Pentaerythritol tetrakis(2-mercaptoacetate) supplier

Name
Pentaerythritol tetrakis(2-mercaptoacetate)
EINECS 233-482-8
CAS No. 10193-99-4
Article Data4
CAS DataBase
Density 1.385 g/cm³
Solubility 693mg/L at 21℃
Melting Point
Formula C₁₃H₂₀O₈S₄
Boiling Point 486.6 °C at 760 mmHg
Molecular Weight 432.561
Flash Point 484.6 °C
Transport Information
Appearance
Safety 26-37/39-36/37
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Aceticacid, mercapto-, 2,2-bis[[(mercaptoacetyl)oxy]methyl]-1,3-propanediyl ester(9CI);Acetic acid, mercapto-, neopentanetetrayl ester (7CI,8CI);Acetic acid,mercapto-, tetraester with pentaerythritol (6CI);Pentaerythritol,tetrakis(mercaptoacetate) (8CI);2,2-Bis[[(mercaptoacetyl)oxy]methyl]-1,3-propanediyl bis(mercaptoacetate);NSC528294;NSC 65476;Pentaerythritol tetra(mercaptoacetate);Pentaerythritoltetra(thioglycolate);Pentaerythritol tetrakis(2-mercaptoacetate);Pentaerythritol tetrakis(thioglycolate);
PSA 260.40000
LogP -0.13520

Synthetic route

: 115-77-5
Pentaerythritol

: 68-11-1
mercaptoacetic acid

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	52%
With toluene-4-sulfonic acid In toluene at 110 - 120℃; for 4h;
With toluene-4-sulfonic acid In toluene at 130℃; for 9h; Dean-Stark; Inert atmosphere;	76 %Chromat.

: 115-77-5
Pentaerythritol

: 126-58-9
Dipentaerythritol

: 68-11-1
mercaptoacetic acid

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

Conditions

Conditions	Yield
toluene-4-sulfonic acid In water; toluene at 104 - 121℃; for 5h; Product distribution / selectivity; Heating / reflux;

...Expand

: 115-77-5
Pentaerythritol

: 68-11-1
mercaptoacetic acid

A: 82575-20-0
pentaerythritol tris(thioglycolate)

B: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 130℃; for 9h; Dean-Stark; Inert atmosphere;	A 79 %Chromat. B 20 %Chromat.

...Expand

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: 818-08-6
di(n-butyl)tin oxide

: 7,7,21,21-tetrabutyl-2,12,16,26-tetraoxa-6,8,20,22-tetrathia-7,21-distanna-spiro[13.13]heptacosane-3,11,17,25-tetraone

Conditions

Conditions	Yield
In toluene at 110℃; for 29h; Dean-Stark;	96%

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: 597-71-7
pentaerythritol tetracetate

Conditions

Conditions	Yield
With di-tert-butyl peroxide; triethyl phosphite In acetonitrile at 20℃; UV-irradiation;	94%
With di-tert-butyl peroxide; triethyl phosphite In acetonitrile at 25℃; for 6h; Irradiation;	94%

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: 2,2-bis((acetoxy-2-d)methyl)propane-1,3-diylbis(acetate-2, 2’-d2)

Conditions

Conditions	Yield
With di-tert-butyl peroxide; water-d2; ethydiphenylphosphine oxide In dichloromethane at 20℃; for 10h; Solvent; Irradiation; Green chemistry;	94%

: 634607-40-2
4-(diphenylamino)benzaldehyde N-2,3-epoxypropyl-N-phenylhydrazone

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: C125H120N12O12S4

Conditions

Conditions	Yield
triethylamine In tetrahydrofuran for 12h; Heating / reflux;	73%

: 909781-41-5
C20H19NO4

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: 877614-05-6
C93H96N4O24S4

Conditions

Conditions	Yield
tributyl-amine In dichloromethane at 20℃; for 72h;	72%

: 156842-95-4
MoCl(CO)2(1,10-phenanthroline)(η(3)-CH2C(COCl)C=CH2)

: 75-09-2
dichloromethane

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: C(MoCl(CO)2(C12H8N2)CH2CCCH2COSCH2COOCH2)4*CH2Cl2

Conditions

Conditions	Yield
With triethylamine In dichloromethane (N2); addn. of amine to a soln. of molybdenum complex in CH2Cl2, addn. of a soln. of thiol in CH2Cl2, stirring for 3 h; filtration, washing with cold CH2Cl2, recrystn. (CH2Cl2/petrol); elem. anal.;	46%

...Expand

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: 532-27-4
1-chloroacetophenone

: C45H44O12S4

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 18h;	45%

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: 627-41-8
propargyl alcohol methyl ether

: 6,19-Bis-methoxymethyl-2,11,15,24-tetraoxa-5,8,18,21-tetrathia-spiro[12.12]pentacosane-3,10,16,23-tetraone

Conditions

Conditions	Yield
With tripropylborane In methanol; hexane; benzene at 20℃;	42%

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: 693-02-7
hex-1-yne

: 6,19-Dibutyl-2,11,15,24-tetraoxa-5,8,18,21-tetrathia-spiro[12.12]pentacosane-3,10,16,23-tetraone

Conditions

Conditions	Yield
With tripropylborane In methanol; hexane; benzene at 20℃;	25%

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: (+/-)-(E)-1-((1RS,2SR)-2,6,6-trimethylcyclohex-3-enyl)but-2-en-1-one

: (±)-3-{[({4-oxo-4-[(1RS,2SR)-2,6,6-trimethylcyclohex-3-en-1-yl]butan-2-yl}sulfanyl)-acetyl]oxy}-2,2-bis({[({4-oxo-4-[(1RS,2SR)-2,6,6-trimethylcyclohex-3-en-1-yl]butan-2-yl}sulfanyl)acetyl]oxy}methyl)propyl ({4-oxo-4-[(1RS,2SR)-2,6,6-trimethylcyclohex-3-en-1-yl]butan-2-yl}sulfanyl)acetate

Conditions

Conditions	Yield
at 20℃; for 336h; Michael Addition;	23%

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: 123-61-5
1,3-Phenylene diisocyanate

poly(thioglycolic acid pentaerythritol ester)-co-(m-xylene diisocyanate): poly(thioglycolic acid pentaerythritol ester)-co-(m-xylene diisocyanate)

Conditions

Conditions	Yield
With Zerec UN (acidic phosphate ester); BioSorb 583 (UV absorber); dibutyltin chloride at 10 - 120℃; for 18h; Product distribution / selectivity; Heating / reflux;

: 1390628-51-9
C10H10ClNO5S

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: 1390628-52-0
C53H56N4O28S8

Conditions

Conditions	Yield
With triethylamine In 1,2-dimethoxyethane; tert-butyl methyl ether at 0℃; for 3h;

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: 359865-01-3
(E)-1-((1RS,2SR)-2,6,6-trimethylcyclohex-3-enyl)but-2-en-1-one

A: 2-((2-mercaptoacetoxy)methyl)-2-((2-((4-oxo-4-((1RS,2SR)-2,6,6-trimethylcyclohex-3-en-1-yl)butan-2-yl)thio)acetoxy)methyl)propane-1,3-diyl bis(2-mercaptoacetate)

B: 2-((2-mercaptoacetoxy)methyl)-2-((2-((4-oxo-4-((1RS,2SR)-2,6,6-trimethylcyclohex-3-en-1-yl)butan-2-yl)thio)acetoxy)methyl)propane-1,3-diyl bis(2-((4-oxo-4-((1RS,2SR)-2,6,6-trimethylcyclohex-3-en-1-yl)butan-2-yl)thio)acetate)

C: 2,2-bis((2-((4-oxo-4-((1RS,2SR)-2,6,6-trimethylcyclohex-3-en-1-yl)butan-2-yl)thio)acetoxy)methyl)propane-1,3-diyl bis(2-mercaptoacetate)

Conditions

Conditions	Yield
at 20℃; for 336h;

...Expand

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: 359865-01-3
(E)-1-((1RS,2SR)-2,6,6-trimethylcyclohex-3-enyl)but-2-en-1-one

: 2-((2-mercaptoacetoxy)methyl)-2-((2-((4-oxo-4-((1RS,2SR)-2,6,6-trimethylcyclohex-3-en-1-yl)butan-2-yl)thio)acetoxy)methyl)propane-1,3-diyl bis(2-((4-oxo-4-((1RS,2SR)-2,6,6-trimethylcyclohex-3-en-1-yl)butan-2-yl)thio)acetate)

Conditions

Conditions	Yield
at 20℃; for 192h;

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: 2,15,19,32-tetraoxa-6,11,23,28-tetrathia-spiro[16.16]tritriacontan-3,7,10,14,20,24,27,31-octaone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene / 29 h / 110 °C / Dean-Stark 2: [2,2]bipyridinyl / chloroform / Reflux View Scheme

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: 2'-acryloyl taxol

: C63H73NO23S4

Conditions

Conditions	Yield
In N,N-dimethyl-formamide

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: 5-acryloxymethyl-5-ethyl-1,3-dioxacyclohexane

: C23H36O12S4

Conditions

Conditions	Yield
With triethylamine In ethyl acetate at 50℃; for 10h; Temperature;

: 13048-33-4
hexamethylene glycol diacrylate

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: C38H58O20S8

Conditions

Conditions	Yield
With triethylamine In ethyl acetate at 50℃; for 10h; Temperature;

: 10193-99-4
3-[(sulfanylacetyl)oxy]-2,2-bis{[(sulfanylacetyl)oxy]methyl}propyl sulfanylacetate

: 15625-89-5
2-((acryloyloxy)methyl)-2-ethylpropane-1,3-diyl diacrylate

: C51H74O30S12

Conditions

Conditions	Yield
With triethylamine In ethyl acetate at 50℃; for 10h; Temperature; Michael Addition; Green chemistry;

Pentaerythritol tetrakis(2-mercaptoacetate) Specification

The Pentaerythritol tetrakis(2-mercaptoacetate), with the CAS registry number 10193-99-4, is also known as Pentaaerythritol tetrakis(mercaptoacetate). It belongs to the product categories of Chain Transfer Agents; Polymer Additives; Polymer Science. Its EINECS registry number is 233-482-8. This chemical's molecular formula is C₁₃H₂₀O₈S₄ and molecular weight is 432.55. Its IUPAC name is called [3-(2-sulfanylacetyl)oxy-2,2-bis[(2-sulfanylacetyl)oxymethyl]propyl]
2-sulfanylacetate.

Physical properties of Pentaerythritol tetrakis(2-mercaptoacetate): (1)ACD/LogP: 1.90; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.9; (4)ACD/LogD (pH 7.4): 1.53; (5)ACD/BCF (pH 5.5): 16.19; (6)ACD/BCF (pH 7.4): 6.98; (7)ACD/KOC (pH 5.5): 254.56; (8)ACD/KOC (pH 7.4): 109.76; (9)#H bond acceptors: 8 ; (10)#Freely Rotating Bonds: 20; (11)Index of Refraction: 1.557; (12)Molar Refractivity: 100.92 cm³; (13)Molar Volume: 313.2 cm³; (14)Surface Tension: 54.3 dyne/cm; (15)Density: 1.38 g/cm³; (16)Flash Point: 484.6 °C; (17)Enthalpy of Vaporization: 75.23 kJ/mol; (18)Boiling Point: 486.6 °C at 760 mmHg; (19)Vapour Pressure: 1.28E-09 mmHg at 25°C.

Preparation: this chemical can be prepared by mercaptoacetic acid and 2,2-bis-hydroxymethyl-propane-1,3-diol. This reaction will need reagent TsOH and solvent toluene. The yield is about 52%.

Uses of Pentaerythritol tetrakis(2-mercaptoacetate): it can be used to produce 6,19-bis-methoxymethyl-2,11,15,24-tetraoxa-5,8,18,21-tetrathia-spiro[12.12]pentacosane-3,10,16,23-tetraone at temperature of 20 °C. This reaction will need reagent tripropylborane and solvent methanol, benzene, hexane. The yield is about 42%.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection .

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C(C(=O)OCC(COC(=O)CS)(COC(=O)CS)COC(=O)CS)S
(2)InChI: InChI=1S/C13H20O8S4/c14-9(1-22)18-5-13(6-19-10(15)2-23,7-20-11(16)3-24)8-21-12(17)4-25/h22-25H,1-8H2
(3)InChIKey: RUDUCNPHDIMQCY-UHFFFAOYSA-N

Product Name

Pentaerythritol tetrakis(2-mercaptoacetate)

Synthetic route

Pentaerythritol tetrakis(2-mercaptoacetate) Specification

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