Hydroxyurea supplier | CasNO.127-07-1

Name
Hydroxyurea
EINECS 204-821-7
CAS No. 127-07-1
Article Data60
CAS DataBase
Density 1.457 g/cm³
Solubility water: 50 mg/mL
Melting Point 135-140 °C
Formula CH₄N₂O₂
Boiling Point 136.04°C (rough estimate)
Molecular Weight 76.055
Flash Point
Transport Information
Appearance off-white crystalline solid
Safety 53-36/37-45-36-22
Risk Codes 46-63-61-40
Molecular Structure
Hazard Symbols T,Xn
Synonyms Urea,hydroxy- (6CI,8CI,9CI);Biosupressin;Carbamohydroxamic acid;Carbamohydroximicacid;Carbamoyl oxime;Droxia;Hydrea;Hydreia;Hydroxycarbamide;Hydroxylamine, N-(aminocarbonyl)-;Hydura;Hydurea;Onco-Carbide;Oxyrea;Oxyurea;
PSA 75.35000
LogP 0.13510

Synthetic route

: 126669-78-1
N-(trimethylsiloxy)-N,N'-bis(trimethylsilyl)urea

: 127-07-1
N-hydroxyurea

Conditions

Conditions	Yield
With ethanol	96%

: 126669-76-9
N-(trimethylsiloxy)-N'-(trimethylsilyl)urea

: 127-07-1
N-hydroxyurea

Conditions

Conditions	Yield
With ethanol at 20℃; for 15h;	94%

: 1118-02-1
trimethylsilyl isocyanate

: 4-(1-phenylethoxy)-2-hydroxyacetophenone

A: N-hydroxy-N-[1-(4-(1-phenylethoxy)-2-hydroxyphenyl)-ethyl]urea

B: 127-07-1
N-hydroxyurea

Conditions

Conditions	Yield
With pyridine; hydrogenchloride; hydroxylamine hydrochloride; hydroxylamine In tetrahydrofuran; ethanol; dichloromethane; water; toluene	A n/a B 78%

...Expand

: 598-55-0
methyl carbamate

: 127-07-1
N-hydroxyurea

Conditions

Conditions	Yield
With hydroxylamine; sodium hydroxide In water at 20℃; for 3.7h; Time;	62.3%

: 420-05-3
cyanic acid

A: 127-07-1
N-hydroxyurea

B: 683-62-5
amino carbamate

Conditions

Conditions	Yield
With diethyl ether; hydroxylamine

: 590-28-3
potassium cyanate

: 127-07-1
N-hydroxyurea

Conditions

Conditions	Yield
With hydroxylamine sulfate
With hydroxylamine hydrochloride

: 590-28-3
potassium cyanate

A: 127-07-1
N-hydroxyurea

B: 683-62-5
amino carbamate

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; water

: 57-13-6
urea

: 127-07-1
N-hydroxyurea

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; water
With Fe(3+), Cu(2+), H2SO4 In not given other Radiation; 20°C; vac.; X-ray irradiatin; concn. of urea 4.6 until 9.1 M in 0.1 N H2SO4;

: 51-79-6
urethane

: 127-07-1
N-hydroxyurea

Conditions

Conditions	Yield
With sodium hydroxide; hydroxylamine hydrochloride
With potassium hydroxide; hydroxylamine sulfate

: 75-13-8
isocyanic acid

: 127-07-1
N-hydroxyurea

Conditions

Conditions	Yield
With sodium hydroxide; hydroxylamine hydrochloride

: 22509-74-6
N-ethoxycarbonylphthalimide

: 127-07-1
N-hydroxyurea

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium methylate

: 2072-71-1
S-carbamoyl-L-cysteine

A: 52-90-4
L-Cysteine

B: 127-07-1
N-hydroxyurea

Conditions

Conditions	Yield
With hydroxylamine In water at 30℃; Product distribution; Kinetics; different concentrations of NH2OH, reaction rate; also with Pseudomonas sp. CU6 cell extract (Km and Vmax) or without additives;

: 1118-02-1
trimethylsilyl isocyanate

: 127-07-1
N-hydroxyurea

Conditions

Conditions	Yield
With ethanol; hydroxylamine hydrochloride; triethylamine 1) temp. rising to 80 degC (exothermic), 2.) heating; Yield given. Multistep reaction;

: N-trimethylsiloxyurea

: 127-07-1
N-hydroxyurea

Conditions

Conditions	Yield
With ethanol; water Heating;

: 7647-01-0
hydrogenchloride

: 17479-46-8
1-Hydroxy-biuret

: 127-07-1
N-hydroxyurea

: 683-62-5
amino carbamate

: 7732-18-5
water

: 127-07-1
N-hydroxyurea

Conditions

Conditions	Yield
at 25℃; Kinetics; Kinetik der Isomerisierung in gepufferten wss. Loesungen vom pH 9.2 bis pH 12.3;

: 590-28-3
potassium cyanate

nitrate hydroxylamine: nitrate hydroxylamine

: 127-07-1
N-hydroxyurea

Conditions

Conditions	Yield
With ethanol at -15 - -10℃; Darstellung in mehreren Stufen;

: 683-62-5
amino carbamate

: 7732-18-5
water

A: 127-07-1
N-hydroxyurea

B: 7803-49-8
hydroxylamine

C cyanate: cyanate

Conditions

Conditions	Yield
in gepufferter wss. Loesung vom pH 9.2 erfolgt Isomerisierung und Zersetzung;

...Expand

: 590-28-3
potassium cyanate

A: 127-07-1
N-hydroxyurea

B isohydroxylurea: isohydroxylurea

Conditions

Conditions	Yield
With hydroxylamine hydrochloride

: 590-28-3
potassium cyanate

: 7803-49-8
hydroxylamine

A: 127-07-1
N-hydroxyurea

B: 17479-46-8
1-Hydroxy-biuret

C: 57-13-6
urea

D isooxyurea: isooxyurea

...Expand

: N,N''-bis-benzoyloxy-oxy-diazenedicarboxamidine

: furan-2,3,5(4H)-trione pyridine (1:1)

A: 127-07-1
N-hydroxyurea

B: 65-85-0
benzoic acid

C nitrogen: nitrogen

...Expand

: hydroxyammonium sulfate

A: 127-07-1
N-hydroxyurea

B: 7664-41-7
ammonia

C: 57-13-6
urea

Conditions

Conditions	Yield
With K cyanate byproducts: K2SO4; addn. of abs. alcohol carbamide formed; hydroxy carbamide formed on cooling the react mixt. and addn. a mixt. of alcohol and ether; filtered out K2SO4;
With K cyanate byproducts: K2SO4; addn. of abs. alcohol carbamide formed; hydroxy carbamide formed on cooling the react mixt. and addn. a mixt. of alcohol and ether; filtered out K2SO4;

...Expand

: 590-28-3
potassium cyanate

: hydroxyammonium sulfate

: 127-07-1
N-hydroxyurea

Conditions

Conditions	Yield
In not given cooling;

: 127-07-1
N-hydroxyurea

: 4996-21-8
1-(4-chloro-phenyl)-2,2-dihydroxy-ethanone

: 1118067-55-2
5-(4-chlorophenyl)-3-hydroxyimidazolidine-2,4-dione

Conditions

Conditions	Yield
Stage #1: N-hydroxyurea; 1-(4-chloro-phenyl)-2,2-dihydroxy-ethanone In acetonitrile at 20℃; for 51h; Stage #2: In acetonitrile Reflux;	100%
With acetic acid at 18 - 19℃; for 24h;	69%

: 127-07-1
N-hydroxyurea

: 530-59-6
trans-3,5-dimethoxy-4-hydroxycinnamic acid

: 1-hydroxy-1-((E)-3-(4-hydroxy-3,5-dimethoxyphenyl)acryloyl)urea

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 2.5h; Inert atmosphere;	100%

: 127-07-1
N-hydroxyurea

: 14737-89-4
3,4-dimethoxy-trans-cinnamic acid

: 1-hydroxy-1-((E)-3-(3,4-dimethoxyphenyl)acryloyl)urea

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 2.5h; Inert atmosphere;	100%

: 127-07-1
N-hydroxyurea

: 16208-17-6
2,2-dihydroxy-1-(4-methoxyphenyl)ethan-1-one

: 3-hydroxy-5-(4-methoxyphenyl)imidazolidine-2,4-dione

Conditions

Conditions	Yield
With acetic acid at 19 - 20℃; for 96h;	95%

: 863718-32-5
4-chloro-2-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine

: 127-07-1
N-hydroxyurea

: 1448530-58-2
1-hydroxy-3-[2-( 3 ,4 ,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl]urea

Conditions

Conditions	Yield
In neat (no solvent) for 0.0125h; Microwave irradiation;	93%

: 127-07-1
N-hydroxyurea

: 139491-37-5
methyl (5'S)-N-<1,3-butadienyl>-2'-oxo-pyrrolidine-5'-carboxylate

A: (S)-1-((S)-2-Carbamoyl-3,6-dihydro-2H-[1,2]oxazin-6-yl)-5-oxo-pyrrolidine-2-carboxylic acid methyl ester

B: (S)-1-((R)-2-Carbamoyl-3,6-dihydro-2H-[1,2]oxazin-6-yl)-5-oxo-pyrrolidine-2-carboxylic acid methyl ester

Conditions

Conditions	Yield
With tetrapropylammonium periodate; 4 A molecular sieve In methanol; dichloromethane at 0℃; for 16h;	A 28% B 92%

...Expand

: 127-07-1
N-hydroxyurea

: 76981-77-6
ethyl 2-cinnamamido-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

: 1448530-47-9
(E)-N-hydroxy-4-oxo-2-styryl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-3(4H)-carboxamide

Conditions

Conditions	Yield
With phosphorus pentoxide; trichlorophosphate for 5h; Reflux;	92%

: 127-07-1
N-hydroxyurea

: 101130-32-9
4-chloro-2-styryl-5,6,7,8-tetrahydrobenzothieno<2,3-d>pyrimidine

: 1448530-59-3
(E)-1-hydroxy-3-(2-styryl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)urea

Conditions

Conditions	Yield
In neat (no solvent) for 0.0125h; Microwave irradiation;	92%

: 127-07-1
N-hydroxyurea

: 100-44-7
benzyl chloride

: 2048-50-2
benzyloxyurea

Conditions

Conditions	Yield
With potassium hydroxide In methanol for 6h; Reflux;	91%
With potassium hydroxide In methanol Reflux;	80%

: 127-07-1
N-hydroxyurea

: 100-39-0
benzyl bromide

: 2048-50-2
benzyloxyurea

Conditions

Conditions	Yield
With potassium hydroxide In methanol for 6h; Reflux; Inert atmosphere;	91%
With potassium hydroxide In methanol for 6h; Reflux;	91%
With potassium hydroxide In methanol for 6h; Reflux;	91%
With potassium hydroxide In methanol for 6h; Reflux;	91%

: 127-07-1
N-hydroxyurea

: 1165952-91-9
cyclohexa-1,3-diene

: 2-oxa-3-azabicyclo[2.2.2]oct-5-ene-3-carboxamide

Conditions

Conditions	Yield
With pyridine; copper(l) chloride In tetrahydrofuran at 20℃; for 2h;	89%
With phosphate buffer; horseradish peroxidase at 20℃; for 1h; pH=7.4;	42%
With Dess-Martin periodane In dichloromethane; N,N-dimethyl-formamide at 20℃; for 1.5h; Oxidation; cycloaddition;	39%
With D-glucose; glucose oxidase; bovine liver catalase In phosphate buffer at 20℃; for 3h; pH=7.4;

: 127-07-1
N-hydroxyurea

: 7550-45-0
titanium tetrachloride

: tetrachlorobis(N-hydroxyurea-N)titanium(IV)

Conditions

Conditions	Yield
In methanol at 20℃; for 18 - 20h; Reflux;	85%

: 127-07-1
N-hydroxyurea

: 824-94-2
p-methoxybenzyl chloride

: 4-methoxybenzyloxyurea

Conditions

Conditions	Yield
With potassium hydroxide In methanol Reflux;	84%

: 127-07-1
N-hydroxyurea

: ruthenium(III) chloride trihydrate

: [aquachlorobis(N′-hydroxycarbamimidato-κO,κN)ruthenium(III)]

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	84%

: 127-07-1
N-hydroxyurea

: 158440-71-2
[14C]-Irofulven

: (R)-1-hydroxy-1-((6’-hydroxy-2’,4’,6’-trimethyl-7’-oxo-6’,7’-dihydrospiro[cyclopropane-1,5’-inden]-3’-yl)methyl)urea

Conditions

Conditions	Yield
With sulfuric acid In water; acetone at 20℃; for 1h;	83%
With sulfuric acid In acetone at 20℃; for 1h; Inert atmosphere;	83%
With sulfuric acid In water; acetone at 20℃; for 24h;	61%

: 51868-95-2
1-(benzo[b]thiophen-2-yl)ethanol

: 127-07-1
N-hydroxyurea

: 142606-21-1, 143200-94-6, 111406-87-2
zileuton

Conditions

Conditions	Yield
With potassium hydrogensulfate; acetic acid In water at 40 - 45℃; for 6h; Product distribution / selectivity;	82%
With hydrogenchloride In tetrahydrofuran; water at 50℃; for 4h;	59.7%
With zinc(II) chloride at 135 - 140℃; for 1h; Product distribution / selectivity;
With hydrogenchloride

: 127-07-1
N-hydroxyurea

: 104-82-5
4-Methylbenzyl chloride

: 338756-47-1
4-methylbenzyloxyurea

Conditions

Conditions	Yield
With potassium hydroxide In methanol Reflux;	82%

: 127-07-1
N-hydroxyurea

: 115-37-7
thebaine

: 75848-83-8
6β,14β-(N-carbamoylepoxyimino)-6,14-dihydrothebaine

Conditions

Conditions	Yield
With sodium periodate; sodium acetate In water; ethyl acetate at 0℃; for 0.5h;	79%

: 127-07-1
N-hydroxyurea

: 638-10-8
ethyl 3-methylbut-2-enoate

: 62243-00-9
5,5-dimethyl-3-isoxazolidinone

Conditions

Conditions	Yield
With potassium methanolate In methanol at 20℃; for 2h;	78.3%

: 127-07-1
N-hydroxyurea

: 1074-12-0
phenylglyoxal hydrate

: 1034164-79-8
3-hydroxy-5-phenylimidazolidine-2,4-dione

Conditions

Conditions	Yield
With water at 18℃; for 24h;	77%

: 72625-07-1
ethyl 2-(3,4,5-trimethoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

: 127-07-1
N-hydroxyurea

: 1448530-34-4
N-hydroxy-4-oxo-2-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-3(4H)-carboxamide

Conditions

Conditions	Yield
With phosphorus pentoxide; trichlorophosphate for 5h; Reflux;	77%

: 127-07-1
N-hydroxyurea

: 80352-42-7
1-(4-bromophenyl)-2,2-dihydroxyethanone

: 5-(4-bromophenyl)-3-hydroxyimidazolidine-2,4-dione

Conditions

Conditions	Yield
With acetic acid at 17 - 18℃; for 26h;	77%

: 127-07-1
N-hydroxyurea

: 589-15-1
1-bromomethyl-4-bromobenzene

: 4-bromobenzyloxyurea

Conditions

Conditions	Yield
With potassium hydroxide In methanol Reflux;	76%

: 127-07-1
N-hydroxyurea

: 1075-06-5
2,2-dihydroxy-1-phenyl-ethanone

: 1034164-79-8
3-hydroxy-5-phenylimidazolidine-2,4-dione

Conditions

Conditions	Yield
With acetic acid at 18 - 19℃; for 24h;	76%
Stage #1: N-hydroxyurea; 2,2-dihydroxy-1-phenyl-ethanone In water at 20℃; Stage #2: In water Heating;

: 127-07-1
N-hydroxyurea

: 4998-15-6
4-chlorophenylglyoxal

: 1118067-55-2
5-(4-chlorophenyl)-3-hydroxyimidazolidine-2,4-dione

Conditions

Conditions	Yield
With water	74%

: 127-07-1
N-hydroxyurea

: 762-42-5
dimethyl acetylenedicarboxylate

A: 77094-88-3
ureidoxymaleate de methyle

B: 77094-89-4
ureidoxyfumarate de methyle

C: 10068-07-2
methyl 3-hydroxy-5-isoxazolecarboxylate

Conditions

Conditions	Yield
With triethylamine In methanol for 0.333333h; Ambient temperature;	A 20% B 7% C 73%
With triethylamine In methanol for 0.333333h; Ambient temperature;	A 20% B 7% C 73%

...Expand

: 127-07-1
N-hydroxyurea

: 345-35-7
2-fluorobenzyl chloride

: 339017-53-7
1-(2-fluorobenzyloxy)urea

Conditions

Conditions	Yield
With potassium hydroxide In methanol Reflux;	73%

Hydroxyurea Consensus Reports

NCI Carcinogenesis Studies (ipr); No Evidence: mouse CANCAR Cancer. 40 (1977),1935. . NCI Carcinogenesis Studies (ipr); Equivocal Evidence: rat CANCAR Cancer. 40 (1977),1935. . EPA Genetic Toxicology Program.

Hydroxyurea Specification

The Hydroxyurea, with the CAS registry number 127-07-1, is also known as Urea, N-hydroxy-. It belongs to the product categories of Miscellaneous Biochemicals; Pharmacetical; Aliphatics; Nucleotides and Nucleosides; Hydroxylamines; Hydroxylamines (N-Substituted); Bases & Related Reagents; Nitric Oxide Reagents; Nucleotides; Carbonyl Compounds; Organic Building Blocks; Ureas; DNA Synthesis Inhibitors; DNA Synthesis Inhibitors Cancer Research; Antitumor Agents; Apoptosis and Cell Cycle; DNA Metabolism; Aids Aided Treatment; Amines. Its EINECS registry number is 204-821-7. This chemical's molecular formula is CH₄N₂O₂ and molecular weight is 76.05. What's more, its IUPAC name is called 1-Hydroxyurea. It should be stored in a cool, dry and well-ventilated place. This chemical can be prepared by Ethyl Carbamate with hydroxylamine hydrochloride.

Physical properties about Hydroxyurea are: (1)ACD/LogP: -1.8; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.80; (4)ACD/LogD (pH 7.4): -1.80; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 2.50; (8)ACD/KOC (pH 7.4): 2.49; (9)#H bond acceptors: 4; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 75.35 Å²; (13)Index of Refraction: 1.501; (14)Molar Refractivity: 15.376 cm³; (15)Molar Volume: 52.161 cm³; (16)Polarizability: 6.096×10^-24 cm³; (17)Surface Tension: 69.72 dyne/cm; (18)Density: 1.458 g/cm³.

Uses of Hydroxyurea: (1) it is used as an anticancer drug; (2) it is used to produce other chemicals. For example, it can react with 2-methyl-3-oxo-butyric acid ethyl ester to get 1-hydroxy-5,6-dimethyl-1H-pyrimidine-2,4-dione. This reaction needs reagent NaOEt and solvent ethanol at ambient temperature. The reaction time is 72 hours. The yield is 60 %.

Hydroxyurea can react with 2-methyl-3-oxo-butyric acid ethyl ester to get 1-hydroxy-5,6-dimethyl-1H-pyrimidine-2,4-dione.

When you are dealing with this chemical, you should be very careful. This chemical may cause damage to health at low levels and may cause heritable genetic damage. It has a carcinogenic effect and may cause harm to the unborn child. Therefore, you should wear suitable protective clothing and gloves. In addition, you should avoid exposuring and obtain special instructions before using it. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice. And in case of accident or if you feel unwell seek medical advice immediately.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C(N)NO
(2) InChI: InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
(3) InChIKey: VSNHCAURESNICA-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	> 1gm/kg (1000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.
dog	LD50	oral	> 2gm/kg (2000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.
human	TDLo	intravenous	86mg/kg (86mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: OTHER CHANGES	Cancer Chemotherapy Reports, Part 1. Vol. 57, Pg. 369, 1973.
human	TDLo	oral	80mg/kg/D (80mg/kg)	BLOOD: NORMOCYTIC ANEMIA BLOOD: LEUKOPENIA BLOOD: THROMBOCYTOPENIA	Cancer Chemotherapy Reports. Vol. 29, Pg. 103, 1963.
man	TDLo	oral	14mg/kg (14mg/kg)		Annals of Pharmacotherpy. Vol. 29, Pg. 132, 1995.
man	TDLo	oral	450mg/kg/21D- (450mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"	Netherlands Journal of Medicine. Vol. 51, Pg. 110, 1997.
man	TDLo	unreported	64mg/kg/3D-I (64mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: COUGH	Australian and New Zealand Journal of Medicine. Vol. 28, Pg. 347, 1998.
mouse	LD10	subcutaneous	2400mg/kg (2400mg/kg)		European Journal of Cancer. Vol. 10, Pg. 667, 1974.
mouse	LD50	intraperitoneal	5800mg/kg (5800mg/kg)		Cancer Research. Vol. 39, Pg. 3575, 1979.
mouse	LD50	intravenous	2350mg/kg (2350mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.
mouse	LD50	oral	7330mg/kg (7330mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.
rat	LD50	intraperitoneal	> 4700mg/kg (4700mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 645, 1968.
rat	LD50	intravenous	4730mg/kg (4730mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.
rat	LD50	oral	5760mg/kg (5760mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.
rat	LD50	unreported	4300mg/kg (4300mg/kg)		Proceedings of the American Association for Cancer Research. Vol. 4, Pg. 10, 1963.
women	TDLo	oral	600mg/kg/30D- (600mg/kg)		Netherlands Journal of Medicine. Vol. 51, Pg. 110, 1997.
women	TDLo	oral	600mg/kg/30D- (600mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Netherlands Journal of Medicine. Vol. 51, Pg. 110, 1997.

Product Name

Hydroxyurea

Synthetic route

Hydroxyurea Consensus Reports

Hydroxyurea Specification

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