• Name

  Fosfomycin tromethamine

• EINECS 279-018-8
• CAS No. 78964-85-9
• Article Data5
• CAS DataBase
• Density
• Solubility
• Melting Point
• Formula C₄H₁₁NO₃^.C₃H₇O₄P
• Boiling Point 357 °C at 760 mmHg
• Molecular Weight 259.196
• Flash Point 169.7 °C
• Transport Information
• Appearance white or off-white powder
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Monurol (TN);Phosphonic acid, (3-methyloxiranyl)-, (2R-cis)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);Fosfomycin tromethamine (USAN);(1R,2S)-(1,2-Epoxypropyl)phosphonic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1);Monurol;Fosfomycin compd. with trometamol;Z 1282;(2R-cis)-(3-Methyloxiranyl)phosphonic acid, compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1);Tromethamine-fosfomycin;
• PSA 166.58000
• LogP -1.73000

Synthetic route

fosfomycin bis tromethamine

78964-85-9

fosfomycin trometamol

Conditions

Conditions	Yield
With acetic anhydride In methanol at 20 - 30℃; for 1.33333h;	95.1%

fosfomycin bis-tromethamine

78964-85-9

fosfomycin trometamol

Conditions

Conditions	Yield
Stage #1: fosfomycin bis-tromethamine In methanol at 20℃; for 0.25h; Stage #2: With Cyclohexyl isocyanate In methanol at 20℃; for 0.633333h; Reagent/catalyst;	90.5%

(1R,2S)-(-)-cis-1,2-epoxypropyl phosphoric acid-R-(+)-α-phenethylamine salt

77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

78964-85-9

fosfomycin trometamol

Conditions

Conditions	Yield
Stage #1: (1R,2S)-(-)-cis-1,2-epoxypropyl phosphoric acid-R-(+)-α-phenethylamine salt; 2-amino-2-hydroxymethyl-1,3-propanediol In methanol at 20℃; for 0.25h; Stage #2: With Cyclohexyl isocyanate In methanol at 20 - 33℃; for 0.633333h; Reagent/catalyst;	86.2%

C3H7O4P*C8H11N*C4H11NO3

78964-85-9

fosfomycin trometamol

Conditions

Conditions	Yield
With methanesulfonic acid In ethanol at 48 - 50℃; for 0.833333h; Reagent/catalyst; Temperature;	72.3%
With methanesulfonic acid In ethanol at 48 - 50℃; for 0.833333h; Temperature;

855392-18-6

2-amino-2-hydroxymethyl-propane-1,3-diol; hydrogenoxalate

26016-99-9

phosphomycin disodium salt

78964-85-9

fosfomycin trometamol

Conditions

Conditions	Yield
In methanol at 20 - 65℃; for 3 - 4h;

Fosfomycin tromethamine Standards and Recommendations

Fosfomycin tromethamine Specification