Product Name

  • Name

    N,N-Dimethylbenzamide

  • EINECS 210-279-2
  • CAS No. 611-74-5
  • Article Data274
  • CAS DataBase
  • Density 1.03 g/cm3
  • Solubility Soluble in water.
  • Melting Point 41-45 °C
  • Formula C9H11NO
  • Boiling Point 256.1 °C at 760 mmHg
  • Molecular Weight 149.192
  • Flash Point 111.9 °C
  • Transport Information
  • Appearance white to off-white crystals.
  • Safety 26-36-37/39
  • Risk Codes 22-36/37/38
  • Molecular Structure Molecular Structure of 611-74-5 (N,N-Dimethylbenzamide)
  • Hazard Symbols IrritantXi,HarmfulXn
  • Synonyms Dimethylbenzamide;NSC 10996;
  • PSA 20.31000
  • LogP 1.38840

Synthetic route

benzoic acid methyl ester
93-58-3

benzoic acid methyl ester

methylchloroaluminum N,N-dimethylamide
84738-97-6

methylchloroaluminum N,N-dimethylamide

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
In benzene for 12h; Heating;100%
N,N-dimethylthiobenzamide
15482-60-7

N,N-dimethylthiobenzamide

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With 6H(1+)*Mo9O40PV3(6-); oxygen In acetonitrile at 90℃; under 760.051 Torr; for 2h; Inert atmosphere; Glovebox;99%
With hydrogenchloride; N-nitrosopiperidine; potassium iodide In dichloromethane; water at 22℃; for 50h;94%
With hydrogenchloride; sodium nitrite In water at 20℃; for 0.5h;94%
tris(dimethylamino)borane
4375-83-1

tris(dimethylamino)borane

benzaldehyde
100-52-7

benzaldehyde

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With tert.-butylhydroperoxide In acetonitrile at 80℃; for 24h;99%
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

benzoic acid
65-85-0

benzoic acid

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With tert.-butylhydroperoxide; copper(II) oxide In water at 80℃; for 20h; Catalytic behavior;99%
With tert.-butylhydroperoxide; copper(II) perchlorate hexahydrate at 100℃; for 15h;90%
With trichlorophosphate at 120℃; for 1h; Sealed tube;90%
dimethylamine borane
74-94-2

dimethylamine borane

benzoic acid
65-85-0

benzoic acid

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
In 5,5-dimethyl-1,3-cyclohexadiene for 12h; Reflux;99%
benzoyl chloride
98-88-4

benzoyl chloride

A

2,4,6-Triphenyl-thiopyrylium-chlorid
2930-27-0

2,4,6-Triphenyl-thiopyrylium-chlorid

B

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With 2-Dimethylamino-2,4,6-triphenyl-2H-thiopyran In diethyl ether for 1h; Heating;A 98%
B 40%
2-Dimethylamino-2,4,6-triphenyl-2H-thiopyran
87691-75-6

2-Dimethylamino-2,4,6-triphenyl-2H-thiopyran

A

2,4,6-Triphenyl-thiopyrylium-chlorid
2930-27-0

2,4,6-Triphenyl-thiopyrylium-chlorid

B

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With benzoyl chloride In diethyl ether for 1h; Heating;A 98%
B 40%
dimethyl amine
124-40-3

dimethyl amine

benzoic acid
65-85-0

benzoic acid

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride In dichloromethane at 0℃; for 0.5h;98%
With tetrabutylammomium bromide; iodine; potassium hydroxide In water at 20℃; for 2.5h; Irradiation;75%
With dichloro(dimethylglyoxime)(dimethylglyoximato)cobalt(III); [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; triphenylphosphine In dichloromethane at 20℃; for 12h; Inert atmosphere; Sealed tube; Irradiation;74%
Stage #1: dimethyl amine; benzoic acid at 60℃; Autoclave; Cooling with dry ice;
Stage #2: at 290℃; under 22502.3 Torr; for 0.0136111h; Microwave irradiation;
bromobenzene
108-86-1

bromobenzene

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With sodium methylate; nickel diacetate In 1,4-dioxane at 110℃;98%
Stage #1: N,N-dimethyl-formamide With 1,3,5-trichloro-2,4,6-triazine at 20℃; for 1h;
Stage #2: bromobenzene With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate In N,N-dimethyl-formamide at 120℃; for 6h;
81%
With palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; trichlorophosphate at 165℃; for 24h; Inert atmosphere;72%
iodobenzene
591-50-4

iodobenzene

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With Pd nanoparticles supported on reduced graphene oxide nanosheets at 200℃; for 6h; Temperature; Concentration; Autoclave;98%
With palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; trichlorophosphate at 135℃; for 6h; Inert atmosphere;93%
Stage #1: N,N-dimethyl-formamide With tungsten(VI) chloride at 20℃; for 0.25h; Inert atmosphere;
Stage #2: iodobenzene With palladium dichloride at 140℃; for 5h; Catalytic behavior; Reagent/catalyst; Temperature; Inert atmosphere;
93%
N,N-dimethylbenzamide dimethyl acetal
35452-04-1

N,N-dimethylbenzamide dimethyl acetal

A

2-(trichloromethyl)-4-(dimethylamino)-4-phenyl-1,3-diaza-1,3-butadiene

2-(trichloromethyl)-4-(dimethylamino)-4-phenyl-1,3-diaza-1,3-butadiene

B

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With trichloroacetamidine In tetrahydrofuran at 40 - 50℃; for 3h; Title compound not separated from byproducts;A 96%
B 5%
N,N-dimethylbenzamide dimethyl acetal
35452-04-1

N,N-dimethylbenzamide dimethyl acetal

trichloroacetamidine
2533-68-8

trichloroacetamidine

A

2-(trichloromethyl)-4-(dimethylamino)-4-phenyl-1,3-diaza-1,3-butadiene

2-(trichloromethyl)-4-(dimethylamino)-4-phenyl-1,3-diaza-1,3-butadiene

B

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
In tetrahydrofuran at 40 - 50℃; for 3h; Title compound not separated from byproducts;A 96%
B 5%
tert-butyl benzoyl(phenyl)carbamate
101137-69-3

tert-butyl benzoyl(phenyl)carbamate

dimethyl amine
124-40-3

dimethyl amine

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 23℃; for 15h; Inert atmosphere; Schlenk technique;96%
1,3-diphenylpropanedione
120-46-7

1,3-diphenylpropanedione

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With iodosylbenzene at 25℃; for 24h;96%
benzoyl chloride
98-88-4

benzoyl chloride

dimethyl amine
124-40-3

dimethyl amine

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; Inert atmosphere;95%
With triethylamine In dichloromethane at 0 - 20℃;93%
With dmap; triethylamine In tetrahydrofuran; dichloromethane at 0 - 20℃; for 12h;91%
1-(benzoyl)piperidine-2,6-dione

1-(benzoyl)piperidine-2,6-dione

dimethyl amine
124-40-3

dimethyl amine

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 23℃; for 15h; Inert atmosphere; Schlenk technique;95%
N,N-phenyl-p-toluenesulfonylbenzamide
74542-54-4

N,N-phenyl-p-toluenesulfonylbenzamide

dimethyl amine
124-40-3

dimethyl amine

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 23℃; for 15h; Inert atmosphere; Schlenk technique;94%
2-bromo-N,N-dimethyl benzamide
54616-47-6

2-bromo-N,N-dimethyl benzamide

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; potassium tert-butylate; isopropyl alcohol at 100℃; Schlenk technique; Inert atmosphere;93%
dimethyl amine
124-40-3

dimethyl amine

polymer-bound mixed benzoic dithiocarbamic anhydride

polymer-bound mixed benzoic dithiocarbamic anhydride

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
In chloroform for 1h;92%
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

acetophenone
98-86-2

acetophenone

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With sodium iodide In dimethyl sulfoxide at 20℃; for 6h; Solvent; Reagent/catalyst; Electrochemical reaction;92%
benzoyl chloride
98-88-4

benzoyl chloride

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With dysprosium at 20℃; for 0.333333h; Inert atmosphere;91%
Stage #1: N,N-dimethyl-formamide With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.25h; Schlenk technique;
Stage #2: benzoyl chloride In tetrahydrofuran at 50℃; for 12h;
84%
benzoyl chloride
98-88-4

benzoyl chloride

2-Dimethylamino-3-methyl-2,4,6-triphenyl-2H-pyran
79962-35-9

2-Dimethylamino-3-methyl-2,4,6-triphenyl-2H-pyran

A

3-Methyl-2,4,6-triphenylpyryliumchlorid
92919-44-3

3-Methyl-2,4,6-triphenylpyryliumchlorid

B

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
In diethyl ether for 1h; Heating;A 91%
B 54%
2-Dimethylamino-3-methyl-2,4,6-triphenyl-2H-pyran
79962-35-9

2-Dimethylamino-3-methyl-2,4,6-triphenyl-2H-pyran

A

3-Methyl-2,4,6-triphenylpyryliumchlorid
92919-44-3

3-Methyl-2,4,6-triphenylpyryliumchlorid

B

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With benzoyl chloride In diethyl ether for 1h; Heating;A 91%
B 54%
dimethyl amine
124-40-3

dimethyl amine

benzyl alcohol
100-51-6

benzyl alcohol

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With oxygen; sodium hydroxide In water at 25℃; for 24h; Green chemistry;91%
With oxygen; sodium hydroxide In water at 25℃; for 24h;90%
With tert.-butylhydroperoxide; [bis(acetoxy)iodo]benzene In acetonitrile Reagent/catalyst; Solvent; Reflux;86%
benzaldehyde
100-52-7

benzaldehyde

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With tert.-butylhydroperoxide; iodine at 70 - 80℃; for 24h;91%
With hydrogenchloride; tert.-butylhydroperoxide; iodine In cyclohexane; water at 80℃;88%
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide at 80℃; for 24h;85%
2-formylbenzoyl(N,N-dimethyl)amine

2-formylbenzoyl(N,N-dimethyl)amine

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
With (R)-(+)-2,2'-bis[bis(3,5-dimethylphenyl)phosphino]-1,1'-binaphthyl; bis(1,5-cyclooctadiene)iridium(I) tetrakis[3,5-bis(trifluoromethyl)phenyl]borate In tetrahydrofuran at 135℃; for 24h; Reagent/catalyst; Sealed tube; Inert atmosphere;91%
tetrakis(dimethylamino)silane
1624-01-7

tetrakis(dimethylamino)silane

benzaldehyde
100-52-7

benzaldehyde

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
bis(di-tert-butylphosphinous acid)PdCl2 In acetonitrile at 25℃; for 24h;90%
Benzotrichlorid
98-07-7

Benzotrichlorid

dimethyl amine
124-40-3

dimethyl amine

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
In methanol at 20℃; for 3h; UV-irradiation;90%
N-methylbenzamide
88070-48-8

N-methylbenzamide

tetramethylammonium fluoride
373-68-2

tetramethylammonium fluoride

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
In toluene at 100℃; for 12h;90%
benzoyl cyanide
613-90-1

benzoyl cyanide

Bis(dimethylamino)acetonitrile
2214-82-6

Bis(dimethylamino)acetonitrile

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Conditions
ConditionsYield
In N,N-dimethyl-formamide88%
benzylpentacarbonylmanganese

benzylpentacarbonylmanganese

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

(η2-O,C-1-(N,N-dimethylaminocarbonyl)-2-phenyl)tetracarbonylmanganese

(η2-O,C-1-(N,N-dimethylaminocarbonyl)-2-phenyl)tetracarbonylmanganese

Conditions
ConditionsYield
In n-heptane soln. was refluxed for 5 h, after cooling, heptane was removed under vac.; elem.anal.;100%
N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

N,N'-dimethylbenzylamine
103-83-3

N,N'-dimethylbenzylamine

Conditions
ConditionsYield
With C37H46FeN4; diphenylsilane In tetrahydrofuran at 70℃; for 24h; Schlenk technique; Inert atmosphere;99%
With Pt(ItBu)(divinyltetramethyldisiloxane); diphenylsilane In tetrahydrofuran; Hexadecane at 40℃; for 1h; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere;99%
With triethyl borane; phenylsilane; sodium hydroxide In tetrahydrofuran; tert-butyl methyl ether at 20℃; Reagent/catalyst; Solvent; Inert atmosphere; Schlenk technique; Sealed tube; chemoselective reaction;99%
N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

N,N-dimethylthiobenzamide
15482-60-7

N,N-dimethylthiobenzamide

Conditions
ConditionsYield
With thiophosphorylated amine resin In toluene at 90℃; for 30h;99%
With tetraphosphorus decasulfide In dichloromethane for 0.25h; Inert atmosphere; Reflux;99%
With tetraphosphorus decasulfide; sodium carbonate In tetrahydrofuran at 25℃; for 4h;90%
1,2-bis(4-methylphenyl)acetylene
2789-88-0

1,2-bis(4-methylphenyl)acetylene

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

N,N-dimethyl-1,2,3,4,5,6,7,8-octa-(p-tolyl)anthracene-9-carboxamide

N,N-dimethyl-1,2,3,4,5,6,7,8-octa-(p-tolyl)anthracene-9-carboxamide

Conditions
ConditionsYield
With silver hexafluoroantimonate; copper diacetate; C46H44I4Ir2N2O4 In 1,4-dioxane at 100℃; for 24h; Glovebox; Inert atmosphere;99%
N-Bromosuccinimide
128-08-5

N-Bromosuccinimide

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

N-methyl-N-succinimidomethylbenzamide
87329-69-9

N-methyl-N-succinimidomethylbenzamide

Conditions
ConditionsYield
With dibenzoyl peroxide In tetrachloromethane Product distribution; Heating; succinimidation by N-bromosuccinimide of N,N-dimethylamides and N,N-dimethylamines;98%
With dibenzoyl peroxide In tetrachloromethane Heating;98%
N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

benzyl alcohol
100-51-6

benzyl alcohol

Conditions
ConditionsYield
With n-butyllithium; borane-THF; diisopropylamine at 25℃;98%
With diisobutylaluminum borohydride In tetrahydrofuran at 0 - 25℃; Inert atmosphere;98%
With diisobutylaluminum borohydride In tetrahydrofuran at 25℃; for 1h; Inert atmosphere;98%
acrylic acid n-butyl ester
141-32-2

acrylic acid n-butyl ester

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

N,N-dimethyl-2-[(E)-(n-butoxycarbonyl)ethenyl]benzamide
1373338-22-7

N,N-dimethyl-2-[(E)-(n-butoxycarbonyl)ethenyl]benzamide

Conditions
ConditionsYield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; Ag(1+)*(x)F6Sb; copper(II) acetate monohydrate In tert-Amyl alcohol at 100℃; for 4h; Inert atmosphere; regioselective reaction;98%
With silver hexafluoroantimonate; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer In chlorobenzene at 80℃; for 16h; Heck Reaction; Irradiation;91%
N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

benzaldehyde
100-52-7

benzaldehyde

Conditions
ConditionsYield
With lithium diisobutylmorpholinoaluminum hydride In tetrahydrofuran; hexane at 0℃; for 0.5h; Concentration; Time;97%
Stage #1: N,N-dimethylbenzamide With chloromagnesium dimethylaminoborohydride In tetrahydrofuran at 25℃; for 0.5h; Inert atmosphere;
Stage #2: With acetaldehyde; acetic acid In tetrahydrofuran; pentane for 5h; Inert atmosphere;
74%
With diethyl ether; diisobutylaluminium hydride
1,3-diphenyl-1H-pyrazol-5-amine
5356-71-8

1,3-diphenyl-1H-pyrazol-5-amine

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

N'-(1,3-diphenyl-1H-pyrazol-5-yl)-N,N-dimethylbenzenecarboximidamide

N'-(1,3-diphenyl-1H-pyrazol-5-yl)-N,N-dimethylbenzenecarboximidamide

Conditions
ConditionsYield
With trichlorophosphate at 30 - 40℃; Microwave irradiation;97%
4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

N-[2-(4-methoxyphenyl)ethyl]benzamide
3278-19-1

N-[2-(4-methoxyphenyl)ethyl]benzamide

Conditions
ConditionsYield
With Imidazole hydrochloride at 150℃; for 3h; Sealed tube;97%
Li{(CH2)(CH2)P(C6H5)2}
59983-62-9

Li{(CH2)(CH2)P(C6H5)2}

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

A

Methyl-diphenyl-phenacyl-phosphonium
19023-66-6

Methyl-diphenyl-phenacyl-phosphonium

B

acetophenone
98-86-2

acetophenone

C

diphenyl(methyl)phosphine oxide
2129-89-7

diphenyl(methyl)phosphine oxide

Conditions
ConditionsYield
With HX In water 1.) 2 h, -55 deg C; 2.) 13 h, 21 deg C;A 96%
B 20%
C 20%
With HX In water 1.) 2 h, -55 deg C; 2.) 13 h, 21 deg C;A 80%
B 20%
C 20%
N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

[2',6'-2H2]-N,N-dimethylbenzamide

[2',6'-2H2]-N,N-dimethylbenzamide

Conditions
ConditionsYield
With C34H43IrN3(1+)*F6P(1-); deuterium In dichloromethane at -78℃; for 16h; Reagent/catalyst; Inert atmosphere;96%
With Crabtree's catalyst; water-d2; deuterium In dichloromethane at 20℃;
With silver tetrafluoroborate; bis(1,5-cyclooctadiene)diiridium(I) dichloride; deuterium; triphenylphosphine In dichloromethane at 20℃;2 mg
With water-d2; Ir(cod)(hfac) In N,N-dimethyl acetamide at 160℃; for 0.0333333h; microwave irradiation;
With 2,6-(2,6-iPr2-C6H3-4,5-H2-imidazol-2-ylidene)2C5H3NFe(N2)2; deuterium In tetrahydrofuran at 45℃; under 3040.2 Torr; for 24h;
tris(1,3-diphenyl-1,3-propanedionato)aquoeuropium(III)
12121-06-1

tris(1,3-diphenyl-1,3-propanedionato)aquoeuropium(III)

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

Eu(dibenzoylmethanate)3(dimethylbenzamide)

Eu(dibenzoylmethanate)3(dimethylbenzamide)

Conditions
ConditionsYield
In acetone Eu complex in acetone reacted with dimethylbenzamide; solvent evapd., ppt. washed with water, vac. dried; elem. anal.;96%
1H-imidazole
288-32-4

1H-imidazole

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

N-((1H-imidazol-1-yl)methyl)-N-methylbenzamide
1402844-74-9

N-((1H-imidazol-1-yl)methyl)-N-methylbenzamide

Conditions
ConditionsYield
With di-tert-butyl peroxide; iron(II) chloride In chlorobenzene at 120℃; for 3h; Inert atmosphere; Schlenk technique;96%
2-chloro-1H-benzoimidazole
4857-06-1

2-chloro-1H-benzoimidazole

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

N-((2-chloro-1H-benzo[d]imidazol-1-yl)methyl)-N-methylbenzamide

N-((2-chloro-1H-benzo[d]imidazol-1-yl)methyl)-N-methylbenzamide

Conditions
ConditionsYield
With dipotassium peroxodisulfate; potassium iodide at 80℃; for 6h; Schlenk technique;96%
C54H62N6

C54H62N6

N,N-dimethylbenzamide
611-74-5

N,N-dimethylbenzamide

C61H65N6(1+)*F6P(1-)

C61H65N6(1+)*F6P(1-)

Conditions
ConditionsYield
Stage #1: C54H62N6; N,N-dimethylbenzamide With trichlorophosphate In 1,2-dichloro-ethane at 20 - 40℃; for 2h; Vilsmeier-Haack Formylation; Inert atmosphere;
Stage #2: With potassium hexafluorophosphate; sodium hydrogencarbonate In water
96%

N,N-Dimethylbenzamide Consensus Reports

Reported in EPA TSCA Inventory.

N,N-Dimethylbenzamide Specification

The N,N-Dimethylbenzamide, with the CAS registry number 611-74-5, is also known as Benzamide, N,N-dimethyl-. It belongs to the product categories of Amide; Amides; Carbonyl Compounds; Organic Building Blocks. Its EINECS registry number is 210-279-2. This chemical's molecular formula is C9H11NO and molecular weight is 149.19. What's more, its IUPAC name is the same with its product name.

Physical properties about N,N-Dimethylbenzamide are: (1)ACD/LogP: 0.44; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.43; (4)ACD/LogD (pH 7.4): 0.43; (5)ACD/BCF (pH 5.5): 1.26; (6)ACD/BCF (pH 7.4): 1.26; (7)ACD/KOC (pH 5.5): 41.07; (8)ACD/KOC (pH 7.4): 41.07;(9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 20.31 Å2; (13)Index of Refraction: 1.529; (14)Molar Refractivity: 44.63 cm3; (15)Molar Volume: 144.7 cm3; (16)Surface Tension: 37.4 dyne/cm; (17)Density: 1.03 g/cm3; (18)Flash Point: 111.9 °C; (19)Enthalpy of Vaporization: 49.36 kJ/mol; (20)Boiling Point: 256.1 °C at 760 mmHg; (21)Vapour Pressure: 0.0157 mmHg at 25 °C.

Preparation of N,N-Dimethylbenzamide: this chemical can be prepared by Benzoyl chloride with Dimethylamine. This reaction needs reagent Et3N and solvent diethyl ether. The yield is 90 %.

N,N-Dimethylbenzamide can be prepared by Benzoyl chloride with Dimethylamine.

Uses of N,N-Dimethylbenzamide: (1) it is used for deoxidizing reaction of secondary alcohol; (2) it is used to produce other chemicals. For example, it can produce Benzyl-dimethyl-amine. The reaction occurs with reagents HSiEt3, Et2NH and solvent toluene at temperature of 100 °C. The yield is 99.5 %.

N,N-Dimethylbenzamide can produce Benzyl-dimethyl-amine.

When you are dealing with this chemical, you should be very careful. This chemical is inflammation to the skin, eyes and respiratory system or other mucous membranes. If swallowed, it's harmful to health. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. And in case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C(N(C)C)c1ccccc1
(2) InChI: InChI=1S/C9H11NO/c1-10(2)9(11)8-6-4-3-5-7-8/h3-7H,1-2H3
(3) InChIKey: IMNDHOCGZLYMRO-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 960mg/kg (960mg/kg)   Toxicology and Applied Pharmacology. Vol. 19, Pg. 20, 1971.
 

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