L-Leucine supplier | CasNO.61-90-5

Name
L-Leucine
EINECS 200-522-0
CAS No. 61-90-5
Article Data417
CAS DataBase
Density 1.036 g/cm³
Solubility 22.4 g/L (20 °C) in water
Melting Point >300 °C(lit.)
Formula C₆H₁₃NO₂
Boiling Point 225.8 °C at 760 mmHg
Molecular Weight 131.175
Flash Point 90.3 °C
Transport Information
Appearance White crystalline powder
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms L(+)-Leucine;.alpha.-Aminoisocaproic acid;2-Amino-4-methylpentanoic acid, (S)-;L-Norvaline, 4-methyl-;L-alpha-Aminoisocaproic acid;Leucine (USP);2-Amino-4-methylvaleric acid (L);(2S)-alpha-Leucine;Pentanoic acid, 2-amino-4-methyl-, (S)-;(S)-2-Amino-4-methyl-pentanoic acid;Leucine, L-;2-Amino-4-methylpentanoic acid;(S)-(+)-leucine;Pentanoic acid, 2-amino-4-methyl-;Leu;Valeric acid, 2-amino-4-methyl-, (S)-;(2S)-2-azaniumyl-4-methyl-pentanoate;(S)-2-Amino-4-methylvaleric acid;(2S)-2-amino-4-methylpentanoic acid;Norvaline, 4-methyl-;L-Leuzin;L-2-Amino-4-methylpentanoic acid;(2S)-alpha-2-Amino-4-methylvaleric acid;FEMA No. 3297;2-Amino-4-methylpentanoic acid (L);(S)-leucine;
PSA 63.32000
LogP 1.14470

Synthetic route

: 439912-47-7
Poc-Leu-OH

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With resin bound tetrathiomolybdate In methanol at 28℃; for 1.5h; ultrasonic bath;	100%

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With water at 170℃; for 0.05h; Microwave irradiation;	100%
With tetradecyl(trihexyl)phosphonium bistriflamide; trifluoroacetic acid at 130℃; for 0.166667h; Ionic liquid;	98%
Multi-step reaction with 3 steps 1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 2: trifluoroacetic acid 3: E. coli BL21 Star (DE3) S30 extract / aq. buffer / 6 h / 37 °C / pH 7.5 View Scheme
Multi-step reaction with 3 steps 1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 2: trifluoroacetic acid 3: E. coli BL21 Star (DE3) S30 extract / aq. buffer / 6 h / 37 °C / pH 7.5 View Scheme
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 2h;

: N-(L-leucyl)-β-D-glucopyranosylamine

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With pronase In water at 37℃; for 46h; Time; Enzymatic reaction;	100%

: 2899-43-6
DL-leucine ethyl ester

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With 3,5-dinitrosalicylaldehyde; Alcalase In water; acetonitrile at 35℃; for 3h; pH=7.5; Enzymatic reaction; optical yield given as %ee;	99%

: (3S,5S)-3-Isobutyl-5-phenyl-morpholin-2-one

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With hydrogen; trifluoroacetic acid; palladium dihydroxide In methanol; water under 3750.3 Torr; for 24h;	98%

: 111-26-2
hexan-1-amine

: 78641-71-1
(S)-2-(3,5-Dinitro-4-oxo-4H-pyridin-1-yl)-4-methyl-pentanoic acid

A: 61-90-5
L-leucine

B: 74197-48-1
1-hexyl-3,5-dinitro-4-pyridone

Conditions

Conditions	Yield
In pyridine Product distribution;	A 97% B n/a

...Expand

: 108437-94-1
(2S,5S)-N-<(S)-N-bis(methylthio)methyleneleucyl>-2,5-bis(methoxymethoxymethyl)pyrrolidine

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With hydrogenchloride for 4h; Heating;	96%

: 328-39-2
LEUCINE

: 61-90-5
L-leucine

Conditions

Conditions	Yield
In water at 37℃; for 2h; NADH, ammonium chloride, sodium formate, D-amino acid oxidase, catalase, leucine dehydrogenase, formate dehydrogenase, Tris-HCl buffer, pH 8.5;	95%
With porcine kidney D-amino acid oxidase (EC 1.4.3.3.); sodium cyanoborohydride; flavin adenine dinucleotide In phosphate buffer at 37℃;	90%
With D-amino acid oxidase; E. coli branched-chain amino acid aminotransferase In water at 37℃; for 72h; Tris buffer, pH 8.5, 1mM EDTA, monosodium glutamate, bovine serum albumin, catalase, pyridoxal 5'-phosphate;	87%

: 98204-51-4
(S)-2-[{(allyloxy)carbonyl}amino]-4-methylpentanoic acid

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With tri-n-butyl-tin hydride; bis-triphenylphosphine-palladium(II) chloride In dichloromethane Ambient temperature;	95%

: 26117-20-4
N-carbamoyl-L-leucine

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With NH4Cl-NH4OH buffer pH 8.5; nickel dichloride at 60℃; for 24h; N-carbamyl-L-amino acid aminohydrolase;	94%
With Tris-HCl buffer; N-carbamoyl-L-amino acid hydrolase; iron(II) sulfate at 30℃; for 2h;
With potassium phosphate buffer; Pseudomonas sp. AJ-11220 In various solvent(s) at 30℃; for 1h;

: 126306-95-4
Diphenyl-N-(benzyloxycarbonyl)-L-leucyl-(2-decarboxy-L-alanin-2-yl)phosphonat

A: 61-90-5
L-leucine

B: 60687-36-7
(R)-(1-aminoethyl)phosphonic acid

Conditions

Conditions	Yield
With hydrogenchloride for 24h; Heating;	A 10% B 88%

: 72-18-4
L-valine

: 3190-70-3, 26334-33-8, 51018-87-2, 51248-35-2
L-Leucin-N-carbonsaeureanhydrid

A: 61-90-5
L-leucine

B: 686-50-0
L-leucyl-glycine

C: 462-60-2
N-carbamoylglycine

D oligomers of leu: oligomers of leu

Conditions

Conditions	Yield
With water; potassium hydroxide; potassium borate buffer at 3℃; Product distribution; effect of use of various amino acid and NCA with various concentrations; effect of use various temp.; extent of hydrolysis;	A n/a B 87.1% C n/a D n/a

...Expand

: 1258442-23-7
C72H135NO7

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃;	86%

: 161123-34-8
(SS,S)-2-(p-toluenesulfinylamino)-4-methylpentanenitrile

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With hydrogenchloride In water for 6h; Heating;	85%

: 66866-66-8
phenylmethyl (4S)-4-(2-methylpropyl)-5-oxo-1,3-oxazolidine-3-carboxylate

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With boron trichloride In dichloromethane at 25℃; for 0.333333h;	84%

: 10250-86-9
4-methyloxovaleric acid anion

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With ammonium formate; tris hydrochloride; nicotinamide adenine dinucleotide; formate dehydrogenase; phenylalanine dehydrogenase In water at 30℃; for 24h;	83%
With L-glutamic acid; pyridoxal 5'-phosphate In water at 40℃; for 18h; E.coli Aspartate transaminase, pH 8;	40%

: 631921-66-9
((S)-1-Cyano-3-methyl-butyl)-carbamic acid methyl ester

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With hydrogenchloride In water for 7h; Heating;	81%

: 1738-77-8
L-leucine benzyl ester p-toluenesulfonate

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With sodium hydrogen telluride In N,N-dimethyl-formamide at 70℃; for 3.5h;	80%

: 2018-66-8
Z-Leu-OH

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With boron trichloride In dichloromethane at 25℃; for 0.333333h;	77%
With hydrogen; palladium on activated charcoal In ethanol at 20℃; for 1h;	22 mg
With cell extract of Sphingomonas paucimobilis SC 16113 In water at 42℃; for 20h; Enzymatic reaction;	100 % Chromat.
With ethylenediaminetetraacetic acid; phenylmethylsulphonyl fluoride; water In aq. phosphate buffer at 30℃; Kinetics; Reagent/catalyst; Microbiological reaction; Enzymatic reaction;
Multi-step reaction with 3 steps 1.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / Cooling with ice 1.2: 15 h / 10 - 35 °C 2.1: 2% active carbon-supported palladium; hydrogen / methanol / 1 h / 10 - 35 °C / 760.05 Torr 3.1: pronase / water / 46 h / 37 °C / Enzymatic reaction View Scheme

: 1374963-75-3
D,L-leucine benzyl ester hydrochloride

: 61-90-5
L-leucine

Conditions

Conditions	Yield
Stage #1: D,L-leucine benzyl ester hydrochloride With lithium carbonate In water; tert-butyl alcohol at 23℃; for 0.166667h; Resolution of racemate; Stage #2: With 2-Hydroxymethylpyridine; Alcalase; water; zinc(II) acetate dihydrate In tert-butyl alcohol at 23℃; for 4h; Resolution of racemate; Enzymatic reaction; optical yield given as %ee;	77%

: Diphenyl-N-(benzyloxycarbonyl)-L-leucyl-(2-decarboxy-D-alanin-2-yl)phosphonat

A: 61-90-5
L-leucine

B: 66068-76-6
(S)-1-aminoethylphosphonic acid

Conditions

Conditions	Yield
With hydrogenchloride for 16h; Heating;	A 28% B 70%

: 4502-00-5
sodium 4-methyl-2-oxovalerate

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With zinc(II) perchlorate; (R)-15-amino-methyl-14-hydroxy-5,5-dimethyl-2,8-dithia<9>(2,5)pyridinophane In methanol for 24h; Ambient temperature;	68%
With leucine dehydrogenase Yield given;

: 67337-73-9
5-isobutyl-imidazolidine-2,4-dione

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With sodium hydroxide; air at 30℃; for 72h; Pseudomonas sp. Strain NS671;	68%

: 95853-80-8
(2S)-(+)-2-<(1S,2S)-(2-Hydroxy-1-hydroxymethyl-2-phenylethyl)amino>-4-methylvaleriansaeure

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With ammonium hydroxide; periodic acid In water for 14h; Ambient temperature;	67%

: C6H13NO2*H3N*ClH

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With ruthenium nanoparticles dispersed in a polyvinylpyrrolidone matrix; amberlyst A-21 In methanol; dichloromethane	65%

: 18869-43-7
DL-leucine methyl ester

: 97985-98-3
p-methoxybenzyloxycarbonyl-Phe-OMe

A: 61-90-5
L-leucine

B: 150296-51-8
Moz-Phe-D-Leu-OMe

Conditions

Conditions	Yield
Stage #1: DL-leucine methyl ester With Alcalase; water In tert-butyl alcohol at 25℃; pH=8.5; kinetic resolution; Stage #2: p-methoxybenzyloxycarbonyl-Phe-OMe With Alcalase In tert-butyl alcohol Condensation;	A n/a B 59%

...Expand

: 1-(1-cyano-3-methyl-butylamino)-5-isopropenyl-2-methyl-cyclohexane-1,3-dicarbonitrile

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With hydrogenchloride at 110℃; for 12h;	52%

: 64143-84-6
(2S)-(N-para-toluenesulphonylamino)-4-methylpentanoic acid tert-butyl ester

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid; phenol for 24h; Ambient temperature;	49%
With hydrogen bromide; acetic acid 1.) phenol, 25 deg C, 24 h;

: 99-15-0
N-acetylleucine

: 61-90-5
L-leucine

Conditions

Conditions	Yield
With sodium hydroxide; acylase Amano 30000 from Aspergillus spp. (30 u/mg); water; cobalt(II) chloride at 37 - 40℃; for 48h;	39%
Herstellung mit Hilfe eines Enzym-Praeparats aus Aspergillus und Penicillium;

: 67-56-1
methanol

: 61-90-5
L-leucine

: 2666-93-5
(S)-Leu-OMe

Conditions

Conditions	Yield
With thionyl chloride	100%
With thionyl chloride	100%
With thionyl chloride at 0 - 20℃;	94%

: 64-17-5
ethanol

: 61-90-5
L-leucine

: 2743-60-4
L-Leucine ethyl ester

Conditions

Conditions	Yield
With thionyl chloride	100%
With amberlyst-15 Ambient temperature;	77%
With thionyl chloride for 10h; Heating;	70%

: 61-90-5
L-leucine

: 501-53-1
benzyl chloroformate

: 2018-66-8
Z-Leu-OH

Conditions

Conditions	Yield
With sodium hydroxide In water at 0 - 20℃;	100%
With sodium hydroxide at 0℃; for 1h;	99%
With sodium hydroxide In water at 20℃; for 2h;	92%

: 61-90-5
L-leucine

: 79-22-1
methyl chloroformate

: 74761-37-8
(S)-2-(methoxycarbonylamino)-4-methylpentanoic acid

Conditions

Conditions	Yield
Stage #1: L-leucine; methyl chloroformate With sodium hydroxide In 1,4-dioxane; water at 0 - 60℃; for 18h; pH=8 - 9; Stage #2: With hydrogenchloride In water	100%
Stage #1: L-leucine; methyl chloroformate With sodium hydroxide In water at 0 - 20℃; Stage #2: With hydrogenchloride In water	84%
With alkali In water	75%

: 61-90-5
L-leucine

: 99-33-2
3,5-dinitrobenoyl chloride

: 7495-01-4
(S)-N-(3,5-dinitrobenzoyl)leucine

Conditions

Conditions	Yield
With methyloxirane In tetrahydrofuran at 25℃; for 0.25h;	100%
With methyloxirane In tetrahydrofuran for 2h; Ambient temperature;	94%
With sodium hydroxide
In tetrahydrofuran Ambient temperature; 7 - 10 days; Yield given;

: 50-00-0
formaldehyd

: 61-90-5
L-leucine

: 2439-37-4
(S)-2-dimethylamino-4-methyl-pentanoic acid

Conditions

Conditions	Yield
With sodium cyanoborohydride; acetic acid In water; acetonitrile at 22℃; for 1h; pH=Ca.7; Inert atmosphere;	100%
With sodium dihydrogenphosphate; zinc at 30℃; for 20h;	95%
With sodium tetrahydroborate In 2,2,2-trifluoroethanol for 48h; Reflux;	88%

: 61-90-5
L-leucine

: 24424-99-5
di-tert-butyl dicarbonate

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane at 25℃; for 23h;	100%
With sodium hydroxide In 1,4-dioxane; water at 0℃;	100%
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 19h;	99%

: 67-56-1
methanol

: 61-90-5
L-leucine

: 7517-19-3
methyl (L)-leucinate hydrochloride

Conditions

Conditions	Yield
Stage #1: methanol With thionyl chloride for 1h; Cooling with ice; Stage #2: L-leucine at 20 - 66℃; for 6.5h;	100%
With thionyl chloride at 20℃; for 4h;	99%
With thionyl chloride	99%

: 61-90-5
L-leucine

: 22509-74-6
N-ethoxycarbonylphthalimide

: 2419-38-7
N-phthaloyl-(S)-leucine

Conditions

Conditions	Yield
With sodium carbonate In water at 20℃; for 2h;	100%
With sodium carbonate In water at 20℃; for 2h;	100%
With sodium hydrogencarbonate In water for 1h; Ambient temperature;	66%
With sodium carbonate In water	35%
With sodium carbonate In water at 20℃; for 5h;

: 61-90-5
L-leucine

: 104-15-4
toluene-4-sulfonic acid

: 100-51-6
benzyl alcohol

: 1738-77-8
L-leucine benzyl ester p-toluenesulfonate

Conditions

Conditions	Yield
In cyclohexane; water for 4h; Dean-Stark; Reflux;	100%
In toluene for 20h; Reflux;	85%
In toluene for 4h; Reflux; Inert atmosphere;	82%

...Expand

: 61-90-5
L-leucine

: 128-69-8
perylene-3,4,9,10-tetracarboxylic acid 3,4:9,10-dianhydride

: N,N'-bis((S)-1-carboxy-3-methylbutyl)-3,4:9,10-perylenetetracarboxylic diimide

Conditions

Conditions	Yield
With 1H-imidazole at 100℃; for 1h; Inert atmosphere;	100%
With 1H-imidazole at 120℃; for 0.5h;	97%
With 1H-imidazole at 120℃;	95.4%

: 61-90-5
L-leucine

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 893447-84-2
L,L-leucine 1,4-cyclohexanedimethanol diester

Conditions

Conditions	Yield
Stage #1: L-leucine; bis-1,4-(hydroxymethyl)cyclohexane With toluene-4-sulfonic acid In toluene at 150℃; for 30h; Heating / reflux; Stage #2: With sodium hydrogencarbonate In water; toluene at 60℃;	100%

: 61-90-5
L-leucine

: 105-08-8
bis-1,4-(hydroxymethyl)cyclohexane

: 893447-84-2
L,L-leucine 1,4-cyclohexanedimethanol diester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 20 - 150℃; for 30h; Heating / reflux;	100%

: 878630-78-5
1-[(1-benzothien-2-ylcarbonyl)oxy]-2,5-pyrrolidinedione

: 61-90-5
L-leucine

: 215941-14-3
(benzo[b]thiophene-2-carbonyl)-l-leucine

Conditions

Conditions	Yield
With triethylamine In ethanol; dichloromethane; water at 20℃;	100%
Stage #1: 1-[(1-benzothien-2-ylcarbonyl)oxy]-2,5-pyrrolidinedione; L-leucine With triethylamine In ethanol; dichloromethane; water at 20℃; Stage #2: With hydrogenchloride In dichloromethane; water	100%
Stage #1: 1-[(1-benzothien-2-ylcarbonyl)oxy]-2,5-pyrrolidinedione; L-leucine With triethylamine In ethanol; dichloromethane; water at 5 - 20℃; for 18.1667h; Stage #2: With hydrogenchloride In ethanol; dichloromethane; water
With triethylamine In ethanol; dichloromethane; water at 5 - 20℃;
With triethylamine In ethanol; dichloromethane; water at 5 - 20℃;

: 61-90-5
L-leucine

: 63-91-2
L-phenylalanine

: 60-18-4
L-tyrosine

: 56-40-6
glycine

: 60117-24-0
H-Tyr-Gly-Gly-Phe-Leu-NH2

Conditions

Conditions	Yield
Stage #1: L-tyrosine With BF4(1-)*C7H13N3Pol(1+); benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 25℃; for 1h; Ionic liquid; Automated synthesizer; solid phase reaction; Stage #2: glycine In 1-methyl-pyrrolidin-2-one at 25℃; for 1h; Ionic liquid; Automated synthesizer; solid phase reaction; Stage #3: L-leucine; L-phenylalanine Further stages;	100%

Yield

Stage #1: L-tyrosine With BF4(1-)*C7H13N3Pol(1+); benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 25℃; for 1h; Ionic liquid; Automated synthesizer; solid phase reaction;
Stage #2: glycine In 1-methyl-pyrrolidin-2-one at 25℃; for 1h; Ionic liquid; Automated synthesizer; solid phase reaction;
Stage #3: L-leucine; L-phenylalanine Further stages;

100%

...Expand

: 59985-82-9
5-phenylisoxazole-3-carbaldehyde

: 61-90-5
L-leucine

: C16H17N2O3(1-)*Li(1+)

Conditions

Conditions	Yield
With lithium hydride In methanol Reflux;	100%

: 59985-82-9
5-phenylisoxazole-3-carbaldehyde

: 61-90-5
L-leucine

: C16H17N2O3(1-)*Na(1+)

Conditions

Conditions	Yield
With sodium methylate In methanol Reflux;	100%

: 59985-82-9
5-phenylisoxazole-3-carbaldehyde

: 61-90-5
L-leucine

: C16H17N2O3(1-)*Cs(1+)

Conditions

Conditions	Yield
With caesium carbonate In methanol Reflux;	100%

: 59985-82-9
5-phenylisoxazole-3-carbaldehyde

: 61-90-5
L-leucine

: 2C16H17N2O3(1-)*Ca(2+)

Conditions

Conditions	Yield
With calcium hydride In methanol Reflux;	100%

: 61-90-5
L-leucine

: 640292-02-0
5-(4-methylphenyl)-1,2-oxazole-3-carbaldehyde

: C17H19N2O3(1-)*Li(1+)

Conditions

Conditions	Yield
With lithium hydride In methanol Reflux;	100%

: 61-90-5
L-leucine

: 640292-02-0
5-(4-methylphenyl)-1,2-oxazole-3-carbaldehyde

: C17H19N2O3(1-)*Na(1+)

Conditions

Conditions	Yield
With sodium methylate In methanol Reflux;	100%

: 61-90-5
L-leucine

: 640292-02-0
5-(4-methylphenyl)-1,2-oxazole-3-carbaldehyde

: C17H19N2O3(1-)*Cs(1+)

Conditions

Conditions	Yield
With caesium carbonate In methanol Reflux;	100%

: 61-90-5
L-leucine

: 640292-02-0
5-(4-methylphenyl)-1,2-oxazole-3-carbaldehyde

: 2C17H19N2O3(1-)*Ca(2+)

Conditions

Conditions	Yield
With calcium hydride In methanol Reflux;	100%

: 61-90-5
L-leucine

: 5394-63-8
2,2,6-trimethyl-4H-1,3-dioxin-4-one

: 1803-64-1
(3-oxobutanoyl)-L-leucine

Conditions

Conditions	Yield
With potassium carbonate In water for 2h; Reflux;	100%

: 61-90-5
L-leucine

: 60702-69-4
2-chloro-4-fluorobenzonitrile

: N-(3-chloro-4-cyanophenyl)-L-leucine

Conditions

Conditions	Yield
With caesium carbonate at 90℃; for 12h;	100%

: 61-90-5
L-leucine

: 17720-18-2
1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate

: 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate (S)-2-ammonio-4-methylpentanoate

Conditions

Conditions	Yield
In water pH=5.61; Cooling with ice;	100%

L-Leucine Consensus Reports

Reported in EPA TSCA Inventory.

L-Leucine Specification

1. Introduction of L-Leucine

L-Leucine, with the IUPAC Nameof (2S)-2-amino-4-methylpentanoic acid, is one kind of white crystalline powder. For being stable in the normal condition, it si sensitive to moisture and light, and this chemical is incompatible with strong oxidising agents. Besides, it belongs to the Product Categories which include Food and Feed Additive; Amino Acid Derivatives; Leucine [Leu, L]; Amino Acids; Amino Acids and Derivatives; alpha-Amino Acids; Biochemistry; Nutritional Supplements; L-Amino Acids; Amino Acids.

2. Properties of L-Leucine

L-Leucine has the following property datas: (1)Index of Refraction: 1.462; (2)Molar Refractivity: 34.86 cm³; (3)Molar Volume: 126.6 cm³; (4)Polarizability: 13.82×10-24cm³; (5)Surface Tension: 39 dyne/cm; (6)Density: 1.035 g/cm³; (7)Flash Point: 90.3 °C; (8)Enthalpy of Vaporization: 50.93 kJ/mol; (9)Melting Point: >300 °C(lit.); (10)Boiling Point: 225.8 °C at 760 mmHg; (11)Vapour Pressure: 0.0309 mmHg at 25°C; (12)Solubility: 1 M HCl: 50 mg/mL; (13)Water Solubility: 22.4 g/L (20 C).

3. Structure Descriptors of L-Leucine

You could convert the following datas into the molecular structure:
(1). InChI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
(2). InChIKey: InChIKey=ROHFNLRQFUQHCH-YFKPBYRVSA-N
(3). Smiles: C([C@@H](C(O)=O)N)C(C)C

4. Toxicity of L-Leucine

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rabbit	LDLo	subcutaneous	2620mg/kg (2620mg/kg)		Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 40, Pg. 313, 1898.
rat	LD50	intraperitoneal	5379mg/kg (5379mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives of Biochemistry and Biophysics. Vol. 58, Pg. 253, 1955.

5. Safety Information of L-Leucine

Safety Statements of L-Leucine (CAS NO.61-90-5): 24/25
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
RTECS: OH2850000
HS Code: 29224995
Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.

6. Use and Preparation of L-Leucine

L-Leucine is used for pharmaceutical raw materials and food additives. As a food additive, it has E number E641 and is classified as a flavour enhancer.

Product Name

L-Leucine

Synthetic route

L-Leucine Consensus Reports

L-Leucine Specification

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