Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:78-59-1
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquirySpecifications: Isophorone,99.7% 1. High quality 2. Competitive price 3. Good service 4. Flexible payment Appearance:Light yellow clear liquid Storage:dry environment Package:25kg/drum or as your needs Application:solvent;chemical interme
T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:W
Isophorone 1. Physical and chemical properties Appearance:White or pale yellow liquid at room temperature, smell like camphor Molecular Weight: 138.21 g/moL Density:0.919-0.923 Molecular Formula:C9H14O Melting Point:-8℃ Boiling Point
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:78-59-1
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:78-59-1
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Trading Company
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:78-59-1
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:78-59-1
Min.Order:1 Kilogram
FOB Price: $7.0 / 9.0
Type:Trading Company
inquiryProduct Name: Isophorone Synonyms: 3,5,5-Trimethyl-2-cyclohexen-1-one; Isophorone,(3,5,5-Trimethyl-2-cyclohexen-1-one); 3,5,5-trimethylcyclohex-2-en-1-one; IPHO; Isophoron
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:liquid Storage:Store in sealed containers at cool & dry pla
Cas:78-59-1
Min.Order:100 Gram
Negotiable
Type:Other
inquiryAppearance:Clear liquid Storage:R.T Package:25kg/Barrel Application:It is an excellent solvent for oils, gums, resins, etc., and is especially suitable for vinyl resins. Transportation:Express/Sea/Air Port:Any port in China
Cas:78-59-1
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:78-59-1
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryIsophorone Basic information Product Name: Isophorone Synonyms: FEMA 3553;ISOPHORONE;ISOPHORONE 97+%;ISOPHORONE, 5000MG, NEAT;IsophoroneForSynthesis;1,1,3-TRIMETHYLCYCLOHEXEN-3-ONE-5;1,5,5-Trimethyl-1-cyclohexen-3-one;ai3-00046 CAS: 78-59-1
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At presen
Cas:78-59-1
Min.Order:1 Kilogram
FOB Price: $15.0 / 20.0
Type:Trading Company
inquiryIsophorone CAS:78-59-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s
Cas:78-59-1
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Product Detail Minimum Order Qty. 10 Gram
Cas:78-59-1
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryAppearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda
Cas:78-59-1
Min.Order:1 Kilogram
FOB Price: $10.0
Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Shandong Baimao Chemical Co., Ltd is a private joint-stock fine chemical enterprises, with a sound management system. Long-term commitment to chemical products research and development, production and marketing. Our products include organic chemical
Cas:78-59-1
Min.Order:5 Metric Ton
FOB Price: $2.0 / 3.0
Type:Trading Company
inquiryConditions | Yield |
---|---|
With bis(1,5-cyclooctadiene)nickel(0); potassium tert-butylate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In 2,4-dichlorotoluene at 25℃; for 2h; Inert atmosphere; | 99% |
With pyridine; oxygen; Pd(II)-hydrotalcite In toluene at 80℃; for 3h; | 96% |
With iodosylbenzene; N,N-ethylenebis(3,5-dichlorosalicylideneiminato)Cr(III)Cl In dichloromethane at 20℃; for 0.666667h; | 95% |
isophorone oxide
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With iodine; triphenylphosphine In acetonitrile at 20℃; for 0.25h; | 98% |
With sodium hydroxide; thiourea dioxide; tetrabutylammomium bromide In tetrahydrofuran at 50℃; for 0.5h; | 95% |
Stage #1: isophorone oxide With bis(cyclopentadienyl)titanium dichloride; zinc In tetrahydrofuran; acetonitrile for 0.5h; Inert atmosphere; Stage #2: With sodium dihydrogenphosphate; water In tetrahydrofuran; acetonitrile for 0.333333h; Inert atmosphere; | 88% |
Trimethyl-(3,5,5-trimethyl-cyclohex-2-enyloxy)-silane
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With chromium(VI) oxide; tert.-butylhydroperoxide; triphenylhydroxysilane In dichloromethane for 17h; Ambient temperature; | 98% |
6-Benzenesulfinyl-3,5,5-trimethyl-cyclohex-2-enone
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With ammonium chloride; zinc In tetrahydrofuran at 25℃; for 2h; | 98% |
3,5,5-Trimethyl-6-phenylsulfanyl-cyclohex-2-enone
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With ammonium chloride; zinc In tetrahydrofuran at 25℃; for 3h; | 95% |
3-bromo-5,5-dimethlycyclohex-2-en-1-one
methyllithium
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With copper(I) thiophenolate In tetrahydrofuran; diethyl ether at 0℃; for 2.5h; | 94% |
C9H14OS
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
In chloroform for 25h; Ambient temperature; Irradiation; | 90% |
With oxygen; methylene blue In chloroform for 24h; Irradiation; Yield given; |
(3,5,5-trimethyl-2-cyclohexenyl) ethyl ether
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With pyridinium chlorochromate In dichloromethane for 8h; Heating; | 90% |
(3,5,5-trimethyl-cyclohex-2-enyloxymethyl)-benzene
A
3,5,5-Trimethylcyclohex-2-en-1-one
B
benzaldehyde
Conditions | Yield |
---|---|
With pyridinium chlorochromate In dichloromethane for 8h; Heating; | A 87% B 60% |
7-Bromo-9,9-dimethyl-1,4-dioxa-spiro[4.5]dec-7-ene
methyl iodide
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran | 86% |
With n-butyllithium 1.) THF, -78 deg C, 2 h, 2.) a) -78 deg C, 1 h, b) RT, 1 h; Yield given. Multistep reaction; |
3,5,5-trimethyl-2-<(dimethylthiocarbamoyl)oxy>-2-cyclohexen-1-one
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With lithium acetate; lithium; acetic acid for 0.25h; Heating; | 83% |
4-methyl-pent-3-en-2-one
2-acetoacetic acid
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
Stage #1: 4-methyl-pent-3-en-2-one; 2-acetoacetic acid With copper(II) bis(trifluoromethanesulfonate) at 20℃; for 12h; Inert atmosphere; Stage #2: With toluene-4-sulfonic acid In tetrahydrofuran at 20℃; Reagent/catalyst; Inert atmosphere; | 83% |
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With pyridinium chlorochromate In dichloromethane for 12h; Heating; | 82% |
2-bromoisophorone
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate; sodium iodide In 1,2-dichloro-ethane at 85℃; for 2h; | 80% |
1'p.methoxyphenyl 1'-cyano 1,3,5,5-tetramethyl 2-cyclohexen 1-ol
A
3,5,5-Trimethylcyclohex-2-en-1-one
B
p-methoxyphenyl-3' cyano-3' tetramethyl-3,3,5,5 cyclohexanone
C
p-methoxybenzylnitrile
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide at -70℃; for 0.0833333h; Yield given; | A n/a B 80% C n/a |
With n-butyllithium In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide at -70℃; for 0.0833333h; Yields of byproduct given; | A n/a B 80% C n/a |
1-methoxy-3,5,5-trimethyl-2-cyclohexene
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With pyridinium chlorochromate In dichloromethane for 4h; Heating; | 80% |
A
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With dirhodium(II) tetrakis(caprolactam) In dichloromethane Heating; Yields of byproduct given; | A n/a B 77% |
Conditions | Yield |
---|---|
With diphenylgermylenedipotassium In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide for 0.5h; Product distribution; Ambient temperature; KH as reagent; | A 76% B n/a |
4-methyl-pent-3-en-2-one
ethyl acetoacetate
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With potassium tert-butylate In tert-butyl alcohol for 20h; Heating; | 75% |
(+/-)-6-acetoxy-3,3,5-trimethylcyclohex-2-en-1-one
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With 2 In dichloromethane for 0.17h; Ambient temperature; | 74% |
7,9,9-trimethyl-1,4-dithiaspiro<4,5>dec-6-ene
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With Oxone; potassium bromide In water; acetonitrile at 20℃; for 1h; | 72% |
With O-phenyl phosphorodichloridate; N,N-dimethyl-formamide; sodium iodide 1.) acetonitrile, few min, room temp., 2.) 5 h, room temp.; Yield given. Multistep reaction; |
1-amino-3,3,5-trimethyl-cyclohexyl hydroperoxide
cycloheptanone
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With ammonium acetate In ethanol | 70.9% |
With ammonium acetate In ethanol | 70.9% |
trimethyl-3,5,5 cyclohexene-2 thione
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With oxygen; methylene blue In dichloromethane for 5h; Irradiation; | 70% |
With oxygen In chloroform Product distribution; Rate constant; Mechanism; Irradiation; investigation of different oxidation methods; |
Conditions | Yield |
---|---|
In tetrahydrofuran -40 deg C -> R.T., 90 min; | 70% |
5,5-dimethyl-3-((trimethylsilyl)oxy)cyclohex-2-en-1-one
methyllithium
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
In diethyl ether for 20h; Ambient temperature; | 69% |
Conditions | Yield |
---|---|
With formic acid; dihydrogen peroxide | 69% |
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
In acetonitrile Photolysis; | 68% |
3,5,5-trimethylcyclohex-3-en-1-one
A
3,5,5-Trimethylcyclohex-2-en-1-one
B
2,6,6-trimethyl-2-cyclohexene-1,4-dione
C
4-hydroxy-3,5,5-trimethyl-cyclohex-2-enone
Conditions | Yield |
---|---|
With Tri-n-octylamine; sodium tungstate (VI) dihydrate; phosphoric acid; dihydrogen peroxide In water at 70℃; for 2h; pH=1.5 - 2; Temperature; Reagent/catalyst; | A 8% B 24% C 67% |
With Tri-n-octylamine; sodium tungstate (VI) dihydrate; phosphoric acid; dihydrogen peroxide In water at 90℃; for 2h; pH=1.5 - 2; Catalytic behavior; Reagent/catalyst; Temperature; | A 15% B 46% C 16% |
With sodium tungstate (VI) dihydrate; phosphoric acid; dihydrogen peroxide In water at 80℃; for 2h; pH=1.5 - 2; Temperature; | A 22% B 5% C 13% |
With oxygen; triethylamine; iron tetrasulfophthalocyanine-TiO2 In dimethyl sulfoxide at 60℃; under 1500.12 Torr; for 24h; | A 10 % Chromat. B 57 % Chromat. C 21 % Chromat. |
Conditions | Yield |
---|---|
With bis(methyldiphenylphosphine)nickel(II) chloride In tetrahydrofuran at 20℃; for 43h; cross-coupling; | 64% |
Conditions | Yield |
---|---|
With limonene.; Pd-BaSO4 for 0.5h; Heating; | 100% |
With limonene.; Pd-BaSO4 for 0.5h; Product distribution; Heating; further carrier of catalyst; | 100% |
With hydrogen; β-cyclodextrin/Pd In water at 25℃; under 15001.2 Torr; for 2h; | 100% |
3,5,5-Trimethylcyclohex-2-en-1-one
ethyl 3-trimethylsiloxy-2-butenoate
1,3,3,8-Tetramethyl-5-oxo-8-trimethylsilanyloxy-bicyclo[4.2.0]octane-7-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
In benzene for 24h; Ambient temperature; Irradiation; | 100% |
3,5,5-Trimethylcyclohex-2-en-1-one
2-chloroisophorone
Conditions | Yield |
---|---|
With Oxone; sodium chloride In tetrachloromethane; water at 0 - 25℃; | 100% |
With pyridine; sulfuryl dichloride | |
With fluorosulfonylchloride | |
With calcium hypochlorite; Methamphetamin In dichloromethane; water for 3h; | |
With chlorine 1.) CH2Cl2, -3 - 8 deg C; 2.) CCl4, DMF, 75-80 deg C, 30 min; Yield given. Multistep reaction; |
3,5,5-Trimethylcyclohex-2-en-1-one
acetic acid
(+/-)-6-acetoxy-3,3,5-trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
Stage #1: acetic acid With potassium permanganate; acetic anhydride In benzene at 85℃; for 0.5h; Stage #2: 3,5,5-Trimethylcyclohex-2-en-1-one In benzene at 85℃; Temperature; | 100% |
With potassium permanganate In benzene Heating; | 86% |
3,5,5-Trimethylcyclohex-2-en-1-one
(R)-3,3,5-trimethylcyclohexanone
Conditions | Yield |
---|---|
With dodecacarbonyltetrarhodium(0); (S)-bis(4-(tert-butyl)phenyl)methyl-3-(1-acetyl-1H-indol-3-yl)-2-aminopropanoate; hydrogen; triphenylphosphine In toluene at 90℃; under 60006 Torr; for 10h; Autoclave; | 99.8% |
Stage #1: 3,5,5-Trimethylcyclohex-2-en-1-one With polymethylhydrosiloxane; copper(l) chloride; sodium t-butanolate; (R)-(2,3-methylenedioxy-6-(4-MeO-3,5-tBu2-C6H2)2P-C6H2)2 In tetrahydrofuran at -35℃; for 1h; Stage #2: In tetrahydrofuran Alkaline hydrolysis; | 95% |
With (R)-(-)-DTBM-SEGPHOS; sodium phenoxide; poly(methylhydrosiloxane); copper carbide In toluene; tert-butyl alcohol at 20℃; for 3h; ultrasonication; | 86% |
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With (acetylacetonato)dicarbonylrhodium (l); L-valine; hydrogen; Oxalsaeurebis<(3R,4R)-3,4-bis(diphenylphosphino)pyrrolidid> at 25℃; under 45004.5 Torr; for 36h; Autoclave; | 99.1% |
3,5,5-Trimethylcyclohex-2-en-1-one
tetraallyl tin
1-allyl-3,5,5-trimethyl-2-cyclohexen-1-ol
Conditions | Yield |
---|---|
With n-butyllithium; neodymium(III) chloride In tetrahydrofuran; hexane for 1h; Ambient temperature; | 99% |
With n-butyllithium; neodymium(III) chloride 1.) hexane, THF, RT, 1 h, 2.) hexane, THF, 0 deg C, 1 h; Yield given. Multistep reaction; |
3,5,5-Trimethylcyclohex-2-en-1-one
manganese triacetate
(+/-)-6-acetoxy-3,3,5-trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With acetic acid In benzene for 7h; Heating; | 99% |
Conditions | Yield |
---|---|
With 2-(2,6-dimethoxyphenyl)-1-methyl-3-(diphenylphosphino)-1H-indole; palladium diacetate; lithium tert-butoxide In 1,4-dioxane at 100℃; for 1h; Schlenk technique; Inert atmosphere; | 99% |
3,5,5-Trimethylcyclohex-2-en-1-one
3-chlorobenzoic acid tert-butyl ester
Conditions | Yield |
---|---|
With 2-(2,6-dimethoxyphenyl)-1-methyl-3-(diphenylphosphino)-1H-indole; palladium diacetate; lithium tert-butoxide In 1,4-dioxane at 100℃; for 1h; Schlenk technique; Inert atmosphere; | 99% |
3,5,5-Trimethylcyclohex-2-en-1-one
6-chloro-2-methoxypyridine
Conditions | Yield |
---|---|
With 2-(2,6-dimethoxyphenyl)-1-methyl-3-(diphenylphosphino)-1H-indole; palladium diacetate; lithium tert-butoxide In 1,4-dioxane at 100℃; for 1h; Schlenk technique; Inert atmosphere; | 99% |
2-chloro-3-methylthiophene
3,5,5-Trimethylcyclohex-2-en-1-one
Conditions | Yield |
---|---|
With 2-(2,6-dimethoxyphenyl)-1-methyl-3-(diphenylphosphino)-1H-indole; palladium diacetate; lithium tert-butoxide In 1,4-dioxane at 100℃; for 1h; Schlenk technique; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With 2-(2,6-dimethoxyphenyl)-1-methyl-3-(diphenylphosphino)-1H-indole; palladium diacetate; lithium tert-butoxide In 1,4-dioxane at 100℃; for 1h; Schlenk technique; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
at 206℃; under 750.075 Torr; for 48h; Catalytic behavior; Pressure; Temperature; Inert atmosphere; | 98.3% |
at 210 - 240℃; under 375.038 Torr; Pressure; Molecular sieve; | 91.72% |
With methylmagnesium bromide; acetic acid Isomerization; | 82% |
3,5,5-Trimethylcyclohex-2-en-1-one
isophorone oxide
Conditions | Yield |
---|---|
With sodium hydroxide; dihydrogen peroxide In ethanol at 30 - 35℃; for 1h; | 98% |
With 3,3-dimethyldioxirane In dichloromethane; acetone at 20℃; for 24h; | 90% |
With Oxone; 1,1,1-trifluoro-2-propanone; edetate disodium; sodium hydrogencarbonate In acetonitrile at 0 - 1℃; for 1.5h; | 90% |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In diethyl ether at 20℃; for 6h; | 98% |
With lithium aluminium tetrahydride In diethyl ether at -20℃; | 95% |
With Co-doped ammonia borane In methanol at 20℃; for 2h; Reagent/catalyst; chemoselective reaction; | 95% |
3,5,5-Trimethylcyclohex-2-en-1-one
2-hydroxy-4,4,6-trimethylcyclohexa-2,5-diene-1-one
Conditions | Yield |
---|---|
With 18-crown-6 ether In benzene for 2h; Ambient temperature; | 98% |
With KO2; 18-crown-6 ether In benzene for 2h; Ambient temperature; | |
With potassium superoxide In benzene |
3,5,5-Trimethylcyclohex-2-en-1-one
3,5,5-trimethyl-3-vinylcyclohexanone
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate; vinyl(2-thienyl)Cu(CN)Li2 In tetrahydrofuran; diethyl ether at -78℃; for 1h; Product distribution; Mechanism; effect of BF3*Et2O and other Lewis Acids; | 98% |
With (CH2=C)2Cu(CN)Li2 In diethyl ether at -50℃; for 2.5h; Product distribution; other solvents; | 98% |
With 2-ThNa*CuCN*C2H3Li Product distribution; with and without BF3*Et2O additive; | |
Multi-step reaction with 2 steps 1: 1) CuCN, TMEDA / 1) THF, -78 deg C, 20 min, 2) THF, 30 min 2: 1 M HCl View Scheme |
3,5,5-Trimethylcyclohex-2-en-1-one
3,5,5-trimethyl-3-vinylcyclohexanone
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate at -78℃; for 3h; | 98% |
3,5,5-Trimethylcyclohex-2-en-1-one
3,5,5-trimethyl-3-vinylcyclohexanone
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In tetrahydrofuran; diethyl ether at -78℃; for 1h; | 98% |
Conditions | Yield |
---|---|
With 2-(2,6-dimethoxyphenyl)-1-methyl-3-(diphenylphosphino)-1H-indole; palladium diacetate; lithium tert-butoxide In 1,4-dioxane at 100℃; for 1h; Schlenk technique; Inert atmosphere; | 98% |
Conditions | Yield |
---|---|
With 2-(2,6-dimethoxyphenyl)-1-methyl-3-(diphenylphosphino)-1H-indole; palladium diacetate; lithium tert-butoxide In 1,4-dioxane at 100℃; for 1h; Schlenk technique; Inert atmosphere; | 98% |
Conditions | Yield |
---|---|
With 2-(2,6-dimethoxyphenyl)-1-methyl-3-(diphenylphosphino)-1H-indole; palladium diacetate; lithium tert-butoxide In 1,4-dioxane at 100℃; for 1h; Schlenk technique; Inert atmosphere; | 98% |
chloro-trimethyl-silane
3,5,5-Trimethylcyclohex-2-en-1-one
vinyl magnesium bromide
trimethyl-(3,5,5-trimethyl-3-vinylcyclohex-1-enyloxy)silane
Conditions | Yield |
---|---|
With N,N,N,N,N,N-hexamethylphosphoric triamide; magnesium; copper(I) bromide dimethylsulfide complex In tetrahydrofuran at -70℃; for 1.5h; | 97% |
With N,N,N,N,N,N-hexamethylphosphoric triamide; copper(I) bromide dimethylsulfide complex In tetrahydrofuran at -78℃; | 97% |
Stage #1: vinyl magnesium bromide With copper(l) iodide In tetrahydrofuran at -10℃; for 0.0333333h; Metallation; Stage #2: 3,5,5-Trimethylcyclohex-2-en-1-one In tetrahydrofuran at -78℃; for 0.5h; Addition; Stage #3: chloro-trimethyl-silane With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; triethylamine In tetrahydrofuran at -78 - 20℃; silylation; | 93% |
With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at -78℃; | 80% |
With N,N,N,N,-tetramethylethylenediamine 1) THF, -78 deg C, 20 min, 2) THF, 30 min; Multistep reaction; |
Conditions | Yield |
---|---|
With sodium ethanolate In ethanol at 120℃; for 0.5h; Knoevenagel Condensation; Microwave irradiation; | 97% |
With ethanol; sodium at 85℃; for 1h; pH=13; Temperature; Microwave irradiation; | 97% |
With sodium ethanolate In ethanol at 80℃; for 8h; pH=13; | 65% |
Conditions | Yield |
---|---|
Stage #1: 3,5,5-Trimethylcyclohex-2-en-1-one With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane In tetrahydrofuran at -78 - 0℃; for 1.66667h; Sealed tube; Inert atmosphere; Stage #2: di-isopropyl azodicarboxylate In tetrahydrofuran at -78℃; for 0.0833333h; Inert atmosphere; Sealed tube; regioselective reaction; | 97% |
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