at 50℃; for 24h;

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Fmoc-Ile-Wang resin: Fmoc-Ile-Wang resin

Ala-Ile-Wang resin: Ala-Ile-Wang resin

Conditions

Conditions	Yield
Stage #1: Fmoc-Ile-Wang resin With piperidine In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 3h; Stage #3: With piperidine In N,N-dimethyl-formamide at 20℃; for 0.25h;	100%

Yield

Stage #1: Fmoc-Ile-Wang resin With piperidine In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 3h;
Stage #3: With piperidine In N,N-dimethyl-formamide at 20℃; for 0.25h;

100%

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 104090-93-9
N-Fmoc-D-Glu α-amide γ-tert-butyl ester

: 364368-47-8
2-N-acetyl-1-β-O-allyl 4,6-O-isopropylidenemuramic acid

: 364368-41-2
2-N-acetyl-1-β-O-allyl-muramoyl-L-alanyl-D-isoglutamine tert-butyl ester

Conditions

Conditions	Yield
Multistep reaction.;	100%

...Expand

: 916598-58-8
(3,4-dimethoxy-phenethylamino)acetic acid allyl ester

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 916598-60-2
N-[(9H-fluorenyl-9-ylmethoxy)carbonyl]-L-alanyl-N-(3,4-dimethoxyphenethyl)glycine allyl ester

Conditions

Conditions	Yield
Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine With 4-methyl-morpholine; isobutyl chloroformate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: (3,4-dimethoxy-phenethylamino)acetic acid allyl ester In N,N-dimethyl-formamide at 20℃;	100%

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

monomethoxy-polyethylene glycol: monomethoxy-polyethylene glycol

N-(9-fluorenylmethoxycarbonyl)-L-alanine terminated monomethoxy-polyethylene glycol: N-(9-fluorenylmethoxycarbonyl)-L-alanine terminated monomethoxy-polyethylene glycol

Conditions

Conditions	Yield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃;	100%

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 35661-38-2, 35661-39-3, 79990-15-1
N-(9-fluorenylmethoxycarbonyl)-D-alanine

: 959924-65-3
H-(D)Ala-Ala-(D)-Ala-Lys(Boc)-(D)Ala-Lys(Boc)-OH

Conditions

Conditions	Yield
Multistep reaction.;	100%

...Expand

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 68858-20-8
Fmoc-Val-OH

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 1000018-75-6
Boc-Ahx-Val-Ala-OH

Conditions

Conditions	Yield
Multistep reaction.;	100%

...Expand

: C42H37ClNO6Pol

: C29H31NO5

: 1161-13-3
N-Cbz-L-Phe

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 122889-11-6, 83792-48-7
O-benzyl-N-Fmoc-L-serine

: 71989-31-6
Fmoc-Pro-OH

: 71989-33-8
Fmoc-Ser(tBu)-OH

: 71989-28-1
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

: 139090-50-9, 83792-47-6
Nα-FMOC-Nω-L-tosylarginine

: 146346-82-9
N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyldimethylsilyl)-L-threonine

: 146982-24-3
N-alpha-(9-fluorenylmethyloxycarbonyl)-L-aspartic acid beta-allyl ester

: 1240360-55-7
Z-Phe-Ala-Thr(TBS)-Met-Arg(Tos)-Tyr(Pen)-Pro-Ser(tBu)-Asp(OAll)-Ser(Bzl)-Asp(OtBu)-OH

Conditions

Conditions	Yield
Stage #1: C42H37ClNO6Pol With morpholine Automated synthesizer; solid phase reaction; Stage #2: O-benzyl-N-Fmoc-L-serine With O‑(6‑chlorobezotriazol‑1‑yl)‑N,N,N,N‑tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 6-chloro-1-hydroxybenzotriazole In 1-methyl-pyrrolidin-2-one Automated synthesizer; solid phase reaction; Stage #3: C29H31NO5; N-Cbz-L-Phe; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-Pro-OH; Fmoc-Ser(tBu)-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine; Nα-FMOC-Nω-L-tosylarginine; N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyldimethylsilyl)-L-threonine; N-alpha-(9-fluorenylmethyloxycarbonyl)-L-aspartic acid beta-allyl ester Further stages;	100%

Yield

Stage #1: C42H37ClNO6Pol With morpholine Automated synthesizer; solid phase reaction;
Stage #2: O-benzyl-N-Fmoc-L-serine With O‑(6‑chlorobezotriazol‑1‑yl)‑N,N,N,N‑tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 6-chloro-1-hydroxybenzotriazole In 1-methyl-pyrrolidin-2-one Automated synthesizer; solid phase reaction;
Stage #3: C29H31NO5; N-Cbz-L-Phe; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-Pro-OH; Fmoc-Ser(tBu)-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine; Nα-FMOC-Nω-L-tosylarginine; N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyldimethylsilyl)-L-threonine; N-alpha-(9-fluorenylmethyloxycarbonyl)-L-aspartic acid beta-allyl ester Further stages;

100%

...Expand

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 35661-60-0
Fmoc-Leu-OH

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 71989-23-6
Fmoc-Ile-OH

: 143824-78-6
3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester

: 1234926-33-0
H2N-Gly-Trp(Boc)-Leu-Ala-Ala-Ile-Leu-Gly-OH

Conditions

Conditions	Yield
Stage #1: N-(fluoren-9-ylmethoxycarbonyl)glycine With N-ethyl-N,N-diisopropylamine In dichloromethane for 3h; Automated synthesizer; solid phase reaction; Stage #2: With piperidine In N,N-dimethyl-formamide for 0.1h; Automated synthesizer; solid phase reaction; Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Leu-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-Ile-OH; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester Further stages;	100%

Yield

Stage #1: N-(fluoren-9-ylmethoxycarbonyl)glycine With N-ethyl-N,N-diisopropylamine In dichloromethane for 3h; Automated synthesizer; solid phase reaction;
Stage #2: With piperidine In N,N-dimethyl-formamide for 0.1h; Automated synthesizer; solid phase reaction;
Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Leu-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-Ile-OH; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester Further stages;

100%

...Expand

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 5-fluoro-N1-(4-fluorophenyl)benzene-1,2-diamine

: 1338481-96-1
(S)-(9H-fluoren-9-yl)methyl 1-(4-fluoro-2-(4-fluorophenylamino)phenylamino)-1-oxopropan-2-ylcarbamate

Conditions

Conditions	Yield
Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane at -10℃; for 0.5h; Stage #2: 5-fluoro-N1-(4-fluorophenyl)benzene-1,2-diamine In dichloromethane at -10℃; for 1h;	100%
Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane at -10℃; for 0.5h; Stage #2: 5-fluoro-N1-(4-fluorophenyl)benzene-1,2-diamine In dichloromethane at -10℃; for 1h;

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 71989-31-6
Fmoc-Pro-OH

: 76-05-1
trifluoroacetic acid

: 312746-41-1
N-(9-fluorenylmethoxycarbonyl)-L-β-phenylselenocysteine

: 1607794-60-4
C2HF3O2*C17H24N4O3Se

Conditions

Conditions	Yield
Stage #1: Fmoc-Pro-OH With ethyl cyanoglyoxylate-2-oxime; diisopropyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 1.5h; Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 0.2h; Stage #3: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; trifluoroacetic acid; N-(9-fluorenylmethoxycarbonyl)-L-β-phenylselenocysteine Further stages;	100%

...Expand

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 71989-31-6
Fmoc-Pro-OH

: 76-05-1
trifluoroacetic acid

: 312746-41-1
N-(9-fluorenylmethoxycarbonyl)-L-β-phenylselenocysteine

: 1607794-62-6
C2HF3O2*C26H33N5O4Se2

Conditions

Conditions	Yield
Stage #1: N-(9-fluorenylmethoxycarbonyl)-L-β-phenylselenocysteine With ethyl cyanoglyoxylate-2-oxime; diisopropyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 1.5h; Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 0.2h; Stage #3: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-Pro-OH; trifluoroacetic acid; N-(9-fluorenylmethoxycarbonyl)-L-β-phenylselenocysteine Further stages;	100%

Yield

Stage #1: N-(9-fluorenylmethoxycarbonyl)-L-β-phenylselenocysteine With ethyl cyanoglyoxylate-2-oxime; diisopropyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 1.5h;
Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 0.2h;
Stage #3: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-Pro-OH; trifluoroacetic acid; N-(9-fluorenylmethoxycarbonyl)-L-β-phenylselenocysteine Further stages;

100%

...Expand

: 159610-89-6
6-azido-2S-{[(9H-fluorenyl-9-ylmethoxy)carbonyl]amino}hexanoic acid

: Fmoc-gly-wang resin

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 71989-31-6
Fmoc-Pro-OH

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 146987-10-2
N-α-Fmoc-N-ε-biotinyl-L-lysine

: C67H113N21O17S

Conditions

Conditions	Yield
Stage #1: Fmoc-gly-wang resin With piperidine In N,N-dimethyl-formamide for 0.333333h; SASRIN®-resin; Stage #2: Fmoc-Pro-OH With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide pH=8 - 9; SASRIN®-resin; Stage #3: 6-azido-2S-{[(9H-fluorenyl-9-ylmethoxy)carbonyl]amino}hexanoic acid; N-(fluoren-9-ylmethoxycarbonyl)glycine; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-Lys(tert-butoxycarbonyl); N-α-Fmoc-N-ε-biotinyl-L-lysine Further stages;	100%

Yield

Stage #1: Fmoc-gly-wang resin With piperidine In N,N-dimethyl-formamide for 0.333333h; SASRIN®-resin;
Stage #2: Fmoc-Pro-OH With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide pH=8 - 9; SASRIN®-resin;
Stage #3: 6-azido-2S-{[(9H-fluorenyl-9-ylmethoxy)carbonyl]amino}hexanoic acid; N-(fluoren-9-ylmethoxycarbonyl)glycine; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-Lys(tert-butoxycarbonyl); N-α-Fmoc-N-ε-biotinyl-L-lysine Further stages;

100%

...Expand

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 147221-33-8
1-methyl-1-phenylethyl 2,2,2-trichloroacetimidoate

: Fmoc-Ala-OCumyl

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 16h;	100%
In dichloromethane at 10℃; for 1h;	98%

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: HCl*H-Gln(Trt)-Ser(ψMe,M ePro)-Gly-Leu-Gly-Cys(Trt)-Asn(Trt)-Ser(tBu)-Phe-Arg(Pbf)-Tyr(tBu)-Okb, Kb=2,4-didocosyloxybenzyl

: HCl*H-Ala-Gln(Trt)-Ser(ψM e,M ePro)-Gly-Leu-Gly-Cys(Trt)-Asn(Trt)-Ser(tBu)-Phe-Arg(Pbf)-Tyr(tBu)-Okb, Kb=2,4-didocosyloxybenzyl

Conditions

Conditions	Yield
Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; HCl*H-Gln(Trt)-Ser(ψMe,M ePro)-Gly-Leu-Gly-Cys(Trt)-Asn(Trt)-Ser(tBu)-Phe-Arg(Pbf)-Tyr(tBu)-Okb, Kb=2,4-didocosyloxybenzyl With N-ethyl-N,N-diisopropylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: With piperidine; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #3: With hydrogenchloride In tetrahydrofuran; water; N,N-dimethyl-formamide pH=Ca. 6;	100%

Yield

Stage #1: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; HCl*H-Gln(Trt)-Ser(ψMe,M ePro)-Gly-Leu-Gly-Cys(Trt)-Asn(Trt)-Ser(tBu)-Phe-Arg(Pbf)-Tyr(tBu)-Okb, Kb=2,4-didocosyloxybenzyl With N-ethyl-N,N-diisopropylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: With piperidine; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #3: With hydrogenchloride In tetrahydrofuran; water; N,N-dimethyl-formamide pH=Ca. 6;

100%

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 34294-79-6
(S)-(-)-3-aminopiperidin-2-one

: (9H-fluoren-9-yl)methyl ((S)-1-oxo-1-(((S)-2-oxopiperidin-3-yl)amino)propan-2-yl)carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide Inert atmosphere;	100%

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 108-24-7
acetic anhydride

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 109425-51-6
Fmoc-His(Trt)-OH

: 143824-78-6
3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester

: Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

: Ac-GGAK(Boc)R(Pbf)H(Trt)R(Pbf)W(Boc)W(Boc)-NH2

Conditions

Conditions	Yield
Stage #1: 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1h; Enzymatic reaction; Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 0.2h; Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; acetic anhydride; Fmoc-Lys(tert-butoxycarbonyl); Fmoc-His(Trt)-OH; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine Further stages;	100%

Yield

Stage #1: 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1h; Enzymatic reaction;
Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 0.2h;
Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; acetic anhydride; Fmoc-Lys(tert-butoxycarbonyl); Fmoc-His(Trt)-OH; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine Further stages;

100%

...Expand

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: C62H119NO4

: C80H134N2O7

Conditions

Conditions	Yield
With benzotriazol-1-ol; diisopropyl-carbodiimide In dichloromethane at 20℃; for 5h;	100%

: 50-00-0
formaldehyd

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 83999-95-5
9H-fluoren-9-ylmethyl (S)-4-methyl-5-oxo-1,3-oxazolidine-3-carboxylate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 2h; Reagent/catalyst; Temperature; Reflux;	99%
With toluene-4-sulfonic acid In acetonitrile at 120℃; for 0.0333333h; microwave irradiation;	97%
With toluene-4-sulfonic acid In toluene for 0.5h; Heating;	96%

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 126771-40-2
2,4-dichlorophenyl-4-bromomethyl-phenoxyacetate

: 126771-54-8
(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 3h; Ambient temperature;	99%

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: Met-Ala-Ile-Pro-t-Bu

: N-Fmoc-L-Ala-L-Met-L-Ala-L-Ile-L-Pro-t-Bu

Conditions

Conditions	Yield
With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Addition; Peptide-bond formation;	99%

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 873-76-7
para-Chlorobenzyl alcohol

: (S)-2-[(4-Chloro-benzyl)-(2-nitro-benzenesulfonyl)-amino]-propionic acid

Conditions

Conditions	Yield
Multistep reaction;	99%

...Expand

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 71989-31-6
Fmoc-Pro-OH

: 110637-44-0
(2S)-N-allyloxycarbonyl-L-proline

: Pro-Pro-Ala-Fmoc

Conditions

Conditions	Yield
Multistep reaction;	99%

...Expand

: 863671-84-5
(4R,2'S)-2-[1'-Alloc-Thr(propargyl)-pyrrolidin-2'-yl]-4-(3"-chloro-benzyl)-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 863671-85-6
(4R,2'S)-2-[1'-Fmoc-Ala-Thr(propargyl)-pyrrolidin-2'-yl]-4-(3-chloro-benzyl)-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

Conditions

Yield

Stage #1: (4R,2'S)-2-[1'-Alloc-Thr(propargyl)-pyrrolidin-2'-yl]-4-(3"-chloro-benzyl)-4,5-dihydro-oxazole-4-carboxylic acid methyl ester; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 2h;
Stage #2: (4R,2'S)-2-[1'-Alloc-Thr(propargyl)-pyrrolidin-2'-yl]-4-(3"-chloro-benzyl)-4,5-dihydro-oxazole-4-carboxylic acid methyl ester With 1,4-diaza-bicyclo[2.2.2]octane; tetrakis(triphenylphosphine) palladium(0) In dichloromethane at 20℃; for 0.333333h;

99%

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 566-66-5
3β-hydroxy-pregn-4-en-20-one

: 1185296-15-4
C39H47NO5

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane Inert atmosphere;	99%

Fmoc-L-alpha-Alanine Standards and Recommendations

APPEARANCE OF FMOC-l-ALANINE: White to off-white crystalline powder
ASSAY OF FMOC-L-AL: 99.0% min
OPTICAL ROTATION [a]20: -17.5 ° ~ -29.5°(C=1 in DMF)
SOLUTION CLARITY: clear
Fe: 10ppm max
HEAVY METALS 10ppm max
As: 2ppm max
LOSS ON DRYING: 0.5% max

Fmoc-L-alpha-Alanine Specification

The Fmoc-L-alpha-Alanine, with the CAS registry number 35661-39-3, is also known as NSC334296. It belongs to the product categories of Protected Amino Acids; Fluorenes, Flurenones; Amino Acids; Alanine [Ala, A]; Fmoc-Amino Acids and Derivatives; Amino Acids (N-Protected); Biochemistry; Fmoc-Amino Acids; Fmoc-Amino Acid Series. Its EINECS registry number is 252-660-6. This chemical's molecular formula is C₁₈H₁₇NO₄ and molecular weight is 311.33188. Its IUPAC name is called 2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid. The product should be sealed and stored in cool and dry place.

Physical properties of Fmoc-L-alpha-Alanine: (1)ACD/LogP: 3.54; (2)ACD/LogD (pH 5.5): 1.52; (3)ACD/LogD (pH 7.4): 0.02; (4)ACD/BCF (pH 5.5): 2.78; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 19.31; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 5; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 5; (11)Index of Refraction: 1.607; (12)Molar Refractivity: 83.91 cm³; (13)Molar Volume: 242.7 cm³; (14)Surface Tension: 55.3 dyne/cm; (15)Density: 1.282 g/cm³; (16)Flash Point: 282.9 °C; (17)Enthalpy of Vaporization: 86.58 kJ/mol; (18)Boiling Point: 544.1 °C at 760 mmHg; (19)Vapour Pressure: 1.13E-12 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
(2)InChI: InChI=1S/C18H17NO4/c1-11(17(20)21)19-18(22)23-10-16-14-8-4-2-6-12(14)13-7-3-5-9-15(13)16/h2-9,11,16H,10H2,1H3,(H,19,22)(H,20,21)
(3)InChIKey: QWXZOFZKSQXPDC-UHFFFAOYSA-N

Product Name

FMOC-Ala-OH

Synthetic route

Fmoc-L-alpha-Alanine Standards and Recommendations

Fmoc-L-alpha-Alanine Specification

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