naproxen
Naprelan
Conditions | Yield |
---|---|
With sodium hydroxide In water; toluene |
naproxen
Naprelan
Conditions | Yield |
---|---|
With sodium hydroxide In toluene |
(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
Naprelan
Conditions | Yield |
---|---|
In methanol | |
With sodium hydroxide In methanol | |
With sodium hydroxide In methanol at 55℃; Industry scale; | |
With sodium hydroxide In water Schlenk technique; Inert atmosphere; |
A
heptakis(2,6-di-O-methyl)cyclomaltoheptaose
B
Naprelan
Conditions | Yield |
---|---|
With pluronic copolymer F127 In water at 25℃; Equilibrium constant; Reagent/catalyst; |
Naprelan
(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 20℃; | 98% |
With hydrogenchloride In water pH=< 2; Inert atmosphere; | 94.3% |
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
Naprelan
Conditions | Yield |
---|---|
In methanol at 20℃; for 1h; Schlenk technique; Inert atmosphere; | 87% |
In methanol at 20℃; for 4h; | 78% |
cis-dichlorobis(2,2′-bipyridine)ruthenium(II)
Naprelan
Conditions | Yield |
---|---|
Stage #1: Naprelan With triethylamine In ethanol at 24.84℃; Stage #2: cis-dichlorobis(2,2′-bipyridine)ruthenium(II) In ethanol for 8h; Reflux; Stage #3: ammonium hexafluorophosphate In ethanol | 66% |
Naprelan
Conditions | Yield |
---|---|
Stage #1: Naprelan With triethylamine In ethanol at 24.84℃; Stage #2: [Ru(1,10-phenanthroline)2Cl2] In ethanol for 8h; Reflux; Stage #3: ammonium hexafluorophosphate In ethanol | 61% |
didecyldimethylammonium chloride
Naprelan
didecyldimethylammonium (S)-6-methoxy-α-methyl-2-naphthaleneacetate
Conditions | Yield |
---|---|
In water at 20℃; for 1h; | 95% |
Conditions | Yield |
---|---|
In water at 20℃; | 86% |
Naprelan
Conditions | Yield |
---|---|
With water; calcium chloride at 20℃; | 76% |
Naprelan
2-bromoethanol
2-Hydroxyethyl 2-(6-methoxy-2-naphthyl)propionat
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 60 - 80℃; for 3.5h; | 84% |
Conditions | Yield |
---|---|
In dimethyl sulfoxide for 120h; | 75% |
1,3-dibromo-propane
Naprelan
3-bromopropyl (2S)-2-(6-methoxy-2-naphthyl)propanoate
Conditions | Yield |
---|---|
In DMF (N,N-dimethyl-formamide) at 20℃; for 24h; |
Conditions | Yield |
---|---|
With sodium carbonate In N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate |
Conditions | Yield |
---|---|
In acetone at 20℃; for 24h; |
Naprelan
[2-(2,6-dichloroanilino)phenyl]acetic acid
Conditions | Yield |
---|---|
With hydrogenchloride In water at 20℃; | 82.2% |
zirconium phosphate chloride dimethyl sulfoxide
water
(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
Naprelan
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 75℃; for 72h; | 0.34 g |
Naprelan
(+)-6-O-Demethylnaproxen
Conditions | Yield |
---|---|
With glucose dehydrogenase; D-glucose; cytochrome P450BM3 R47L/Y51F/A191T/N239H/I259V/A276T/P329V/A330P/L353I mutant; β-nicotinamide adenine dinucleotide phosphate sodium salt In methanol; aq. phosphate buffer at 25℃; for 2h; pH=7.5; Enzymatic reaction; | 57% |
Conditions | Yield |
---|---|
In water for 1h; |
Conditions | Yield |
---|---|
In water for 1h; |
Conditions | Yield |
---|---|
In water for 1h; |
Conditions | Yield |
---|---|
In water for 1h; |
Conditions | Yield |
---|---|
In water for 1h; |
Conditions | Yield |
---|---|
In water for 1h; |
Conditions | Yield |
---|---|
In water for 1h; |
Conditions | Yield |
---|---|
In water for 1h; |
Conditions | Yield |
---|---|
In water for 1h; |
The Naproxen sodium, with the CAS registry number 26159-34-2, is also known as 2-Naphthaleneacetic acid,6-methoxy-alpha-methyl-,sodium salt,(S)-. It belongs to the product categories of Essential Chemicals;Reagent Grade;Routine Reagents.Its EINECS number is 247-486-2. This chemical's molecular formula is C14H13NaO3 and molecular weight is 252.24.What's more,Its systematic name is Sodium (-)-2-(6-methoxy-2-naphthyl)propionate.It is an anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.
Physical properties about Midazolam are:
(1)ACD/LogP: 2.998; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 3; (4)#H bond donors: 1; (5)#Freely Rotating Bonds: 3; (6)Flash Point: 154.5 °C; (7)Enthalpy of Vaporization: 69.1 kJ/mol; (8)Boiling Point: 403.9 °C at 760 mmHg; (9)Vapour Pressure: 3.01E-07 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES:[Na+].[O-]C(=O)[C@H](c1ccc2c(c1)ccc(OC)c2)C;
(2)Std. InChI:InChI=1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1;
(3)Std. InChIKey:CDBRNDSHEYLDJV-FVGYRXGTSA-M.
The toxicity data of Midazolam as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | TDLo | oral | 600mg/kg/30D- (600mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS | American Journal of Diseases of Children. Vol. 142, Pg. 524, 1988. |
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