Product Name

  • Name

    Methylacetate

  • EINECS 201-185-2
  • CAS No. 79-20-9
  • Article Data815
  • CAS DataBase
  • Density 0.908 g/cm3
  • Solubility water: 250 g/L (20 °C)
  • Melting Point -98 °C
  • Formula C3H6O2
  • Boiling Point 44 °C at 760 mmHg
  • Molecular Weight 74.0794
  • Flash Point 3.2°F
  • Transport Information UN 1231 3/PG 2
  • Appearance colourless liquid
  • Safety 16-26-29-33
  • Risk Codes 11-36-66-67
  • Molecular Structure Molecular Structure of 79-20-9 (Methylacetate)
  • Hazard Symbols FlammableF,IrritantXi
  • Synonyms Devoton;Methyl ester acetic acid;Methyl ethanoate;NSC 405071;Tereton;
  • PSA 26.30000
  • LogP 0.17930

Synthetic route

methanol
67-56-1

methanol

acetic acid
64-19-7

acetic acid

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
ConditionsYield
phosphotungstic acid at 65 - 70℃;100%
With 4-cyclopentyl-2,2,6,6-tetramethyl-[1,4,2,6]oxazadisilinan-4-ium tetrafluroborate for 0.333333h; Microwave irradiation;99%
With iodine In toluene for 6h; Ionic liquid; Reflux;92%
methanol
67-56-1

methanol

ethyl acetate
141-78-6

ethyl acetate

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
ConditionsYield
With dilithium tetra(tert-butyl)zincate at 0℃; for 1h; Temperature; Inert atmosphere;100%
K2CO3 + 5percent Carbowax 6000 at 170℃; Product distribution; various catalysts, various amounts of catalysts;54 % Chromat.
With trans-5,15-bis(2-hydroxy-1-naphthyl)octaethylporphyrine; silver perchlorate In benzene at 50℃; without AgClO4, other catalysts;
3-O-acetyl-1,2,5,6-di-isopropylidene-α-D-glucofuranose
29586-98-9

3-O-acetyl-1,2,5,6-di-isopropylidene-α-D-glucofuranose

A

1,2:5,6-Di-O-isopropylidene-α-D-glucofuranose
582-52-5, 2595-05-3, 10368-86-2, 13100-30-6, 14686-89-6, 23262-79-5, 26597-74-0, 26623-15-4, 38166-58-4, 38166-60-8, 79943-22-9, 83730-28-3

1,2:5,6-Di-O-isopropylidene-α-D-glucofuranose

B

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
ConditionsYield
With n-butylstannoic acid In methanol at 65.4℃; for 2h;A 100%
B n/a
methanol
67-56-1

methanol

acetic acid tert-butyl ester
540-88-5

acetic acid tert-butyl ester

A

acetic acid methyl ester
79-20-9

acetic acid methyl ester

B

tert-butyl alcohol
75-65-0

tert-butyl alcohol

Conditions
ConditionsYield
With triethylamine at 20℃; under 8250660 Torr; for 2h; Product distribution;A 100%
B n/a
...Expand
methanol
67-56-1

methanol

Isopropyl acetate
108-21-4

Isopropyl acetate

A

acetic acid methyl ester
79-20-9

acetic acid methyl ester

B

isopropyl alcohol
67-63-0

isopropyl alcohol

Conditions
ConditionsYield
With triethylamine at 20℃; under 8250660 Torr; for 2h; Product distribution;A 100%
B n/a
...Expand
methanol
67-56-1

methanol

prednisolone 21-acetate
52-21-1

prednisolone 21-acetate

A

prednisolon
50-24-8

prednisolon

B

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
ConditionsYield
With triethylamine at 20℃; under 8250660 Torr; for 2h; Product distribution;A n/a
B 100%
...Expand
triacetylglycerol
102-76-1

triacetylglycerol

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
ConditionsYield
With C16H25N3O2S In methanol at 23℃; for 24h;99%
methanol
67-56-1

methanol

N-acetyl-1,3-oxazol-2-one
60759-49-1

N-acetyl-1,3-oxazol-2-one

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
ConditionsYield
for 10h; Ambient temperature;98%
acetone
67-64-1

acetone

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
ConditionsYield
With triethylamine at 160℃; for 5h; Autoclave; Green chemistry;98%
Acetyl bromide
506-96-7

Acetyl bromide

methoxytriphenylmethane
596-31-6

methoxytriphenylmethane

A

acetic acid methyl ester
79-20-9

acetic acid methyl ester

B

bromo-triphenyl-methane
596-43-0

bromo-triphenyl-methane

Conditions
ConditionsYield
at 70℃; for 13h;A 81%
B 97%
at 70℃; for 13h;A 0.65 g
B 3.39 g
...Expand
sodium acetate
127-09-3

sodium acetate

dimethyl sulfate
77-78-1

dimethyl sulfate

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
ConditionsYield
at 140℃; distillation throuh a vigreux column;95%
4-methylbenzenesulfenic acid methyl ester
67764-21-0

4-methylbenzenesulfenic acid methyl ester

cyclohexene
110-83-8

cyclohexene

A

acetic acid methyl ester
79-20-9

acetic acid methyl ester

B

p-Tolylchlorcyclohexensulfid
29903-51-3

p-Tolylchlorcyclohexensulfid

Conditions
ConditionsYield
With acetyl chloride at 0℃;A n/a
B 95%
...Expand
methanol
67-56-1

methanol

sodium acetate
127-09-3

sodium acetate

A

ethane
74-84-0

ethane

B

acetic acid methyl ester
79-20-9

acetic acid methyl ester

C

acetic acid
64-19-7

acetic acid

Conditions
ConditionsYield
In methanol byproducts: C2H4, CO2; Electrolysis; electrolysis of 3 % soln. of NaCH3CO2 in methanol using polished Pt sheet as anode, no formation of O, HCO2H or CH2O, yield of C2H6 does not depend on temperature;;A 95%
B n/a
C n/a
In methanol byproducts: C2H4, CO2; Electrolysis; electrolysis of 3 % soln. of NaCH3CO2 in methanol using polished Pt sheet as anode, no formation of O, HCO2H or CH2O, yield of C2H6 does not depend on temperature;;A 95%
B n/a
C n/a
...Expand
3,4-dihydronaphthalen-1-yl acetate
19455-84-6

3,4-dihydronaphthalen-1-yl acetate

tributyltin methoxide
1067-52-3

tributyltin methoxide

A

acetic acid methyl ester
79-20-9

acetic acid methyl ester

B

4-tri(n-butyl)stannyloxy-1,2-dihydronaphthalene

4-tri(n-butyl)stannyloxy-1,2-dihydronaphthalene

Conditions
ConditionsYield
at 20℃; for 12h; Inert atmosphere;A n/a
B 95%
...Expand
methyl chloroacetate
96-34-4

methyl chloroacetate

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
ConditionsYield
With sodium tetrahydroborate; tin(ll) chloride In tetrahydrofuran for 2h; Heating;94%
With sodium hydrogensulfide; tin(ll) chloride In tetrahydrofuran; water for 2h; other sulfur and aromatic compounds as hydro-dehalogenation agents; Yield given;
methanol
67-56-1

methanol

acetyl chloride
75-36-5

acetyl chloride

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
ConditionsYield
With zinc(II) oxide at 20℃; for 0.166667h;94%
With 1,4-diaza-bicyclo[2.2.2]octane for 0.0333333h;92%
In acetonitrile at 0 - 25℃; Kinetics; Mechanism; also in the presence of NEt4Cl;
O-methyl selenoacetate
64713-88-8

O-methyl selenoacetate

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
ConditionsYield
With oxygen; methyl iodide; triethylphosphine In benzene at 50℃; for 5h;93%
With oxygen; methyl iodide; triethylphosphine In benzene at 50℃; for 5h; Mechanism; other O-alkyl selenoesters; the other products in the anaerobic conditions;93%
2-(1-ethoxy-ethylidene)-indan-1,3-dione
39560-91-3

2-(1-ethoxy-ethylidene)-indan-1,3-dione

A

acetic acid methyl ester
79-20-9

acetic acid methyl ester

B

Phthalonsaeure-anhydrid
6328-17-2

Phthalonsaeure-anhydrid

Conditions
ConditionsYield
With ozone In dichloromethane at -70℃;A n/a
B 92%
Isopropenyl acetate
108-22-5

Isopropenyl acetate

2-methylphenyl bromide
95-46-5

2-methylphenyl bromide

tributyltin methoxide, acetonyltributyltin

tributyltin methoxide, acetonyltributyltin

A

acetic acid methyl ester
79-20-9

acetic acid methyl ester

B

1-(2-methylphenyl)acetone
51052-00-7

1-(2-methylphenyl)acetone

Conditions
ConditionsYield
dichlorobis(tri-O-tolylphosphine)palladium In toluene at 100℃; for 5h;A n/a
B 91%
...Expand
trans-MeOIr(CO)(PPh3)2
94070-38-9

trans-MeOIr(CO)(PPh3)2

A

HIrCl2(CO)(PPh3)2
17000-10-1

HIrCl2(CO)(PPh3)2

B

CH3C(O)IrCl2(CO){P(C6H5)3}2
33394-10-4

CH3C(O)IrCl2(CO){P(C6H5)3}2

C

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
ConditionsYield
With acetyl chloride In benzene soln. placed in a pressure tube fitted with a Teflon stopcock, degassed (vac.), acetyl chloride distilled onto the soln., stirred (1 h); solvent removed by vac. distillation; relation of yield to by-product yield depending on the purity of CH3COCl used and on the care of work up;A n/a
B n/a
C 91%
...Expand
(acetoxymethyl)dimethylmethoxysilane
18162-90-8

(acetoxymethyl)dimethylmethoxysilane

A

acetic acid methyl ester
79-20-9

acetic acid methyl ester

B

2,2,5,5-tetramethyl-1,4-dioxa-2,5-disilacyclohexane
5895-82-9

2,2,5,5-tetramethyl-1,4-dioxa-2,5-disilacyclohexane

Conditions
ConditionsYield
With dioctyltin(IV) oxide at 120℃; under 52.5053 Torr; for 3h; Concentration; Reagent/catalyst; Inert atmosphere;A 17.9 g
B 91%
acetic acid methyl ester
79-20-9

acetic acid methyl ester

acetic acid methyl ester; deprotonated form
64723-96-2

acetic acid methyl ester; deprotonated form

Conditions
ConditionsYield
With helium; methoxide-d3 anion at 24.85℃; under 0.5 Torr; Kinetics; proton transfer; flowing afterglow;100%
With trifluoromethanide In gas Rate constant; Thermodynamic data; ΔH0, nucleophilic reactions of F3C- at sp2 and sp3 carbon in the gas phase, competitive reactions;
With fluoride In gas production of ionic species in an ion cyclotron spectrometer for laser photodissociation studies;
acetic acid methyl ester
79-20-9

acetic acid methyl ester

acrolein
107-02-8

acrolein

3-hydroxypent-4-enoic acid methyl ester
80959-53-1

3-hydroxypent-4-enoic acid methyl ester

Conditions
ConditionsYield
Stage #1: acetic acid methyl ester With lithium diisopropyl amide In tetrahydrofuran at -78℃;
Stage #2: acrolein In tetrahydrofuran for 0.0833333h;		100%
With lithium diisopropyl amide 1.) THF, -95 deg C, 3 min, 2. ) THF, -95 deg C; Multistep reaction;
With lithium diisopropyl amide 1.) THF, hexanes, -78 deg C, 50 min, 2.) THF, hexanes, -78 deg C, 5 min; Yield given. Multistep reaction;
Stage #1: acetic acid methyl ester With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; Inert atmosphere;
Stage #2: acrolein In tetrahydrofuran; hexane for 0.0833333h; Inert atmosphere;
acetic acid methyl ester
79-20-9

acetic acid methyl ester

benzyl alcohol
100-51-6

benzyl alcohol

Benzyl acetate
140-11-4

Benzyl acetate

Conditions
ConditionsYield
With dilithium tetra(tert-butyl)zincate at 0℃; for 1h; Temperature; Inert atmosphere; Molecular sieve;100%
1,3-dicyclohexyl-imidazol-2-ylidene In tetrahydrofuran at 20℃; for 1h;95%
With 4 A molecular sieve; 1,3-di-tBu-2,3-dihydroimidazole carbene-polydimethylsiloxane at 20℃; for 6h;95%
trans-dichloro(ethylene)(2,4,6-trimethylpyridine)platinum
52341-13-6, 12264-20-9

trans-dichloro(ethylene)(2,4,6-trimethylpyridine)platinum

acetic acid methyl ester
79-20-9

acetic acid methyl ester

trans-dichloro(methyl acetate)(2,4,6-trimethylpyridine)platinum(II)
91068-21-2

trans-dichloro(methyl acetate)(2,4,6-trimethylpyridine)platinum(II)

Conditions
ConditionsYield
In acetic acid methyl ester byproducts: ethylene; Irradiation (UV/VIS);100%
In acetic acid methyl ester Irradiation (UV/VIS); the Pt-complex dissolved in methyl acetate was introduced into a muffshaped Schlenk tube surrounding a 125-W medium-pressure mercury lamp, Philips HPK 125, irradn. for 15 min at room temp., λ<310 nm was eliminated by Pyrex filter; the solvent was removed under reduced pressure at -30°C, the solid was recrystd. at -30°C in pentane-CH2Cl2;85%
acetic acid methyl ester
79-20-9

acetic acid methyl ester

C39H52O5Si
1365268-33-2

C39H52O5Si

C42H58O7Si
1365268-48-9

C42H58O7Si

Conditions
ConditionsYield
Stage #1: acetic acid methyl ester With lithium diisopropyl amide In tetrahydrofuran at -78℃;
Stage #2: C39H52O5Si In tetrahydrofuran at -78℃;		100%
acetic acid methyl ester
79-20-9

acetic acid methyl ester

(4R,5R,6R)-7-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4,6-dimethylhept-2-ynoic acid ethyl ester

(4R,5R,6R)-7-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4,6-dimethylhept-2-ynoic acid ethyl ester

C26H40O6Si

C26H40O6Si

Conditions
ConditionsYield
Stage #1: acetic acid methyl ester With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78 - 0℃; Inert atmosphere;
Stage #2: (4R,5R,6R)-7-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-4,6-dimethylhept-2-ynoic acid ethyl ester In tetrahydrofuran; hexane at -78 - 20℃; for 18h; Inert atmosphere;		100%
acetic acid methyl ester
79-20-9

acetic acid methyl ester

(4R,5R,6R)-7-benzyloxy-5-(4-methoxy-benzyloxy)-4,6-dimethyl-hept-2-ynoic acid ethylester

(4R,5R,6R)-7-benzyloxy-5-(4-methoxy-benzyloxy)-4,6-dimethyl-hept-2-ynoic acid ethylester

C27H32O6

C27H32O6

Conditions
ConditionsYield
Stage #1: acetic acid methyl ester With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78 - 0℃; Inert atmosphere;
Stage #2: (4R,5R,6R)-7-benzyloxy-5-(4-methoxy-benzyloxy)-4,6-dimethyl-hept-2-ynoic acid ethylester In tetrahydrofuran; Hexachlorobutadiene at -78 - 20℃; for 18h; Inert atmosphere;		100%
acetic acid methyl ester
79-20-9

acetic acid methyl ester

(S)-(thiazol-2-ylmethilidene)-p-toluenesulfinamide
1138161-37-1

(S)-(thiazol-2-ylmethilidene)-p-toluenesulfinamide

C14H16N2O3S2

C14H16N2O3S2

Conditions
ConditionsYield
With sodium hexamethyldisilazane In tetrahydrofuran at -78℃; diastereoselective reaction;100%
acetic acid methyl ester
79-20-9

acetic acid methyl ester

propan-1-ol-3-amine
156-87-6

propan-1-ol-3-amine

N-(3-hydroxypropyl)acetamide
10601-73-7

N-(3-hydroxypropyl)acetamide

Conditions
ConditionsYield
for 12h; Heating;99%
In toluene for 120h; Heating / reflux;93%
With Merrifield resin-supported N3=P(MeNCH2CH2)3N In tetrahydrofuran at 23 - 25℃; Inert atmosphere;74%
acetic acid methyl ester
79-20-9

acetic acid methyl ester

ethanolamine
141-43-5

ethanolamine

2-acetylaminoethanol
142-26-7

2-acetylaminoethanol

Conditions
ConditionsYield
With N,N'-Mes2imidazol-2-ylidene In tetrahydrofuran at 23℃; for 24h;99%
With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine In acetonitrile at 20℃; for 15h; Schlenk technique; Inert atmosphere;97%
With Merrifield resin-supported N3=P(MeNCH2CH2)3N In tetrahydrofuran at 23 - 25℃; Inert atmosphere;66%
for 6h; Acylation; Heating;
acetic acid methyl ester
79-20-9

acetic acid methyl ester

A

acetic acid methyl ester; deprotonated form
64723-96-2

acetic acid methyl ester; deprotonated form

B

acetamide anion
63285-19-8

acetamide anion

Conditions
ConditionsYield
With helium; amide at 24.85℃; under 0.5 Torr; Kinetics; Substitution; proton transfer; flowing afterglow;A 99%
B 1%
acetic acid methyl ester
79-20-9

acetic acid methyl ester

(2R,5S,6S,7S)-9-bromo-5-(tert-butyldimethylsilanoxy)-6,7-epoxy-2-methyl-3-methylene-dec-9-enal

(2R,5S,6S,7S)-9-bromo-5-(tert-butyldimethylsilanoxy)-6,7-epoxy-2-methyl-3-methylene-dec-9-enal

5-[2-[3-(2-bromo-allyl)-oxiranyl]-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxy-4-methyl-hex-5-enoic acid methyl ester

5-[2-[3-(2-bromo-allyl)-oxiranyl]-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxy-4-methyl-hex-5-enoic acid methyl ester

Conditions
ConditionsYield
Stage #1: acetic acid methyl ester With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.25h; Inert atmosphere;
Stage #2: (2R,5S,6S,7S)-9-bromo-5-(tert-butyldimethylsilanoxy)-6,7-epoxy-2-methyl-3-methylene-dec-9-enal In tetrahydrofuran; hexane at -78℃; for 0.333333h; Inert atmosphere;		99%
(2R,5S,6S,7S)-9-bromo-5-(tert-butyldimethylsilanyloxy)-6,7-epoxy-2-methyl-3-methylene-dec-9-enal

(2R,5S,6S,7S)-9-bromo-5-(tert-butyldimethylsilanyloxy)-6,7-epoxy-2-methyl-3-methylene-dec-9-enal

acetic acid methyl ester
79-20-9

acetic acid methyl ester

(4R,7S)-7-[(2R,3R)-3-(2-Bromo-allyl)-oxiranyl]-7-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-4-methyl-5-methylene-heptanoic acid methyl ester

(4R,7S)-7-[(2R,3R)-3-(2-Bromo-allyl)-oxiranyl]-7-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-4-methyl-5-methylene-heptanoic acid methyl ester

Conditions
ConditionsYield
Stage #1: acetic acid methyl ester With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.25h; Metallation;
Stage #2: (2R,5S,6S,7S)-9-bromo-5-(tert-butyldimethylsilanyloxy)-6,7-epoxy-2-methyl-3-methylene-dec-9-enal In tetrahydrofuran for 0.166667h; Addition; aldol reaction; Further stages.;		99%
acetic acid methyl ester
79-20-9

acetic acid methyl ester

(-)-(1S,2R,3S,4aR,5S,8S,8aS)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3,8-dimethyl-5-triisopropylsilanyloxy-decahydro-naphthalene-2-carbaldehyde
1187676-83-0

(-)-(1S,2R,3S,4aR,5S,8S,8aS)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3,8-dimethyl-5-triisopropylsilanyloxy-decahydro-naphthalene-2-carbaldehyde

3-[(1S,2R,3S,4aR,5S,8S,8aS)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3,8-dimethyl-5-triisopropylsilanyloxy-decahydro-naphthalen-2-yl]-3-hydroxy-propionic acid methyl ester
1187676-94-3

3-[(1S,2R,3S,4aR,5S,8S,8aS)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3,8-dimethyl-5-triisopropylsilanyloxy-decahydro-naphthalen-2-yl]-3-hydroxy-propionic acid methyl ester

Conditions
ConditionsYield
Stage #1: acetic acid methyl ester With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78 - 0℃; for 0.333333h; Inert atmosphere;
Stage #2: (-)-(1S,2R,3S,4aR,5S,8S,8aS)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3,8-dimethyl-5-triisopropylsilanyloxy-decahydro-naphthalene-2-carbaldehyde In tetrahydrofuran; hexane		99%
Stage #1: acetic acid methyl ester With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78 - 0℃; Inert atmosphere;
Stage #2: (-)-(1S,2R,3S,4aR,5S,8S,8aS)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3,8-dimethyl-5-triisopropylsilanyloxy-decahydro-naphthalene-2-carbaldehyde In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
acetic acid methyl ester
79-20-9

acetic acid methyl ester

ethyl 2-diazo-3-oxobutanoate
2009-97-4

ethyl 2-diazo-3-oxobutanoate

ethyl 2-diazo-3-hydroxy-3-methyl-4-(methoxycarbonyl)butanoate
1443778-65-1

ethyl 2-diazo-3-hydroxy-3-methyl-4-(methoxycarbonyl)butanoate

Conditions
ConditionsYield
Stage #1: acetic acid methyl ester With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
Stage #2: ethyl 2-diazo-3-oxobutanoate In tetrahydrofuran; hexane at -70℃; for 1.5h; Inert atmosphere;
Stage #3: With acetic acid In tetrahydrofuran; hexane at -70 - 20℃; for 0.333333h; Inert atmosphere;		99%

Methyl acetate Chemical Properties

Molecular Structure of Methyl acetate (CAS NO.79-20-9):

IUPAC Name: methyl acetate
Molecular formula: C3H6O2
Molar mass: 74.08 g/mol
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 1
Polar Surface Area: 26.3Å2
Index of Refraction: 1.353
Molar Refractivity: 17.72 cm
Molar Volume: 81.5 cm3
Surface Tension: 21.8 dyne/cm
Density: 0.908 g/cm3
Enthalpy of Vaporization: 30.32 kJ/mol
Boiling Point: 44 °C at 760 mmHg
Vapour Pressure: 368 mmHg at 25°C
Melting point: -98 °C
InChI
InChI=1/C3H6O2/c1-3(4)5-2/h1-2H3
Smiles
C(OC)(C)=O
EINECS: 201-185-2
Storage temp: Flammables area
Water Solubility: 250 g/L (20 ºC)
Merck: 14,6008
BRN: 1736662
Stability: Stable. Extremely flammable - readily forms explosive mixtures with air. Note low flash point and wide explosion limits. Incompatible with strong oxidizing agents, strong bases, strong acids, nitrates. May be moisture sensitive
Classification Code: Human Data; Mutation data; Skin / Eye Irritant; TSCA Flag T [Subject to the Section 4 test rule under TSCA]

Methyl acetate Uses

 Methyl acetate (CAS NO.79-20-9) is used as a solvent in glues, paints, and nail polish removers, in chemical reactions, and for extractions.

Methyl acetate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LCLo inhalation 67gm/m3/1H (67000mg/m3) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS		 Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.
cat LDLo subcutaneous 3gm/kg (3000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA		 Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.
guinea pig LD50 skin > 20mL/kg (20mL/kg)   National Technical Information Service. Vol. OTS0556681,
guinea pig LDLo subcutaneous 3gm/kg (3000mg/kg)   Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.
human TCLo inhalation 15000mg/m3 (15000mg/m3) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: COUGH

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.
mammal (species unspecified) LD50 unreported 214mg/kg (214mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(8), Pg. 107, 1968.
mouse LCLo inhalation 34gm/m3/4H (34000mg/m3) BEHAVIORAL: GENERAL ANESTHETIC Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.
rabbit LD50 intraduodenal 3700mg/kg (3700mg/kg)   Food and Cosmetics Toxicology. Vol. 17, Pg. 859, 1979.
rabbit LD50 oral 3705mg/kg (3705mg/kg)   Industrial Medicine and Surgery. Vol. 41, Pg. 31, 1972.
rabbit LD50 skin > 5gm/kg (5000mg/kg)   Food and Cosmetics Toxicology. Vol. 17, Pg. 859, 1979.
rat LCLo inhalation 32000ppm/4H (32000ppm)   American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.
rat LD50 oral > 5gm/kg (5000mg/kg)   Food and Cosmetics Toxicology. Vol. 17, Pg. 859, 1979.
rat LDLo subcutaneous 8gm/kg (8000mg/kg)   Bolletino della Societe Italiana di Biologia Sperimentale. Vol. 18, Pg. 45, 1943.

Methyl acetate Consensus Reports

Reported in EPA TSCA Inventory.

Methyl acetate Safety Profile

Moderately toxic by several routes. A human systemic irritant by inhalation. A moderate skin and eye irritant. Mutation data reported. Dangerous fire hazard when exposed to heat, flame, or oxidizers. Moderate explosion hazard when exposed to heat or flame. When heated to decomposition it emits acrid smoke and fumes. See also ESTERS.
Hazard Codes of Methyl acetate (CAS NO.79-20-9): FlammableF,IrritantXi
Risk Statements: 11-36-66-67
R11: Highly flammable. 
R36: Irritating to eyes. 
R66: Repeated exposure may cause skin dryness or cracking. 
R67: Vapours may cause drowsiness and dizziness.
Safety Statements: 16-26-29-33
S16: Keep away from sources of ignition. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S29: Do not empty into drains. 
S33: Take precautionary measures against static discharges.
RIDADR: UN 1231 3/PG 2
WGK Germany: 1
RTECS: AI9100000
HazardClass: 3
PackingGroup: II

Methyl acetate Standards and Recommendations

OSHA PEL: TWA 200 ppm; STEL 250 ppm
ACGIH TLV: TWA 200 ppm; STEL 250 ppm
DFG MAK: 200 ppm (610 mg/m3)
DOT Classification:  3; Label: Flammable Liquid

Methyl acetate Analytical Methods

For occupational chemical analysis use NIOSH: Methyl Acetate S42.

Methyl acetate Specification

  Methyl acetate (CAS NO.79-20-9), also known as methyl ethanoate or acetic acid methyl ester , is a clear, flammable liquid with a characteristic, not unpleasant smell. 

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