• Name

  1,3,3,5,5-pentamethylcyclohexylamine methanesulfonate

• EINECS
• CAS No. 457068-92-7
• Article Data3
• CAS DataBase
• Density
• Solubility
• Melting Point
• Formula C₁₂H₂₇NO₃S
• Boiling Point
• Molecular Weight 265.417
• Flash Point
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Cyclohexanamine, 1,3,3,5,5-pentamethyl-, methanesulfonate;1,3,3,5,5-Pentamethylcyclohexanamine methanesulfonate;
• PSA 88.77000
• LogP 4.22520

Synthetic route

78-59-1

3,5,5-Trimethylcyclohex-2-en-1-one

457068-92-7

Neramexane mesylate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: copper(l) iodide; lithium chloride / tetrahydrofuran / 1 h / 5 - 15 °C 2.1: tetrahydrofuran / 5 - 15 °C 3.1: sulfuric acid / acetic acid / 1 h / 5 - 10 °C 4.1: hydrogenchloride; thiourea / water / 6 h / Reflux 4.2: pH 7 5.1: ethyl acetate / 1 h / 0 - 5 °C View Scheme
Multi-step reaction with 5 steps 1.1: copper(l) iodide; lithium chloride / tetrahydrofuran / 1 h / 5 - 15 °C 2.1: tetrahydrofuran / 1 h / 5 - 15 °C 3.1: sulfuric acid / acetic acid / 1 h / 5 - 10 °C 4.1: hydrogenchloride; thiourea / water / 6 h / Reflux 4.2: pH 7 5.1: ethyl acetate / 1 h / 0 - 5 °C View Scheme

75-75-2

methanesulfonic acid

219810-59-0

neramexane

457068-92-7

Neramexane mesylate

Conditions

Conditions	Yield
In ethyl acetate at 0 - 5℃; for 1h;
In ethyl acetate at 0 - 5℃; for 1h;
In butanone

14376-79-5

3,3,5,5-tetramethylcyclohexanone

457068-92-7

Neramexane mesylate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: tetrahydrofuran / 5 - 15 °C 2.1: sulfuric acid / acetic acid / 1 h / 5 - 10 °C 3.1: hydrogenchloride; thiourea / water / 6 h / Reflux 3.2: pH 7 4.1: ethyl acetate / 1 h / 0 - 5 °C View Scheme
Multi-step reaction with 4 steps 1.1: tetrahydrofuran / 1 h / 5 - 15 °C 2.1: sulfuric acid / acetic acid / 1 h / 5 - 10 °C 3.1: hydrogenchloride; thiourea / water / 6 h / Reflux 3.2: pH 7 4.1: ethyl acetate / 1 h / 0 - 5 °C View Scheme

38490-33-4

1,3,3,5,5-pentamethylcyclohexanol

457068-92-7

Neramexane mesylate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sulfuric acid / acetic acid / 1 h / 5 - 10 °C 2.1: hydrogenchloride; thiourea / water / 6 h / Reflux 2.2: pH 7 3.1: ethyl acetate / 1 h / 0 - 5 °C View Scheme

316364-93-9

N-Chloroacetyl-1,3,3,5,5-pentamethylcyclohexanamine

457068-92-7

Neramexane mesylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogenchloride; thiourea / water / 6 h / Reflux 1.2: pH 7 2.1: ethyl acetate / 1 h / 0 - 5 °C View Scheme

457068-92-7

Neramexane mesylate

219810-59-0

neramexane

Conditions

Conditions	Yield
With sodium hydroxide In water at 20℃;	100%

457068-92-7

Neramexane mesylate

neramexane stearate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide / water / 20 °C 2: dichloromethane / 2 h / 20 °C View Scheme

457068-92-7

Neramexane mesylate

neramexane undecylenate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide / water / 20 °C 2: neat (no solvent) / 20 °C / Cooling View Scheme

457068-92-7

Neramexane mesylate

neramexane oleate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide / water / 20 °C 2: neat (no solvent) / 20 °C / Cooling View Scheme

Neramexane Mesylate Specification