Product Name

  • Name

    Phenyl chloroformate

  • EINECS 217-547-8
  • CAS No. 1885-14-9
  • Article Data79
  • CAS DataBase
  • Density 1.283 g/cm3
  • Solubility hydrolysis in water
  • Melting Point -28 °C
  • Formula C7H5ClO2
  • Boiling Point 186.5 °C at 760 mmHg
  • Molecular Weight 156.569
  • Flash Point 79 °C
  • Transport Information UN 2746 6.1/PG 2
  • Appearance colorless liquid with a strong odor
  • Safety 26-28-36/37/39-45-28A
  • Risk Codes 22-26-34-41-38-29
  • Molecular Structure Molecular Structure of 1885-14-9 (Phenyl chloroformate)
  • Hazard Symbols VeryT+
  • Synonyms Phenoxycarbonyl chloride;Formic acid, chloro-, phenyl ester;4-06-00-00629 (Beilstein Handbook Reference);Fenylester kyseliny chlormravenci [Czech];Fenylester kyseliny chlormravenci;Formic acid, chloro-, phenyl ester (8CI);carbonochloridic acid, phenyl ester;
  • PSA 26.30000
  • LogP 2.42420

Synthetic route

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

phenol
108-95-2

phenol

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0℃; for 2h;99%
With sodium hydroxide In dichloromethane at 20℃; for 2h;88.4%
Stage #1: bis(trichloromethyl) carbonate With sodium carbonate; N,N-dimethyl-formamide In toluene at 0℃; for 0.5h;
Stage #2: phenol In toluene at 0℃; for 8.5h;
66%
phenol
108-95-2

phenol

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
With CoCl2 In triphenylphosphine91.5%
With water Behandeln mit Phosgen und Trichloraethylen;
phosgene
75-44-5

phosgene

N-methyl-stearylformamide

N-methyl-stearylformamide

carbon dioxide
124-38-9

carbon dioxide

phenol
108-95-2

phenol

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
91%
phosgene
75-44-5

phosgene

phenol
108-95-2

phenol

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; Temperature;89.4%
With sodium hydroxide; water; toluene at 30℃; bis:>40 degreeC.;
With N,N-dimethyl-aniline; benzene
5-tert-Butoxycarbonylamino-3-methyl-thiophene-2-carboxylic acid ethyl ester
851443-09-9

5-tert-Butoxycarbonylamino-3-methyl-thiophene-2-carboxylic acid ethyl ester

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
Stage #1: 5-tert-Butoxycarbonylamino-3-methyl-thiophene-2-carboxylic acid ethyl ester With trifluoroacetic acid In dichloromethane at 0℃; for 2h;
Stage #2: With sodium hydroxide; water In ethyl acetate Product distribution / selectivity;
89%
S-methyl O-phenyl carbonothioate
13509-28-9

S-methyl O-phenyl carbonothioate

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
With sulfuryl dichloride at 20℃; for 1h;78%
phosgene
75-44-5

phosgene

sodium phenoxide
139-02-6

sodium phenoxide

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
at 30℃;
With toluene
phosgene
75-44-5

phosgene

antipyrine
60-80-0

antipyrine

phenol
108-95-2

phenol

phenyl chloroformate
1885-14-9

phenyl chloroformate

carbonic acid phenyl ester-trichloromethyl ester
861340-55-8

carbonic acid phenyl ester-trichloromethyl ester

A

phosgene
75-44-5

phosgene

B

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
at 180 - 210℃;
phosgene
75-44-5

phosgene

phenol
108-95-2

phenol

A

bis(phenyl) carbonate
102-09-0

bis(phenyl) carbonate

B

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
at 140 - 150℃; im geschlossenen Rohr;
at 140 - 150℃;
sodium phenoxide
139-02-6

sodium phenoxide

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
With water
1-trifluoromethoxybenzene
456-55-3

1-trifluoromethoxybenzene

A

bis(phenyl) carbonate
102-09-0

bis(phenyl) carbonate

B

phenyl fluoroformate
351-80-4

phenyl fluoroformate

C

phenyl chloroformate
1885-14-9

phenyl chloroformate

D

phenol
108-95-2

phenol

Conditions
ConditionsYield
With aluminium trichloride In fluorobenzene at 90℃; for 0.0833333h;
3-chloro-3-phenyl-3H-diazirine
4460-46-2

3-chloro-3-phenyl-3H-diazirine

A

benzoyl chloride
98-88-4

benzoyl chloride

B

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
With oxygen In solid matrix at -263.2℃; Irradiation;
3-chloro-3-phenyl-3H-diazirine
4460-46-2

3-chloro-3-phenyl-3H-diazirine

A

carbon dioxide
124-38-9

carbon dioxide

B

carbon monoxide
201230-82-2

carbon monoxide

C

chlorophenyldiazomethane
19016-92-3

chlorophenyldiazomethane

D

benzoyl chloride
98-88-4

benzoyl chloride

E

phenyl chloroformate
1885-14-9

phenyl chloroformate

F

1-chlorocyclohepta-1,2,4,6-tetraene
107135-21-7

1-chlorocyclohepta-1,2,4,6-tetraene

Conditions
ConditionsYield
With oxygen In solid matrix at -263.2℃; Product distribution; Mechanism; Irradiation; different O2 concentrations and wavelengths of irradiation;
water
7732-18-5

water

phenol
108-95-2

phenol

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
Reaktion von Natriumphenolat (2 Mol);
trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

aqueous sodium phenolate

aqueous sodium phenolate

A

bis(phenyl) carbonate
102-09-0

bis(phenyl) carbonate

B

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
je nach den angewandten Mengenverhaeltnissen;
3-chloro-3-phenyl-3H-diazirine
4460-46-2

3-chloro-3-phenyl-3H-diazirine

A

benzoyl chloride
98-88-4

benzoyl chloride

B

chlorobenzene
108-90-7

chlorobenzene

C

phenyl chloroformate
1885-14-9

phenyl chloroformate

D

2-chlorobenzaldehyde-O-oxide

2-chlorobenzaldehyde-O-oxide

E

3-Chloro-3-phenyl-dioxirane

3-Chloro-3-phenyl-dioxirane

F

O3, CO2

O3, CO2

Conditions
ConditionsYield
With oxygen at -247.2℃; under 150 - 200 Torr; Product distribution; Mechanism; Irradiation; study of the oxygen trapping of phenylchlorocarbene intermediate formed from phenylchlorodiazirine in oxigen-doped matrix by irradiation, mechanism is discussed;
phenol
108-95-2

phenol

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
With pyrographite; triethylamine In tetrahydrofuran at 120℃; for 3h; Condensation;
With dmap In toluene at 20℃; for 24h;
With dmap In toluene at 20℃; for 24h;
phenol
108-95-2

phenol

cyclic dichloride of/the/ benzoic acid sulfinic acid-(2)

cyclic dichloride of/the/ benzoic acid sulfinic acid-(2)

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: DBU / tetrahydrofuran / 1 h / 20 °C / 750.06 Torr
1.2: 25 percent / tetrahydrofuran / 2 h / 20 °C / 750.06 Torr
2.1: 78 percent / SO2Cl2 / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: S; DBU / tetrahydrofuran / 6 h / 80 °C / 7500.6 Torr
1.2: 49 percent / tetrahydrofuran / 16 h / 20 °C / 750.06 Torr
2.1: 78 percent / SO2Cl2 / 1 h / 20 °C
View Scheme
phosgene
75-44-5

phosgene

hypophosphorous acid
6303-21-5

hypophosphorous acid

phenol
108-95-2

phenol

A

bis(phenyl) carbonate
102-09-0

bis(phenyl) carbonate

B

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
In Diphenylmethane
phenyl oxalyl chloride
51719-70-1

phenyl oxalyl chloride

2-amino-5-trifluoromethyl-1,3,4-thiadiazole
10444-89-0

2-amino-5-trifluoromethyl-1,3,4-thiadiazole

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
With triethylamine
With triethylamine
phenyl carbonic acid
13932-55-3

phenyl carbonic acid

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
With thionyl chloride for 2h; Reflux; Cooling with ice;
With thionyl chloride In toluene for 1h; Reflux;
2-oxo-2-(pyren-1-yl)ethyl phenyl carbonate
1449331-31-0

2-oxo-2-(pyren-1-yl)ethyl phenyl carbonate

phenyl chloroformate
1885-14-9

phenyl chloroformate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: water / acetonitrile / pH 7.5 / Photolysis; Inert atmosphere
2: sodium carbonate / toluene / 6 h / 0 °C
View Scheme
4-methoxy-aniline
104-94-9

4-methoxy-aniline

phenyl chloroformate
1885-14-9

phenyl chloroformate

(4-methoxyphenyl)carbamic acid phenyl ester
20950-96-3

(4-methoxyphenyl)carbamic acid phenyl ester

Conditions
ConditionsYield
With pyridine In ethyl acetate at 20℃; for 1h;100%
With sodium hydrogencarbonate In tetrahydrofuran; water at 0 - 20℃; for 0.0833333h;97%
With sodium carbonate In tetrahydrofuran; water; ethyl acetate at 0 - 20℃;92%
allyl alcohol
107-18-6

allyl alcohol

phenyl chloroformate
1885-14-9

phenyl chloroformate

allyl phenyl carbonate
16308-68-2

allyl phenyl carbonate

Conditions
ConditionsYield
With pyridine In dichloromethane at 23℃; for 4h; Inert atmosphere;100%
With pyridine In dichloromethane for 3h;90%
aniline
62-53-3

aniline

phenyl chloroformate
1885-14-9

phenyl chloroformate

phenyl N-phenylcarbamate
4930-03-4

phenyl N-phenylcarbamate

Conditions
ConditionsYield
With triethylamine In dichloromethane for 3h;100%
With triethylamine In dichloromethane at 0 - 20℃; for 2.5h;100%
With triethylamine In dichloromethane at 0℃; for 0.5h;100%
phenyl chloroformate
1885-14-9

phenyl chloroformate

benzyl alcohol
100-51-6

benzyl alcohol

benzyl phenyl carbonate
28170-07-2

benzyl phenyl carbonate

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 16h; Inert atmosphere;100%
With pyridine In dichloromethane at 23℃; Cooling with ice; Inert atmosphere;99%
With pyridine; dmap In dichloromethane at 0 - 20℃; for 13.5h;95%
benzoic acid hydrazide
613-94-5

benzoic acid hydrazide

phenyl chloroformate
1885-14-9

phenyl chloroformate

1-benzoyl-2-phenoxycarbonylhydrazine
15081-44-4

1-benzoyl-2-phenoxycarbonylhydrazine

Conditions
ConditionsYield
With pyridine In tetrahydrofuran 1) -10 deg C, 30 min, 2) 1 h, room temperature;100%
In benzene
1-methyl-1-phenylethyl alcohol
617-94-7

1-methyl-1-phenylethyl alcohol

phenyl chloroformate
1885-14-9

phenyl chloroformate

2-phenylisopropyloxycarbonyl phenyl carbonate
53933-09-8

2-phenylisopropyloxycarbonyl phenyl carbonate

Conditions
ConditionsYield
With pyridine In dichloromethane at -5 - 0℃;100%
With pyridine In dichloromethane
indole
120-72-9

indole

phenyl chloroformate
1885-14-9

phenyl chloroformate

phenyl 1H-indole-1-carboxylate
74117-31-0

phenyl 1H-indole-1-carboxylate

Conditions
ConditionsYield
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane at 20℃; for 1h;100%
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane at 0℃; for 2h;75%
With sodium hydride In N,N-dimethyl-formamide at 70℃; for 20h;52%
6,7-Dimethoxy-1-(3-pentyl)-3,4-dihydroisoquinoline
128425-87-6

6,7-Dimethoxy-1-(3-pentyl)-3,4-dihydroisoquinoline

phenyl chloroformate
1885-14-9

phenyl chloroformate

Phenyl 6,7-Dimethoxy-1-(3-pentylidene)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate
128425-88-7

Phenyl 6,7-Dimethoxy-1-(3-pentylidene)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane; benzene Heating;100%
2-hydroxy-2-methylpropanenitrile
75-86-5

2-hydroxy-2-methylpropanenitrile

phenyl chloroformate
1885-14-9

phenyl chloroformate

1-cyano-1-methyl-ethylphenylcarbonate
130312-20-8

1-cyano-1-methyl-ethylphenylcarbonate

Conditions
ConditionsYield
With pyridine for 0.5h;100%
L-valine
72-18-4

L-valine

phenyl chloroformate
1885-14-9

phenyl chloroformate

(2S)-3-Methyl-2-(phenoxycarbonyl)aminobutyric acid
126147-70-4

(2S)-3-Methyl-2-(phenoxycarbonyl)aminobutyric acid

Conditions
ConditionsYield
With sodium hydroxide; potassium hydrogencarbonate for 1.5h; Ambient temperature;100%
With aluminum oxide; lithium chloride; lithium hydroxide In water at -20 - -10℃; for 5h; pH=9.5 - 10.2; Schotten-Baumann Reaction; Inert atmosphere;92%
Stage #1: L-valine; phenyl chloroformate With sodium hydroxide In water at 0℃; for 5h;
Stage #2: With hydrogenchloride In water pH=2;
75.9%
2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

phenyl chloroformate
1885-14-9

phenyl chloroformate

2,2,2-trifluoroethyl phenyl carbonate
152899-11-1

2,2,2-trifluoroethyl phenyl carbonate

Conditions
ConditionsYield
With pyridine100%
With pyridine In dichloromethane at 20℃; for 1h;
4-(Tetradecyloxy)-benzyl alcohol
62443-00-9

4-(Tetradecyloxy)-benzyl alcohol

phenyl chloroformate
1885-14-9

phenyl chloroformate

phenyl <4-(tetradecyloxy)phenyl>methyl carbonate
147219-70-3

phenyl <4-(tetradecyloxy)phenyl>methyl carbonate

Conditions
ConditionsYield
With pyridine In dichloromethane 1.) 0 deg C, 15 min, 2.) RT, 30 min;100%
With pyridine In dichloromethane
(4S,5S)-4-benzyloxymethyl-5-hydroxymethyl-2,2-dimethyl-1,3-dioxolane
78469-77-9, 81076-11-1, 128820-40-6, 78513-03-8

(4S,5S)-4-benzyloxymethyl-5-hydroxymethyl-2,2-dimethyl-1,3-dioxolane

phenyl chloroformate
1885-14-9

phenyl chloroformate

Carbonic acid (4S,5S)-5-benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester phenyl ester

Carbonic acid (4S,5S)-5-benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester phenyl ester

Conditions
ConditionsYield
With pyridine In dichloromethane100%
2'-methyl-2',3'-dihydrospiro
86485-18-9

2'-methyl-2',3'-dihydrospiro

phenyl chloroformate
1885-14-9

phenyl chloroformate

N-phenoxycarbonyl-2',3'-dihydrospiro
86485-19-0

N-phenoxycarbonyl-2',3'-dihydrospiro

Conditions
ConditionsYield
In dichloromethane Ambient temperature; overnight;100%
In dichloromethane; ethyl acetate2.6 g (69.7%)
4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenylamine
74852-62-3

4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenylamine

phenyl chloroformate
1885-14-9

phenyl chloroformate

phenyl (4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)carbamate
74853-06-8

phenyl (4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)carbamate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;100%
With pyridine In dichloromethane at 0 - 20℃; for 2h;92.1%
With pyridine for 3h;90%
phenyl chloroformate
1885-14-9

phenyl chloroformate

3-O-<<2-(dimethylamino)ethyl>carbamoyl>-2-O-methyl-1-O-(octadecylcarbamoyl)glycerol
116970-37-7

3-O-<<2-(dimethylamino)ethyl>carbamoyl>-2-O-methyl-1-O-(octadecylcarbamoyl)glycerol

3-O--N-(phenoxycarbonyl)carbamoyl>-2-O-methyl-1-O-(octadecylcarbamoyl)glycerol
116953-42-5

3-O--N-(phenoxycarbonyl)carbamoyl>-2-O-methyl-1-O-(octadecylcarbamoyl)glycerol

Conditions
ConditionsYield
With pyridine In dichloromethane for 4h; Ambient temperature;100%
(trimethylsilyl)ethynylmagnesium bromide
61210-52-4

(trimethylsilyl)ethynylmagnesium bromide

phenyl chloroformate
1885-14-9

phenyl chloroformate

4-[1-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-quinoline

4-[1-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-quinoline

4-[1-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2-trimethylsilanylethynyl-2H-quinoline-1-carboxylic acid phenyl ester

4-[1-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2-trimethylsilanylethynyl-2H-quinoline-1-carboxylic acid phenyl ester

Conditions
ConditionsYield
In dichloromethane at -20℃;100%
phenyl chloroformate
1885-14-9

phenyl chloroformate

C17H20N2O8

C17H20N2O8

C31H28N2O12

C31H28N2O12

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 22℃;100%
phenyl chloroformate
1885-14-9

phenyl chloroformate

(R)-2-((R)-2-Methyl-pent-4-enyl)-2,3-dihydro-1H-pyridin-4-one
223545-26-4

(R)-2-((R)-2-Methyl-pent-4-enyl)-2,3-dihydro-1H-pyridin-4-one

(R)-2-((R)-2-Methyl-pent-4-enyl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester
223545-28-6

(R)-2-((R)-2-Methyl-pent-4-enyl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester

Conditions
ConditionsYield
With n-butyllithium100%
Stage #1: (R)-2-((R)-2-Methyl-pent-4-enyl)-2,3-dihydro-1H-pyridin-4-one With n-butyllithium Inert atmosphere;
Stage #2: phenyl chloroformate Inert atmosphere;
100%
phenyl chloroformate
1885-14-9

phenyl chloroformate

3-amino-6-(3-pyridyl)pyridine
35989-06-1

3-amino-6-(3-pyridyl)pyridine

[2,3']bipyridinyl-5-yl-carbamic acid phenyl ester
264617-08-5

[2,3']bipyridinyl-5-yl-carbamic acid phenyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 18h; Condensation;100%
phenyl chloroformate
1885-14-9

phenyl chloroformate

2-chloro-3-(3-pyridyl)aniline
264617-06-3

2-chloro-3-(3-pyridyl)aniline

(2-chloro-3-pyridin-3-yl-phenyl)-carbamic acid phenyl ester
264617-22-3

(2-chloro-3-pyridin-3-yl-phenyl)-carbamic acid phenyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 18h; Condensation;100%
phenyl chloroformate
1885-14-9

phenyl chloroformate

3-(4-methyl-3-pyridyl)aniline
264616-98-0

3-(4-methyl-3-pyridyl)aniline

[3-(4-methyl-pyridin-3-yl)-phenyl]-carbamic acid phenyl ester
264617-09-6

[3-(4-methyl-pyridin-3-yl)-phenyl]-carbamic acid phenyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 18h; Condensation;100%
phenyl chloroformate
1885-14-9

phenyl chloroformate

5-ethyl-3-(3-pyridyl)aniline

5-ethyl-3-(3-pyridyl)aniline

(3-ethyl-5-pyridin-3-yl-phenyl)-carbamic acid phenyl ester

(3-ethyl-5-pyridin-3-yl-phenyl)-carbamic acid phenyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 18h; Condensation;100%
phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

phenyl chloroformate
1885-14-9

phenyl chloroformate

phenyl diethoxyphosphorylformate
132916-41-7

phenyl diethoxyphosphorylformate

Conditions
ConditionsYield
at 120℃; for 1.5h;100%
phenyl chloroformate
1885-14-9

phenyl chloroformate

1-amino-6,8-dimethoxy-3,4-dihydroquinolin-2(1H)-one
436155-90-7

1-amino-6,8-dimethoxy-3,4-dihydroquinolin-2(1H)-one

phenyl (6,8-dimethoxy-2-oxo-1,2,3,4-tetrahydroquinolin-1-yl)carbamate
156141-49-0

phenyl (6,8-dimethoxy-2-oxo-1,2,3,4-tetrahydroquinolin-1-yl)carbamate

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane at 20℃;100%
phenyl chloroformate
1885-14-9

phenyl chloroformate

trans-2-(2-Vinylstyryl)pyrrole
174004-33-2

trans-2-(2-Vinylstyryl)pyrrole

trans-N-phenoxycarbonyl-2-[2-(2-vinylphenyl)ethenyl]pyrrole

trans-N-phenoxycarbonyl-2-[2-(2-vinylphenyl)ethenyl]pyrrole

Conditions
ConditionsYield
With sodium hydroxide; tetrabutyl-ammonium chloride In dichloromethane for 0.25h;100%
phenyl chloroformate
1885-14-9

phenyl chloroformate

3-tert-butyl-1-p-tolyl-1H-pyrazol-5-amine
285984-25-0

3-tert-butyl-1-p-tolyl-1H-pyrazol-5-amine

[5-tert-butyl-2-(4-methylphenyl)-2H-pyrazol-3-yl]carbamic acid phenyl ester
285984-47-6

[5-tert-butyl-2-(4-methylphenyl)-2H-pyrazol-3-yl]carbamic acid phenyl ester

Conditions
ConditionsYield
With pyridine In tetrahydrofuran at 0 - 20℃; Inert atmosphere;100%
With sodium hydroxide In water; ethyl acetate at 10.9 - 25.5℃; for 1h;95%
With sodium carbonate In Isopropyl acetate; water at 20℃;88%
phenyl chloroformate
1885-14-9

phenyl chloroformate

(3R,4S,5S,6R)-4-((E)-1,5-Dimethyl-hexa-1,4-dienyl)-5-methoxy-1-oxa-spiro[2.5]octan-6-ol
220496-61-7

(3R,4S,5S,6R)-4-((E)-1,5-Dimethyl-hexa-1,4-dienyl)-5-methoxy-1-oxa-spiro[2.5]octan-6-ol

Carbonic acid (3R,4S,5S,6R)-4-((E)-1,5-dimethyl-hexa-1,4-dienyl)-5-methoxy-1-oxa-spiro[2.5]oct-6-yl ester phenyl ester

Carbonic acid (3R,4S,5S,6R)-4-((E)-1,5-dimethyl-hexa-1,4-dienyl)-5-methoxy-1-oxa-spiro[2.5]oct-6-yl ester phenyl ester

Conditions
ConditionsYield
With dmap In dichloromethane at 0℃;100%
phenyl chloroformate
1885-14-9

phenyl chloroformate

1-((3R,4S,5S,6R)-6-Hydroxy-5-methoxy-1-oxa-spiro[2.5]oct-4-yl)-ethanone O-benzyl-oxime
654055-80-8

1-((3R,4S,5S,6R)-6-Hydroxy-5-methoxy-1-oxa-spiro[2.5]oct-4-yl)-ethanone O-benzyl-oxime

Carbonic acid (3R,4S,5S,6R)-4-{1-[(E)-benzyloxyimino]-ethyl}-5-methoxy-1-oxa-spiro[2.5]oct-6-yl ester phenyl ester

Carbonic acid (3R,4S,5S,6R)-4-{1-[(E)-benzyloxyimino]-ethyl}-5-methoxy-1-oxa-spiro[2.5]oct-6-yl ester phenyl ester

Conditions
ConditionsYield
With dmap In dichloromethane at 0℃;100%
2-thioxo-3H-1,3-benzothiazole
149-30-4

2-thioxo-3H-1,3-benzothiazole

phenyl chloroformate
1885-14-9

phenyl chloroformate

S-(1,3-benzothiazol-2-yl) O-phenyl thiocarbonate
61588-20-3

S-(1,3-benzothiazol-2-yl) O-phenyl thiocarbonate

Conditions
ConditionsYield
With triethylamine In benzene at 20℃; for 1h;100%

Phenyl chloroformate Consensus Reports

Reported in EPA TSCA Inventory.

Phenyl chloroformate Standards and Recommendations

DOT Classification:  6.1; Label: Poison, Corrosive

Phenyl chloroformate Specification

The Phenyl chlorocarbonate, with the CAS registry number 1885-14-9 and EINECS registry number 217-547-8, has the systematic name of phenyl carbonochloridate. And the molecular formula of this chemical is C16H36ClN. It is a kind of clear liquid with a strong odor, and belongs to the following product categories: Miscellaneous; Organics; Chloroformates. In addition, it is sensitive to moisture, and should be stored in the refrigerator. Besides, it is used as reagents for organic synthesis.

The physical properties of Phenyl chlorocarbonate are as following: (1)ACD/LogP: 2.66; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.66; (4)ACD/LogD (pH 7.4): 2.66; (5)ACD/BCF (pH 5.5): 62.02; (6)ACD/BCF (pH 7.4): 62.02; (7)ACD/KOC (pH 5.5): 667.87; (8)ACD/KOC (pH 7.4): 667.87; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 26.3 Å2; (13)Index of Refraction: 1.532; (14)Molar Refractivity: 37.81 cm3; (15)Molar Volume: 121.9 cm3; (16)Polarizability: 14.98×10-24cm3; (17)Surface Tension: 40.4 dyne/cm; (18)Density: 1.283 g/cm3; (19)Flash Point: 79 °C; (20)Enthalpy of Vaporization: 42.28 kJ/mol; (21)Boiling Point: 186.5 °C at 760 mmHg; (22)Vapour Pressure: 0.66 mmHg at 25°C.

Preparation of Phenyl chlorocarbonate: It can be prepared by phenol and phosgene. Dissolve phenol in chloroform, and then pass phosgene. Dilute with water after addition of equimolar N,N-Dimethylaniline. Wash the oil layer with diluted hydrochloric acid and water, and then dry with anhydrous calcium chloride. Heat to get rid of chloroform, and collect the distillate in 74-75°C(1.73kPa) after reduced pressure distillation. The distillate is the product you desired. And the yield is 90%.

Uses of Phenyl chlorocarbonate: It can react with phenylhydrazine to produce 3-phenyl-carbazic acid phenyl ester. This reaction will need solvents diethyl ether and tetrahydrofuran. The reaction time is 0.5 hours with heating, and the yield is about 32%.

Phenyl chlorocarbonate can react with phenylhydrazine to produce 3-phenyl-carbazic acid phenyl ester

You should be cautious while dealing with this chemical. If contact with water, it will liberate toxic gas. It irritates skin, and has risk of serious damage to eyes. It is very toxic by inhalation, and may also cause burns. In addition, it is harmful if swallowed. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer); In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(Cl)Oc1ccccc1
(2)InChI: InChI=1/C7H5ClO2/c8-7(9)10-6-4-2-1-3-5-6/h1-5H
(3)InChIKey: AHWALFGBDFAJAI-UHFFFAOYAM

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LC inhalation > 800mg/m3/10M (800mg/m3)   National Defense Research Committee, Office of Scientific Research and Development, Progress Report.Vol. NDCrc-132, Pg. Dec, 1942.
rabbit LD50 skin 3970uL/kg (3.97mL/kg)   American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rat LCLo inhalation 44ppm/4H (44ppm)   American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rat LD50 oral 1410uL/kg (1.41mL/kg)   American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View