N-Ethylcarbazole supplier

Name
N-Ethylcarbazole
EINECS 201-660-4
CAS No. 86-28-2
Article Data147
CAS DataBase
Density 1.07 g/cm³
Solubility Insoluble
Melting Point 68-70 °C(lit.)
Formula C₁₄H₁₃N
Boiling Point 348.3 °C at 760 mmHg
Molecular Weight 195.264
Flash Point 164.4 °C
Transport Information
Appearance brown solid
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms NSC 60585;9-Ethyl-9H-carbazole;Carbazole,9-ethyl- (6CI,7CI,8CI);9-Ethylcarbazole;
PSA 4.93000
LogP 3.81440

Synthetic route

: 86-74-8
9H-carbazole

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
	100%
	98.1%
	93.1%
With sodium amide; toluene und Erwaermen des Reaktionsgemisches mit Aethylbromid;
Multi-step reaction with 2 steps 1: potassium hydroxide; decalin / 170 °C 2: nickel; methanol / 80 °C / 11032.6 Torr / Hydrogenation View Scheme

: 74-96-4
ethyl bromide

: 86-74-8
9H-carbazole

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
Stage #1: 9H-carbazole With potassium hydroxide In dimethyl sulfoxide at 20℃; for 0.333333h; Stage #2: ethyl bromide In dimethyl sulfoxide at 35℃; for 0.05h; Solvent; Sonication;	99%
With sodium hydroxide In N,N-dimethyl-formamide at 20℃; for 0.666667h; Cooling with ice;	95%
With potassium hydroxide; PEG-400-Et2 In water; benzene at 30℃; for 2h;	92%

: 1484-13-5
9-vinyl-9H-carbazole

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With ethanol; (BQ‑NCOP)IrHCl; sodium t-butanolate at 60℃; for 3h; Inert atmosphere; Schlenk technique; Sealed tube;	98%
With Rh4Co; cetyltrimethylammonim bromide; hydrazine hydrate In toluene at 60℃; for 3h; Schlenk technique; Inert atmosphere;	95%
With methanol; nickel at 80℃; under 11032.6 Torr; Hydrogenation;

: 36368-72-6
N-ethylphenothiazine sulfoxide

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With sodium; lithium In tetrahydrofuran for 24h; Heating;	98%

: 74-85-1
ethene

: 86-74-8
9H-carbazole

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With sodium In acetonitrile at 90℃; under 37503.8 Torr; for 6h; Pressure; Temperature; Autoclave;	97.53%

: 86-74-8
9H-carbazole

: 95-92-1
oxalic acid diethyl ester

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide Heating;	97%

: 86-74-8
9H-carbazole

: 75-03-6
ethyl iodide

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
Stage #1: 9H-carbazole With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: ethyl iodide In N,N-dimethyl-formamide at 20℃; for 12h;	96%
Stage #1: 9H-carbazole With potassium hydroxide In N,N-dimethyl-formamide for 0.0833333h; Stage #2: ethyl iodide In N,N-dimethyl-formamide at 20℃; for 24h;	90%
With potassium tert-butylate In N,N-dimethyl-formamide at 75℃; for 24h; Reflux;

: 146530-09-8
9-(1-Benzotriazol-1-yl-ethyl)-9H-carbazole

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With sodium tetrahydroborate at 150℃; for 7h;	95%

: 77035-48-4
N(10)-ethylphenothiazine-S,S-dioxide

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With sodium; lithium In tetrahydrofuran for 24h; Heating;	94%

: 86-74-8
9H-carbazole

ethyl halide: ethyl halide

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
Stage #1: 9H-carbazole With sodium hydroxide In water; dimethyl sulfoxide at 20℃; for 0.0833333h; Stage #2: ethyl halide In water; dimethyl sulfoxide at 20℃;	94%

: 95249-52-8
9-<1-(Phenylthio)ethyl>carbazole

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
W-2 Raney nickel In ethanol for 4h; Heating;	93%

: 64-67-5
diethyl sulfate

: 86-74-8
9H-carbazole

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With potassium hydroxide In acetone for 4h; Reflux;	90%
In acetone at 40℃; for 0.333333h;	76.3%
With sodium hydroxide In acetone	75%

: 37391-52-9
9-ethyl-1,2,3,4-tetrahydrocarbazole

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With iodine In dimethyl sulfoxide at 100℃; for 8h;	87%
With palladium on activated charcoal; xylene
5% Pd(II)/C(eggshell) In o-xylene at 200℃; for 10h; Product distribution / selectivity; Inert atmosphere;

: 1637-16-7
10-ethyl-phenothiazine

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With sodium; lithium In tetrahydrofuran for 24h; Heating;	86%

: 617-86-7
triethylsilane

: 4901-29-5
9-(1-acetoxyethyl)carbazole

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -78℃;	82%

: 1'-ethylspiro[cyclopent[3]ene-1,2'-indolin]-3'-one

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 80℃; for 3h; Inert atmosphere;	82%

: 86-00-0
2-nitrobiphenyl

: 122-52-1
triethyl phosphite

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With 1-methyl-4-nitrobenzene at 160℃; for 5h; Inert atmosphere;	81%

: 77989-56-1
N-ethyl-[1,1'-biphenyl]-2-amine

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
Stage #1: N-ethyl-[1,1'-biphenyl]-2-amine With palladium diacetate In toluene at 20℃; for 1h; Stage #2: With [bis(acetoxy)iodo]benzene In toluene at 20℃; for 3h;	81%

: 606-99-5
N,N-diphenylethylamine

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With tris(1,10-phenanthroline)iron(II) bis(bis(trifluoromethane)sulfonimide); oxygen In tetrahydrofuran at 20℃; under 2068.65 Torr; for 4h; Irradiation; Inert atmosphere;	80%
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 2.9-dimethyl-1,10-phenanthroline; iodine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; methyloxirane In tetrahydrofuran at 20℃; for 20h; Catalytic behavior; Flow reactor; Inert atmosphere; Irradiation;	79%

: 383-63-1
ethyl trifluoroacetate,

: 86-74-8
9H-carbazole

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; for 0.116667h; Microwave irradiation;	76%

: 86-74-8
9H-carbazole

: 106-93-4
ethylene dibromide

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
Stage #1: 9H-carbazole With potassium hydroxide In acetone at 20℃; for 0.5h; Stage #2: ethylene dibromide In acetone at 20℃; for 10h;	74.3%

: 146900-30-3
dodecahydro-N-ethyl-1H-carbazole

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With boron nitride at 120℃; for 12h; Reagent/catalyst;	74%
With 5%-palladium/activated carbon In decalin at 169.84℃; under 757.576 Torr; for 1.56667h; Kinetics; Temperature; Time;
With platinum at 106.84℃; Mechanism; Temperature;

: 101089-79-6
2-(ethyl(phenyl)amino)benzoic acid

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With pyridine In dimethylsulfoxide-d6 for 48h; Irradiation;	72%
With copper diacetate; palladium diacetate In N,N-dimethyl acetamide at 130℃; for 72h; Inert atmosphere; chemoselective reaction;	37%

: 574-39-0
9-acetylcarbazole

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
Stage #1: 9-acetylcarbazole With sodium triethylborohydride; benzo[1,3,2]dioxaborole In tetrahydrofuran at 80℃; for 12h; Inert atmosphere; Sealed tube; Stage #2: With hydrogenchloride In tetrahydrofuran; water at 20℃; for 2h;	72%

: 1806-29-7
2,2'-dihydroxybiphenyl

: 75-04-7
ethylamine

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With 10 wt% Pd(OH)2 on carbon; sodium formate; trifluoroacetic acid In m-xylene at 140℃; for 24h; Inert atmosphere;	72%

: 1187235-04-6
1-(1-ethyl-1H-indol-2-yl)buta-2,3-dien-1-ol

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With platinum(II) chloride In toluene at 20℃; for 4h; Inert atmosphere;	70%
With platinum(II) chloride In toluene at 20℃; for 4h; Inert atmosphere;	70%

: 86-74-8
9H-carbazole

: 21872-75-3, 102651-94-5
diethoxy(methyl)carbenium tetrafluoroborate

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
In dichloromethane for 96h; Ambient temperature;	67%

: 615-42-9
1,2-Diiodobenzene

: 103-69-5
N-ethyl-N-phenylamine

: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
In n-heptane Inert atmosphere; UV-irradiation;	52%

: 146900-30-3
dodecahydro-N-ethyl-1H-carbazole

A: 861622-66-4
9-ethyl-2,3,4,5,6,7,8,9-octahydrocarbazole

B: 86-28-2
N-ethylcarbazole

Conditions

Conditions	Yield
With RhCl(CO)(PMe3)2 for 3h; Irradiation; Inert atmosphere; Overall yield = 80 %;	A 48% B 22%

: 86-28-2
N-ethylcarbazole

: 146900-30-3
dodecahydro-N-ethyl-1H-carbazole

Conditions

Conditions	Yield
With hydrogen at 150℃; under 22502.3 Torr; for 5.6h; Kinetics; Reagent/catalyst; Temperature; Autoclave; Glovebox;	100%
With 1,4-dioxane; nickel at 200℃; under 183877 - 220652 Torr; Hydrogenation;
With 5 wt% Ru/C; hydrogen at 160℃; under 37503.8 Torr; for 48h; Inert atmosphere;	> 99 %Chromat.

: 86-28-2
N-ethylcarbazole

: 144434-81-1
9-ethyl-1,3,6-trisbromocarbazole

Conditions

Conditions	Yield
With N-Bromosuccinimide; silica gel In dichloromethane at 18℃; for 72h;	100%

: 86-28-2
N-ethylcarbazole

: 20466-00-6
9,9'-diethyl-9H,9'H-3,3'-bicarbazole

Conditions

Conditions	Yield
Stage #1: N-ethylcarbazole With methanesulfonic acid In dichloromethane at 0℃; Inert atmosphere; Stage #2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane at 20℃; for 0.0166667h; Reagent/catalyst; Inert atmosphere; regioselective reaction;	99%
With iron(III) chloride In chloroform at 20℃; for 24h;	92.7%
With iron(III) chloride In chloroform at 20℃;	90%

: 86-28-2
N-ethylcarbazole

: 33255-13-9
3,6-dibromo-9-ethyl-9H-carbazole

Conditions

Conditions	Yield
With N-Bromosuccinimide In dichloromethane at 25℃;	98%
With N-Bromosuccinimide In chloroform at 20℃; for 5h;	91%
With N-Bromosuccinimide In N,N-dimethyl-formamide at 20℃;	68%

: 86-28-2
N-ethylcarbazole

: 76-05-1
trifluoroacetic acid

: 407-25-0
trifluoroacetic anhydride

: C16H12F3NO

Conditions

Conditions	Yield
In 1,2-dichloro-ethane at 100℃; Friedel-Crafts Acylation; Schlenk technique;	98%

...Expand

: 86-28-2
N-ethylcarbazole

: 422-64-0
pentafluoropropionic acid

: 356-42-3
2,2,3,3,3-pentafluoropropanoic anhydride

: C17H12F5NO

Conditions

Conditions	Yield
In 1,2-dichloro-ethane at 100℃; Friedel-Crafts Acylation; Schlenk technique;	96%

...Expand

: 25726-04-9
phenylglyoxylyl chloride

: 86-28-2
N-ethylcarbazole

: C22H17NO2

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 20℃; for 0.166667h; Cooling with ice;	95%

: 86-28-2
N-ethylcarbazole

: 57102-97-3
3-bromo-9-ethyl-9H-carbazole

Conditions

Conditions	Yield
With N-Bromosuccinimide In acetonitrile for 0.5h; Cooling with ice;	94%
With N-Bromosuccinimide In N,N-dimethyl-formamide at 20℃; Inert atmosphere; Darkness;	88%
With silica-supported quinolinium tribromide In acetonitrile at 20℃; for 5h; regioselective reaction;	87%

: 86-28-2
N-ethylcarbazole

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 7570-45-8
N-ethyl-3-carbazolealdehyde

Conditions

Conditions	Yield
With trichlorophosphate at 100℃; for 1.16667h; Inert atmosphere;	93%
Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 20℃; for 1.16667h; Cooling with ice; Inert atmosphere; Stage #2: N-ethylcarbazole at 100℃; for 1.16667h; Microwave irradiation; Inert atmosphere;	93%
With trichlorophosphate for 0.025h; Vilsmeier reaction; microwave irradiation;	89%

: 86-28-2
N-ethylcarbazole

: 874-60-2
4-methyl-benzoyl chloride

: 857503-95-8
C30H25NO2

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 20℃; for 8h;	92%

: 86-28-2
N-ethylcarbazole

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 70207-46-4
3,6-diformyl-9-ethylcarbazole

Conditions

Conditions	Yield
With trichlorophosphate for 24h; Reflux;	90%
With trichlorophosphate In 1,2-dichloro-benzene at 85℃; Vilsmeier reaction;	78%
Stage #1: N-ethylcarbazole; N,N-dimethyl-formamide With zinc(II) chloride at 100℃; for 0.25h; Stage #2: With trichlorophosphate at 100℃; for 24.25h; Cooling with ice;	75%

: 86-28-2
N-ethylcarbazole

: 57103-07-8
3,6-diiodo-9-ethylcarbazole

Conditions

Conditions	Yield
With Iodine monochloride In ethanol for 2h; Heating;	90%
With potassium iodate; potassium iodide In acetic acid
With potassium iodate; acetic acid; potassium iodide

: 86-28-2
N-ethylcarbazole

: 75-36-5
acetyl chloride

: 1483-97-2
1,1′-(9-ethyl-9H-carbazole-3,6-diyl)diethanone

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 20℃; for 50h; Friedel-Crafts Acylation; Cooling with ice;	90%
Stage #1: N-ethylcarbazole; acetyl chloride; aluminum (III) chloride In dichloromethane at 0 - 20℃; for 7h; Stage #2: With water In dichloromethane at 0℃;	85%
Stage #1: N-ethylcarbazole; acetyl chloride With aluminum (III) chloride In dichloromethane at 0 - 20℃; Stage #2: With water In dichloromethane Cooling with ice;	85%

: 86-28-2
N-ethylcarbazole

: 598-21-0
2-Bromoacetyl bromide

: 1,1′-(9-ethyl-9H-carbazole-3, 6-diyl)bis(2-bromoethanone)

Conditions

Conditions	Yield
Stage #1: N-ethylcarbazole With aluminum (III) chloride In dichloromethane at 20℃; for 0.0833333h; Stage #2: 2-Bromoacetyl bromide In dichloromethane at 0 - 20℃; for 17h;	90%
With aluminum (III) chloride In dichloromethane at 0 - 5℃; Friedel-Crafts Acylation;	60%
With aluminum (III) chloride In dichloromethane Friedel-Crafts Alkylation;

: 86-28-2
N-ethylcarbazole

: 102-92-1
cinnamoyl chloride

: 879212-03-0
1‐(9‐ethyl‐9H‐carbazol‐3‐yl)‐3‐phenylprop‐2‐en‐1‐one

Conditions

Conditions	Yield
With aluminum (III) chloride In 1,2-dichloro-ethane at 0℃; Reflux;	89.3%

: 86-28-2
N-ethylcarbazole

: 86-20-4
9-ethyl-3-nitro-carbazole

Conditions

Conditions	Yield
With nitric acid In acetic acid at 23℃; for 6h;	89%
With uronium nitrate In acetic acid for 20h;	81%
With nitric acid In water; 1,2-dichloro-ethane at 10℃; for 1h;	81%

: 86-28-2
N-ethylcarbazole

: 802034-95-3
9-ethyl-carbazole-3-sulfonic acid

Conditions

Conditions	Yield
With chlorosulfonic acid In dichloromethane at -5℃; for 2h;	89%

: 86-28-2
N-ethylcarbazole

: 506-96-7
Acetyl bromide

: 1483-97-2
1,1′-(9-ethyl-9H-carbazole-3,6-diyl)diethanone

Conditions

Conditions	Yield
With aluminum (III) chloride In 1,2-dichloro-ethane at 20℃; for 5h;	89%
Stage #1: N-ethylcarbazole With tin(IV) chloride In dichloromethane at 20℃; for 0.166667h; Stage #2: Acetyl bromide In dichloromethane at 20℃; for 24h;	62%
With carbon disulfide; aluminum (III) chloride for 3h; Friedel-Crafts Acylation; Cooling with ice; Reflux;	7.2 g

N-Ethylcarbazole Chemical Properties

Empirical Formula: C₁₄H₁₃N
Molecular Weight: 195.2597 g/mol
Index of Refraction: 1.609
Density: 1.07 g/cm³
Flash Point: 164.4 °C
Melting point: 68-70 °C(lit.)
Water solubility: Insoluble
Appearance: Brown solid
Enthalpy of Vaporization: 59.26 kJ/mol
Boiling Point: 348.3 °C at 760 mmHg
Vapour Pressure: 5.09E-05 mmHg at 25 °C
Structure of N-Ethylcarbazole (CAS NO.86-28-2):

Product Category of N-Ethylcarbazole (CAS NO.86-28-2): Miscellaneous;Carbazoles;Functional Materials;carbazole;Heterocyclic Building Blocks

N-Ethylcarbazole Toxicity Data With Reference

dns-rat:lvr 50 µmol/L

FCTOD7 Food and Chemical Toxicology. 31 (1993),707.

N-Ethylcarbazole (CAS NO.86-28-2) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65. You can see actual entry in RTECS for complete information.

N-Ethylcarbazole Consensus Reports

Reported in EPA TSCA Inventory.

N-Ethylcarbazole Safety Profile

Mutation data reported. When heated to decomposition it emits toxic vapors of NO_x.
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.

N-Ethylcarbazole Specification

N-Ethylcarbazole , its cas register number is 86-28-2. It also can be called 9-Ethylcarbazole . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, N-Ethylcarbazole (CAS NO.86-28-2) could be stable under normal temperatures and pressures. And you must not take it with Strong oxidants.. And also prevent it to broken down into hazardous decomposition products: irritating and toxic fumes and gases.

Product Name

N-Ethylcarbazole

Synthetic route

N-Ethylcarbazole Chemical Properties

N-Ethylcarbazole Toxicity Data With Reference

N-Ethylcarbazole Consensus Reports

N-Ethylcarbazole Safety Profile

N-Ethylcarbazole Specification

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