Hexamethylenetetramine supplier

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Name
Hexamethylenetetramine
EINECS 202-905-8
CAS No. 100-97-0
Article Data93
CAS DataBase
Density 1.428 g/cm³
Solubility 895 g/L (20 °C)
Melting Point 280 °C (subl.)(lit.)
Formula C₆H₁₂N₄
Boiling Point 252.704 °C at 760 mmHg
Molecular Weight 140.188
Flash Point 103.945 °C
Transport Information UN 1328 4.1/PG 3
Appearance white crystalline powder
Safety 16-22-24-37
Risk Codes 11-42/43
Molecular Structure
Hazard Symbols F,Xn
Synonyms Hexamethylenetetramine(8CI);1,3,5,7-Tetraazaadamantane;Aceto HMT;Aminoform;Ammoform;Antihydral;1,3,5,7-Tetraazatricyclo[3.3.1.1^3,7]decane;Formamine;Formin;Heterin;HexaB;Hexamine(heterocycle);Hexasan;Methenamin;Methenamine;NSC 26346;Nocceler H;Preparation AF;Sanceler H;Sanceler HT;Uramin;Uratrine;Uritone;Urodeine;Urotropin;Urotropine;Vulkacit H;Xametrin;
PSA 12.96000
LogP -1.26820

Synthetic route

: 2691-41-0
octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine

: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
With 1-Benzyl-1,4-dihydronicotinamide In N,N-dimethyl-formamide for 24h; Kinetics; Ambient temperature; Irradiation; other nitramines, var. solvents, var. temperatures;	100%

: 121-82-4
Hexahydro-1,3,5-trinitro-1,3,5-triazine

: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
With borohydride exchange resin; nickel diacetate In methanol for 3h;	100%

: C17H30B2O2

: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
With ammonium hydroxide; Fe(H)2(1,2-bis(dimethylphosphino)ethane)2 In tetrahydrofuran at 20 - 60℃; for 36h; Reagent/catalyst; Schlenk technique; Glovebox; Inert atmosphere;	98%

: 50-00-0
formaldehyd

: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
With ammonium hydroxide In water Schlenk technique; Glovebox; Inert atmosphere;	97%
With ammonium hydroxide at 15 - 20℃;	83%
With ammonium sulfate

: 50-00-0
formaldehyd

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

A: 107-46-0
Hexamethyldisiloxane

B: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 1h;	A 93% B 77%

...Expand

: 50-00-0
formaldehyd

A: 5962-66-3
1,3,5-dithiazinane

B: 281-20-9
1,5-dithia-3,7-diazabicyclo<3.3.1>nonane

C: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
With ammonium hydroxide; hydrogen sulfide In water at 15℃;	A 4% B 44% C 29%
With ammonium hydroxide; hydrogen sulfide In water at 40℃;	A 5% B 19% C 42%

...Expand

: 2035-89-4
N-methyl-N-(methyleneamino)methanamine

: 107-13-1
acrylonitrile

A: 34714-77-7
dimethylaminomethyleneacetonitrile

B: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
With hydroquinone In acetonitrile at 100℃; for 10h; Product distribution;	A 36% B 12%

...Expand

: (1,2-di-tert-butyldiaziridin-3-ylidene)(methyl)amine

A: 691-24-7
1,3-di-tert-butylcarbodiimide

B: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
With sodium hydride In cyclohexane at 180℃; for 0.583333h;	A n/a B 32%

: 5805-57-2
2-Aminomethylbenzimidazole

: 75-09-2
dichloromethane

A: 100-97-0
hexamethylenetetramine

B: 7H,16H-8,17-Methano-9H,18H-benzimidazolo<1,2-c><8,2'>-spiro-benzimidazolidino<1,3,6>triazonin

Conditions

Conditions	Yield
With ammonia at 40℃; for 10h;	A 12% B 27%

...Expand

: 34557-54-5
methane

: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
With ammonia; oxygen; copper at 500 - 700℃;
With silver copper; ammonia; oxygen at 500 - 700℃;

: 75-09-2
dichloromethane

: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
With ammonium hydroxide at 100 - 120℃;
With sodium hydroxide; ammonia at 100 - 120℃;
With ammonium hydroxide at 100 - 120℃;

: 26940-74-9, 59481-40-2, 59481-41-3, 81646-16-4
hexamethylenetetramine; compound with phenol

: 71-43-2
benzene

A: 100-97-0
hexamethylenetetramine

B: 108-95-2
phenol

...Expand

: 135-19-3
β-naphthol

A: 100-97-0
hexamethylenetetramine

B: 1096-84-0
bis(2-hydroxy-1-naphthyl)methane

C: 77204-14-9
1,3-diformyl-2-naphthol

D: 77204-15-0
2-formyl-2,3-dihydro-1H-naphth<1,2-e><1,3>oxazine

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid 1) 2h, steambath, 2) 30 min.; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 2-c,3-t-diisopropyl-1-r-methyltriaziridin

A: 15464-00-3
azobisisopropane

B: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
for 10h; Product distribution; thermolysis;

: 4857-04-9
2-chloromethyl-1H-benzimidazole

: 75-09-2
dichloromethane

A: 100-97-0
hexamethylenetetramine

B: 7H,16H-8,17-Methano-9H,18H-benzimidazolo<1,2-c><8,2'>-spiro-benzimidazolidino<1,3,6>triazonin

Conditions

Conditions	Yield
With ammonia at 40℃; for 10h; Yield given. Yields of byproduct given;

...Expand

: 50-00-0
formaldehyd

: 74-89-5
methylamine

A: 100-97-0
hexamethylenetetramine

B: N-methylhexamethylenetetrammonium fluoride

Conditions

Conditions	Yield
With hydrogen fluoride; ammonia In methanol

...Expand

: 56-81-5
glycerol

A: 100-97-0
hexamethylenetetramine

B: 541-43-5
barium formate

Conditions

Conditions	Yield
With barium dihydroxide; phosphoric acid; ammonia; periodic acid Product distribution; multistep reaction;

: 50-00-0
formaldehyd

ammonium carbonate: ammonium carbonate

: 100-97-0
hexamethylenetetramine

carbon monoxide: carbon monoxide

: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
With nickel kieselguhr; ammonia; hydrogen at 250 - 280℃;

: 67-56-1
methanol

NH3: NH3

: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
With water bei der Beruehrung mit einem gluehenden Nickel-Draht;

: 50-00-0
formaldehyd

NH3: NH3

: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
With water

: 64-17-5
ethanol

NH3: NH3

: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
bei der Einwirkung dunkler elektrischer Entladungen;

: 75-09-2
dichloromethane

NH3: NH3

: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
With ethanol at 125℃;

: 5342-31-4
bis(benzoyloxy)methane

NH3: NH3

: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
With ethanol

methylene glycol diacetate: methylene glycol diacetate

NH3: NH3

: 100-97-0
hexamethylenetetramine

Conditions

Conditions	Yield
With ethanol

polyoxymethylene: polyoxymethylene

NH3: NH3

: 100-97-0
hexamethylenetetramine

: 7664-41-7
ammonia

: sodium amide

: 106-89-8
epichlorohydrin

A: 35042-52-5
(E)-2-penten-4-yn-1-ol

B: 100-97-0
hexamethylenetetramine

C: 107-19-7
propargyl alcohol

...Expand

: 13372-32-2
5-methyl-4-oxo-1,3-dioxolane

: 7664-41-7
ammonia

A: 100-97-0
hexamethylenetetramine

B: 598-81-2, 2043-43-8, 65144-02-7, 89673-71-2
(+/-)-lactamide

...Expand

: 63579-00-0
tris(chloromethyl)-s-triazinetrione

: 7664-41-7
ammonia

A: 100-97-0
hexamethylenetetramine

B: ammonium chloride

C: 108-80-5
isocyanuric acid

Conditions

Conditions	Yield
at 100℃;

...Expand

: 1476-11-5
Z-1,4-dichlorobutene

: 100-97-0
hexamethylenetetramine

: 117175-09-4
1-<(Z)-4-Chloro-2-butenyl>-1-azonia-3,5,7-triazatricyclo<3.3.1.1.3,7>decane chloride

Conditions

Conditions	Yield
In dichloromethane for 5h; Reflux; Large scale reaction;	100%
In ethanol; chloroform for 4h; Heating;	99%
In chloroform at 60℃; for 4h;	94%
In chloroform for 4h; Heating;	91%
In chloroform for 4h; Reflux;	91%

: 19381-40-9
1-(3-(benzyloxy)phenyl)-2-bromoethanone

: 100-97-0
hexamethylenetetramine

: 115851-98-4
1-[2-(3-Benzyloxy-phenyl)-2-oxo-ethyl]-3,5,7-triaza-1-azonia-tricyclo[3.3.1.13,7]decane; bromide

Conditions

Conditions	Yield
In diethyl ether; chloroform Ambient temperature;	100%

: 100-97-0
hexamethylenetetramine

: 3752-97-4
1,4-bis(chloromethyl)-2,5-dimethoxybenzene

: 114558-97-3
1,1'-(2,5-dimethoxy-p-xylylene)-bis-hexamethylenetetraminium; dichloride

Conditions

Conditions	Yield
In dichloromethane for 16h; Heating;	100%
In chloroform 1.) reflux, 30 min, 2.) r.t., overnight;
In chloroform at 90℃; for 24h;

: 100-97-0
hexamethylenetetramine

: 99-81-0
4-Nitrophenacyl bromide

: 88260-40-6
(4-nitrophenacyl)hexaminium bromide

Conditions

Conditions	Yield
In chloroform for 2h;	100%
In chloroform at 20℃; for 12h; Delepine reaction;

: 100-97-0
hexamethylenetetramine

: 3289-75-6
2-chloro-N-(4-chlorophenyl)acetamide

: 79988-56-0
N,N'-methylenebis<3-(4-chlorophenyl)>-4-imidazolidinone

Conditions

Conditions	Yield
In ethanol 60 deg C, 1 h, then reflux, 1.5 h;	100%

: 100-97-0
hexamethylenetetramine

: 74-88-4
methyl iodide

: 50982-79-1
N-methylhexamethylenetetrammonium iodide

Conditions

Conditions	Yield
In chloroform at 20℃;	100%
at 80℃; for 7h; Temperature;	95.8%
In ethanol
In chloroform

: 100-97-0
hexamethylenetetramine

: 60254-03-7
4-tert-butyl-2-(diphenyl-phosphinoyl)-phenol

: 5-tert-butyl-3-(diphenyl-phosphinoyl)-2-hydroxy-benzaldehyde

Conditions

Conditions	Yield
With trifluoroacetic acid for 20h; Heating;	100%

: 858037-60-2
1-benzo[1,3]dioxol-5-yl-2-(2,5-dichloro-phenyl)-ethane-1,2-dione

: 100-97-0
hexamethylenetetramine

: 858037-61-3
5-benzo[1,3]dioxol-5-yl-4-(2,5-dichloro-phenyl)-1H-imidazole

Conditions

Conditions	Yield
With ammonium acetate In acetic acid at 95℃; for 2.5h;	100%

: 835-64-3
2-(2-Hydroxyphenyl)benzoxazole

: 100-97-0
hexamethylenetetramine

: 1275589-01-9
5-(1,3-benzoxazol-2-yl)-4-hydroxyisophthalic aldehyde

Conditions

Conditions	Yield
With trifluoroacetic acid for 48h; Reflux;	100%
With acetic acid In toluene for 18h; Duff reaction; Reflux;	91%
With trifluoroacetic acid Reflux;	91%

: 100-97-0
hexamethylenetetramine

: 2100-42-7
2-chloro-1,4-dimethoxybenzene

: 90064-48-5
2,5-dimethoxy-4-chlorobenzaldehyde

Conditions

Conditions	Yield
With trifluoroacetic acid at 95℃; for 5h;	100%
With trifluoroacetic acid at 95℃;	72.7%

: 120-47-8
Ethyl 4-hydroxybenzoate

: 100-97-0
hexamethylenetetramine

: 329904-04-3
3,5-diformyl-4-hydroxybenzoic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: Ethyl 4-hydroxybenzoate; hexamethylenetetramine With trifluoroacetic acid Reflux; Stage #2: With water at 20 - 80℃; for 2h;	100%
With trifluoroacetic acid
With trifluoroacetic acid Duff Aldehyde Synthesis; Reflux;
With trifluoroacetic acid Duff Aldehyde Synthesis;

: 100-97-0
hexamethylenetetramine

: 99-96-7
4-hydroxy-benzoic acid

: 1384440-57-6
3,5-diformyl-4-hydroxybenzoic acid

Conditions

Conditions	Yield
Stage #1: hexamethylenetetramine; 4-hydroxy-benzoic acid With trifluoroacetic acid for 72h; Reflux; Stage #2: With water at 20 - 80℃; for 4h;	100%
With trifluoroacetic acid at 110℃; for 48h;	70%
With trifluoroacetic acid at 110℃; for 48h;	70%

: cyclopentadienecarboxylic acid manganese tricarbonyl

: 100-97-0
hexamethylenetetramine

: 1416228-92-6
C9H5MnO5*C6H12N4

Conditions

Conditions	Yield
In methanol at 20 - 60℃; Darkness;	100%

: 60468-36-2
α-chloro-2',5'-difluoroacetophenone

: 100-97-0
hexamethylenetetramine

: 1-(2,5-difluorophenyl)ethanone-2-hexamethylentetrammonium chloride

Conditions

Conditions	Yield
In chloroform Solvent; Temperature; Reflux;	100%

: 100-97-0
hexamethylenetetramine

: 69267-75-0
2-bromo-1-cyclopropylethan-1-one

: 1-(2-cyclopropyl-2-oxoethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane bromide

Conditions

Conditions	Yield
In chloroform at 20℃; for 12h;	100%
In chloroform at 20℃; for 12h;	100%

: 542-75-6
E/Z-1,3-Dichloropropene

: 100-97-0
hexamethylenetetramine

: 1-(3-chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride

Conditions

Conditions	Yield
In chloroform at 60℃; for 12h;	99.9%

: 100-97-0
hexamethylenetetramine

: 452-07-3
2,4-difluorobenzyl chloride

: (2,4-difluoro-benzyl)-hexamethylenetetraminium; chloride

Conditions

Conditions	Yield
In toluene for 2h; Solvent; Reflux; Industrial scale;	99.9%

: 10436-39-2
1,1,2,3-Tetrachloropropene

: 100-97-0
hexamethylenetetramine

: N-β,γ,γ-trichloroallylhexamethylenetetramine chloride

Conditions

Conditions	Yield
In chloroform at 60℃; for 12h;	99.6%

: 100-97-0
hexamethylenetetramine

: 16395-67-8
tris-(chloromethyl)amine

Conditions

Conditions	Yield
With phosphorus pentachloride at 100℃; for 5.5h; Neat (no solvent);	99%
With phosphorus pentachloride
With phosphorus pentachloride

: 63158-38-3
2-bromoacetyl-1-methyl-5-nitropyrrole

: 100-97-0
hexamethylenetetramine

: 1-[2-(1-methyl-5-nitro-1H-pyrrol-2-yl)-2-oxo-ethyl]-3,5,7-triaza-1-azonia-tricyclo[3.3.1.13,7]decane; bromide

Conditions

Conditions	Yield
In chloroform Alkylation;	99%
In chloroform	99%

: 100-97-0
hexamethylenetetramine

: 256950-23-9
2-bromo-1-[5-fluoro-2-(methylthio)phenyl]ethanone

: 1-[5-fluoro-2-(methylthio)phenyl]ethanone-2-hexaminium bromide

Conditions

Conditions	Yield
In chloroform at 20℃;	99%

: 100-97-0
hexamethylenetetramine

: 1835-02-5
2-Bromo-1-(3,4-dimethoxyphenyl)ethanone

: 1234216-77-3
2-hexamethylenetetramino-1-(3,4-dimethoxyphenyl)ethanone-2-ium bromide

Conditions

Conditions	Yield
In chloroform at 20℃; for 4h;	99%
In chloroform at 20℃;

: 100-97-0
hexamethylenetetramine

: 1528493-04-0
C76H120O4

: 1528492-99-0
C78H120O6

Conditions

Conditions	Yield
Stage #1: hexamethylenetetramine; C76H120O4 With trifluoroacetic acid at 125℃; for 4h; Stage #2: With hydrogenchloride; water In dichloromethane at 20℃; for 3h;	99%

: 100-97-0
hexamethylenetetramine

: 301221-79-4
4-Bromoacetyl-1-(t-butoxycarbonyl)piperidine

: 1-[2-(1-tert-butoxycarbonyl-piperidin-4-yl)-2-oxo-ethyl]-3,5,7-triaza-1-azonia-tricyclo[3.3.1.13,7]decane bromide

Conditions

Conditions	Yield
In chloroform at 50℃; for 1h;	99%

: 100-97-0
hexamethylenetetramine

: (Z)-3-chloro-2-fl uoro-1-phenylpropene

: (Z)-N-(2-fluoro-3-phenylallyl)urotropinium chloride

Conditions

Conditions	Yield
In dichloromethane for 24h; Reflux;	99%

: 533939-04-7
6-ethyl-1H-pyrrolo[2,3-b]pyridine

: 100-97-0
hexamethylenetetramine

: 6-ethyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde

Conditions

Conditions	Yield
With acetic acid In water at 120℃; for 8h;	99%

: 100-97-0
hexamethylenetetramine

: 2-bromo-1-(tetrahydro-2H-pyran-3-yl)ethan-1-one

: rac-1-{2-[oxan-3-yl]-2-oxoethyl}-1,3,5,7-tetraazatricyclo[3.3.1.13,7]decan-1-ium bromide

Conditions

Conditions	Yield
In chloroform at 20℃; for 12h;	99%

: 271-63-6
7-Azaindole

: 100-97-0
hexamethylenetetramine

: 4649-09-6
1H-pyrrolo[2,3-b]pyridin-3-carbaldehyde

Conditions

Conditions	Yield
With propionic acid In ethanol at 80℃; for 6h; Temperature;	98.9%
Stage #1: 7-Azaindole; hexamethylenetetramine With acetic acid for 6h; Duff reaction; Heating; Stage #2: With water at 20℃; Further stages.;	77%
With acetic acid In water for 12h; Heating / reflux;	76%

Hexamethylenetetramine Consensus Reports

EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

Hexamethylenetetramine Standards and Recommendations

DOT Classification: 4.1; Label: Flammable Solid

Hexamethylenetetramine Specification

The Hexamethylenetetramine is an organic compound with the formula C₆H₁₂N₄. The systematic name of this chemical is 1,3,5,7-tetraazatricyclo[3.3.1.1^3,7]decane. With the CAS registry number 100-97-0, it is also named as 1,3,5,7-tetraazaadamantane. The product's categories are Organics; Amination; Synthetic Organic Chemistry; Organic Chemicals. Besides, it is a white crystalline powder, which should be stored in a cool and ventilated place.

The Hexamethylenetetramine is used in the plastics indusrty, as a solid fuel and in some drugs. The term methenamine (an International Nonproprietary Name) is more common in its medicinal uses, and hexamine is more common in commercial uses. The primary use of Hexamethylenetetramine is in the manufacture of powdery or liquid preparations of phenolic resins and phenolic resin moulding compounds, where hexamine is added as a hardening component. These products are used as binders, e.g. in brake and clutch linings, abrasive products, non-woven textiles, formed parts produced by moulding processes, and fireproof materials. Hexamethylenetetramine is also used as an accelerator for rubber. It is used to some extent in medicine as an internal.

Physical properties about Hexamethylenetetramine are: (1)ACD/BCF (pH 5.5): 1; (2)ACD/BCF (pH 7.4): 1; (3)ACD/KOC (pH 5.5): 12.039; (4)ACD/KOC (pH 7.4): 19.127; (5)#H bond acceptors: 4; (6)Polar Surface Area: 12.96 Å²; (7)Index of Refraction: 1.731; (8)Molar Refractivity: 39.223 cm³; (9)Molar Volume: 98.175 cm³; (10)Polarizability: 15.549×10^-24cm³; (11)Surface Tension: 73.069 dyne/cm; (12)Density: 1.428 g/cm³; (13)Flash Point: 103.945 °C; (14)Enthalpy of Vaporization: 49.006 kJ/mol; (15)Boiling Point: 252.704 °C at 760 mmHg; (16)Vapour Pressure: 0.019 mmHg at 25°C.

Preparation: this chemical can be prepared by 1,3,5,7-tetranitro-[1,3,5,7]tetrazocane. This reaction will need reagent 1-benzyl-1,4-dihydronicotinamide (BNAH, 1) and solvent dimethylformamide. The reaction time is 24 hours. The yield is about 100%.

Uses of Hexamethylenetetramine: it can be used to produce 5-tert-butyl-2-hydroxy-isophthalaldehyde by heating. It will need reagent TFA with reaction time of 24 hours. The yield is about 65%.

When you are using this chemical, please be cautious about it as the following:
It is highly flammable. Besides, this chemical may cause sensitisation by inhalation and skin contact. When you are using it, Wear suitable gloves, do not breathe dust, avoid contact with skin and keep away from sources of ignition - No smoking.

You can still convert the following datas into molecular structure:
(1)SMILES: C1N2CN3CN1CN(C2)C3
(2)InChI: InChI=1/C6H12N4/c1-7-2-9-4-8(1)5-10(3-7)6-9/h1-6H2 CopyCopied
(3)InChIKey: VKYKSIONXSXAKP-UHFFFAOYAW
(4)Std. InChI: InChI=1S/C6H12N4/c1-7-2-9-4-8(1)5-10(3-7)6-9/h1-6H2
(5)Std. InChIKey: VKYKSIONXSXAKP-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	parenteral	200mg/kg (200mg/kg)		International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.
cat	LDLo	subcutaneous	200mg/kg (200mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 84, 1955.
guinea pig	LDLo	subcutaneous	300mg/kg (300mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 84, 1955.
mammal (species unspecified)	LDLo	parenteral	300mg/kg (300mg/kg)		International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.
mouse	LD50	intravenous	17700uL/kg (17.7mL/kg)		Antibiotiki. Vol. 20, Pg. 891, 1975.
mouse	LD50	oral	569mg/kg (569mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 35(3), Pg. 115, 1970.
mouse	LD50	subcutaneous	215mg/kg (215mg/kg)	BEHAVIORAL: TREMOR GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 225, Pg. 428, 1955.
mouse	LDLo	parenteral	450mg/kg (450mg/kg)		International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.
rat	LD50	intravenous	9200mg/kg (9200mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 221, Pg. 166, 1954.
rat	LDLo	parenteral	200mg/kg (200mg/kg)		International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.
rat	LDLo	subcutaneous	200mg/kg (200mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 84, 1955.

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