Phenol, 2-(2-hydroxyethoxy)- supplier

Name
2-(2-HYDROXYETHOXY)PHENOL
EINECS 225-346-1
CAS No. 4792-78-3
Article Data23
CAS DataBase
Density 1.224 g/cm³
Solubility
Melting Point 99-100 °C(lit.)
Formula C₈H₁₀O₃
Boiling Point 300.7 °C at 760 mmHg
Molecular Weight 154.166
Flash Point 135.7 °C
Transport Information
Appearance
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Ethanol,2-(o-hydroxyphenoxy)- (7CI,8CI);2-(2-Hydroxyethoxy)phenol;2-(2-Hydroxyphenoxy)ethanol;2-(2'-Hydroxyethoxy)phenol;2-(o-Hydroxyphenoxy)ethanol;2-[(2-Hydroxyphenyl)oxy]ethanol;
PSA 49.69000
LogP 0.76330

Synthetic route

: 96-49-1
[1,3]-dioxolan-2-one

: 120-80-9
benzene-1,2-diol

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide at 160℃; for 1h;	77%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 150℃; Reagent/catalyst; Temperature; Autoclave;	72%
With tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 170℃; for 2h; Inert atmosphere; Schlenk technique;	55%
With tetrabutylammomium bromide at 180℃; for 3.5h;	25.8 g

: 120-80-9
benzene-1,2-diol

: 107-07-3
2-chloro-ethanol

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
With potassium hydroxide In water for 4h; Reflux;	48%
With potassium carbonate In acetonitrile for 48h; Heating;	40%
With sodium hydroxide In 2-methoxy-ethanol at 100 - 102℃; for 48h; Substitution;	40%
With sodium hydroxide
With ethanol; sodium ethanolate

: 96-49-1
[1,3]-dioxolan-2-one

: 311-28-4
tetra-(n-butyl)ammonium iodide

: 120-80-9
benzene-1,2-diol

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
	46%

...Expand

: 18181-71-0
2-(2-methoxyphenoxy)ethanol

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
With n-butyllithium; lithium diphenylphosphide In tetrahydrofuran for 3h;	45%

: 122-99-6
2-Phenoxyethanol

A: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

B: 49650-88-6
O-(2-hydroxyethyl)resorcinol

C: 13427-53-7
4-(2-hydroxyethoxy)-phenol

Conditions

Conditions	Yield
With recombinant toluene o-xylene monooxygenase from Pseudomonas sp. OX1 expressed in Escherichia coli strain JM109 In methanol at 28℃; for 2h; Enzymatic reaction; Overall yield = 15.3 %;	A 18.3% B 43.8% C 37.8%

...Expand

: 584-08-7
potassium carbonate

: 120-80-9
benzene-1,2-diol

: 107-07-3
2-chloro-ethanol

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
In acetonitrile	40%

...Expand

: 120-80-9
benzene-1,2-diol

: 107-07-3
2-chloro-ethanol

A: 10234-40-9
2,2'-(1,2-phenylenedioxy)diethanol

B: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
With potassium carbonate In acetone for 24h; Heating;	A 10% B 30%

...Expand

: 75-21-8
oxirane

: 120-80-9
benzene-1,2-diol

A: 10234-40-9
2,2'-(1,2-phenylenedioxy)diethanol

B: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
anion exchange resin A (Cl-type) In toluene at 100℃; for 1.5 - 3.5h;	A 2.6% B 83 - 96.8 %Chromat.
diaion TSA1200 In toluene at 100℃; for 9h;	A 0.4 - 0.6 %Chromat. B 99.4 - 99.5 %Chromat.

...Expand

: 75-21-8
oxirane

: 120-80-9
benzene-1,2-diol

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
With sodium hydroxide
at 140 - 150℃; unter Druck;
anion exchange resin A (Cl-type) In 2-methoxy-ethanol at 100℃; for 3.5h;	82 - 83 %Chromat.

: 4385-48-2
1,4-benzodioxan-2-one

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
With copper oxide-chromium oxide at 250℃; under 73550.8 - 147102 Torr; Hydrogenolyse;

: 493-09-4
benzo-1,4-dioxane

A: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

B: 120-80-9
benzene-1,2-diol

Conditions

Conditions	Yield
With sulfuric acid; water In acetonitrile Quantum yield; Mechanism; Irradiation; other alkoxy-substituted benzenes;

: 4385-48-2
1,4-benzodioxan-2-one

copper oxide-chromium oxide: copper oxide-chromium oxide

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
at 250℃; under 73550.8 - 147102 Torr; Hydrogenation;

: 2-tert-butyldimethylsilyloxy-(2-tert-butyldimethylsilyloxyethoxy)benzene

A: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

B: 2-tert-butyldimethylsilyloxy(2-hydroxyethoxy)benzene

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 24h; desilylation;
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 24h; Title compound not separated from byproducts;

: 90-05-1
2-methoxy-phenol

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 65 percent / aliquat 336, potassium hydroxide / H2O / 96 h / 60 °C 2: 45 percent / lithium diphenylphosphide, butyllithium / tetrahydrofuran / 3 h View Scheme

: 75-21-8
oxirane

: 120-80-9
benzene-1,2-diol

A: 10234-40-9
2,2'-(1,2-phenylenedioxy)diethanol

B: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

C: 41757-99-7
1,2-bis[2-(2-hydroxyethoxy)ethoxy]benzene

Conditions

Conditions	Yield
diaion TSA1200 In 2-methoxy-ethanol at 100℃; for 9h;	A 2.9 %Chromat. B 96.9 %Chromat. C 0.1 %Chromat.
potassium hydroxide In 2-methoxy-ethanol at 100℃; for 7h;	A 3.9 %Chromat. B 95.9 %Chromat. C 0.1 %Chromat.

...Expand

: 120-80-9
benzene-1,2-diol

: 540-51-2
2-bromoethanol

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 110 - 120℃; for 24h;

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: (1S,2R)-2-(2-Hydroxy-ethoxy)-cyclohexanol

Conditions

Conditions	Yield
With hydrogen; rhodium on strontium titanate In methanol; chloroform under 760 Torr; for 12h; Ambient temperature;	98%

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane for 3h; Reflux;	97%
With 1,4-diaza-bicyclo[2.2.2]octane; carbonic acid dimethyl ester at 90℃; for 2h; Reagent/catalyst; Time;	92%
With phosphorus pentoxide
Multi-step reaction with 2 steps 1: pyridine; PBr3 2: aqueous alkaline solution View Scheme

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 3355-28-0
1-Bromo-2-butyne

: 2-[2-(but-2-yn-1-yloxy)phenoxy]ethan-1-ol

Conditions

Conditions	Yield
Stage #1: 2-(2-hydroxy-phenoxy)-ethanol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: 1-Bromo-2-butyne In N,N-dimethyl-formamide at 20℃;	95%

: 1623-05-8
perfluoro(propyl vinyl ether)

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 1609114-82-0
2-(2-(1,1,2-trifluoro-2-(perfluoropropoxy)ethoxy)phenoxy)ethanol

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran Reflux;	94.86%
With potassium carbonate In tetrahydrofuran Reflux;	94.8%

: 623-24-5
1,4-bis(bromomethyl)benzene

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 1012793-42-8
p-bis(2-ethoxyphenyloxy)xylene

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In acetone Heating;	94%

: 3099-28-3
2,6-bis(chloromethyl)pyridine

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 269409-29-2
2-(2-{6-[2-(2-hydroxy-ethoxy)-phenoxymethyl]-pyridin-2-ylmethoxy}-phenoxy)-ethanol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 7h;	92%

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 626-16-4
3-(chloromethyl)benzyl chloride

: 1012793-41-7
m-bis(2-ethoxyphenyloxy)xylene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 7h;	91%

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 111-44-4
3-oxa-1,5-dichloropentane

: 38371-37-8
bis<2-<2-(2-hydroxyethoxy)phenoxy>ethyl> ether

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide for 24h; Ambient temperature;	90%
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 7h;	86%

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 623-25-6
p-Xylylene dichloride

: 1012793-42-8
p-bis(2-ethoxyphenyloxy)xylene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 7h;	88%

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 60232-82-8
2,6-bis bromomethyl-4-methylanisole

: 269409-30-5
2-(2-{3-[2-(2-hydroxy-ethoxy)-phenoxymethyl]-2-methoxy-5-methyl-benzyloxy}-phenoxy)-ethanol

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 24h; Substitution; Heating;	82%

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 6315-52-2
1,2-bis-tosyloxyethane

: 68380-65-4
1,2-bis(2-ethoxyphenol)ethane

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide for 24h; Ambient temperature;	81%
With NaH In N-methyl-acetamide; dichloromethane; N,N-dimethyl-formamide	81%
With sodium hydride

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 109-64-8
1,3-dibromo-propane

: 188120-97-0
[2-(3-bromopropoxy)phenoxy]ethanol

Conditions

Conditions	Yield
With potassium carbonate In acetone for 24h; Heating;	81%

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 112-26-5
1,2-bis(2-chloroethoxy)ethane

: 193531-54-3
2-{2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-phenoxy}-ethanol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 7h;	81%

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 112633-26-8
2,6-bis[(tosyloxy)methyl]pyridine

: 269409-29-2
2-(2-{6-[2-(2-hydroxy-ethoxy)-phenoxymethyl]-pyridin-2-ylmethoxy}-phenoxy)-ethanol

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 24h; Substitution; Heating;	80%

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 106-96-7
propargyl bromide

: 2-[2-(prop-2-yn-1-yloxy)phenoxy]ethan-1-ol

Conditions

Conditions	Yield
Stage #1: 2-(2-hydroxy-phenoxy)-ethanol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: propargyl bromide In N,N-dimethyl-formamide; toluene at 20℃; for 16h;	79%

: 96-49-1
[1,3]-dioxolan-2-one

: 120-80-9
benzene-1,2-diol

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide at 160℃; for 1h;	77%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 150℃; Reagent/catalyst; Temperature; Autoclave;	72%
With tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 170℃; for 2h; Inert atmosphere; Schlenk technique;	55%
With tetrabutylammomium bromide at 180℃; for 3.5h;	25.8 g

: 120-80-9
benzene-1,2-diol

: 107-07-3
2-chloro-ethanol

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
With potassium hydroxide In water for 4h; Reflux;	48%
With potassium carbonate In acetonitrile for 48h; Heating;	40%
With sodium hydroxide In 2-methoxy-ethanol at 100 - 102℃; for 48h; Substitution;	40%
With sodium hydroxide
With ethanol; sodium ethanolate

: 96-49-1
[1,3]-dioxolan-2-one

: 311-28-4
tetra-(n-butyl)ammonium iodide

: 120-80-9
benzene-1,2-diol

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
	46%

...Expand

: 18181-71-0
2-(2-methoxyphenoxy)ethanol

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
With n-butyllithium; lithium diphenylphosphide In tetrahydrofuran for 3h;	45%

: 122-99-6
2-Phenoxyethanol

A: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

B: 49650-88-6
O-(2-hydroxyethyl)resorcinol

C: 13427-53-7
4-(2-hydroxyethoxy)-phenol

Conditions

Conditions	Yield
With recombinant toluene o-xylene monooxygenase from Pseudomonas sp. OX1 expressed in Escherichia coli strain JM109 In methanol at 28℃; for 2h; Enzymatic reaction; Overall yield = 15.3 %;	A 18.3% B 43.8% C 37.8%

...Expand

: 584-08-7
potassium carbonate

: 120-80-9
benzene-1,2-diol

: 107-07-3
2-chloro-ethanol

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
In acetonitrile	40%

...Expand

: 120-80-9
benzene-1,2-diol

: 107-07-3
2-chloro-ethanol

A: 10234-40-9
2,2'-(1,2-phenylenedioxy)diethanol

B: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
With potassium carbonate In acetone for 24h; Heating;	A 10% B 30%

...Expand

: 75-21-8
oxirane

: 120-80-9
benzene-1,2-diol

A: 10234-40-9
2,2'-(1,2-phenylenedioxy)diethanol

B: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
anion exchange resin A (Cl-type) In toluene at 100℃; for 1.5 - 3.5h;	A 2.6% B 83 - 96.8 %Chromat.
diaion TSA1200 In toluene at 100℃; for 9h;	A 0.4 - 0.6 %Chromat. B 99.4 - 99.5 %Chromat.

...Expand

: 75-21-8
oxirane

: 120-80-9
benzene-1,2-diol

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
With sodium hydroxide
at 140 - 150℃; unter Druck;
anion exchange resin A (Cl-type) In 2-methoxy-ethanol at 100℃; for 3.5h;	82 - 83 %Chromat.

: 4385-48-2
1,4-benzodioxan-2-one

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
With copper oxide-chromium oxide at 250℃; under 73550.8 - 147102 Torr; Hydrogenolyse;

: 493-09-4
benzo-1,4-dioxane

A: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

B: 120-80-9
benzene-1,2-diol

Conditions

Conditions	Yield
With sulfuric acid; water In acetonitrile Quantum yield; Mechanism; Irradiation; other alkoxy-substituted benzenes;

: 4385-48-2
1,4-benzodioxan-2-one

copper oxide-chromium oxide: copper oxide-chromium oxide

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
at 250℃; under 73550.8 - 147102 Torr; Hydrogenation;

: 2-tert-butyldimethylsilyloxy-(2-tert-butyldimethylsilyloxyethoxy)benzene

A: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

B: 2-tert-butyldimethylsilyloxy(2-hydroxyethoxy)benzene

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 24h; desilylation;
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 24h; Title compound not separated from byproducts;

: 90-05-1
2-methoxy-phenol

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 65 percent / aliquat 336, potassium hydroxide / H2O / 96 h / 60 °C 2: 45 percent / lithium diphenylphosphide, butyllithium / tetrahydrofuran / 3 h View Scheme

: 75-21-8
oxirane

: 120-80-9
benzene-1,2-diol

A: 10234-40-9
2,2'-(1,2-phenylenedioxy)diethanol

B: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

C: 41757-99-7
1,2-bis[2-(2-hydroxyethoxy)ethoxy]benzene

Conditions

Conditions	Yield
diaion TSA1200 In 2-methoxy-ethanol at 100℃; for 9h;	A 2.9 %Chromat. B 96.9 %Chromat. C 0.1 %Chromat.
potassium hydroxide In 2-methoxy-ethanol at 100℃; for 7h;	A 3.9 %Chromat. B 95.9 %Chromat. C 0.1 %Chromat.

...Expand

: 120-80-9
benzene-1,2-diol

: 540-51-2
2-bromoethanol

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 110 - 120℃; for 24h;

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: (1S,2R)-2-(2-Hydroxy-ethoxy)-cyclohexanol

Conditions

Conditions	Yield
With hydrogen; rhodium on strontium titanate In methanol; chloroform under 760 Torr; for 12h; Ambient temperature;	98%

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 493-09-4
benzo-1,4-dioxane

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane for 3h; Reflux;	97%
With 1,4-diaza-bicyclo[2.2.2]octane; carbonic acid dimethyl ester at 90℃; for 2h; Reagent/catalyst; Time;	92%
With phosphorus pentoxide
Multi-step reaction with 2 steps 1: pyridine; PBr3 2: aqueous alkaline solution View Scheme

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 3355-28-0
1-Bromo-2-butyne

: 2-[2-(but-2-yn-1-yloxy)phenoxy]ethan-1-ol

Conditions

Conditions	Yield
Stage #1: 2-(2-hydroxy-phenoxy)-ethanol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: 1-Bromo-2-butyne In N,N-dimethyl-formamide at 20℃;	95%

: 1623-05-8
perfluoro(propyl vinyl ether)

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 1609114-82-0
2-(2-(1,1,2-trifluoro-2-(perfluoropropoxy)ethoxy)phenoxy)ethanol

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran Reflux;	94.86%
With potassium carbonate In tetrahydrofuran Reflux;	94.8%

: 623-24-5
1,4-bis(bromomethyl)benzene

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 1012793-42-8
p-bis(2-ethoxyphenyloxy)xylene

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In acetone Heating;	94%

: 3099-28-3
2,6-bis(chloromethyl)pyridine

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 269409-29-2
2-(2-{6-[2-(2-hydroxy-ethoxy)-phenoxymethyl]-pyridin-2-ylmethoxy}-phenoxy)-ethanol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 7h;	92%

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 626-16-4
3-(chloromethyl)benzyl chloride

: 1012793-41-7
m-bis(2-ethoxyphenyloxy)xylene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 7h;	91%

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 111-44-4
3-oxa-1,5-dichloropentane

: 38371-37-8
bis<2-<2-(2-hydroxyethoxy)phenoxy>ethyl> ether

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide for 24h; Ambient temperature;	90%
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 7h;	86%

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 623-25-6
p-Xylylene dichloride

: 1012793-42-8
p-bis(2-ethoxyphenyloxy)xylene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 7h;	88%

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 60232-82-8
2,6-bis bromomethyl-4-methylanisole

: 269409-30-5
2-(2-{3-[2-(2-hydroxy-ethoxy)-phenoxymethyl]-2-methoxy-5-methyl-benzyloxy}-phenoxy)-ethanol

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 24h; Substitution; Heating;	82%

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 6315-52-2
1,2-bis-tosyloxyethane

: 68380-65-4
1,2-bis(2-ethoxyphenol)ethane

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide for 24h; Ambient temperature;	81%
With NaH In N-methyl-acetamide; dichloromethane; N,N-dimethyl-formamide	81%
With sodium hydride

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 109-64-8
1,3-dibromo-propane

: 188120-97-0
[2-(3-bromopropoxy)phenoxy]ethanol

Conditions

Conditions	Yield
With potassium carbonate In acetone for 24h; Heating;	81%

: 4792-78-3
2-(2-hydroxy-phenoxy)-ethanol

: 112-26-5
1,2-bis(2-chloroethoxy)ethane

: 193531-54-3
2-{2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-phenoxy}-ethanol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 7h;	81%

Phenol, 2-(2-hydroxyethoxy)- Specification

This chemical is called Phenol, 2-(2-hydroxyethoxy)-, and it can also be named as 2-(2-Hydroxyethoxy)phenol. With the molecular formula of C₈H₁₀O₃, its molecular weight is 154.16. The CAS registry number of this chemical is 4792-78-3. Additionally, this chemical should be sealed in the cool and dry place.

Other characteristics of the Phenol, 2-(2-hydroxyethoxy)- can be summarised as followings: (1)ACD/LogP: 0.21; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.21; (4)ACD/LogD (pH 7.4): 0.21; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 31.07; (8)ACD/KOC (pH 7.4): 30.86; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 27.69 Å²; (13)Index of Refraction: 1.564; (14)Molar Refractivity: 40.98 cm³; (15)Molar Volume: 125.8 cm³; (16)Polarizability: 16.24×10^-24cm³; (17)Surface Tension: 50.4 dyne/cm; (18)Density: 1.224 g/cm³; (19)Flash Point: 135.7 °C; (20)Enthalpy of Vaporization: 57.11 kJ/mol; (21)Boiling Point: 300.7 °C at 760 mmHg; (22)Vapour Pressure: 0.00049 mmHg at 25°C.

Production method of this chemical: The Phenol, 2-(2-hydroxyethoxy)- could be obtained by the reactants of benzene-1,2-diol and 2-chloro-ethanol. This reaction needs the reagents of sodium ethylate, ethanol.

Uses of this chemical: The Phenol, 2-(2-hydroxyethoxy)- could react with toluene-4-sulfonyl chloride, and obtain the 2-(2-hydroxyethoxy)phenol ditosylate. This reaction needs the reagent of pyridine. The yield is 61 %. In addition, this reaction should be taken for 40 hours at the ambient temperature.

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.SMILES: O(c1ccccc1O)CCO
2.InChI: InChI=1/C8H10O3/c9-5-6-11-8-4-2-1-3-7(8)10/h1-4,9-10H,5-6H2
3.InChIKey: AMCOCUDBDKVWRZ-UHFFFAOYAF

Product Name

2-(2-HYDROXYETHOXY)PHENOL

Synthetic route

Phenol, 2-(2-hydroxyethoxy)- Specification

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