N,N-Dimethylglycine supplier

Name
N,N-Dimethylglycine
EINECS 214-267-8
CAS No. 1118-68-9
Article Data52
CAS DataBase
Density 1.069 g/cm³
Solubility soluble in water
Melting Point 178-182 °C(lit.)
Formula C₄H₉NO₂
Boiling Point 175.2 °C at 760 mmHg
Molecular Weight 103.121
Flash Point 59.8 °C
Transport Information
Appearance white to slightly yellow crystalline powder
Safety 24/25-36/37-26
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms (Dimethylamino)aceticacid;2-(Dimethylamino)acetic acid;2-(N,N-Dimethylamino)acetic acid;DMG;Dimethylglycine;N,N-Dimethylaminoacetic acid;N-Methylsarcosine;N,N-Dimthylglycine;
PSA 40.54000
LogP -0.36740

Synthetic route

: 50-00-0
formaldehyd

: 56-40-6
glycine

: 1118-68-9
dimethylaminoacetic acid

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol; water under 2068.6 Torr; for 10h; Ambient temperature;	98%
With sodium dihydrogenphosphate; zinc at 30℃; for 1h;	94%
With sodium tetrahydroborate In 2,2,2-trifluoroethanol for 24h; Reflux;	91%

: 33229-89-9
N,N-dimethylglycine ethyl ester

: 1118-68-9
dimethylaminoacetic acid

Conditions

Conditions	Yield
With sodium hydroxide In water Heating;	30%

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 1118-68-9
dimethylaminoacetic acid

Conditions

Conditions	Yield
With chromium(VI) oxide; sulfuric acid; acetone

: 6027-13-0
L-homocysteine

: 107-43-7
betaine

A: 1118-68-9
dimethylaminoacetic acid

B: 63-68-3
L-methionine

Conditions

Conditions	Yield
in Gegenwart von Leber-Praeparaten;

...Expand

: 926-64-7
N,N-Dimethylamino acetonitrile

: 1118-68-9
dimethylaminoacetic acid

Conditions

Conditions	Yield
With potassium hydroxide at 100℃;

: 89222-12-8
2-dimethylaminomalonic acid diethyl ester

: 1118-68-9
dimethylaminoacetic acid

Conditions

Conditions	Yield
With hydrogenchloride

: 124-40-3
dimethyl amine

: 107-16-4
glycolonitrile

: 1118-68-9
dimethylaminoacetic acid

Conditions

Conditions	Yield
anschliessend Behandeln mit Barytwasser;

: 124-40-3
dimethyl amine

: 79-11-8
chloroacetic acid

: 1118-68-9
dimethylaminoacetic acid

: 50-00-0
formaldehyd

: 56-40-6
glycine

A: 107-97-1
sarcosine

B: 1118-68-9
dimethylaminoacetic acid

Conditions

Conditions	Yield
With hydrogenchloride; tin

...Expand

: 124225-44-1
1-methyl-4-(phenylacetyl)pyridinium cation

: 20837-43-8
dimethylaminoacetate

A: 1118-68-9
dimethylaminoacetic acid

B: 114444-46-1
C14H13NO

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant; Rate constant; Thermodynamic data; ΔH0, ΔS0, ΔG0; kinetics, other temperatures; activation parameters: ΔH(excit.), ΔS(excit.), ΔG(excit.);

...Expand

: 133604-81-6
3,5-dimethylphenyl (N,N-dimethylamino)acetate

A: 1118-68-9
dimethylaminoacetic acid

B: 108-68-9
3,5-Dimethylphenol

Conditions

Conditions	Yield
With sodium hydroxide; water In ethanol at 30℃; Rate constant;

: 7647-01-0
hydrogenchloride

: 50-00-0
formaldehyd

: 56-40-6
glycine

tin: tin

A: 107-97-1
sarcosine

B: 1118-68-9
dimethylaminoacetic acid

...Expand

: 50-00-0
formaldehyd

: 64-18-6
formic acid

: 56-40-6
glycine

A: 1118-68-9
dimethylaminoacetic acid

B: 124-38-9
carbon dioxide

C: 75-50-3
trimethylamine

...Expand

: 50-00-0
formaldehyd

: 64-19-7
acetic acid

: 56-40-6
glycine

A: 1118-68-9
dimethylaminoacetic acid

B: 124-38-9
carbon dioxide

C: 75-50-3
trimethylamine

...Expand

: 7647-01-0
hydrogenchloride

: 50-00-0
formaldehyd

: 56-40-6
glycine

tin: tin

A: 1118-68-9
dimethylaminoacetic acid

B: 302-72-7
rac-Ala-OH

...Expand

: 50-00-0
formaldehyd

: 124-40-3
dimethyl amine

CO: CO

: 1118-68-9
dimethylaminoacetic acid

Conditions

Conditions	Yield
With hydrogenchloride at 150℃; under 661957 Torr;

...Expand

: 50-00-0
formaldehyd

: 56-40-6
glycine

dideuteroformic acid: dideuteroformic acid

: 1118-68-9
dimethylaminoacetic acid

Conditions

Conditions	Yield
Herstellung von -essigsaeure (Hydrochlorid. Krystalle (aus Eg.). F:187grad);

...Expand

: 107-97-1
sarcosine

A: 50-00-0
formaldehyd

B: 1118-68-9
dimethylaminoacetic acid

C: 74-89-5
methylamine

D CO2: CO2

Conditions

Conditions	Yield
With Carbonate buffer Product distribution; controlled potential electrolysis: glassy-carbon plate electrode, pH 10;

...Expand

: 6000-59-5
glyoxalic acid monohydrate

: 124-40-3
dimethyl amine

: 1118-68-9
dimethylaminoacetic acid

Conditions

Conditions	Yield
With dihydroxyborane In dichloromethane at 20℃; for 48h; Petasis boronic acid-Mannich reaction;

: 124-40-3
dimethyl amine

: 298-12-4
Glyoxilic acid

: 1118-68-9
dimethylaminoacetic acid

Conditions

Conditions	Yield
With dihydroxyborane In dichloromethane at 20℃; for 48h;

: 18319-88-5
N,N-dimethylglycine sodium salt

: 1118-68-9
dimethylaminoacetic acid

Conditions

Conditions	Yield
With sulfuric acid In water at 50 - 80℃; pH=5 - 7;

: 7148-06-3
N,N-dimethylglycine methyl ester

: 4229-44-1
N-methylhydroxyamine hydrochloride

A: 1118-68-9
dimethylaminoacetic acid

B: 65753-93-7
N-methyl-2-dimethylamino-acetohydroxamic acid

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water
With sodium hydroxide In water

...Expand

: C4H10NO4P(2-)

: 1118-68-9
dimethylaminoacetic acid

Conditions

Conditions	Yield
With Leisingera caerulea TmpB oxygenase; oxygen; sodium L-ascorbate In aq. buffer at 0.3℃; for 4h; pH=7.5; Enzymatic reaction;

: 67-56-1
methanol

: 107-97-1
sarcosine

: 1118-68-9
dimethylaminoacetic acid

Conditions

Conditions	Yield
With Ru on activatedcarbon cloth; activatedcarbon cloth In aq. phosphate buffer at 60℃; for 10h; pH=7.5; Electrochemical reaction;

: 1118-68-9
dimethylaminoacetic acid

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 864246-28-6
tert-butyl [1-(2-dimethylaminoacetyl)piperidin-4-yl]carbamate

Conditions

Conditions	Yield
Stage #1: dimethylaminoacetic acid; (piperidin-4-yl)carbamic acid tert-butyl ester With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 46h; Stage #2: With sodium hydroxide In water; ethyl acetate; N,N-dimethyl-formamide; sodium chloride at 20℃; for 0.5h;	100%
With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 46h;	100%

: 129487-92-9
tert-butyl 5-amino-2,3-dihydro-1H-indole-1-carboxylate

: 1118-68-9
dimethylaminoacetic acid

: 536760-01-7
tert-butyl 5-[(N,N-dimethylglycyl)amino]-1-indolinecarboxylate

Conditions

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine In DMF (N,N-dimethyl-formamide) for 0.166667h;	100%

: 1118-68-9
dimethylaminoacetic acid

: 1035345-81-3
4-aminomethyl-4-[3-(1-methyl-1H-pyrazol-4-yl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

: 1035346-28-1
tert-butyl 4-((2-(dimethylamino)acetamido)methyl)-4-(3-(1-methyl-1H-pyrazol-4-yl)phenyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 4h;	100%

: 1118-68-9
dimethylaminoacetic acid

: 6-fluoro-1-(phenylsulfonyl)-3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-indole hydrochloride

: 2-(dimethylamino)-1-(4-(4-(6-fluoro-1-(phenylsulfonyl)-1H-indol-3-yl)-1H-pyrazol-1-yl)piperidin-1-yl)ethanone

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran Inert atmosphere;	100%

: 1118-68-9
dimethylaminoacetic acid

: (4-(3-amino-2-(butyl(λ1-oxidanyl)-λ3-sulfanyl)-6-(thiazol-2-yl)thieno[2,3-b]pyridin-4-yl)phenyl)methanol

: 4-(3-amino-2-(butylsulfinyl)-6-(thiazol-2-yl)thieno[2,3-b]-pyridin-4-yl)benzyl Dimethylglycinate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;	100%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;	100%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;	100%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;	100%

: 1118-68-9
dimethylaminoacetic acid

: 4-(6-fluoro-1-(phenylsulfonyl)-1H-indol-3-yl)benzene-1,2-diamine

: N-(2-amino-5-(6-fluoro-1-(phenylsulfonyl)-1H-indol-3-yl)phenyl)-2-(dimethylamino)acetamide

Conditions

Conditions	Yield
Stage #1: dimethylaminoacetic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: 4-(6-fluoro-1-(phenylsulfonyl)-1H-indol-3-yl)benzene-1,2-diamine In tetrahydrofuran at 20℃; for 1h;	100%

: 1118-68-9
dimethylaminoacetic acid

: 8-methyl-7-[4-(4-piperidyloxy)phenyl]quinoline

: 2-(dimethylamino)-1-[4-[4-(8-methyl-7-quinolyl)phenoxy]-1-piperidyl]ethanone

Conditions

Conditions	Yield
Stage #1: dimethylaminoacetic acid With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃; for 0.00333333h; Inert atmosphere; Stage #2: 8-methyl-7-[4-(4-piperidyloxy)phenyl]quinoline In dichloromethane at 20℃;	99%

: 1118-68-9
dimethylaminoacetic acid

: tert-butyl 4-[2-chloro-4-[[1-methyl-5-[3-(trifluoromethyl)-1H-pyrazol-4-yl]imidazole-2-carbonyl]amino]phenyl]sulfonylpiperazine-1-carboxylate

: N-(3-chloro-4-((4-(dimethylglycyl)-piperazin-1-yl)sulfonyl)phenyl)-1-methyl-5-(3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	99%

: 1118-68-9
dimethylaminoacetic acid

: 3282-30-2
pivaloyl chloride

: 883564-82-7
C9H17NO3

Conditions

Conditions	Yield
	98%

: 1118-68-9
dimethylaminoacetic acid

: 88192-19-2
3-azidopropylamine

: 1236145-09-7
N-(3-azidopropyl)-2-(dimethylamino)-acetamide

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 0 - 20℃; for 7.58333h;	98%

: 1118-68-9
dimethylaminoacetic acid

: diphenyl-boronic acid

: C16H18BNO2

Conditions

Conditions	Yield
In ethyl acetate at 20℃; for 2h; Inert atmosphere; Schlenk technique;	98%

: 1118-68-9
dimethylaminoacetic acid

: 769-39-1
2,3,5,6-tetraflourophenol

: 2,3,5,6-tetrafluorophenyl dimethylglycinate

Conditions

Conditions	Yield
Stage #1: dimethylaminoacetic acid With triethylamine In dichloromethane at 0℃; for 0.166667h; Stage #2: 2,3,5,6-tetraflourophenol With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 5h;	98%

: 1118-68-9
dimethylaminoacetic acid

: 2325-10-2
(S,S)-hydrobenzoin

: Dimethylamino-acetic acid (1S,2S)-2-(2-dimethylamino-acetoxy)-1,2-diphenyl-ethyl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 20h;	97%

: 1118-68-9
dimethylaminoacetic acid

: 22751-68-4, 60508-97-6, 60509-62-8, 70749-06-3, 118628-68-5
(S,S)-N,N'-dimethyl-1,2-diphenylethane-1,2-diamine

: 1105044-51-6
N,N'-[(1S,2S)-1,2-diphenylethane-1,2-diyl] bis[2-(dimethylamino)-N-methylacetamide]

Conditions

Conditions	Yield
Stage #1: dimethylaminoacetic acid With chloroformic acid ethyl ester; triethylamine In dichloromethane at 0℃; for 0.5h; Inert atmosphere; Stage #2: (S,S)-N,N'-dimethyl-1,2-diphenylethane-1,2-diamine In dichloromethane at 0℃; for 12h; Inert atmosphere;	97%

: 1118-68-9
dimethylaminoacetic acid

: C10H13N3O3

: C14H18N4O3

Conditions

Conditions	Yield
Stage #1: dimethylaminoacetic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: C10H13N3O3 In N,N-dimethyl-formamide at 20 - 80℃; for 6h;	96.37%

: 911417-28-2
tert-butyl 5-(2-(3-aminophenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

: 1118-68-9
dimethylaminoacetic acid

: 911417-32-8
tert-butyl 5-(2-(3-(2-(dimethylamino)acetamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Conditions

Conditions	Yield
Stage #1: dimethylaminoacetic acid With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.166667 - 0.25h; Stage #2: tert-butyl 5-(2-(3-aminophenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate In dichloromethane at 20℃; for 17.5h;	96%
Stage #1: dimethylaminoacetic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.25h; Stage #2: tert-butyl 5-(2-(3-aminophenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate In dichloromethane at 20℃; for 17.5h;	96%
Stage #1: dimethylaminoacetic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.166667 - 0.25h; Stage #2: tert-butyl 5-(2-(3-aminophenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate In dichloromethane at 20℃; for 1.5h; Stage #3: dimethylaminoacetic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;	96%

: 1118-68-9
dimethylaminoacetic acid

: 1204343-70-3
(3aR,7S,7aS)-7-(4-amino-3-fluorobenzyl)-3-(3-(tert-butyl)benzyl)hexahydro-2H-thiopyrano[3,4-d]oxazol-2-one 5,5-dioxide

: 1367877-43-7
N-(4-(((3aR,7S,7aS)-3-(3-(tert-butyl)benzyl)-5,5-dioxido-2-oxohexahydro-2H-thiopyrano[3,4-d]oxazol-7-yl)methyl)-2-fluorophenyl)-2-(dimethylamino) acetamide

Conditions

Conditions	Yield
With 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In N,N-dimethyl-formamide at 25℃; for 19h; Inert atmosphere;	96%

: 1118-68-9
dimethylaminoacetic acid

: N-((1S,3R)-3-aminocyclopentyl)-5-(2-methyl-4-phenoxyphenyl)-4-oxo-4,5-dihydro-3H-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide

: N-((1S,3R)-3-(2-(dimethylamino)acetamido)cyclopentyl)-5-(2-methyl-4-phenoxyphenyl)-4-oxo-4,5-dihydro-3H-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide

Conditions

Conditions	Yield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;	96%
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h; Time; Inert atmosphere;	96%

: 661485-12-7
methyl 4'-{[(3-aminopyridin-2-yl)amino]methyl}-biphenyl-2-carboxylate

: 1118-68-9
dimethylaminoacetic acid

: 4'-{[3-(2-dimethylamino-acetylamino)-pyridin-2-ylamino]-methyl}-biphenyl-2-carboxylic acid methyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride	95%

: 1118-68-9
dimethylaminoacetic acid

: 99438-28-5
(+)-B-methoxydiisocamphenylborane

: (C10H17)2BOCOCH2N(CH3)2

Conditions

Conditions	Yield
In tetrahydrofuran; ethanol; water dropwise addn. of 1 M soln. of (+)(C10H17)2BOCH3 in THF to N,N-dimethylglycine in ethanol/H2O (1:1), stirring at 80-100°C; control of completion of the reaction by (11)B-NMR, removing of solvent under vacuum (1-2.0 mm), treating with methanol, obtaining viscous liquid;	95%
In tetrahydrofuran; dimethyl sulfoxide dropwise addn. of 1 M soln. of (+)(C10H17)2BOCH3 in THF to N,N-dimethylglycine in DMSO, stirring at 80-100°C; control of completion of the reaction by (11)B-NMR, removing of solvent under vacuum (1-2.0 mm), treating with methanol, obtaining viscous liquid;	95%

: 1118-68-9
dimethylaminoacetic acid

: 32705-46-7
B-methoxydicyclohexylborane

: 117195-42-3
(C6H11)2BOCOCH2N(CH3)2

Conditions

Conditions	Yield
In tetrahydrofuran; dimethyl sulfoxide dropwise addn. of 1 M soln. of (C6H11)2BOCH3 in THF to N,N-dimethylglycine in DMSO, stirring at 80-100°C; control of completion of the reaction by (11)B-NMR, removing of solvent under vacuum (1-2.0 mm), treating with methanol, obtaining viscous liquid;	95%
In tetrahydrofuran; ethanol; water dropwise addn. of 1 M soln. of (C6H11)2BOCH3 in THF to N,N-dimethylglycine in ethanol/H2O (1:1), stirring at 80-100°C; control of completion of the reaction by (11)B-NMR, removing of solvent under vacuum (1-2.0 mm), treating with methanol, obtaining viscous liquid;	95%

: 684249-45-4
4-(4-iodophenoxy)piperidine

: 1118-68-9
dimethylaminoacetic acid

: 1430471-90-1
2-(dimethylamino)-1-(4-(4-iodophenoxy)piperidin-1-yl)ethanone

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	95%

: 1118-68-9
dimethylaminoacetic acid

: (±)-6,7-dichloro-2,3-dihydro-1-benzothiophen-3-amine

: (±)-N-(6,7-dichloro-2,3-dihydro-1-benzothiophen-3-yl)-N2,N2-dimethylglycinamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 4h;	95%

: 479079-15-7, 479080-20-1
tert-butyl [2-amino-2-(hydroxyimino)ethyl]carbamate

: 1118-68-9
dimethylaminoacetic acid

: C11H20N4O3

Conditions

Conditions	Yield
Stage #1: dimethylaminoacetic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: tert-butyl [2-amino-2-(hydroxyimino)ethyl]carbamate In N,N-dimethyl-formamide at 20 - 80℃; for 6h;	94.99%

: 1118-68-9
dimethylaminoacetic acid

: 85134-98-1
(-)-B-methoxydiisopinocampheylborane

: (C10H17)2BOCOCH2N(CH3)2

Conditions

Conditions	Yield
In tetrahydrofuran; ethanol; water dropwise addn. of 1 M soln. of (-)(C10H17)2BOCH3 in THF to N,N-dimethylglycine in ethanol/H2O (1:1), stirring at 80-100°C; control of completion of the reaction by (11)B-NMR, removing of solvent under vacuum (1-2.0 mm), treating with methanol, obtaining viscous liquid;	94%
In tetrahydrofuran; dimethyl sulfoxide dropwise addn. of 1 M soln. of (-)(C10H17)2BOCH3 in THF to N,N-dimethylglycine in DMSO, stirring at 80-100°C; control of completion of the reaction by (11)B-NMR, removing of solvent under vacuum (1-2.0 mm), treating with methanol, obtaining viscous liquid;	94%

: 1118-68-9
dimethylaminoacetic acid

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 942919-64-4
dimethylamino-acetic acid pentafluorophenyl ester

Conditions

Conditions	Yield
Stage #1: dimethylaminoacetic acid With triethylamine In dichloromethane at 0℃; for 0.166667h; Stage #2: 2,3,4,5,6-pentafluorophenol With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 5h;	94%
With dicyclohexyl-carbodiimide In ethyl acetate at 20℃; for 12h;
With diisopropyl-carbodiimide In ethyl acetate at 20℃; for 12h;
With dicyclohexyl-carbodiimide In ethyl acetate

: 1118-68-9
dimethylaminoacetic acid

: 144183-31-3
N-(8-hydroxyoctyl)carbamic acid tert-butyl ester

: 1260379-56-3
8-(t-butoxycarbonylamino)octyl 2-(dimethylamino)acetate

Conditions

Conditions	Yield
With 4-methyl-morpholine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane	94%

: 1118-68-9
dimethylaminoacetic acid

: 173606-54-7
(10-hydroxydecyl)carbamic acid tert-butyl ester

: 1260379-57-4
10-(t-butoxycarbonylamino)decyl 2-(dimethylamino)acetate

Conditions

Conditions	Yield
With 4-methyl-morpholine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane	94%

: 1118-68-9
dimethylaminoacetic acid

: 7336-36-9
2-demethylcolchicine

: dimethylamino-acetic acid 7-acetylamino-1,3,10-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-2-yl ester

Conditions

Conditions	Yield
Stage #1: dimethylaminoacetic acid With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine In dichloromethane at 0 - 20℃; for 0.5h; Stage #2: 2-demethylcolchicine In dichloromethane for 18h;	93%

N,N-Dimethylglycine Specification

The CAS register number of Glycine, N,N-dimethyl- is 1118-68-9. It also can be called as N,N-Dimethylglycine and the systematic name about this chemical is 2-(dimethylamino)acetic acid. The molecular formula about this chemical is C₄H₉NO₂and the molecular weight is 103.12. It belongs to the Miscellaneous Biochemicals. This chemical can be used as pharmaceutical intermediate. This chemical is stable under normal temperatures and pressures, please avoid contact with oxidizing agents and water. If you want to store it, please keep it in a closed container and store it in a cool, dry place.

Physical properties about Glycine, N,N-dimethyl- are: (1)ACD/LogP: -0.30; (2)ACD/LogD (pH 5.5): -2.8; (3)ACD/LogD (pH 7.4): -2.8; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 3; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 29.54Å²; (12)Index of Refraction: 1.448; (13)Molar Refractivity: 25.86 cm³; (14)Molar Volume: 96.4 cm³; (15)Polarizability: 10.25x10^-24cm³; (16)Surface Tension: 37.5 dyne/cm; (17)Enthalpy of Vaporization: 45.38 kJ/mol; (18)Boiling Point: 175.2 °C at 760 mmHg; (19)Vapour Pressure: 0.556 mmHg at 25°C.

Preparation: this chemical can be prepared by N,N-dimethyl-glycine ethyl ester. This reaction will need reagent NaOH and solvent H₂O at heating. The yield is about 30%.

Uses of Glycine, N,N-dimethyl-: it can be used to produce N,N-dimethyl-N-oxy-glycine. This reaction will need reagent aq. H₂O₂ and solvent acetic acid.

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful if swallowed and it is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing and gloves, you also need avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)CN(C)C
(2)InChI: InChI=1/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7)
(3)InChIKey: FFDGPVCHZBVARC-UHFFFAOYAX
(4)Std. InChI: InChI=1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7)
(5)Std. InChIKey: FFDGPVCHZBVARC-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD50	oral	> 650mg/kg (650mg/kg)	BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: CHANGES IN SPLEEN	Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 199, 1992.

Product Name

N,N-Dimethylglycine

Synthetic route

N,N-Dimethylglycine Specification

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