METHYL LACTATE supplier | CasNO.547-64-8

Name
Methyl lactate
EINECS 208-930-0
CAS No. 547-64-8
Article Data161
CAS DataBase
Density 1.085 g/cm³
Solubility miscible, hydrolyses with water
Melting Point -66°C
Formula C₄H₈O₃
Boiling Point 145.3 °C at 760 mmHg
Molecular Weight 104.106
Flash Point 47.1 °C
Transport Information UN 3272 3/PG 3
Appearance clear colorless liquid
Safety 24
Risk Codes 10-36/37
Molecular Structure
Hazard Symbols Xi
Synonyms DL-Methyllactate;Methyl 2-hydroxypropanoate;Methyl 2-hydroxypropionate;Methyllactate;Methyl a-hydroxypropionate;NSC 406248;
PSA 46.53000
LogP -0.45980

Synthetic route

: 600-22-6
pyruvic acid methyl ester

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With magnesium(II) perchlorate; polymer-bound NADH (2a) In acetonitrile; benzene at 80℃; for 120h; Further byproducts given;	100%
With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)-amino]ruthenium(II); hydrogen; sodium hydrogencarbonate In methanol at 25℃; under 7500.75 Torr; for 12h; Glovebox; Autoclave; chemoselective reaction;	98%
With hydrogen; Et4N	91%

: 67-56-1
methanol

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
tetrabutoxytitanium at 170℃; for 4h; Product distribution / selectivity;	99.8%

: 67-56-1
methanol

: 96-26-4
dihydroxyacetone

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With tin containing MWW type β-zeolite In decane at 119.84℃; for 24h; Reagent/catalyst;	99%
With Y-zeolite H-USY-6 In water at 115℃; for 24h; Inert atmosphere;	96%
With Sn(salen) functionalized [OMIm]Br at 160℃; under 15001.5 Torr; for 2h; Inert atmosphere; Autoclave; chemoselective reaction;	95.5%

: 67-56-1
methanol

: 56-82-6
Glyceraldehyde

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With tin containing MWW type β-zeolite In decane at 119.84℃; for 24h; Reagent/catalyst;	99%
With Y-zeolite H-USY-6 In water at 115℃; for 48h; Inert atmosphere;	98%
With Sn(salen) functionalized [OMIm]Br at 160℃; under 15001.5 Torr; for 2h; Inert atmosphere; Autoclave; chemoselective reaction;	91.7%

: 75-07-0
acetaldehyde

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
	98.8%

: 67-56-1
methanol

: 849585-22-4
LACTIC ACID

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With iron(III) sulfate; sulfuric acid for 3h; Heating;	97%
With ethenetetracarbonitrile for 48h; Ambient temperature;	88%
at 25 - 72℃; Product distribution / selectivity;	87%

: 67-56-1
methanol

: 56-81-5
glycerol

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With phosphotungstic acid at 130℃; for 4h; Reagent/catalyst; Autoclave; Inert atmosphere; Green chemistry;	96%
With Na/MgO at 160℃; under 30402 Torr; for 5h; Reagent/catalyst; Inert atmosphere;	80%
With magnesium oxide at 300℃; under 150015 Torr; for 1.5h; Reagent/catalyst; Temperature; Inert atmosphere; Sealed tube;	23.9 mol
With oxygen at 160℃; under 3750.38 Torr; Reagent/catalyst; Temperature; Autoclave;
With air; AuPd/carbon nanotubes + Sn-MCM-41-XS at 140℃; under 22502.3 Torr; for 4.5h; Catalytic behavior; Reagent/catalyst; Autoclave; Green chemistry;	90 %Chromat.

: 67-56-1
methanol

: 138-22-7
n-butyl lactate

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
iodine for 15h; Heating;	90%

: 67-56-1
methanol

: 96-26-4
dihydroxyacetone

A: 547-64-8
methyl lactate

B: 35830-93-4
2-hydroxy-3-methoxypropionaldehyde

Conditions

Conditions	Yield
With calcined Sn-modified beta zeolite at 70℃; for 4h;	A 86% B n/a

...Expand

: 67-56-1
methanol

: 78-97-7
2-hydroxy-propionitrile

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With hydrogenchloride; water at -10 - -5℃; for 4h; Reflux;	85.58%

: 849585-22-4
LACTIC ACID

: 77-76-9
2,2-dimethoxy-propane

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
In methanol	76%

: 67-56-1
methanol

: 127-17-3
2-oxo-propionic acid

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
Multistep reaction;	75%

: 67-56-1
methanol

: 57-48-7
D-Fructose

A: 1917-64-2
5-(methoxymethyl)-2-furaldehyde

B: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With Sn(salen) functionalized [OMIm]Br at 160℃; under 15001.5 Torr; for 2h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; Autoclave; chemoselective reaction;	A 5.4% B 68.9%

...Expand

: 107729-20-4
1-hydroxy-1-methoxypropan-2-one

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
Sn-BEA In methanol at 160℃; under 15001.5 Torr; Product distribution / selectivity; Inert atmosphere of argon;	66%

: 67-56-1
methanol

: 57-50-1
Sucrose

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
Sn-BEA at 160℃; for 20h; Product distribution / selectivity; Inert atmosphere; autoclave;	66%
With Sn(salen) functionalized [OMIm]Br at 160℃; under 15001.5 Torr; for 2h; Inert atmosphere; Autoclave; chemoselective reaction;	56%
With tin containing MWW type β-zeolite In decane at 159.84℃; for 20h; Catalytic behavior; Reagent/catalyst; Autoclave;	50%

: 67-56-1
methanol

inulin: inulin

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With Sn(salen) functionalized [OMIm]Br at 160℃; under 15001.5 Torr; for 2h; Inert atmosphere; Autoclave; chemoselective reaction;	61.8%

: 67-56-1
methanol

: 50-99-7
D-glucose

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With hierarchical Sn-Beta-H-0.3 zeolite at 160℃; under 3750.38 Torr; for 10h; Catalytic behavior; Reagent/catalyst; Solvent; Inert atmosphere;	60%
With tin containing MWW type β-zeolite In decane at 159.84℃; for 20h; Catalytic behavior; Reagent/catalyst; Autoclave;	44%
Sn-BEA at 160℃; for 20h; Inert atmosphere; autoclave;	41%

: 67-56-1
methanol

: 814-80-2
calcium lactate

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With carbon dioxide at 180℃; for 7.37h; Temperature; Sealed tube; Green chemistry;	58.22%
With sulfuric acid at 60 - 80℃; bei pH 1-1.4;

: 57-50-1
Sucrose

A: 849585-22-4
LACTIC ACID

B: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With tin(II) chloride dihdyrate; magnesium(II) chloride hexahydrate In methanol; water at 130℃; Time; Temperature; Sealed tube; Large scale;	A 29% B 57%

: 67-56-1
methanol

: 470-23-5
D-fructose

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With hierarchical Sn-Beta-H-0.3 zeolite at 160℃; under 3750.38 Torr; for 10h; Reagent/catalyst; Temperature; Inert atmosphere;	55%

: 67-56-1
methanol

: 96-26-4
dihydroxyacetone

A: 6342-56-9
Pyruvic aldehyde dimethyl acetal

B: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With calcined Sn-modified MCM-41 at 70℃; for 4h;	A n/a B 54%
With titanium containing MWW type zeolite In decane at 119.84℃; for 24h;	A 26% B 17%
tin(ll) chloride at 90℃; for 3h; Product distribution; Further Variations:; Catalysts; reaction time;	A 2 % Chromat. B 89 % Chromat.

...Expand

: 67-56-1
methanol

: 3458-28-4
D-Mannose

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With hierarchical Sn-Beta-H-0.3 zeolite at 160℃; under 3750.38 Torr; for 10h; Reagent/catalyst; Inert atmosphere;	54%
With tungsten(VI) oxide at 160℃; under 3750.38 Torr; for 5h; Reagent/catalyst; Inert atmosphere; Autoclave;	50 %Chromat.

: 67-56-1
methanol

: 87-72-9, 608-45-7, 608-46-8, 608-47-9, 2460-44-8, 6748-95-4, 6763-34-4, 7261-26-9, 7283-06-9, 7283-07-0, 7296-55-1, 7296-56-2, 7296-58-4, 7296-59-5, 7296-60-8, 7296-61-9, 7296-62-0, 7322-30-7, 10257-31-5, 10257-32-6, 10257-33-7, 10257-34-8, 10257-35-9, 19982-83-3, 20242-88-0, 28697-53-2, 36562-42-2, 41546-41-2, 89299-64-9, 107655-34-5, 115794-06-4, 115794-07-5, 130550-15-1, 130606-21-2
D-Xylose

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With hierarchical Sn-Beta-H-0.3 zeolite at 160℃; under 3750.38 Torr; for 10h; Reagent/catalyst; Inert atmosphere;	53%

cellulose: cellulose

A: 547-64-8
methyl lactate

B: 29674-47-3
methyl 2-hydroxybutyrate

C: 80-62-6
methacrylic acid methyl ester

Conditions

Conditions	Yield
With ortho-tungstic acid In methanol for 2h; Solvent; Reagent/catalyst; Autoclave;	A 16.1% B 6.5% C 48.7%

...Expand

cellulose: cellulose

A: 547-64-8
methyl lactate

B: 624-45-3
levulinic acid methyl ester

C: 80-62-6
methacrylic acid methyl ester

Conditions

Conditions	Yield
With ortho-tungstic acid In ethanol for 2h; Time; Autoclave;	A 15.1% B 8.3% C 48.7%

...Expand

: 67-56-1
methanol

: 87-72-9, 608-45-7, 608-46-8, 608-47-9, 2460-44-8, 6748-95-4, 6763-34-4, 7261-26-9, 7283-06-9, 7283-07-0, 7296-55-1, 7296-56-2, 7296-58-4, 7296-59-5, 7296-60-8, 7296-61-9, 7296-62-0, 7322-30-7, 10257-31-5, 10257-32-6, 10257-33-7, 10257-34-8, 10257-35-9, 19982-83-3, 20242-88-0, 28697-53-2, 36562-42-2, 41546-41-2, 89299-64-9, 107655-34-5, 115794-06-4, 115794-07-5, 130550-15-1, 130606-21-2
D-Xylose

A: 91-09-8, 612-05-5, 1825-00-9, 2500-78-9, 3867-83-2, 3945-28-6, 5328-63-2, 6206-67-3, 6207-01-8, 6207-03-0, 7404-24-2, 17289-61-1, 18449-76-8, 33509-64-7, 36793-06-3, 41897-31-8, 41897-32-9, 41897-33-0, 41897-34-1, 41897-37-4, 41897-38-5, 41897-39-6, 53448-52-5, 65137-86-2, 89615-04-3, 89615-05-4, 131233-91-5, 14703-09-4
methyl xyloside

B: 30934-97-5
2,2-dimethoxyethanol

C: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With Ti-beta zeolite at 160℃; for 2h; Microwave irradiation;	A 48% B 7% C 11%
With Zr-beta zeolite at 160℃; for 2h; Microwave irradiation;	A 39% B 12% C 10%

...Expand

: 67-56-1
methanol

: 57-48-7
D-Fructose

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With tin containing MWW type β-zeolite In decane at 159.84℃; for 20h; Catalytic behavior; Reagent/catalyst; Autoclave;	46%
Sn-BEA at 160℃; for 20h; Product distribution / selectivity; Inert atmosphere; autoclave;	43%
With NiO#ZrO2 at 160℃; for 12h; Reagent/catalyst; Temperature;	42.57%

cellulose: cellulose

A: 547-64-8
methyl lactate

B: 80-62-6
methacrylic acid methyl ester

Conditions

Conditions	Yield
With ortho-tungstic acid In ethanol at 260℃; for 2h; Temperature; Time; Reagent/catalyst; Autoclave;	A 16.2% B 43.8%

: 50-99-7
D-glucose

A: 849585-22-4
LACTIC ACID

B: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With tin(II) chloride dihdyrate; magnesium(II) chloride hexahydrate In methanol; water at 130℃; Reagent/catalyst; Sealed tube; Large scale;	A 31% B 43%

: 101-53-1
p-benzylphenol

: 547-64-8
methyl lactate

: methyl 2-(4-benzylphenoxy)propanoate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran	100%

: 547-64-8
methyl lactate

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 53346-03-5
2-benzyloxypropionic acid methyl ester

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid In hexane; dichloromethane at 20℃; for 16h;	99%
With trifluorormethanesulfonic acid In dichloromethane; cyclohexane at 20℃; for 40h;	72%

: 547-64-8
methyl lactate

: 1550-50-1
1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine

A: 2366-56-5
methyl 2-fluoropropanoate

B: 667-50-5
Difluoroacetic acid N,N-dimethylamide

Conditions

Conditions	Yield
Stage #1: methyl lactate; 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine at 10 - 40℃; for 5h; Stage #2: With triethylamine at 0℃;	A 98.92% B n/a

...Expand

: 547-64-8
methyl lactate

: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
With hydrogenchloride; zinc(II) nitrate; hydroxylamine hydrochloride; oxygen; copper(II) nitrate; sodium hydroxide at 100℃; under 75.0075 Torr; for 8h; Molecular sieve; Autoclave; Green chemistry;	98.9%
With p-methoxybenzenetellurinic acid anhydride In neat (no solvent) at 130℃; for 1h;	90%
With hydrogenchloride; sodium hypobromide In dichloromethane; water at 25℃; for 5h;	90%

: 547-64-8
methyl lactate

: 57-55-6
propylene glycol

Conditions

Conditions	Yield
With trans-RuCl2(PPh3)[PyCH2NH(CH2)2PPh2]; potassium methanolate; hydrogen In tetrahydrofuran at 40℃; under 37503.8 Torr; for 16h;	98%
With C24H38Cl2N3PRu; hydrogen; sodium methylate In isopropyl alcohol at 100℃; under 38002.6 Torr; for 2h; Autoclave;	97%
With potassium tert-butylate; hydrogen; [tris(μ-chloro)bis((triphos)ruthenium(II))] chloride In methanol at 100℃; under 30003 Torr; for 15h; Product distribution / selectivity; Inert atmosphere; Autoclave;	>= 99.9 %Chromat.

: 547-64-8
methyl lactate

A: 79-33-4
L-Lactic acid

B: 17392-83-5
(R)-Methyl lactate

Conditions

Conditions	Yield
With marine microbial esterase In aq. phosphate buffer at 37℃; for 1h; pH=7.5; pH-value; Temperature; Solvent; Reagent/catalyst; Time; Resolution of racemate; Enzymatic reaction; enantioselective reaction;	A n/a B 98%
With water; Candida rugosa lipase In aq. phosphate buffer at 45℃; for 8h; pH=7.2; Enzymatic reaction; enantioselective reaction;	A n/a B n/a

: 547-64-8
methyl lactate

: 23786-14-3
4-methoxy-phenyl acetic acid methyl ester

: 1019196-87-2
4-hydroxy-3-(4-methoxyphenyl)-5-methylfuran-2(5H)-one

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran for 16h; Heating;	97%

: 547-64-8
methyl lactate

: 98-59-9
p-toluenesulfonyl chloride

: 66648-29-1
methyl 2-{[(4-methylphenyl)sulfonyl]oxy}propanoate

Conditions

Conditions	Yield
With trimethylamine hydrochloride; triethylamine In acetonitrile at 0 - 5℃; for 1h;	95%
With pyridine
With dmap; triethylamine In toluene at 0 - 50℃; for 1h; Temperature;	24.5 g

: 110-78-1
Propyl isocyanate

: 547-64-8
methyl lactate

: 117508-43-7
2-Propylcarbamoyloxy-propionic acid methyl ester

Conditions

Conditions	Yield
In toluene at 100℃; for 4h;	95%

: 547-64-8
methyl lactate

: 1028432-04-3
N-(tert-butyldimethylsilyloxy)-4-methylbenzenesulfonamide

: 1028432-16-7
C17H29NO5SSi

Conditions

Conditions	Yield
Stage #1: methyl lactate; N-(tert-butyldimethylsilyloxy)-4-methylbenzenesulfonamide With triphenylphosphine In tetrahydrofuran; toluene for 0.166667h; Mitsunobu Displacement; Inert atmosphere; Cooling with ice; Stage #2: With diethylazodicarboxylate In tetrahydrofuran; toluene at 0 - 10℃; Mitsunobu Displacement; Inert atmosphere;	95%

: 110-91-8
morpholine

: 110-87-2
3,4-dihydro-2H-pyran

: 547-64-8
methyl lactate

: C12H21NO4

Conditions

Conditions	Yield
Stage #1: morpholine; methyl lactate With pyridinium p-toluenesulfonate In tetrahydrofuran at 10℃; for 3h; pH=10; Stage #2: 3,4-dihydro-2H-pyran In dichloromethane at 5 - 10℃; for 15h;	95%

...Expand

: 675-10-5
4-hydroxy-6-methyl-2-pyron

: 547-64-8
methyl lactate

: methyl 2-((6-methyl-2-oxo-2H-pyran-4-yl)oxy)propanoate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; Inert atmosphere;	95%

: 547-64-8
methyl lactate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 119404-55-6
2-(tert-butyl-dimethyl-silanyloxy)-propionic acid methyl ester

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	94%
With 1H-imidazole In dichloromethane at 0 - 20℃; Inert atmosphere;	91%
With 1H-imidazole In dichloromethane at 0 - 20℃; Inert atmosphere;
With 1H-imidazole at 20℃; Inert atmosphere; Cooling;

: 547-64-8
methyl lactate

: 16837-38-0
nicotinic anhydride

: 121985-91-9
Nicotinic acid 1-methoxycarbonyl-ethyl ester

Conditions

Conditions	Yield
With pyridine	93%

: 547-64-8
methyl lactate

: 2-chloroformylthioxanthon

: methyl 2-(thioxanthon-2-formyloxy)propanoate

Conditions

Conditions	Yield
With triethylamine In chlorobenzene at 60 - 70℃; for 5h;	93%

: 104-76-7
2-Ethylhexyl alcohol

: 547-64-8
methyl lactate

: 6283-86-9
2-ethyl-hexyl lactate

Conditions

Conditions	Yield
iodine for 15h; Heating;	92%
With toluene-4-sulfonic acid unter Entfernen des entstehenden Methanols;

: 67-56-1
methanol

: 547-64-8
methyl lactate

: 17639-76-8
methyl 2-methoxypropionate

Conditions

Conditions	Yield
5% by weight NaH2PO4/SiO2 at 260℃; for 60h; Product distribution / selectivity; Gas phase;	91.7%
(3% Li2HPO4, 0.5% MgHPO4 and 0.05% H3PO4)/Al2O3 at 320℃; for 60h; Product distribution / selectivity; Gas phase;	88%
With hydrogen; zirconium(IV) oxide at 220℃; under 37503.8 Torr; for 12h; Reagent/catalyst;	22%

: 547-64-8
methyl lactate

: 1860-19-1
methyl 2-nitrooxypropionate

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 0℃; for 3h;	91%
With sulfuric acid; nitric acid at 0℃;

: 547-64-8
methyl lactate

: 27081-10-3
tropylium tetrafluoroborate

: 134037-35-7
2-(Cyclohepta-2,4,6-trienyloxy)-propionic acid methyl ester

Conditions

Conditions	Yield
With triethylamine In acetonitrile	91%

: 547-64-8
methyl lactate

: 100540-38-3
4-thioxanthonecarbonyl chloride

: methyl 2-(thioxanthon-4-formyloxy)propanoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In chlorobenzene at 80 - 90℃; for 4h; Reagent/catalyst; Temperature;	91%

: 67-56-1
methanol

: 849585-22-4
LACTIC ACID

: 547-64-8
methyl lactate

: 17639-76-8
methyl 2-methoxypropionate

Conditions

Conditions	Yield
(0.1% CaHPO4 and 5% K2HPO4)/SiO2 at 300℃; for 60h; Product distribution / selectivity; Gas phase;	90%

...Expand

: 547-64-8
methyl lactate

: 598-81-2, 2043-43-8, 65144-02-7, 89673-71-2
(+/-)-lactamide

Conditions

Conditions	Yield
With ammonia In methanol Cooling with ice;	90%

METHYL LACTATE Chemical Properties

Synonyms: METHYL DL-LACTATE;METHYL (+/-) LACTATE;METHYL LACTATE;LACTIC ACID METHYL ESTER;DL-METHYL LACTATE;2-HYDROXYPROPANOIC ACID METHYL ESTER;1-hydroxyethanecarboxylicacid,methylester;2-hydroxy-propanoicacimethylester
EINECS: 208-930-0
METHYL LACTATE is the chemical compound with the formula C₄H₈O₃.Its Molecular Weight is 104.1.
Boiling point:35 °C (6 mmHg)
density:1.093 g/mL at 20 °C(lit.)
refractive index:n20/D 1.413
Flash point:49 °C
storage temp.:Flammables area
Water Solubility:miscible, hydrolyses

METHYL LACTATE Toxicity Data With Reference

ipr-rat LDLo:>2 g/kg

JPPMAB Journal of Pharmacy and Pharmacology. 11 (1959),150.

METHYL LACTATE Consensus Reports

Reported in EPA TSCA Inventory.

METHYL LACTATE Safety Profile

Slightly toxic by intraperitoneal route. When heated to decomposition it emits acrid smoke and irritating vapors.
Hazard Codes:Xi
METHYL LACTATE 's Risk Statements:
10:Flammable
36/37:Irritating to eyes and respiratory system
METHYL LACTATE 's Safety Statements:
24:Avoid contact with skin
RIDADR:UN 3272 3/PG 3
WGK Germany:1
RTECS:OD5670000
HazardClass:3.2
PackingGroup:III

Product Name

Methyl lactate

Synthetic route

METHYL LACTATE Chemical Properties

METHYL LACTATE Toxicity Data With Reference

METHYL LACTATE Consensus Reports

METHYL LACTATE Safety Profile

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