Phenylhydrazine supplier | CasNO.100-63-0

Name
Phenylhydrazine
EINECS 202-873-5
CAS No. 100-63-0
Article Data237
CAS DataBase
Density 1.125 g/cm³
Solubility 145 g/L (20 °C) in water
Melting Point 19 °C
Formula C₆H₈N₂
Boiling Point 243 °C at 760 mmHg
Molecular Weight 108.143
Flash Point 115.4 °C
Transport Information UN 2572 6.1/PG 2
Appearance colourless to pale yellow liquid
Safety 53-45-61
Risk Codes 45-23/24/25-36/38-43-48-50-68
Molecular Structure
Hazard Symbols T,N
Synonyms Hydrazinobenzene;Monophenylhydrazine;AI3-15399;BRN 0606080;CCRIS 511;Fenilidrazina;Fenilidrazina [Italian];Fenylhydrazine;Fenylhydrazine [Dutch];HSDB 1117;Hydrazine, phenyl-;Hydrazine-benzene;Hydrazobenzene;Phenylhydrazin [German];Phenylhydrazine [UN2572] [Poison];Phenylhydrazine and its salts;UN2572;
PSA 38.05000
LogP 1.74550

Synthetic route

: 100-34-5
benzene diazonium chloride

: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen at 30℃; under 3000.3 Torr; for 2h; Temperature; Pressure; Reagent/catalyst; Autoclave;	94%
With hydrogenchloride; potassium chloride Electrolysis;
With hydrogenchloride; tin(ll) chloride

: 62-53-3
aniline

: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
With ammonium hydrogen sulfite; ammonium nitrite; ammonium bisulfite; sulfuric acid at 40 - 70℃; for 4h; pH=3;	87.5%
Stage #1: aniline With hydrogenchloride; sodium nitrite In water at 65℃; pH=2.5; Stage #2: With ammonium hydrogen sulfite In water at 8 - 70℃; for 1.75h; Temperature; pH-value; Further stages;	84%
Stage #1: aniline With hydrogenchloride; sodium nitrite In water for 2h; Stage #2: With hydrogenchloride; sodium sulfite In water at 0 - 100℃; for 4h;	78.74%

: 591-50-4
iodobenzene

: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
With potassium phosphate; copper(l) iodide; Oxalsaeure-bis-<β-benzoylhydrazid>; hydrazine hydrate In dimethyl sulfoxide at 20℃; for 12h;	83%
With hydrazine hydrate for 3h; Reflux;
With potassium phosphate; copper(l) iodide; hydrazine hydrate at 120℃; for 6h; Sealed tube; Inert atmosphere;
Stage #1: iodobenzene With oxalic acid hydrazide; potassium phosphate; cetyltrimethylammonim bromide; 2,5-hexanedione; copper(I) bromide In water at 110℃; for 0.166667h; Sealed tube; Stage #2: With hydrazine hydrate In water at 110℃; for 1h; Sealed tube;	68 %Chromat.

: 369-57-3
benzenediazonium tetrafluoroborate

: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
With nickel dichloride; zinc In tetrahydrofuran Reduction;	80%
Multi-step reaction with 2 steps 1: water; tetrahydrofuran / 0 - 20 °C 2: sulfuric acid / water; isopropyl alcohol / 6 h / Reflux View Scheme

: C24H22N2P(1+)*BF4(1-)

: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
With sulfuric acid In water; isopropyl alcohol for 6h; Reflux;	79%

: triphenyl-(N'-phenyl-hydrazino)-phosphonium; chloride

: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
With sulfuric acid In water; isopropyl alcohol for 6h; Reflux;	75%

: C24H22N2P(1+)*C2H3O2(1-)

: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
With sulfuric acid In water; isopropyl alcohol for 6h; Reflux;	70%

: 90331-10-5
4-tert-butyl-1,3-diphenyl-5-(E)-styryl-1,2,4-triazoline

A: 5894-65-5
N-t-butylbenzamide

B: 104-55-2
3-phenyl-propenal

C: 100-63-0
phenylhydrazine

D: (E)-1,3-diphenyl-5-styryl-1H-1,2,4-triazole

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 4h; Ambient temperature;	A n/a B n/a C n/a D 37%

...Expand

: 62-53-3
aniline

A: 95-54-5
1,2-diamino-benzene

B: 100-63-0
phenylhydrazine

C: 106-50-3
1,4-phenylenediamine

Conditions

Conditions	Yield
With chloroamine; cationic exchanger KU-23 In diethyl ether at 20℃; for 1.5h; Product distribution; var. time;	A 11% B 12% C 5%

...Expand

: 67-56-1
methanol

: 5-oxo-1-phenyl-2,5-dihydro-1H-[1,2,3]triazole-4-carboxylic acid methyl ester; phenylhydrazine salt

A: diazomalonic acid methyl ester-anilide

B: 100-63-0
phenylhydrazine

...Expand

: 2684-02-8
benzenediazonium

: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
With alkali sulfite anschl. mit H2SO3;
With alkali sulfite anschl. mit Zink-Staub und Essigsaeure;
With hydrogenchloride; sodium sulfite
With sodium carbonate; sodium sulfite anschliessend Behandeln mit Schwefeldioxid und Erwaermen mit wss. Salzsaeure;
With alkali disulfite und anschl. Erhitzen mit HCl;

: 29214-73-1
6-methyl-3-(1-phenylhydrazono-ethyl)-pyran-2,4-dione

: furan-2,3,5(4H)-trione pyridine (1:1)

: 100-63-0
phenylhydrazine

: p-phenylene-bis-hydrazine-N,N'-dicarboxylic acid tetramethyl ester

: furan-2,3,5(4H)-trione pyridine (1:1)

A: 100-63-0
phenylhydrazine

B: 106-50-3
1,4-phenylenediamine

...Expand

: 2,4-diphenyl-1-(2,4,5-trimethyl-phenyl)-2,5-dihydro-1H-[1,2,3]triazole

: 64-19-7
acetic acid

: 100-63-0
phenylhydrazine

: 54478-82-9
benzenediazonium; hydroxide

: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
With zinc at 0℃;
With sulphurous acid

: benzenediazonium sulphate

: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
With hydrogenchloride at 0℃; durch elektrolytische Reduktion an einer Quecksilber-Kathode;

: 614-31-3
N-benzyl-N-phenylhydrazine

A: 100-63-0
phenylhydrazine

B: 2725-46-4
1-benzyl-2-benzylidene-1-phenylhydrazine

: 100-34-5
benzene diazonium chloride

: 603-35-0
triphenylphosphine

: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
anschliessende Hydrolyse;

: 142877-70-1
3-phenyl-carbazic acid ; phenylhydrazine salt

A: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

B: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
im geschlossenen Rohr;

: 10458-14-7
Menthone

: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
Kinetics; l-menthone;

: 75205-75-3
1-anilinomalonyl-3-methyl-4-(4'-nitrobenzeneazo)-5-pyrazolone

A: 43019-69-8
4-amino-N-hydroxybenzenamine

B: 125464-25-7
1-anilinomalonyl-3-methyl-4-aminopyrazolone

C: 3-(4-Hydroxy-3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)-3-oxo-N-phenyl-propionamide

D: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
In water; N,N-dimethyl-formamide Mechanism; electrochemical reduction, buffer; pH range of 2-10;

...Expand

: 129302-56-3
3-(N-Nitro-N-phenylhydrazono)pentane-2,4-dione

A: 142414-84-4
3-Aminopentan-2,4-dion

B: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
In water; N,N-dimethyl-formamide at 25℃; Product distribution; Mechanism; coulometry: E = -1.8V, pH 2.5; variation of condition;

: C6H5N2(1+)*O4S(1-)

A: 108-86-1
bromobenzene

B: 92-52-4
biphenyl

C: 108-90-7
chlorobenzene

D: 100-63-0
phenylhydrazine

E: 71-43-2
benzene

F: 108-95-2
phenol

Conditions

Conditions	Yield
for 0.5h; Product distribution; Ambient temperature; in the absence and presence of reductant, stimulants ( SnCl2, Fe salts, ascorbic acid) and halide ions;

...Expand

: 62-53-3
aniline

A: 92-67-1
4-Aminobiphenyl

B: 90-41-5
2-phenylaniline

C: 122-39-4
diphenylamine

D: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
With alkaline chloramine at 50℃; Product distribution; var. time;

...Expand

: 588-64-7
benzaldehyde phenylhydrazone

A: 100-52-7
benzaldehyde

B: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
With hydrogenchloride; water In ethanol at 25℃; Rate constant; Thermodynamic data; Equilibrium constant; other cond.: further reagents; other obj. of st.: E(excit.), ΔH(excit.), -(DS(excit.));

: 7647-01-0
hydrogenchloride

: 3-(β-phenylhydrazono-phenethyl)-phthalide

: 100-63-0
phenylhydrazine

: 7647-01-0
hydrogenchloride

: 3-(3-methyl-β-phenylhydrazono-phenethyl)-3H-benz[de]isochromen-1-one

: 100-63-0
phenylhydrazine

: 28740-63-8
5-methyl-3-phenyl-1,3,4-oxadiazol-2(3H)-one

alcoholic ammonium sulfide solution: alcoholic ammonium sulfide solution

: 100-63-0
phenylhydrazine

Conditions

Conditions	Yield
at 100℃;

: (5-methyl-3-phenyl-3H-[1,3,4]oxadiazol-2-ylidene)-phenyl-amine

alcoholic KOH-solution: alcoholic KOH-solution

: 100-63-0
phenylhydrazine

: 1121-60-4
pyridine-2-carbaldehyde

: 100-63-0
phenylhydrazine

: 30915-38-9
(E)-1-(2-pyridinyl)methylene-2-phenylhydrazine

Conditions

Conditions	Yield
In ethanol for 6h; Reflux;	100%
With acetic acid In ethanol for 3h; Reflux;	91%
With 1-deoxy-1-(methylamino)-D-glucitol In ethanol; water at 20℃; for 0.666667h; Green chemistry;	85%

: 108-30-5
succinic acid anhydride

: 100-63-0
phenylhydrazine

: 14580-01-9
4-oxo-4-(2-phenylhydrazinyl)butanoic acid

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 24h;	100%
With ethanol

: 108-24-7
acetic anhydride

: 100-63-0
phenylhydrazine

: 114-83-0
1-acetyl-2-phenylhydrazine

Conditions

Conditions	Yield
In diethyl ether at 0℃; for 10h;	100%
Stage #1: phenylhydrazine With triethylamine In dichloromethane at 0℃; Inert atmosphere; Stage #2: acetic anhydride In dichloromethane at 0 - 20℃; Inert atmosphere;	97%
With pyridine; aluminum oxide at 90 - 92℃; for 1h; microwave irradiation;	65%

: 104-87-0
4-methyl-benzaldehyde

: 100-63-0
phenylhydrazine

: 2829-25-6
4-methylbenzaldehyde phenylhydrazone

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In dichloromethane	100%
In neat (no solvent) at 20℃; for 0.00277778h;	97%
With oxidized single-walled carbon nanotubes(SWCNs-COOH) In ethanol at 80℃; for 1.25h;	96%

: 141-97-9
ethyl acetoacetate

: 100-63-0
phenylhydrazine

: 89-25-8
edaravone

Conditions

Conditions	Yield
In acetic acid Heating;	100%
for 0.166667h; Irradiation;	100%
at 0 - 90℃; for 1.5h;	100%

: 89-98-5
2-chloro-benzaldehyde

: 100-63-0
phenylhydrazine

: 34158-76-4
2-chlorobenzaldehyde phenylhydrazone

Conditions

Conditions	Yield
In 1-methyl-pyrrolidin-2-one at 160℃; for 0.166667h; microwave irradiation;	100%
With pyridinium p-toluenesulfonate In dichloromethane	100%

: 122-01-0
4-chloro-benzoyl chloride

: 100-63-0
phenylhydrazine

: 15089-07-3
2-(4-Chlorbenzoyl)-1-phenylhydrazid

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran at 5 - 20℃; for 2h;	100%
With pyridine for 20h;	70%
With pyridine

: 832-10-0
cyclotridecanone

: 100-63-0
phenylhydrazine

: 7140-32-1
5,6,7,8,9,10,11,12,13,14,15,16-dodecahydrocyclotridecan[b]indole

Conditions

Conditions	Yield
With trichloroacetic acid at 100℃; for 0.0833333h; Fischer indole synthesis;	100%
With hydrogenchloride; acetic acid

: 100-52-7
benzaldehyde

: 100-63-0
phenylhydrazine

: 588-64-7
(E)-1-benzylidene-2-phenylhydrazine

Conditions

Conditions	Yield
In ethanol for 6h; Reflux;	100%
In water for 0.0833333h; Sonication;	95%
With 1-deoxy-1-(methylamino)-D-glucitol In ethanol; water at 20℃; for 0.666667h; Reagent/catalyst; Solvent; Concentration; Green chemistry;	91%

: 104-55-2
3-phenyl-propenal

: 100-63-0
phenylhydrazine

: 1216-15-5
cinnamaldehyde phenylhydrazone

Conditions

Conditions	Yield
piperidine In ethanol for 5h; Heating;	100%
With oxidized single-walled carbon nanotubes(SWCNs-COOH) In ethanol at 80℃; for 0.75h;	98%
With Dowex resin acid form In ethanol for 0.75h;	88%

: 700-58-3
2-Adamantanone

: 100-63-0
phenylhydrazine

: 94658-14-7
1-(adamantan-2-ylidene)-2-phenylhydrazine

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 2h; Inert atmosphere;	100%
In ethanol; acetic acid	98%
With 1-deoxy-1-(methylamino)-D-glucitol In ethanol; water at 20℃; for 0.583333h; Green chemistry;	82%
With acetic acid for 0.25h; Ambient temperature;

: 20894-58-0
2-carbethoxy-<11>-α-cyclothien-1-one

: 100-63-0
phenylhydrazine

: 2-(Phenyl-hydrazono)-16-thia-bicyclo[11.2.1]hexadeca-1(15),13-diene-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
In toluene at 110℃; for 1h;	100%

: 2142-69-0
2-bromophenyl methyl ketone

: 100-63-0
phenylhydrazine

: 1011736-72-3
N-[1-(2-Bromo-phenyl)-eth-(Z)-ylidene]-N'-phenyl-hydrazine

Conditions

Conditions	Yield
In 1-methyl-pyrrolidin-2-one at 160℃; for 0.166667h; microwave irradiation;	100%
In diethyl ether Heating;
With acetic acid In ethanol for 0.166667h; Heating; Yield given;

: 27704-37-6
2,2,2-trichloro-1-(4-chlorophenyl)ethanone

: 100-63-0
phenylhydrazine

: 15089-07-3
2-(4-Chlorbenzoyl)-1-phenylhydrazid

Conditions

Conditions	Yield
With triethylamine In hexane at 25℃; for 3h;	100%

: 115975-33-2
N,N-Dimethyl-2,4-bis(trifluoroacetyl)-1-naphthylamine

: 100-63-0
phenylhydrazine

: 129602-66-0
2,2,2-trifluoro-1-(2-phenyl-3-(trifluoromethyl)-2H-benzo[g]indazol-5-yl)ethanone

Conditions

Conditions	Yield
In acetonitrile for 24h; Heating;	100%

: 56429-60-8
2-ethyl-4-oxo-1,3-benzoxazinium perchlorate

: 100-63-0
phenylhydrazine

: 120029-39-2
2-(5-Ethyl-2-phenyl-2H-[1,2,4]triazol-3-yl)-phenol

Conditions

Conditions	Yield
In acetic acid Heating;	100%

: 85302-03-0
4-Dimethylaminomethylene-2,6-dimethyl-heptane-3,5-dione

: 100-63-0
phenylhydrazine

: 85302-09-6
1-(5-Isopropyl-1-phenyl-1H-pyrazol-4-yl)-2-methyl-propan-1-one

Conditions

Conditions	Yield
In acetic acid; butan-1-ol for 1h; Heating;	100%

: 85302-05-2
2-((dimethylamino)methylene)-1,3-diphenylpropane-1,3-dione

: 100-63-0
phenylhydrazine

: 85302-11-0
4-Benzoyl-1,5-diphenyl-pyrazol

Conditions

Conditions	Yield
In acetic acid; butan-1-ol for 3h; Heating;	100%
In ethanol at 20℃; for 12h; Solvent; Inert atmosphere; regioselective reaction;	89%

: 73389-18-1
2-(4-chloro-phenyl)-benzo[e][1,3]oxazin-4-one; perchlorate

: 100-63-0
phenylhydrazine

: 120029-44-9
2-[5-(4-Chloro-phenyl)-2-phenyl-2H-[1,2,4]triazol-3-yl]-phenol

Conditions

Conditions	Yield
In acetic acid Heating;	100%

: 100-63-0
phenylhydrazine

: 298-12-4
Glyoxilic acid

: 6000-60-8
phenylhydrazonoacetic acid

Conditions

Conditions	Yield
With hydrogenchloride In water	100%
In water at 20℃; for 1h;	95%
With hydrogenchloride In water at 0 - 20℃; for 1h;	94%

: 100-63-0
phenylhydrazine

: 502-42-1
cycloheptanone

: 2047-89-4
5,6,7,8,9,10-hexahydrocyclohept[b]indole

Conditions

Conditions	Yield
With trichloroacetic acid at 100℃; for 0.0833333h; Fischer indole synthesis;	100%
With 1,3-bis(3-sulfopropyl)-1H-imidazol-3-ium hydrogensulfate In water at 80℃; for 1h; Fischer indole synthesis;	88%
With acetic acid for 0.5h; Heating;	74%

: 100-63-0
phenylhydrazine

: 102-04-5
1,3-Diphenylpropanone

: 4679-91-8
2-benzyl-3-phenyl-1H-indole

Conditions

Conditions	Yield
With trichloroacetic acid at 100℃; for 0.0833333h; Fischer indole synthesis;	100%
With phosphorus trichloride In benzene	80%
With Amberlite IR 120 In ethanol at 80℃; for 12h; Fischer Indole Synthesis;	80%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate at 110℃; for 0.25h; Fischer indole synthesis; Microwave irradiation; Sealed vessel;	77%

: 144017-77-6, 20426-47-5
1-(2-chloro-phenyl)-3-phenyl-2-propen-1-one

: 100-63-0
phenylhydrazine

: 1,5-diphenyl-3-(o-chlorohenyl)pyrazoline

Conditions

Conditions	Yield
With acetic acid In ethanol for 0.5h; Heating;	100%

: 100-63-0
phenylhydrazine

: 6630-33-7
ortho-bromobenzaldehyde

: 10407-11-1
2-Brombenzaldehyd-Phenylhydrazon

Conditions

Conditions	Yield
	100%

: 100-63-0
phenylhydrazine

: 5-methylthio-2-selenophenethiol

: N-[5-Methylsulfanyl-4-(5-methylsulfanyl-selenophen-2-ylsulfanyl)-dihydro-selenophen-(2E)-ylidene]-N'-phenyl-hydrazine

Conditions

Conditions	Yield
With water	100%

: (Z)-methyl 2-hydroxy-4-oxo-4-(o-tolyl)but-2-enoate

: 100-63-0
phenylhydrazine

: 235789-32-9
methyl 5-(2-methylphenyl)-1-phenylpyrazole-3-carboxylate

Conditions

Conditions	Yield
With acetic acid for 2h; Heating;	100%

: 100-63-0
phenylhydrazine

: 113161-58-3
ethyl 3-(diethoxyphosphoryl)-3,3-difluoro-2-oxopropionate

: ethyl 3-diethoxyphosphoryl-3,3-difluoro-2-(phenylhydrazono)propionate

Conditions

Conditions	Yield
In benzene for 2h; Substitution;	100%

: 100-63-0
phenylhydrazine

: 1896-62-4
(E)-benzalacetone

: 358723-67-8
(E)-1-phenyl-2-((E)-4-phenylbut-3-en-2-ylidene)hydrazine

Conditions

Conditions	Yield
at 20℃; for 0.0833333h;	100%
With acetic acid In methanol at 20℃; Inert atmosphere;	85%
With acetic acid In methanol for 0.75h; Heating;
With acetic acid In methanol at 20℃;

: 100-63-0
phenylhydrazine

: 339274-36-1
S-tert-butyl cyclohexylcarbamoylthioacetate

: 62970-56-3
N-Cyclohexyl-2-(N'-phenyl-hydrazinocarbonyl)-acetamide

Conditions

Conditions	Yield
With silver trifluoroacetate In 1,2-dimethoxyethane at 20℃;	100%

: 100-63-0
phenylhydrazine

: 111102-82-0
4,4,4-trifluoro-1-(2-fluorophenyl)butane-1,3-dione

: 5-(2-fluorophenyl)-1-phenyl-3-trifluoromethylpyrazole

Conditions

Conditions	Yield
With sulfuric acid In ethanol	100%

Phenylhydrazine Chemical Properties

IUPAC Name: Phenylhydrazine
Synonyms of Phenylhydrazine (CAS NO.100-63-0): 4-15-00-00050 (Beilstein Handbook Reference) ; AI3-15399 ; BRN 0606080 ; CCRIS 511 ; EINECS 202-873-5 ; Fenilidrazina ; Fenilidrazina [Italian] ; Fenylhydrazine ; Fenylhydrazine [Dutch] ; HSDB 1117 ; Hydrazine, phenyl- ; Hydrazine-benzene ; Hydrazinobenzene ; Hydrazobenzene ; Monophenylhydrazine ; Phenylhydrazin ; Phenylhydrazin [German] ; Phenylhydrazine [UN2572] [Poison] ; Phenylhydrazine and its salts ; UN2572
CAS NO: 100-63-0
Classification Code: Mutation data ; Noxae ; Oxidants ; Reproductive Effect ; Tumor data
Molecular Formula: C₆H₈N₂
Molecular Weight: 108.1411
Molecular Structure:

Melting Point: 19 °C
Polar Surface Area: 6.48 Å²
Index of Refraction: 1.643
Molar Refractivity: 34.76 cm³
Molar Volume: 96 cm³
Surface Tension: 49.9 dyne/cm
Density: 1.125 g/cm³
Flash Point: 115.4 °C
Enthalpy of Vaporization: 48 kJ/mol
Boiling Point: 243 °C at 760 mmHg
Vapour Pressure: 0.0329 mmHg at 25°C

Phenylhydrazine Uses

Phenylhydrazine (CAS NO.100-63-0) is mainly used to produce dyes, pharmaceuticals, reagents,etc.

Phenylhydrazine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	120mg/kg (120mg/kg)		U.S. Public Health Service, Public Health Bulletin. Vol. 271, Pg. 159, 1941.
dog	LDLo	oral	200mg/kg (200mg/kg)		U.S. Public Health Service, Public Health Bulletin. Vol. 271, Pg. 159, 1941.
frog	LDLo	unreported	300mg/kg (300mg/kg)		U.S. Public Health Service, Public Health Bulletin. Vol. 271, Pg. 159, 1941.
guinea pig	LD50	oral	80mg/kg (80mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Hygiene and Sanitation Vol. 30(7-9), Pg. 191, 1965.
mouse	LC50	inhalation	2120mg/m3 (2120mg/m3)		Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. Vol. 115, Pg. 59, 1977.
mouse	LD50	intraperitoneal	170mg/kg (170mg/kg)		Cancer Research. Vol. 41, Pg. 1469, 1981.
mouse	LD50	oral	175mg/kg (175mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 30(8), Pg. 21, 1965.
mouse	LDLo	subcutaneous	170mg/kg (170mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Industrial Hygiene and Toxicology. Vol. 18, Pg. 1, 1936.
rabbit	LD50	oral	80mg/kg (80mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Hygiene and Sanitation Vol. 30(7-9), Pg. 191, 1965.
rabbit	LDLo	skin	90mg/kg (90mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION KIDNEY, URETER, AND BLADDER: HEMATURIA	National Technical Information Service. Vol. OTS0546542,
rat	LC50	inhalation	2610mg/m3 (2610mg/m3)		Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. Vol. 115, Pg. 59, 1977.
rat	LD50	oral	188mg/kg (188mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Hygiene and Sanitation Vol. 30(7-9), Pg. 191, 1965.

Phenylhydrazine Consensus Reports

Reported in EPA TSCA Inventory.

Phenylhydrazine Safety Profile

Hazard Codes of Phenylhydrazine (CAS NO.100-63-0): Toxic T, Dangerous N
Risk Statements: 45-23/24/25-36/38-43-48-50-68
R45: May cause cancer.
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R36/38: Irritating to eyes and skin.
R43: May cause sensitization by skin contact.
R48: Danger of serious damage to health by prolonged exposure.
R50: Very toxic to aquatic organisms.
R68: Possible risk of irreversible effects.
Safety Statements: 53-45-61
S53: Avoid exposure - obtain special instructions before use.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 2572 6.1/PG 2
WGK Germany: 3
RTECS: MV8925000
F: 8-10-23
HazardClass: 6.1
PackingGroup: II
Confirmed carcinogen with experimental carcinogenic data. Poison by ingestion, subcutaneous, and intravenous routes. Experimental reproductive effects. Mutation data reported. Ingestion or subcutaneous injection can cause hemolysis of red blood cells. Other effects are damage to the spleen, liver, kidneys, and bone marrow. The most common effect of occupational exposure is the development of dermatitis, which, in sensitized persons, may be quite severe. Systemic effects include anemia and general weakness, gastrointestinal disturbances, and injury to the kidneys. Flammable when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam. Violent reaction with 2-phenylamino-3-phenyloxazirane. Reacts with perchloryl fluoride to form an explosive product. Vigorous reaction with lead(IV) oxide. Used as a chemical reagent, in organic synthesis, and in the manufacture of dyes and drugs. Dangerous; when heated to decomposition it emits highly toxic fumes of NO_x; can react with oxidizing materials.

Phenylhydrazine Standards and Recommendations

OSHA PEL: TWA 5 ppm (skin); STEL 10 ppm
ACGIH TLV: TWA 0.1 ppm (skin); Animal Carcinogen
DFG MAK: Confirmed Animal Carcinogen with Unknown Relevance to Humans
NIOSH REL: CL 0.6 mg/m³/2H
DOT Classification: 6.1; Label: Poison

Phenylhydrazine Analytical Methods

For occupational chemical analysis use NIOSH: Phenyl Hydrazine, S160.

Product Name

Phenylhydrazine

Synthetic route

Phenylhydrazine Chemical Properties

Phenylhydrazine Uses

Phenylhydrazine Toxicity Data With Reference

Phenylhydrazine Consensus Reports

Phenylhydrazine Safety Profile

Phenylhydrazine Standards and Recommendations

Phenylhydrazine Analytical Methods

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