L-Aspartic acid supplier

Name
L-Aspartic acid
EINECS 200-291-6
CAS No. 56-84-8
Article Data305
CAS DataBase
Density 1.515 g/cm³
Solubility 5 g/L (25 °C) in water
Melting Point >300 °C (dec.)(lit.)
Formula C₄H₇NO₄
Boiling Point 264.121 °C at 760 mmHg
Molecular Weight 133.104
Flash Point 113.536 °C
Transport Information
Appearance White crystalline powder
Safety 26-24/25-22-36
Risk Codes 36-36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms L-Asparaginic acid;(2S)-2-aminobutanedioic acid;(S)-(+)-Aminosuccinic acid;L-(+)-Aspartic acid;(2S)-Aspartic acid;(+)-Aspartic acid;Aspartic acid, L- (8CI);(S)-Aminobutanedioic acid;L-Aspartate;(S)-Aspartic acid;Aspartic acid, L-;Butanedioic acid, amino-, (S)-;
PSA 100.62000
LogP -0.42670

Synthetic route

: 2177-63-1
(S)-2-amino-4-(benzyloxy)-4-oxobutanoic acid

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With sodium carbonate In water for 24h; Ambient temperature;	100%
With dimethylsulfide; trifluorormethanesulfonic acid; 30 (v/v); trifluoroacetic acid at 0℃; for 4h; Yield given;
With trifluoroacetic acid In dichloromethane at 20℃; Rate constant;
With p-cresol; dimethylsulfide; hydrogen fluoride at 0℃; for 1h; Rate constant;
With E. coli BL21 Star (DE3) S30 extract In aq. buffer at 37℃; for 6h; pH=7.5;

: 7536-58-5
BOC-L-aspartic acid 4-benzyl ester

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With Nafion H; trifluoroacetic acid for 3h;	100%
With HBF4-thioanisole; 3-methyl-phenol In trifluoroacetic acid at 4℃; for 1h; removal of various protecting groups used in peptide synthesis; cleavage of amino acid amides from 4-methylbenzhydrylamine resin;	100%

: 98477-96-4
Boc-Asp(OChp)-OH

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate; methyl-phenyl-thioether In trifluoroacetic acid at 0℃; for 30h;	100%
With trimethylsilyl trifluoromethanesulfonate; methyl-phenyl-thioether In trifluoroacetic acid at 0℃; for 0.5h; Product distribution; New peptide deprotection procedure: hard-soft acid-base concept; the role of soft bases (thioanisole, dimethylsulfide, diphenylsulfide) employed.;	100%

: 115545-59-0
H-Asp-(O-1-Ada)-OH

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With trifluoroacetic acid for 0.0833333h; Ambient temperature;	100%
With trifluoroacetic acid for 0.0833333h; Product distribution; Ambient temperature; Effect of reagents and reaction time.;
With trifluoroacetic acid stability and susceptibility of the Ada protecting group to various acids;

: 115545-60-3
H-Asp-(O-2-Ada)-OH

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With methanesulfonic acid for 0.0833333h; Ambient temperature;	100%

: 4427-49-0
Z(OMe)-Asp-(OBzl)-OH

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate; diphenyl sulfide In trifluoroacetic acid at 0℃; for 0.5h; Product distribution; New peptide deprotection procedure: hard-soft acid-base concept; the role of soft bases (thioanisole, dimethylsulfide, diphenylsulfide) employed; effect of var. hard bases; var. reaction cond.;	100%
With methyl-phenyl-thioether; trimethyl(2,4,6-trimethylphenoxy)silane In trifluoroacetic acid at 22℃; for 1h;	100.5 %

: 231302-81-1
(4S)-3,4-Bis(tert-butoxycarbonyl)tetrahydro-1,3-oxazin-6-one

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran at 20℃;	100%

: (2S,1'S)-2-[(1-phenylethyl)amino]-butanedioic acid hydrochloride

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal	100%

: 13726-67-5
Boc-Asp-OH

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With tetradecyl(trihexyl)phosphonium bistriflamide; trifluoroacetic acid at 130℃; for 0.166667h; Ionic liquid;	99%
at 130℃; for 1h;	81%

: 71989-14-5
Fmoc-(tBu)Asp-OH

A: 56-84-8
L-Aspartic acid

B: 3057-74-7
L-Asp(t-Bu)

Conditions

Conditions	Yield
Stage #1: Fmoc-(tBu)Asp-OH With sodium azide In N,N-dimethyl-formamide at 50℃; for 4h; Stage #2: With piperidine In N,N-dimethyl-formamide	A n/a B 97%

: 110-16-7
maleic acid

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
	95.7%

: C4H7NO4*H3N*ClH

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With ruthenium nanoparticles dispersed in a polyvinylpyrrolidone matrix; amberlyst A-21 In methanol; dichloromethane	95%

: L-(S)-Ni(OC(O)CH(CH(CO2C2H5)2)NC(C6H5)C6H4NC(O)CH(CH2)3NCH2C6H5)

: 105-53-3
diethyl malonate

A: 56-84-8
L-Aspartic acid

B: 96293-17-3, 105024-93-9, 105112-33-2
(S)-N-(2-benzoylphenyl)-1-benzylpyrrolidine-2-carboxamide

C: nickel dichloride

Conditions

Conditions	Yield
In hydrogenchloride boiling for 1 h;;	A 50% B 92% C n/a

...Expand

: 110-17-8
(2E)-but-2-enedioic acid

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With ammonium hydroxide; potassium chloride; magnesium chloride at 30℃; for 72h; with 3-methylaspartase;	90%
With ammonia incubated with β-methylaspartase from Clostridium tetanomorphum;	90%
durch das Ferment Aspartase oder in Gegenwart von Bakterien;

: 136083-57-3, 136083-73-3, 119062-05-4
N-α-9-fluorenylmethoxycarbonyl-aspartic acid

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With sodium azide In N,N-dimethyl-formamide at 50℃; for 24h;	90%

: 112259-66-2
β-cyclohexyl L-aspartate

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With methanesulfonic acid for 2h; Ambient temperature;	86%

: (S)-4-(carboxymethyl)-2,2-borabicycle[3.3.1]nonane-1,3,2-oxazaborolidin-5-one

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water at 20℃; for 0.5h; Inert atmosphere;	81%

: (S)-N-hydroxyaspartic acid

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With platinum(IV) oxide; hydrogen; acetic acid In water optical yield given as %ee;	80%

: 142-42-7
fumarate

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With L384A; ammonia; ammonium chloride; magnesium chloride In water-d2; water at 22℃; for 168h; pH=9; Enzymatic reaction; optical yield given as %ee; stereoselective reaction;	80%

: Dimethyl (2S,4RS)-4-nitro-n-phthaloylglutamate

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With hydrogenchloride; water for 12h; Heating;	78%

: L-isoaspartic acid benzylamido methyl ester hydrochloride

: L-aspartic acid benzylamido methyl ester hydrochloride

A: 56-84-8
L-Aspartic acid

B: 124223-92-3
(3S)-3-amino-1-benzylpyrrolidine-2,5-dione

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water at 55℃; for 0.5h; pH=2 - 11;	A 78% B n/a

...Expand

: 127556-07-4
(2R)-N-<(2S)-2-<amino>-3-<(tert-butyl)oxycarbonyl>propan-1-oyl>bornane-10,2-sultam

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With hydrogenchloride; lithium hydroxide 1.) THF/water, r.t., 24 h, 2.) THF/water 2 : 1, r.t., 24 h;	75%

: 60-18-4
L-tyrosine

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With ruthenium trichloride; sodium periodate; phosphate buffer In tetrachloromethane; acetonitrile for 3h; pH=3; Product distribution; Further Variations:; pH-values;	50%

: 29625-73-8
2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-1-N-(4-L-aspartoyl)-2-deoxy-β-D-glucopyranosylamine

A: 672-15-1
L-homoserine

B: 56-84-8
L-Aspartic acid

C: 29886-32-6
β-D-GlcpNAc(1->4)-D-GlcNAc-ol

Conditions

Conditions	Yield
With sodium hydroxide; sodium tetrahydroborate	A 15% B 3% C 20%

...Expand

: 34557-54-5
methane

: 57-13-6
urea

A: 70-47-3
L-asparagine

B: 56-84-8
L-Aspartic acid

C: 108-80-5
isocyanuric acid

Conditions

Conditions	Yield
With nitrogen; hydrogen In water at -5 - 5℃; under 760.051 Torr; pH=7.1; Electrochemical reaction;	A n/a B n/a C 7.1%

...Expand

: 328-42-7
Oxalacetic acid

: 56-86-0
L-glutamic acid

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With transaminase

: 328-42-7
Oxalacetic acid

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With clostridium saccharobutyricum; hydroxylamine

: 3130-87-8
ASPARAGINE

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With nitric acid Hydrolysis;

: 70-47-3
L-asparagine

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
durch Asparaginase katalysierte Hydrolyse;
durch das Enzym Asparaginase;
With acid

: 67-56-1
methanol

: 56-84-8
L-Aspartic acid

: 6384-18-5
L-Aspartic acid dimethyl ester

Conditions

Conditions	Yield
With thionyl chloride	100%
With thionyl chloride Heating;	100%
With sulfuric acid Reflux;	100%

: 67-56-1
methanol

: 56-84-8
L-Aspartic acid

: 32213-95-9
dimethyl L-aspartate hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 0℃; Reflux; Inert atmosphere;	100%
With thionyl chloride at 20℃; for 48h;	100%
With thionyl chloride for 3h; Inert atmosphere; Reflux;	100%

: 56-84-8
L-Aspartic acid

: 1115-63-5
potassium hydrogen L-aspartate

Conditions

Conditions	Yield
With potassium hydroxide In water Ambient temperature;	100%

: 56-84-8
L-Aspartic acid

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 5269-42-1
L-Aspartic acid bis(trimethylsilyl) ester

Conditions

Conditions	Yield
for 5h; Heating;	100%

: 64-17-5
ethanol

: 56-84-8
L-Aspartic acid

: 16115-68-7
diethyl L-aspartate hydrochloride

Conditions

Conditions	Yield
With acetyl chloride Heating;	100%
With acetyl chloride for 4h; Heating;	100%
With acetyl chloride	100%

: 56-84-8
L-Aspartic acid

: 34029-31-7
(S)-3-amino-3,4-dihydrofurane-2,5-dione hydrochloride

Conditions

Conditions	Yield
With phosphorus trichloride In tetrahydrofuran at 20℃;	100%
With phosphorus trichloride In tetrahydrofuran at 20℃; for 6h;	100%
With trichlorophosphate In tetrahydrofuran at 10 - 20℃; for 13h; Temperature; Large scale;

: 67-56-1
methanol

: 56-84-8
L-Aspartic acid

: 24424-99-5
di-tert-butyl dicarbonate

: 130622-08-1, 55747-84-7
dimethyl N-tert-butoxycarbonyl-L-aspartate

Conditions

Conditions	Yield
Stage #1: methanol; L-Aspartic acid With chloro-trimethyl-silane at 0 - 20℃; for 25h; Inert atmosphere; Stage #2: di-tert-butyl dicarbonate With triethylamine for 2h; Inert atmosphere;	100%
Stage #1: methanol; L-Aspartic acid With chloro-trimethyl-silane at 0 - 20℃; for 48h; Stage #2: di-tert-butyl dicarbonate With triethylamine at 20℃; for 21h;	96%
Stage #1: methanol; L-Aspartic acid With thionyl chloride at 0 - 20℃; for 14h; Inert atmosphere; Stage #2: di-tert-butyl dicarbonate With sodium hydrogencarbonate In dichloromethane; water for 4h; Reflux;	92%

...Expand

: 56-84-8
L-Aspartic acid

: 32213-95-9
dimethyl L-aspartate hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In methanol	100%
With thionyl chloride In methanol; benzene

: 56-84-8
L-Aspartic acid

: Mono magnesium-L-aspartate-hydrochloride

Conditions

Conditions	Yield
Stage #1: L-Aspartic acid With hydrogenchloride In water at 60℃; Stage #2: With magnesium oxide In water	100%
With hydrogenchloride; magnesium oxide In water at 60℃; Product distribution / selectivity;	100%
Stage #1: L-Aspartic acid With magnesium oxide In water at 60℃; Stage #2: With magnesium chloride In water at 60℃; for 2h;
With magnesium oxide; magnesium chloride In water at 60℃; for 2h; Product distribution / selectivity;

: 56-84-8
L-Aspartic acid

: calcium L-aspartate hydrochloride

Conditions

Conditions	Yield
Stage #1: L-Aspartic acid With calcium hydroxide In water at 60℃; for 1h; Stage #2: With calcium chloride In water	100%
Stage #1: L-Aspartic acid With calcium hydroxide In water at 60℃; for 1h; Stage #2: With calcium chloride In water	100%

: calcium dichloride dihydrate

: 56-84-8
L-Aspartic acid

: calcium aspartate hydrochloride

Conditions

Conditions	Yield
In water	100%

: 75-77-4
chloro-trimethyl-silane

: 56-84-8
L-Aspartic acid

: 32213-95-9
dimethyl L-aspartate hydrochloride

Conditions

Conditions	Yield
In methanol at 20℃; for 16h; Cooling with ice; enantioselective reaction;	100%
In methanol at 20℃; for 16h; Cooling with ice;	99.9%

: 56-84-8
L-Aspartic acid

: nicotinic acid riboside 5'-monophosphate

: (S)-1,2-dicarboxyethan-1-aminium-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(((hydroxyoxidophosphoryl)oxy)methyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate

Conditions

Conditions	Yield
In water pH=2.06 - 2.31; Inert atmosphere; Cooling with ice;	100%

: 56-84-8
L-Aspartic acid

: nicotinic acid riboside 5'-monophosphate

: bis((S)-1,2-dicarboxyethan-1-aminium)-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-((phosphonatooxy)methyl)tetrahydrofuran-2-yl)pyridin-4-ium-3-carboxylate

Conditions

Conditions	Yield
In water pH=2.06 - 2.41; Inert atmosphere; Cooling with ice;	100%

: 56-84-8
L-Aspartic acid

: 1094-61-7
nicotinamide mononucleotide

: (S)-1,2-dicarboxyethan-1-aminium-((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In water pH=2.99 - 3.39; Inert atmosphere; Cooling with ice;	100%

: 21205-91-4
9-borabicyclo[3.3.1]nonane dimer

: 56-84-8
L-Aspartic acid

: C12H20BNO4

Conditions

Conditions	Yield
In methanol at 55℃; for 3h; Inert atmosphere;	100%

: 67-56-1
methanol

: 56-84-8
L-Aspartic acid

: 16856-13-6
(+)-β-methyl-L-aspartate hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 5℃; under 825.083 Torr; for 6h; Temperature;	99%
With thionyl chloride at -10 - 20℃; for 0.416667h;	97%
With hydrogenchloride	95%

: 56-84-8
L-Aspartic acid

: 98015-53-3
1,2,2,2-tetrachloroethyl chloroformate

: 114858-45-6
(S)-2-(1,2,2,2-Tetrachloro-ethoxycarbonylamino)-succinic acid

Conditions

Conditions	Yield
In 1,4-dioxane for 2h; Heating;	99%

: 56-84-8
L-Aspartic acid

: 108-24-7
acetic anhydride

: 997-55-7
N-Acetyl-L-aspartic acid

Conditions

Conditions	Yield
In water for 0.0666667h; Irradiation;	99%

: 56-84-8
L-Aspartic acid

: 372-09-8
cyanoacetic acid

Conditions

Conditions	Yield
With sodium hydroxide; trichloroisocyanuric acid at 25℃; for 1h;	99%
With vanadium chloroperoxidase; dihydrogen peroxide; sodium bromide In aq. buffer at 20 - 22℃; for 1h; pH=5.6; Kinetics; Catalytic behavior; Reagent/catalyst; Time; Enzymatic reaction;
With hydrogenchloride; sode de l'acide trichloroisocyanurique In water for 3h;

: 64-18-6
formic acid

: 56-84-8
L-Aspartic acid

: 116147-62-7
n-formyl-l-aspartic anhydride

Conditions

Conditions	Yield
In acetic anhydride at 20 - 70℃; for 12h;	99%

L-Aspartic acid Specification

The L-Aspartic acid, with the CAS registry number 56-84-8,is also known as L(+)-Aspartic acid; L-2-Aminobutanedioic acid; L-Aminosuccinic acid. It belongs to the product categories of pharmaceutical intermediate;sweetener. This chemical's molecular formula is C₄H₇NO₄ and molecular weight is 133.10.Its EINECS number is 200-291-6. What's more,Its systematic name is L-Aspartic acid. It is a White crystalline powder which is used for synthetic sweetener. In medicine, it is used in the treatment of heart disease, and it also used as liver promoting agents, AMMONIA antidote, elimination fatigue, amino acid composition infusion, ect.It is one of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.

L-Aspartic acid has the following datas:
(1)ACD/LogP: -1.075; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -4.50; (4)ACD/LogD (pH 7.4): -4.58; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 5; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 4; (12)Index of Refraction: 1.531; (13)Molar Refractivity: 27.203 cm³; (14)Molar Volume: 87.868 cm³; (15)Surface Tension: 78.2060012817383 dyne/cm; (16)Density: 1.515 g/cm³; (17)Flash Point: 113.536 °C; (18)Enthalpy of Vaporization: 55.259 kJ/mol; (19)Boiling Point: 264.121 °C at 760 mmHg; (20)Vapour Pressure: 0.00300000002607703 mmHg at 25°C.

You could convert the following datas into the molecular structure:
(1)SMILES:C([C@@H](C(=O)O)N)C(=O)O;
(2)Std. InChI:InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1;
(3)Std. InChIKey:CKLJMWTZIZZHCS-REOHCLBHSA-N.

Toxicity of L-Aspartic acid is as follows :

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	6gm/kg (6000mg/kg)		Pharmaceutical Chemistry Journal Vol. 25, Pg. 569, 1991.

Safety Information of L-Aspartic acid:
The L-Aspartic acid is Irritating to eyes, respiratory system and skin and harmful by inhalation, in contact with skin and if swallowed. When you use it ,wear suitable protective clothing,avoid contact with skin and eyes and do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Product Name

L-Aspartic acid

Synthetic route

L-Aspartic acid Specification

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