N-Nitrosodiethylamine supplier

Name
N-NITROSODIETHYLAMINE
EINECS 200-226-1
CAS No. 55-18-5
Article Data97
CAS DataBase
Density 0.95g/cm³
Solubility substantial

Stability

Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents,reducing agents.

Toxicology

Harmful if swallowed. Experimental carcinogen, teratogen, mutagen.May c

Melting Point <25℃
Formula C4H10 N2 O
Boiling Point 173.9°Cat760mmHg
Molecular Weight 102.136
Flash Point 59°C
Transport Information
Appearance yellow liquid
Safety Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A transplacental carcinogen. When heated to decomposition it emits toxic fumes of NO_x. See also N-NITROSO COMPOUNDS and AMINES.
Analytical Methods:

For occupational chemical analysis use OSHA: #27 or NIOSH: Nitrosamines, 2522.
Risk Codes R45; R22; R39/23/24/25; R23/24/25; R11
Molecular Structure
Hazard Symbols T,F
Synonyms Diethylamine,N-nitroso- (6CI,8CI); DEN; DEN (mutagen); DENA; Diethylnitrosamide;Diethylnitrosamine; Diethylnitrosoamine; N,N-Diethylnitrosoamine;N-Ethyl-N-nitrosoethanamine; N-Nitroso-N,N-diethylamine; N-Nitrosodiethylamine;NDEA; NSC 132; Nitrosodiethylamine
PSA 32.67000
LogP 1.00960

Synthetic route

: 109-89-7
diethylamine

: 55-18-5
N-Nitrosodiethylamine

Conditions

Conditions	Yield
With [NO(1+)18-crown-6H(NO3)2(1-)] In dichloromethane at 20℃; for 0.0833333h;	100%
With magnesium hydrogen sulfate; silica gel; sodium nitrite In dichloromethane at 20℃; for 1h; Nitrosation;	98%
With aluminium trichloride; silica gel; sodium nitrite In dichloromethane at 20℃; for 0.5h; Nitrosation;	98%

: 121-44-8
triethylamine

: 55-18-5
N-Nitrosodiethylamine

Conditions

Conditions	Yield
With tin(IV) chloride; sodium nitrite In tetrachloromethane for 14h; Heating;	96%
With bromine; triphenylphosphine In dichloromethane at 20℃; for 0.0166667h;	92%
With dinitrogen tetroxide impregnated on activated charcoal In tetrachloromethane for 10h; Heating;	85%

: 660-68-4
diethyl amine hydrochloride

: 55-18-5
N-Nitrosodiethylamine

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In water at 70 - 75℃; for 3h; Inert atmosphere;	68%
With citrate buffer; sodium nitrite In acetone at 37℃; for 4h;
With sodium nitrite In acetone at 37℃; for 4h; effect of varios organic solvents;
With sodium nitrite In water at 37℃; for 4h; inhibitory effect of organic and inorganic salts;

: 109-89-7
diethylamine

A: 55-18-5
N-Nitrosodiethylamine

B: 125227-79-4
C4H10FN

Conditions

Conditions	Yield
With trifluoroamine oxide at -10℃; for 1.5h;	A 30% B 45%

: 110-86-1
pyridine

: 509-14-8
tetranitromethane

: 121-44-8
triethylamine

: 55-18-5
N-Nitrosodiethylamine

...Expand

: 34155-23-2
N1,N1,N3,N3-tetraethyl-propane-1,2,3-triyltriamine

A: N1,N1,N3,N3-tetraethyl-N2-nitroso-propane-1,2,3-triyltriamine

B: 55-18-5
N-Nitrosodiethylamine

Conditions

Conditions	Yield
With cis-nitrous acid

: 27096-30-6
diethylammonium, NO3(1-)-salt

: 55-18-5
N-Nitrosodiethylamine

Conditions

Conditions	Yield
at 170℃;

: 75-04-7
ethylamine

: 55-18-5
N-Nitrosodiethylamine

Conditions

Conditions	Yield
With diethyl ether; nitrosylchloride at -20 - -15℃;

: 64-17-5
ethanol

: 509-14-8
tetranitromethane

: 64-19-7
acetic acid

: 121-44-8
triethylamine

: 55-18-5
N-Nitrosodiethylamine

Conditions

Conditions	Yield
at 100℃;
at 100℃;

...Expand

: 88-10-8
N,N-diethylcarbamyl chloride

A: 55-18-5
N-Nitrosodiethylamine

B: 7119-92-8
diethyl-N-nitroamine

Conditions

Conditions	Yield
With silver nitrate; acetonitrile

: 935-05-7
benzyl nitrite

: 109-89-7
diethylamine

: 55-18-5
N-Nitrosodiethylamine

: 935-05-7
benzyl nitrite

: 109-89-7
diethylamine

A: 55-18-5
N-Nitrosodiethylamine

B: 100-51-6
benzyl alcohol

...Expand

: 509-14-8
tetranitromethane

: 121-44-8
triethylamine

: 55-18-5
N-Nitrosodiethylamine

Conditions

Conditions	Yield
With ethanol; acetic acid at 100℃;
With ethanol; acetic acid at 100℃;
With pyridine

: 595-86-8
1,1,1-trinitroethane

: 121-44-8
triethylamine

: 71-43-2
benzene

: 55-18-5
N-Nitrosodiethylamine

...Expand

: 29344-13-6
N,N-diethylmethyleneammonium ion

A: 50-00-0
formaldehyd

B: 55-18-5
N-Nitrosodiethylamine

Conditions

Conditions	Yield
With Nitrite at 25℃; Rate constant;

: 7119-92-8
diethyl-N-nitroamine

A: 75-17-2
formaldoxime

B: 55-18-5
N-Nitrosodiethylamine

C: 10605-31-9
diethyl nitroxide

Conditions

Conditions	Yield
In gas under 0.2 Torr; Rate constant; Mechanism; Irradiation; steady-state rate constant for unimolecular dissociation (photolysis at 1075.9 cm-1); in the presence of scavenger gases;

...Expand

: 7119-92-8
diethyl-N-nitroamine

: 55-18-5
N-Nitrosodiethylamine

Conditions

Conditions	Yield
In 2,2,4-trimethylpentane at 240℃; Rate constant; Thermodynamic data; decomposition in sealed tube;
In benzene at 240℃; Rate constant; decomposition in sealed tube;
In benzene-d6 at 240℃; Rate constant; decomposition in sealed tube;

: 543-67-9
n-propyl nitrite

: 109-89-7
diethylamine

A: 71-23-8
propan-1-ol

B: 55-18-5
N-Nitrosodiethylamine

Conditions

Conditions	Yield
With sodium hydroxide In water at 25℃; Rate constant;

...Expand

: 543-67-9
n-propyl nitrite

: 109-89-7
diethylamine

: 55-18-5
N-Nitrosodiethylamine

Conditions

Conditions	Yield
With sodium perchlorate at 25℃; Rate constant;

: 80-11-5
N-methyl-N-nitrosotoluene-p-sulfonamide

: 109-89-7
diethylamine

A: 55-18-5
N-Nitrosodiethylamine

B: 640-61-9
N-methyl-p-toluenesulfonylamide

Conditions

Conditions	Yield
In dichloromethane for 16h; Product distribution; Heating;
In 1,4-dioxane; water at 25℃; Rate constant; solvent isotope effect (kH/kD);

...Expand

: 70434-12-7
2-hydroxyethyl nitrite

: 109-89-7
diethylamine

: 55-18-5
N-Nitrosodiethylamine

Conditions

Conditions	Yield
With sodium perchlorate at 25℃; Rate constant;

: 109-89-7
diethylamine

: 115335-20-1
5-nitro-3,4-diphenyl-4,5-dihydroisoxazole

A: 55-18-5
N-Nitrosodiethylamine

B: 2431-96-1
N,N-diethylphenylacetamide

C: 100-47-0
benzonitrile

Conditions

Conditions	Yield
In benzene for 0.5h; Product distribution; Ambient temperature; other amines and solvents;

...Expand

: 109-89-7
diethylamine

A: 55-18-5
N-Nitrosodiethylamine

B: 7119-92-8
diethyl-N-nitroamine

Conditions

Conditions	Yield
With potassium hydroxide; tetra(n-butyl)ammonium hydroxide; potassium nitrate In dichloromethane; water Product distribution; Mechanism; electrolysis, Pt anode; other amines;
With potassium hydroxide; tetra(n-butyl)ammonium hydroxide; potassium nitrate In dichloromethane; water electrolysis, Pt anode; Yield given. Yields of byproduct given;
With diethylenetriaminopentaacetic acid; peroxynitrite In phosphate buffer at 37℃; for 0.25h; pH=7.4; Product distribution; Further Variations:; pH-values;

: 121-44-8
triethylamine

A: 55-18-5
N-Nitrosodiethylamine

B: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
With potassium nitrososulfonate; sodium carbonate

: 60-29-7
diethyl ether

: 75-04-7
ethylamine

nitrosyl chloride: nitrosyl chloride

: 55-18-5
N-Nitrosodiethylamine

...Expand

: 7647-01-0
hydrogenchloride

: 121-44-8
triethylamine

sodium nitrite: sodium nitrite

: 55-18-5
N-Nitrosodiethylamine

...Expand

: 60-29-7
diethyl ether

: 10544-72-6
dinitrogen tetraoxide

: 109-89-7
diethylamine

A: 55-18-5
N-Nitrosodiethylamine

B: 7119-92-8
diethyl-N-nitroamine

Conditions

Conditions	Yield
at -80℃;

...Expand

: 75-09-2
dichloromethane

: 10544-72-6
dinitrogen tetraoxide

: 109-89-7
diethylamine

A: 55-18-5
N-Nitrosodiethylamine

B: 7119-92-8
diethyl-N-nitroamine

Conditions

Conditions	Yield
at 0℃;
at -80℃;

...Expand

: 7697-37-2
nitric acid

: 108-24-7
acetic anhydride

: 109-89-7
diethylamine

ZnCl2: ZnCl2

A: 685-91-6
diethylacetamide

B: 55-18-5
N-Nitrosodiethylamine

C: 7119-92-8
diethyl-N-nitroamine

...Expand

: silver nitrate

: 88-10-8
N,N-diethylcarbamyl chloride

: 75-05-8
acetonitrile

A: 55-18-5
N-Nitrosodiethylamine

B: 7119-92-8
diethyl-N-nitroamine

C: 27096-30-6
diethylammonium, NO3(1-)-salt

D: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

Conditions

Conditions	Yield
Produkt5:Distickstoffmonooxid;

...Expand

: 41636-35-5
2,3,7,8,12,13,17,18-octaethyl-21H,23H-porphine ruthenium(II) carbonyl

: 55-18-5
N-Nitrosodiethylamine

: (2,3,7,8,12,13,17,18-octaethylporphyrinato)Ru(CO)(N-nitrosodiethylamine) * 0.2 CH2Cl2

Conditions

Conditions	Yield
In dichloromethane N2-atmosphere; excess nitrosamine, 40°C, 10 min;	99%
In dichloromethane N2-atmosphere; excess nitrosamine, 10 min; hexane addn., crystn. (-20°C, 5 d), hand sepn. from Ru-educt;	71%

: 55-18-5
N-Nitrosodiethylamine

: (C20H8N4)(C6H5)4FeOClO3*2C4H8O

: 177778-61-9
[(5,10,15,20-tetraphenylporphyrinato)Fe(N-nitrosodiethylamine)2]ClO4

Conditions

Conditions	Yield
In toluene (N2); stirring (10 min), addn. of hexane; elem. anal.;	96%

: 55-18-5
N-Nitrosodiethylamine

: 165605-12-9
[(5,10,15,20-tetraphenylporphyrinato)Fe(THF)2]ClO4

: 177778-61-9
[(5,10,15,20-tetraphenylporphyrinato)Fe(N-nitrosodiethylamine)2]ClO4

Conditions

Conditions	Yield
In toluene byproducts: THF; N2-atmosphere; excess nitrosamine, stirring for 10 min (pptn.); hexane addn., decantation, drying (vac.); elem. anal.;	96%

: 177778-47-1
aquanitrosyl(octaethylporphyrinato)ruthenium(II)(1+)

: 55-18-5
N-Nitrosodiethylamine

: 177778-50-6
[(2,3,7,8,12,13,17,18-octaethylporphyrinato)Ru(NO)(N-nitrosodiethylamine)](1+)

Conditions

Conditions	Yield
In not given	82%

: 55-18-5
N-Nitrosodiethylamine

: [(2,3,7,8,12,13,17,18-octaethylporphyrinato)Ru(NO)(H2O)]BF4 * H2O * 0.4 CH2Cl2

: 177778-51-7
[(2,3,7,8,12,13,17,18-octaethylporphyrinato)Ru(NO)(N-nitrosodiethylamine)]BF4

Conditions

Conditions	Yield
In dichloromethane byproducts: water; N2-atmosphere; excess nitrosamine, stirring for 5 min; hexane addn., cooling to -20°C for 3 d (pptn.), decantation, drying (vac.); elem. anal.;	82%

: 55-18-5
N-Nitrosodiethylamine

: 184014-74-2
carbonyl(5,10,15,20-tetra-p-tolyl-porphyrinato)osmium(II)

(5,10,15,20-tetra-p-tolylporphyrinato)Os(CO)(N-nitrosodiethylamine) * 0.5 hexane: (5,10,15,20-tetra-p-tolylporphyrinato)Os(CO)(N-nitrosodiethylamine) * 0.5 hexane

Conditions

Conditions	Yield
In dichloromethane N2-atmosphere; excess nitrosamine, heating and stirring for 10 min; solvent removal, recrystn. (CH2Cl2/hexane, -20°C overnight), decantation, washing (hexane), drying (vac.); elem. anal.;	74%

: 55-18-5
N-Nitrosodiethylamine

: 109-89-7
diethylamine

Conditions

Conditions	Yield
With isocyanate de chlorosulfonyle In diethyl ether for 10h; Ambient temperature;	72%

: 55-18-5
N-Nitrosodiethylamine

Conditions

Conditions	Yield
In dichloromethane N2-atmosphere; excess ligand, stirring for 30 min; hexane addn., cooling to -22°C overnight, decantation, washing (hexane), drying (vac., 10 min); elem. anal.;	70%

: 77244-32-7
carbonylosmium(II) 2,3,7,8,12,13,17,18-octaethylporphyrinate

: 55-18-5
N-Nitrosodiethylamine

: 213115-01-6
(2,3,7,8,12,13,17,18-octaethylporphyrinato)Os(CO)(N-nitrosodiethylamine)

Conditions

Conditions	Yield
In dichloromethane N2-atmosphere; excess nitrosamine, heating and stirring for 10 min; solvent removal, recrystn. (CH2Cl2/hexane, -20°C overnight), decantation, washing (hexane), drying (vac.); elem. anal.;	66%

: 55-18-5
N-Nitrosodiethylamine

: 165605-12-9
[(5,10,15,20-tetraphenylporphyrinato)Fe(THF)2]ClO4

: 1226896-68-9
[(5,10,15,20-tetra-p-tolylporphyrinato)Fe(ONNEt2)2]ClO4

Conditions

Conditions	Yield
In toluene byproducts: C4H8O; (N2, Schlenk) to a toluene-soln. of complex was added nitrosoamine-compound, the mixt. was stirred for 45 min; the solvent was reduced in vol., hexane was added, -22°C overnight, crystals were filtered, washed with hexane, dried in vac.;	66%

: 55-18-5
N-Nitrosodiethylamine

: [(TTP)Fe(THF)2]ClO4

: [(TTP)Fe(ONNEt2)2]ClO4

Conditions

Conditions	Yield
In toluene for 0.75h;	66%

: trans-bisdinitrogenbis(1,2-diphenylphosphinoethane)molybdenum(0)

: 55-18-5
N-Nitrosodiethylamine

A: 74-85-1
ethene

: trans-bis[1,2-bis(diphenylphosphino)ethane]hydroxo(nitrosyl)molybdenum-tetrahydrofuran (1/2)

C: 7727-37-9
nitrogen

D: 75-04-7
ethylamine

Conditions

Conditions	Yield
With K2CO3; THF In tetrahydrofuran Irradiation (UV/VIS); Et2NNO and K2CO3 added to soln. of Mo complex in THF, heated under reflux under N2 with W-light irrdn. for 4 h; filtered hot, cooled to room temp., crystals recrystd. from THF; elem. anal.;	A n/a B 60% C n/a D n/a

...Expand

: 55-18-5
N-Nitrosodiethylamine

: 616-40-0
N,N-diethylhydrazine

Conditions

Conditions	Yield
With hydrogenchloride; amalgamated zinc	52%
With lithium aluminium tetrahydride; diethyl ether
With water; zinc

: 55-18-5
N-Nitrosodiethylamine

: 95-13-6
1-indene

A: (Z)-2-(diethylamino)-2,3-dihydro-1H-inden-1-one oxime

B: (E)-2-(diethylamino)-2,3-dihydro-1H-inden-1-one oxime

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 23℃; for 48h; Irradiation; Inert atmosphere; Sealed tube; Overall yield = 79 percent; regioselective reaction;	A 39% B 40%

...Expand

: 10467-10-4
ethylmagnesium iodide

: 60-29-7
diethyl ether

: 55-18-5
N-Nitrosodiethylamine

A: 74-84-0
ethane

B: 7422-91-5
aldehyde diethylhydrazone

...Expand

: 10467-10-4
ethylmagnesium iodide

: 55-18-5
N-Nitrosodiethylamine

: 7422-91-5
aldehyde diethylhydrazone

Conditions

Conditions	Yield
With diethyl ether

: 55-18-5
N-Nitrosodiethylamine

: ethyl magnesium (1+); iodide

A: 74-84-0
ethane

B: 7422-91-5
aldehyde diethylhydrazone

Conditions

Conditions	Yield
reagiert analog mit Diphenylnitrosamin;

...Expand

: 55-18-5
N-Nitrosodiethylamine

: phenylmagnesium bromide

: 39837-50-8
N,N-diethyl-N'-phenyl-hydrazine

Conditions

Conditions	Yield
With diethyl ether

: 55-18-5
N-Nitrosodiethylamine

: 74-84-0
ethane

Conditions

Conditions	Yield
at 100℃; Photolysis;

: 55-18-5
N-Nitrosodiethylamine

: 7422-91-5
aldehyde diethylhydrazone

Conditions

Conditions	Yield
With acetic acid; zinc

: 55-18-5
N-Nitrosodiethylamine

: 7119-92-8
diethyl-N-nitroamine

Conditions

Conditions	Yield
With dichloromethane; dihydrogen peroxide; trifluoroacetic anhydride
With oxygen; tetraethylammonium perchlorate In acetonitrile at 0℃; electrolysis;	29 % Turnov.

N-Nitrosodiethylamine Chemical Properties

Empirical Formula: C₄H₁₀N₂O
Molecular Weight: 102.135 g/mol
EINECS: 200-226-1
Index of Refraction: 1.442
Density: 0.95 g/cm³
Flash Point: 59 °C
Enthalpy of Vaporization: 39.34 kJ/mol
Boiling Point: 173.9 °C at 760 mmHg
Vapour Pressure: 1.66 mmHg at 25 °C
Storage tempreture: 2-8 °C
Appearance: Clear slightly yellow liquid
Form: Liquid
Color: Yellow
Stable: Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents, reducing agents.
Structure of N-Nitrosodiethylamine (CAS NO.55-18-5):

IUPAC Name: N,N-Diethylnitrous amide
Product Categories of N-Nitrosodiethylamine (CAS NO.55-18-5): Nitrosamine

N-Nitrosodiethylamine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	intraperitoneal	175mg/kg (175mg/kg)		Carcinogenesis Vol. 5, Pg. 533, 1984.
guinea pig	LD50	oral	250mg/kg (250mg/kg)		Zeitschrift fuer Krebsforschung. Vol. 69, Pg. 103, 1967.
hamster	LD50	subcutaneous	232mg/kg (232mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BLOOD: OTHER CHANGES LIVER: OTHER CHANGES	British Journal of Cancer. Vol. 33, Pg. 411, 1976.
hamster	LD50	unreported	246mg/kg (246mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: "INFLAMMATION, NECROSIS, OR SCARRING OF BLADDER"	Journal of the National Cancer Institute. Vol. 49, Pg. 595, 1972.
mouse	LD50	intramuscular	356mg/kg (356mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 17(10), Pg. 51, 1973.
mouse	LD50	intraperitoneal	132mg/kg (132mg/kg)		JNCI, Journal of the National Cancer Institute. Vol. 62, Pg. 911, 1979.
mouse	LD50	intravenous	293mg/kg (293mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 17(10), Pg. 51, 1973.
mouse	LD50	oral	200mg/kg (200mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	National Technical Information Service. Vol. OTS0555387,
mouse	LD50	unreported	210mg/kg (210mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(8), Pg. 11, 1980.
rat	LD50	intraperitoneal	216mg/kg (216mg/kg)		Biochemical Journal. Vol. 85, Pg. 72, 1962.
rat	LD50	intravenous	280mg/kg (280mg/kg)		IARC Scientific Publications. Vol. 4, Pg. 45, 1973.
rat	LD50	oral	220mg/kg (220mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LIVER: FATTY LIVER DEGERATION	Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 1167, 1964.
rat	LD50	subcutaneous	195mg/kg (195mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE LIVER: OTHER CHANGES	Experimental Pathology Vol. 27, Pg. 171, 1985.
rat	LD50	unreported	245mg/kg (245mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(8), Pg. 11, 1980.

N-Nitrosodiethylamine Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 1 ,1972,p. 107.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) , IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 ,1978,p. 83.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) , IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 28 ,1982,p. 151.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 ,1978,p. 83.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Studies (ipr); Clear Evidence: mouse, rat RRCRBU Recent Results in Cancer Research. 52 (1975),1. . Reported in EPA TSCA Inventory. Community Right-To-Know List.

N-Nitrosodiethylamine Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A transplacental carcinogen. When heated to decomposition it emits toxic fumes of NO_x. See also N-NITROSO COMPOUNDS and AMINES.
Hazard Codes of N-Nitrosodiethylamine (CAS NO.55-18-5): Toxic T,F
Risk Statements: 45-22-39/23/24/25-23/24/25-11
R11:Highly flammable.
R22:Harmful if swallowed.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R39:Danger of very serious irreversible effects.
R45:May cause cancer.
Safety Statements: 53-45-36/37-16
S16:Keep away from sources of ignition.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53:Avoid exposure - obtain special instructions before use.

N-Nitrosodiethylamine Standards and Recommendations

DFG MAK: Animal Carcinogen, Suspected Human Carcinogen

N-Nitrosodiethylamine Analytical Methods

For occupational chemical analysis use OSHA: #27 or NIOSH: Nitrosamines, 2522.

N-Nitrosodiethylamine Specification

N-Nitrosodiethylamine ,its cas register number is 55-18-5. It also can be called Nitrosodiethylamine ; N-ethyl-N-nitrosoethanamine ; Ethanamine, N-ethyl-N-nitroso- ;and Diethylnitrosamine . N-Nitrosodiethylamine (CAS NO.55-18-5) reacts with strong oxidizing agents, and can be hydrolyzed by hydrogen bromide in acetic acid .

Product Name

N-NITROSODIETHYLAMINE

Stability

Toxicology

Synthetic route

N-Nitrosodiethylamine Chemical Properties

N-Nitrosodiethylamine Toxicity Data With Reference

N-Nitrosodiethylamine Consensus Reports

N-Nitrosodiethylamine Safety Profile

N-Nitrosodiethylamine Standards and Recommendations

N-Nitrosodiethylamine Analytical Methods

N-Nitrosodiethylamine Specification

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