Levosulpiride supplier | CasNO.23672-07-3

Name
Levosulpiride
EINECS 239-753-7
CAS No. 23672-07-3
Article Data3
CAS DataBase
Density 1.236 g/cm³
Solubility
Melting Point 183-186 °C(lit.)
Formula C₁₅H₂₃N₃O₄S
Boiling Point
Molecular Weight 341.431
Flash Point
Transport Information
Appearance white crystalline powder
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Benzamide,5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-, (S)-;o-Anisamide, N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-sulfamoyl-, (-)- (8CI);(-)-Sulpiride;L-Sulpiride;Levobren;Levopraid;
PSA 110.11000
LogP 2.66660

Levosulpiride Specification

Levosulpiride, its cas register number is 23672-07-3. It also can be called (S)-(-)-Sulpiride; (S)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide; (-)-N-(((S)-1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide; Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (S)- (9CI); o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-, (S)-(-)- . It is an antipsychotic. Levosulpiride is used in the treatment of psychoses, particularly negative symptoms of schizophrenia, anxiety disorders, dysthymia, vertigo, dyspepsia, irritable bowel syndrome and premature ejaculation.

Physical properties about Levosulpiride are: (1)ACD/LogP: 0.776; (2)ACD/LogD (pH 5.5): -2.24; (3)ACD/LogD (pH 7.4): -1.08; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 7; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 6; (11)Index of Refraction: 1.552; (12)Molar Refractivity: 88.183 cm³; (13)Molar Volume: 276.104 cm³; (14)Polarizability: 34.958 10-24cm³; (15)Surface Tension: 45.8950004577637 dyne/cm; (16)Density: 1.237 g/cm3

You can still convert the following datas into molecular structure:
(1)InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21);
(2)InChIKey=BGRJTUBHPOOWDU-UHFFFAOYSA-N;
(3)Smilesc1(c(ccc(c1)S(N)(=O)=O)OC)C(NC[C@@H]1[N@@](CCC1)CC)=O;

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	170mg/kg (170mg/kg)	European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 17, Pg. 437, 1982.
mouse	LD50	oral	2450mg/kg (2450mg/kg)	Drugs of the Future. Vol. 12, Pg. 944, 1987.
rabbit	LD50	intravenous	42mg/kg (42mg/kg)	Drugs of the Future. Vol. 12, Pg. 944, 1987.
rabbit	LD50	oral	> 1500mg/kg (1500mg/kg)	Drugs of the Future. Vol. 12, Pg. 944, 1987.
rat	LD50	intraperitoneal	270mg/kg (270mg/kg)	Drugs of the Future. Vol. 12, Pg. 944, 1987.
rat	LD50	intravenous	53mg/kg (53mg/kg)	Drugs of the Future. Vol. 12, Pg. 944, 1987.
rat	LD50	oral	2600mg/kg (2600mg/kg)	Drugs of the Future. Vol. 12, Pg. 944, 1987.

Product Name

Levosulpiride

Levosulpiride Specification

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