N,N'-Diaminoguanidine hydrochloride supplier

Name
1,3-Diaminoguanidine monohydrochloride
EINECS 252-854-0
CAS No. 36062-19-8
Article Data13
CAS DataBase
Density 1.94g/cm3
Solubility very faint turbidity
Melting Point 180-182 °C (dec.)(lit.)
Formula CH₈ClN₅
Boiling Point 275.2 °C at 760 mmHg
Molecular Weight 125.561
Flash Point 120.2 °C
Transport Information
Appearance white to light beige granular powder
Safety 26-36-24/25
Risk Codes 36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms Carbonimidicdihydrazide, monohydrochloride (9CI);1,3-Diaminoguanidine monohydrochloride;N,N'-Diaminoguanidine monohydrochloride;
PSA 99.95000
LogP 0.93190

Synthetic route

: 506-77-4
cyanogen chloride

: 36062-19-8
1,3-diaminoguanidine hydrochloride

Conditions

Conditions	Yield
With diethyl ether; hydrazine
With hydrazine In water in NaCl saturated water;
With hydrazine In gas with hydrazine free from water and layered with ether; hydrazine cooled;
With hydrazine In water ClCN/H2N-NH2 = 1:2;
With hydrazine In water in NaCl saturated water;

: 506-77-4
cyanogen chloride

A: 36062-19-8
1,3-diaminoguanidine hydrochloride

B hydrochloride of guanazine: hydrochloride of guanazine

Conditions

Conditions	Yield
With water; hydrazine Nebenprod.2:Hydrazin-N.N'-dicarbonsaeure-amid-hydrazid;

: guanidine hydrochloride salt

: 36062-19-8
1,3-diaminoguanidine hydrochloride

Conditions

Conditions	Yield
With hydrazine hydrate In water; chlorobenzene at 25℃; for 10h; Time;

: 1937-19-5
1-aminoguanidine hydrochloride

: 36062-19-8
1,3-diaminoguanidine hydrochloride

Conditions

Conditions	Yield
With hydrazine

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 555-16-8
4-nitrobenzaldehdye

: 473391-26-3
2,2'-bis[(4-nitrophenyl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	100%
In ethanol at 100℃; for 0.166667h; Microwave irradiation;	81%
In methanol at 20 - 80℃; for 26h;	75%

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 587-04-2
3-Chlorobenzaldehyde

: 2,2′-bis[(3-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	100%
In ethanol for 16h; Reflux;

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 6630-33-7
ortho-bromobenzaldehyde

: 2,2′-bis[(2-bromophenyl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	100%
In ethanol at 100℃; for 0.166667h; Microwave irradiation;	72%

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 57401-20-4
2,2′-bis[(4-(trifluoromethyl)phenyl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	100%
In ethanol for 16h; Reflux;

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 123-08-0
4-hydroxy-benzaldehyde

: 2,2′-bis[(4-hydroxyphenyl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	100%
In ethanol at 100℃; for 0.166667h; Microwave irradiation;	18%

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 3218-36-8
4-Phenylbenzaldehyde

: 2,2′-bis[(1,1'-biphenyl-4-yl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	100%
In ethanol at 100℃; for 0.166667h; Microwave irradiation;	81%

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 2,2′-bis[(3,4-dimethoxyphenyl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions

Conditions	Yield
In ethanol at 100℃; for 0.166667h; Microwave irradiation;	100%

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 105-07-7
4-cyanobenzaldehyde

: 2,2'-bis[(4-cyanophenyl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	100%
In ethanol for 16h; Reflux;

: 24964-64-5
3-Cyanobenzaldehyde

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 2,2'-bis[(3-cyanophenyl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	100%
In ethanol for 16h; Reflux;

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 94651-33-9
2-(trifluoromethoxy)benzaldehyde

: 2,2'-bis[(2-trifluoromethoxyphenyl)methylene]-carbonimidic dihydrazide hydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	100%

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 83882-67-1
4-difluoromethoxy-acetophenone

: 2,2'-bis[(4-difluoromethoxyphenyl)ethylidene]-carbonimidic dihydrazide hydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	100%

: 6051-41-8
4-formylbenzamide

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: C17H17N7O2*ClH

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	100%

: 3240-35-5
4-formyl-benzenesulfonamide

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: C15H17N7O4S2*ClH

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	100%

: 4-propynoxybenzaldehyde

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 2,2'-bis[(4-propynoxyphenyl)methylene]carbonimidic dihydrazide hydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	100%

: silver 1,1'-ethylenebis(oxy)bis(5-nitroiminotetrazolate)

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 2CH7N5*C4H6N12O6

Conditions

Conditions	Yield
In water at 20℃; for 4h;	99%

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 100-52-7
benzaldehyde

: 72463-09-3
2,2′-bis[phenylmethylene]carbonimidic dihydrazide monohydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	99%
In ethanol at 100℃; for 0.166667h; Microwave irradiation;	88%
In ethanol; water at 20 - 80℃; for 2h;	65%
In methanol at 20 - 80℃; for 26h;	64%

: silver 1-methoxy-5-nitroiminotetrazolate

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 1428559-67-4
1,3-diaminoguanidinium 1-methoxy-5-nitroiminotetrazolate

Conditions

Conditions	Yield
In water at 20℃; for 3h; Thermodynamic data;	99%

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 459-57-4
4-fluorobenzaldehyde

: 2,2′-bis[(4-fluorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	99%
In ethanol for 16h; Reflux;

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 446-52-6
2-Fluorobenzaldehyde

: 2,2′-bis[(2-fluorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	99%
In ethanol for 16h; Reflux;

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 218301-22-5
2-fluoro-5-formylbenzonitrile

: 2,2'-bis[(3-cyano-4-fluorophenyl)methylene]-carbonimidic dihydrazide hydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	99%

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 104-88-1
4-chlorobenzaldehyde

: 25875-50-7
2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In methanol at 50℃; for 1h; pH=1.5; pH-value; Temperature;	98.82%
In ethanol for 16h; Reflux;

: 4521-33-9
5-nitro-2-thiophenecarboxaldehyde

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 1206770-32-2
1,3-bis-((5-nitrothiophen-2-yl-methylidene)amino)guanidine hydrochloride

Conditions

Conditions	Yield
In methanol for 5h; Reflux;	98%

: 41792-58-9
1,1,3,6,8,8-Hexanitro-3,6-diaza-octan

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: bis(2,2-dinitroethanide-N-nitro)ethylenediamine bis(diaminoguanidinium) salt

Conditions

Conditions	Yield
Stage #1: 1,3-diaminoguanidine hydrochloride With sodium hydroxide In methanol at 20℃; for 0.166667h; Stage #2: 1,1,3,6,8,8-Hexanitro-3,6-diaza-octan In acetonitrile at 20℃; for 1h;	98%

: 3132-99-8
m-bromobenzoic aldehyde

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 2,2′-bis[(3-bromophenyl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	98%
In ethanol at 100℃; for 0.166667h; Microwave irradiation;	44%

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 5357-76-6
sodium 3,6-dinitro-2,5-dihydroxy-1,4-benzoquinone

: N,N'-diaminoguanidinium nitranilate

Conditions

Conditions	Yield
In water at 20℃;	97%

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 131-73-7
Dipikrylamin

: 1352994-43-4
CH7N5*C12H5N7O12

Conditions

Conditions	Yield
Stage #1: Dipikrylamin With sodium hydroxide In water at 80℃; for 0.5h; Stage #2: 1,3-diaminoguanidine hydrochloride In water at 20℃; for 1h;	97%

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 456-48-4
3-Fluorobenzaldehyde

: 2,2′-bis[(3-fluorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	97%
In ethanol for 16h; Reflux;

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: CH7N5*HN3O4

Conditions

Conditions	Yield
With silver(I) dinitramide In ethanol	96%

: 1122-54-9
methyl (4-pyridyl) ketone

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 1206770-40-2
1,3-bis-((1-(4-pyridyl)ethylidene)amino)guanidine hydrochloride

Conditions

Conditions	Yield
In methanol for 5h; Reflux;	96%

: 36062-19-8
1,3-diaminoguanidine hydrochloride

: 89-98-5
2-chloro-benzaldehyde

: 2,2′-bis[(2-chlorophenyl)methylene]carbonimidic dihydrazide monohydrochloride

Conditions

Conditions	Yield
In ethanol for 16h; Reflux;	96%
In ethanol for 16h; Reflux;

N,N'-Diaminoguanidine hydrochloride Chemical Properties

Molecule structure of N,N'-Diaminoguanidine hydrochloride (CAS NO.36062-19-8):

IUPAC Name: 1,2-Diaminoguanidine hydrochloride
Molecular Weight: 125.56072 [g/mol]
Molecular Formula: CH₈ClN₅
Enthalpy of Vaporization: 51.36 kJ/mol
Boiling Point: 275.2 °C at 760 mmHg
Vapour Pressure: 0.00516 mmHg at 25 °C
Melting Point: 180-182 °C (dec.)(lit.)
Sensitive: Hygroscopic
H-Bond Donor: 5
H-Bond Acceptor: 5
Rotatable Bond Count: 1
Tautomer Count: 2
Exact Mass: 125.046823
MonoIsotopic Mass: 125.046823
Topological Polar Surface Area: 102
Heavy Atom Count: 7
Canonical SMILES: C(=NN)(N)NN.Cl
Isomeric SMILES: C(=N\N)(\N)/NN.Cl
InChI: InChI=1S/CH7N5.ClH/c2-1(5-3)6-4;/h3-4H2,(H3,2,5,6);1H
InChIKey: HAZRIBSLCUYMQP-UHFFFAOYSA-NFlash Point: 120.2 °C
EINECS: 252-854-0
Product Categories of N,N'-Diaminoguanidine hydrochloride (CAS NO.36062-19-8): Amines; API intermediates; Guanidines; Nitrogen Compounds; Organic Building Blocks

N,N'-Diaminoguanidine hydrochloride Uses

N,N'-Diaminoguanidine hydrochloride (CAS NO.36062-19-8) is used as a pharmaceutical intermediate.

N,N'-Diaminoguanidine hydrochloride Safety Profile

Hazard Codes: Irritant Xi, Harmful Xn
Risk Statements: 36/37/38-20/21/22
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3

N,N'-Diaminoguanidine hydrochloride Specification

N,N'-Diaminoguanidine hydrochloride (CAS NO.36062-19-8) is also called 1,3-Diaminoguanidine hydrochloride ; Hydrazinecarbohydrazonamide hydrochloride (1:1) ; 1,3-Diaminoguanidine monohydrochloride ; Carbonimidic dihydrazide, hydrochloride . It is white to light beige granular powder.

Product Name

1,3-Diaminoguanidine monohydrochloride

Synthetic route

N,N'-Diaminoguanidine hydrochloride Chemical Properties

N,N'-Diaminoguanidine hydrochloride Uses

N,N'-Diaminoguanidine hydrochloride Safety Profile

N,N'-Diaminoguanidine hydrochloride Specification

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