N-(4-Hydroxyphenyl)glycine supplier

Name
N-(4-HYDROXYPHENYL)GLYCINE
EINECS 204-580-8
CAS No. 122-87-2
Density 1.411 g/cm³
Solubility
Melting Point 244 °C (dec.)(lit.)
Formula C₈H₉NO₃
Boiling Point 446.3 °C at 760 mmHg
Molecular Weight 167.164
Flash Point 223.7 °C
Transport Information
Appearance white to beige-brown or brown-grey powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Glycine,N-(p-hydroxyphenyl)- (6CI,7CI,8CI);4-(Carboxymethylamino)phenol;Iconyl;Monazol;N-(4-Hydroxyphenyl)glycine;N-(p-Hydroxyphenyl)glycine;NSC 9267;Photoglycine;p-Hydroxyanilinoacetic acid;p-Hydroxyphenylaminoacetic acid;p-Hydroxyphenylglycine;
PSA 69.56000
LogP 0.96170

Synthetic route

: 69489-38-9
5-(P-benzyloxyphenyl) hydantoin

: 901188-62-3
(D)-p-benzyloxyphenylglycine

: 122-87-2
N-(hydroxyphenyl)glycine

Conditions

Conditions	Yield
With acetic acid; Pd-C In conc. NaOH; hydrogen	92%

2N-hydrochloric acid: 2N-hydrochloric acid

2.22N-sodium hydroxide: 2.22N-sodium hydroxide

: 56405-21-1
DL-p-hydroxyphenylglycine methyl ester

: 122-87-2
N-(hydroxyphenyl)glycine

Conditions

Conditions	Yield
	76%

...Expand

2N-sodium hydroxide: 2N-sodium hydroxide

: 26850-28-2
4-hydroxyphenyl-glycine ethyl ester

: 122-87-2
N-(hydroxyphenyl)glycine

Conditions

Conditions	Yield
With hydrogenchloride	66.5%

: 2706-75-4
sodium glyoxylate

: 108-95-2
phenol

: 122-87-2
N-(hydroxyphenyl)glycine

Conditions

Conditions	Yield
With ammonium acetate In water	50.4%

: 58645-34-4
potassium glyoxylate

: 108-95-2
phenol

: 122-87-2
N-(hydroxyphenyl)glycine

Conditions

Conditions	Yield
With ammonium acetate In water	33.6%

: 298-12-4
Glyoxilic acid

: 108-95-2
phenol

: 122-87-2
N-(hydroxyphenyl)glycine

Conditions

Conditions	Yield
With ammonium acetate In water	28.9%

: 28363-27-1
2-((4-hydroxyphenyl)amino)acetonitrile

: 122-87-2
N-(hydroxyphenyl)glycine

Conditions

Conditions	Yield
With sodium hydroxide

: 3926-62-3
sodium monochloroacetic acid

: 123-30-8
4-amino-phenol

: 122-87-2
N-(hydroxyphenyl)glycine

Conditions

Conditions	Yield
With water at 85 - 90℃;

: 123-30-8
4-amino-phenol

: 79-11-8
chloroacetic acid

: 122-87-2
N-(hydroxyphenyl)glycine

Conditions

Conditions	Yield
With water
With water; sodium acetate

: 123-30-8
4-amino-phenol

: 79-11-8
chloroacetic acid

A: 122-87-2
N-(hydroxyphenyl)glycine

B: 3987-54-0
(4-hydroxy-phenylimino)-di-acetic acid

Conditions

Conditions	Yield
With sodium hydroxide

...Expand

: 7732-18-5
water

: 123-30-8
4-amino-phenol

: 79-11-8
chloroacetic acid

: 122-87-2
N-(hydroxyphenyl)glycine

...Expand

: 64-17-5
ethanol

: 123-30-8
4-amino-phenol

glyoxal sodium disulfide: glyoxal sodium disulfide

A: 122-87-2
N-(hydroxyphenyl)glycine

B: 83051-82-5
N-(4-hydroxy-phenyl)-glycine-(4-hydroxy-anilide)

...Expand

: 123-30-8
4-amino-phenol

4-amino-phenol chloroacetate: 4-amino-phenol chloroacetate

: 122-87-2
N-(hydroxyphenyl)glycine

Conditions

Conditions	Yield
With water

: 123-30-8
4-amino-phenol

sodium disulfite-compound of glyoxal: sodium disulfite-compound of glyoxal

A: 122-87-2
N-(hydroxyphenyl)glycine

B: 83051-82-5
N-(4-hydroxy-phenyl)-glycine-(4-hydroxy-anilide)

Conditions

Conditions	Yield
With ethanol

...Expand

: 51-78-5
p-aminophenol hydrochloride

: 122-87-2
N-(hydroxyphenyl)glycine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaHSO3 / 20 °C 2: diluted NaOH-solution View Scheme

aqueous sodium nitrite: aqueous sodium nitrite

: 5-(4'-hydroxyphenyl)hydantoic acid

: 122-87-2
N-(hydroxyphenyl)glycine

Conditions

Conditions	Yield
In water

: d-(-)-alpha-phenylglycinol

: d-bromocamphor sulfonic acid monohydrate

A D-p-hydroxyphenylglycine*d-bromocamphor sulfonic acid: D-p-hydroxyphenylglycine*d-bromocamphor sulfonic acid

B: 122-87-2
N-(hydroxyphenyl)glycine

Conditions

Conditions	Yield
In water

...Expand

salt of l-N-methyl ephedrine: salt of l-N-methyl ephedrine

: N-salicyliden-d-p-hydroxyphenyl glycine

: 122-87-2
N-(hydroxyphenyl)glycine

Conditions

Conditions	Yield
With ammonia In hydrogenchloride; dichloromethane; water

: N-acetyl-D-4-hydroxyphenylglycine methyl ester

: 122-87-2
N-(hydroxyphenyl)glycine

Conditions

Conditions	Yield
In hydrogenchloride

: 122-87-2
N-(hydroxyphenyl)glycine

: 56405-21-1
DL-p-hydroxyphenylglycine methyl ester

Conditions

Conditions	Yield
In methanol; HCl (gas)	99%
With thionyl chloride In methanol

: 67-56-1
methanol

: 122-87-2
N-(hydroxyphenyl)glycine

: 56405-21-1
DL-p-hydroxyphenylglycine methyl ester

Conditions

Conditions	Yield
With 732 strong acid resin at 65 - 70℃; Reagent/catalyst;	96.1%
With hydrogenchloride

: 7664-93-9
sulfuric acid

: 122-87-2
N-(hydroxyphenyl)glycine

: 56405-21-1
DL-p-hydroxyphenylglycine methyl ester

Conditions

Conditions	Yield
With ammonium hydroxide In methanol	89.5%

: 24424-99-5
di-tert-butyl dicarbonate

: 122-87-2
N-(hydroxyphenyl)glycine

: 144-55-8
sodium hydrogencarbonate

: 1101105-15-0
(R)-N-(tert-butoxycarbonyl)-4-hydroxyphenylglycine methyl ester

Conditions

Conditions	Yield
With thionyl chloride In methanol; ethyl acetate	87%

...Expand

: 24424-99-5
di-tert-butyl dicarbonate

: 122-87-2
N-(hydroxyphenyl)glycine

: 53249-34-6
N-t-butoxycarbonyl-p-hydroxyphenylglycine

Conditions

Conditions	Yield
With triethylamine In methanol; water; ethyl acetate; benzene	86%

: 122-87-2
N-(hydroxyphenyl)glycine

: 14191-95-8
4-cyanomethylphenol

Conditions

Conditions	Yield
With sodium hydroxide In water; N,N-dimethyl-formamide	80%

: Isatin-5-sulfonic acid sodium salt dihydrate

: 122-87-2
N-(hydroxyphenyl)glycine

: 7313-70-4
isatin-5-monosulphonic acid

: 123-08-0
4-hydroxy-benzaldehyde

Conditions

Conditions	Yield
With acetic acid In water	79.4%

...Expand

: 122-87-2
N-(hydroxyphenyl)glycine

: 501-53-1
benzyl chloroformate

: DL-N-benzyloxycarbonyl-p-hydroxyphenylglycine

Conditions

Conditions	Yield
In 1-methyl-pyrrolidin-2-one; water	75%

: 122-87-2
N-(hydroxyphenyl)glycine

: 91-56-5
indole-2,3-dione

: 123-08-0
4-hydroxy-benzaldehyde

Conditions

Conditions	Yield
In water; acetic acid	68%

: 122-87-2
N-(hydroxyphenyl)glycine

: 7732-18-5
water

: 7705-08-0
iron(III) chloride

: 90-02-8
salicylaldehyde

: 1310-73-2
sodium hydroxide

: [FeNa((Z)-2-(2-hydroxybenzylideneamino)acetate(2-))2(H2O)4]2*2H2O

Conditions

Conditions	Yield
In methanol; ethanol; water 2-(4-hydroxyphenyl)aminoacetic acid, NaOH and salicylaldehyde dissolved in MeOH; heated with stirring for 2 h; cooled to room temp.; EtOH soln. of FeCl3 added with stirring; stirred for 0.5 h; NaOH in distd. H2O added; stirred for 0.5 h; filtered; crystd. from filtrate by slow evapn. at room temp. for 1 wk; elem. anal.;	63%

...Expand

: 122-87-2
N-(hydroxyphenyl)glycine

: 127-17-3
2-oxo-propionic acid

: 123-08-0
4-hydroxy-benzaldehyde

Conditions

Conditions	Yield
In water	62%

: 122-87-2
N-(hydroxyphenyl)glycine

: 7732-18-5
water

: 7705-08-0
iron(III) chloride

: 90-02-8
salicylaldehyde

: 1310-73-2
sodium hydroxide

: [Fe((E)-2-(2-hydroxybenzylideneamino)-3-hydroxy-3-(2-hydroxyphenyl)propanoate(3-))]2*7.5H2O

Conditions

Conditions	Yield
In methanol; ethanol; water HOC6H4NH2CH2COOH, NaOH and HOC6H4CHO in MeOH heated with stirring (2 h);cooled to room temp.; EtOH soln. of FeCl3 added with stirring; stirred (0.5 h); aq. NaOH added; stirred (0.5 h); filtered; crystd. from filtrat e; more NaOH and HOC6H4CHO added; crystd. for 1 wk; elem. anal.;	45%

...Expand

: 122-87-2
N-(hydroxyphenyl)glycine

: 298-12-4
Glyoxilic acid

: 123-08-0
4-hydroxy-benzaldehyde

Conditions

Conditions	Yield
In water	37.2%

: 10486-19-8
tridecanal

: 122-87-2
N-(hydroxyphenyl)glycine

: 99685-96-8, 161105-99-3, 161106-00-9, 111138-12-6, 133318-63-5, 134053-11-5, 134931-35-4, 134931-36-5, 139703-76-7, 145633-27-8, 175414-73-0, 175414-74-1, 175414-75-2, 175519-12-7, 175519-13-8, 175519-14-9, 175519-15-0, 136376-46-0, 144906-37-6, 144906-38-7, 151767-00-9, 152882-97-8, 152882-98-9, 152882-99-0, 153062-34-1, 154171-74-1, 154171-75-2, 154333-99-0, 154334-00-6, 154397-63-4, 154460-59-0, 199456-56-9, 108739-25-9, 120329-57-9, 120329-58-0
fullerene-C60

: C80H33NO

Conditions

Conditions	Yield
In chlorobenzene for 3h; Reflux;	35.1%

...Expand

: 98-03-3
thiophene-2-carbaldehyde

: 122-87-2
N-(hydroxyphenyl)glycine

: 99685-96-8, 161105-99-3, 161106-00-9, 111138-12-6, 133318-63-5, 134053-11-5, 134931-35-4, 134931-36-5, 139703-76-7, 145633-27-8, 175414-73-0, 175414-74-1, 175414-75-2, 175519-12-7, 175519-13-8, 175519-14-9, 175519-15-0, 136376-46-0, 144906-37-6, 144906-38-7, 151767-00-9, 152882-97-8, 152882-98-9, 152882-99-0, 153062-34-1, 154171-74-1, 154171-75-2, 154333-99-0, 154334-00-6, 154397-63-4, 154460-59-0, 199456-56-9, 108739-25-9, 120329-57-9, 120329-58-0
fullerene-C60

: C72H11NOS

Conditions

Conditions	Yield
In chlorobenzene for 3h; Reflux;	34.8%

...Expand

: 112-31-2
caprinaldehyde

: 122-87-2
N-(hydroxyphenyl)glycine

: 99685-96-8, 161105-99-3, 161106-00-9, 111138-12-6, 133318-63-5, 134053-11-5, 134931-35-4, 134931-36-5, 139703-76-7, 145633-27-8, 175414-73-0, 175414-74-1, 175414-75-2, 175519-12-7, 175519-13-8, 175519-14-9, 175519-15-0, 136376-46-0, 144906-37-6, 144906-38-7, 151767-00-9, 152882-97-8, 152882-98-9, 152882-99-0, 153062-34-1, 154171-74-1, 154171-75-2, 154333-99-0, 154334-00-6, 154397-63-4, 154460-59-0, 199456-56-9, 108739-25-9, 120329-57-9, 120329-58-0
fullerene-C60

: C77H27NO

Conditions

Conditions	Yield
In chlorobenzene for 3h; Reflux;	33.6%

...Expand

: 122-87-2
N-(hydroxyphenyl)glycine

: 99685-96-8, 161105-99-3, 161106-00-9, 111138-12-6, 133318-63-5, 134053-11-5, 134931-35-4, 134931-36-5, 139703-76-7, 145633-27-8, 175414-73-0, 175414-74-1, 175414-75-2, 175519-12-7, 175519-13-8, 175519-14-9, 175519-15-0, 136376-46-0, 144906-37-6, 144906-38-7, 151767-00-9, 152882-97-8, 152882-98-9, 152882-99-0, 153062-34-1, 154171-74-1, 154171-75-2, 154333-99-0, 154334-00-6, 154397-63-4, 154460-59-0, 199456-56-9, 108739-25-9, 120329-57-9, 120329-58-0
fullerene-C60

: 78-84-2
isobutyraldehyde

: C71H15NO

Conditions

Conditions	Yield
In chlorobenzene for 3h; Reflux;	33.4%

...Expand

: 50-00-0
formaldehyd

: 122-87-2
N-(hydroxyphenyl)glycine

: 99685-96-8, 161105-99-3, 161106-00-9, 111138-12-6, 133318-63-5, 134053-11-5, 134931-35-4, 134931-36-5, 139703-76-7, 145633-27-8, 175414-73-0, 175414-74-1, 175414-75-2, 175519-12-7, 175519-13-8, 175519-14-9, 175519-15-0, 136376-46-0, 144906-37-6, 144906-38-7, 151767-00-9, 152882-97-8, 152882-98-9, 152882-99-0, 153062-34-1, 154171-74-1, 154171-75-2, 154333-99-0, 154334-00-6, 154397-63-4, 154460-59-0, 199456-56-9, 108739-25-9, 120329-57-9, 120329-58-0
fullerene-C60

: N-(4-hydroxyphenyl)-3,4-fulleropyrrolidine

Conditions

Conditions	Yield
In toluene Heating;	33%

...Expand

: 122-87-2
N-(hydroxyphenyl)glycine

: 123-72-8
butyraldehyde

: 99685-96-8, 161105-99-3, 161106-00-9, 111138-12-6, 133318-63-5, 134053-11-5, 134931-35-4, 134931-36-5, 139703-76-7, 145633-27-8, 175414-73-0, 175414-74-1, 175414-75-2, 175519-12-7, 175519-13-8, 175519-14-9, 175519-15-0, 136376-46-0, 144906-37-6, 144906-38-7, 151767-00-9, 152882-97-8, 152882-98-9, 152882-99-0, 153062-34-1, 154171-74-1, 154171-75-2, 154333-99-0, 154334-00-6, 154397-63-4, 154460-59-0, 199456-56-9, 108739-25-9, 120329-57-9, 120329-58-0
fullerene-C60

: C71H15NO

Conditions

Conditions	Yield
In chlorobenzene for 3h; Reflux;	32.3%

...Expand

: 122-87-2
N-(hydroxyphenyl)glycine

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 99685-96-8, 161105-99-3, 161106-00-9, 111138-12-6, 133318-63-5, 134053-11-5, 134931-35-4, 134931-36-5, 139703-76-7, 145633-27-8, 175414-73-0, 175414-74-1, 175414-75-2, 175519-12-7, 175519-13-8, 175519-14-9, 175519-15-0, 136376-46-0, 144906-37-6, 144906-38-7, 151767-00-9, 152882-97-8, 152882-98-9, 152882-99-0, 153062-34-1, 154171-74-1, 154171-75-2, 154333-99-0, 154334-00-6, 154397-63-4, 154460-59-0, 199456-56-9, 108739-25-9, 120329-57-9, 120329-58-0
fullerene-C60

: C76H17NO3

Conditions

Conditions	Yield
In chlorobenzene for 3h; Reflux;	32%

...Expand

: 3779-27-9
2,2'-bithiophene-5-carboxaldehyde

: 122-87-2
N-(hydroxyphenyl)glycine

: 99685-96-8, 161105-99-3, 161106-00-9, 111138-12-6, 133318-63-5, 134053-11-5, 134931-35-4, 134931-36-5, 139703-76-7, 145633-27-8, 175414-73-0, 175414-74-1, 175414-75-2, 175519-12-7, 175519-13-8, 175519-14-9, 175519-15-0, 136376-46-0, 144906-37-6, 144906-38-7, 151767-00-9, 152882-97-8, 152882-98-9, 152882-99-0, 153062-34-1, 154171-74-1, 154171-75-2, 154333-99-0, 154334-00-6, 154397-63-4, 154460-59-0, 199456-56-9, 108739-25-9, 120329-57-9, 120329-58-0
fullerene-C60

: C76H13NOS2

Conditions

Conditions	Yield
In chlorobenzene for 3h; Reflux;	31.6%

...Expand

: 111-71-7
heptanal

: 122-87-2
N-(hydroxyphenyl)glycine

: 99685-96-8, 161105-99-3, 161106-00-9, 111138-12-6, 133318-63-5, 134053-11-5, 134931-35-4, 134931-36-5, 139703-76-7, 145633-27-8, 175414-73-0, 175414-74-1, 175414-75-2, 175519-12-7, 175519-13-8, 175519-14-9, 175519-15-0, 136376-46-0, 144906-37-6, 144906-38-7, 151767-00-9, 152882-97-8, 152882-98-9, 152882-99-0, 153062-34-1, 154171-74-1, 154171-75-2, 154333-99-0, 154334-00-6, 154397-63-4, 154460-59-0, 199456-56-9, 108739-25-9, 120329-57-9, 120329-58-0
fullerene-C60

: C74H21NO

Conditions

Conditions	Yield
In chlorobenzene for 3h; Reflux;	30.9%

...Expand

N-(4-Hydroxyphenyl)glycine Specification

This chemical is called N-(4-Hydroxyphenyl)glycine, and it can also be named as Glycin. The CAS registry number of this chemical is 122-87-2, and its product categories are Glycine Derivatives; Peptide Synthesis; Unnatural Amino Acid Derivatives. This chemical is typically characterized as thin plates of white or silvery powder when it's fresh. It is sparingly soluble in water and most organic solvents. The N-(4-Hydroxyphenyl)glycine is rarely used as a developing agent today, because it is expensive and its manufactured for specialty applications only.

Other characteristics of the N-(4-Hydroxyphenyl)glycine can be summarised as followings: (1)ACD/LogP: -0.13; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.37; (4)ACD/LogD (pH 7.4): -3.12; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1.16; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 4; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 38.77 Å²; (13)Index of Refraction: 1.664; (14)Molar Refractivity: 43.94 cm³; (15)Molar Volume: 118.4 cm³; (16)Polarizability: 17.41×10^-24cm³; (17)Surface Tension: 70.1 dyne/cm; (18)Density: 1.411 g/cm³; (19)Flash Point: 223.7 °C; (20)Enthalpy of Vaporization: 74.24 kJ/mol; (21)Boiling Point: 446.3 °C at 760 mmHg; (22)Vapour Pressure: 9.49E-09 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin, so you should wear suitable protective clothing when you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.SMILES: O=C(O)CNc1ccc(O)cc1
2.InChI: InChI=1/C8H9NO3/c10-7-3-1-6(2-4-7)9-5-8(11)12/h1-4,9-10H,5H2,(H,11,12)
3.InChIKey: WRUZLCLJULHLEY-UHFFFAOYAB

Product Name

N-(4-HYDROXYPHENYL)GLYCINE

Synthetic route

N-(4-Hydroxyphenyl)glycine Specification

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