Piperazine supplier | CasNO.110-85-0

Name
1,4-Diazacyclohexane
EINECS 203-808-3
CAS No. 110-85-0
Article Data308
CAS DataBase
Density 0.874 g/cm³
Solubility Soluble in water, ethanol. Insoluble in diethyl ether
Melting Point 109-112 °C(lit.)
Formula C₄H₁₀N₂
Boiling Point 149.324 °C at 760 mmHg
Molecular Weight 86.1368
Flash Point 49.726 °C
Transport Information UN 2579 8/PG 3
Appearance needle-like white or colorless crystals
Safety 22-26-36/37/39-45-61
Risk Codes 34-42/43-52/53
Molecular Structure
Hazard Symbols C
Synonyms 1,4-Diazacyclohexane;1,4-Piperazine;Antiren;Diethylenediamine;Dispermine;Eraverm;Hexahydropyrazine;Lumbrical;Pipersol;Pyrazinehexahydride;Uvilon;Vermex;Wurmirazin;Piperazine anhydrous;
PSA 24.06000
LogP -0.16320

Synthetic route

: 111-41-1
2-(2-Aminoethylamino)ethanol

: 110-85-0
piperazine

Conditions

Conditions	Yield
With hydrogen; sodium sulfate In 1,4-dioxane at 180℃; under 66756.7 Torr; for 6h; Reagent/catalyst; Autoclave;	80.7%
With aluminum oxide; nitrogen at 400 - 450℃;
With 1,4-dioxane; nickel at 200℃;

: 628-87-5
iminodiacetonitrile

A: 110-85-0
piperazine

B: 111-40-0
1,5-diamino-3-azapentane

Conditions

Conditions	Yield
With ammonia; hydrogen; potassium hydroxide In ethanol at 80℃; under 90009 Torr; Pressure; Reagent/catalyst; Solvent; Temperature; Time;	A 1.03% B 97.53%

: 107-21-1
ethylene glycol

A: 110-85-0
piperazine

B: 141-43-5
ethanolamine

Conditions

Conditions	Yield
With ammonia; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In toluene at 155℃; under 42754.3 Torr; for 12h; Autoclave;
With ammonia; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In toluene at 180℃; under 27002.7 Torr; for 12h; Autoclave;
With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); ammonia; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] at 155℃; for 12h; Temperature; Inert atmosphere; Autoclave;

: 107-15-3
ethylenediamine

: 111-40-0
1,5-diamino-3-azapentane

A: 110-85-0
piperazine

B: 280-57-9
1,4-diaza-bicyclo[2.2.2]octane

Conditions

Conditions	Yield
With ZSM-5 type zeolite In water at 370℃; pH=10; Temperature; pH-value;	A 63% B 17%
With ZSM-5 type zeolite In water at 330℃; pH=10; Temperature; pH-value;	A 44% B 56%
With ZSM-5 type zeolite with Na exchange rate of 62percent In water at 290℃; Reagent/catalyst; Temperature;
With Na-ion exchanged ZSM-5 type zeolite In water at 290 - 600℃; Gas phase;
With β-type iron silicate at 320℃; Reagent/catalyst;

...Expand

: 107-21-1
ethylene glycol

: 107-15-3
ethylenediamine

: 110-85-0
piperazine

Conditions

Conditions	Yield
With hydrogen; sodium sulfate at 210℃; under 88508.9 Torr; for 6h; Reagent/catalyst; Autoclave;	70%
With 1,4-dioxane; hydrogen; nickel at 200℃; under 28 Torr;
With palladium on magnesium oxide In acetonitrile at 160℃; for 6.5h; Autoclave; Inert atmosphere;	80 %Chromat.

: 140-31-8
aminoethylpiperazine

A: 110-85-0
piperazine

B: 280-57-9
1,4-diaza-bicyclo[2.2.2]octane

Conditions

Conditions	Yield
With ZSM-5 type zeolite In water at 350℃;	A 26% B 53%
With water; Na-type ZSM-5(2) at 350 - 370℃;	A 20.2% B 47.7%
Na-type ZSM-5(6) at 355 - 380℃;	A 18.9% B 39.9%

: 4461-39-6
2-[(3-aminopropyl)amino]ethanol

: 110-85-0
piperazine

Conditions

Conditions	Yield
With phosphorus pentachloride In tetrachloromethane at 30 - 60℃; for 20h; Inert atmosphere;	90%

: 107-15-3
ethylenediamine

: 110-85-0
piperazine

Conditions

Conditions	Yield
With tetralin; nickel at 150℃;
With tetralin; hydrogen; nickel at 170℃;
With monoaluminum phosphate at 400 - 430℃;

: 106-57-0
Glycine anhydride

: 110-85-0
piperazine

Conditions

Conditions	Yield
With methanesulfonic acid; ruthenium(1,1,1-tris(di(3,5-dimethylphenyl)phosphinomethyl)ethane)(η4-trimethylenemethane); hydrogen In tetrahydrofuran at 180℃; under 75007.5 Torr; for 16h; Autoclave; Schlenk technique;	84%
With i-Amyl alcohol; sodium
With sulfuric acid
With hydrogenchloride at 20℃;

: 107-21-1
ethylene glycol

A: 110-85-0
piperazine

B: 141-43-5
ethanolamine

C: 107-15-3
ethylenediamine

Conditions

Conditions	Yield
With ammonia; C28H44BNOP2Ru In toluene at 180℃; under 21002.1 Torr; for 24h; Product distribution / selectivity; Autoclave; Inert atmosphere;
With ammonia; hydrogen; chlorocarbonylhydrido[4,5-bis(dicyclohexylphosphinomethyl)acridine]ruthenium(II) In toluene at 180℃; under 49580 Torr; for 12h; Product distribution / selectivity; Autoclave; Inert atmosphere;
With ammonia; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In toluene at 155℃; under 31503.2 Torr; for 12h; Autoclave;

...Expand

: 7483-59-2
1-(2,3-dihydroxy propyl)piperazine

A: 110-85-0
piperazine

B: 76950-43-1
2-hydroxymethyl-1,4-diazabicyclo<2.2.2>octane

Conditions

Conditions	Yield
With solid catalyst from aluminum phosphate and cesium nitrate In water at 360℃; for 4h; Inert atmosphere; Large scale;	A 22% B 44%
With cesium phosphate and batium hydroxyapatite on Al2O3 In water at 390℃; for 24h; Reagent/catalyst; Temperature; Overall yield = 95 %;

: 75-21-8
oxirane

A: 110-85-0
piperazine

B: 102-71-6
triethanolamine

C: 141-43-5
ethanolamine

D: 107-15-3
ethylenediamine

E: 111-40-0
1,5-diamino-3-azapentane

F: 111-42-2
2,2'-iminobis[ethanol]

Conditions

Conditions	Yield
With ammonia; hydrogen; Ni-Re-B catalyst In water at 165℃; under 156079 Torr;

...Expand

: 141-43-5
ethanolamine

A: 110-85-0
piperazine

B: 107-15-3
ethylenediamine

C: 111-40-0
1,5-diamino-3-azapentane

Conditions

Conditions	Yield
With ammonia; hydrogen; Nickel/Rhenium/Boron (8.0:2.0: 1.7 wt. percent) catalyst on an alumina/silica (80:20) at 165℃; under 155909 Torr;
With ammonia; hydrogen at 170℃; under 60006 Torr; for 12h; Flow reactor;

...Expand

: 122-96-3
1,4-bis(2-hydroxyethyl)piperazine

: 110-85-0
piperazine

Conditions

Conditions	Yield
With hydrogen In water at 180℃; under 15001.5 Torr;

: 111-42-2
2,2'-iminobis[ethanol]

A: 110-85-0
piperazine

B: 140-31-8
aminoethylpiperazine

Conditions

Conditions	Yield
With ammonia; hydrogen In water at 190℃; under 150015 Torr; Temperature;	A 42.5 %Chromat. B 6.3 %Chromat.

: 141-43-5
ethanolamine

A: 110-85-0
piperazine

B: 107-15-3
ethylenediamine

Conditions

Conditions	Yield
With ammonia; hydrogen In water at 159℃; under 4431.9 Torr; Reagent/catalyst;

: 107-21-1
ethylene glycol

A: 110-85-0
piperazine

B: 107-15-3
ethylenediamine

Conditions

Conditions	Yield
With chlorocarbonylhydrido[4,5-bis(dicyclohexylphosphinomethyl)acridine]ruthenium(II); potassium tert-butylate; ammonia In toluene at 180℃; under 35553.6 Torr; for 12h; Autoclave; Inert atmosphere;

: 141-43-5
ethanolamine

: 111-42-2
2,2'-iminobis[ethanol]

A: 110-85-0
piperazine

B: 103-76-4
1-(2-hydroxyethyl)piperazine

Conditions

Conditions	Yield
With hydrogen In 1,4-dioxane at 200℃; under 30003 Torr; Solvent;
With hydrogen In ethanol at 200℃; under 15001.5 Torr; Solvent; Temperature; Pressure;

...Expand

: 140-31-8
aminoethylpiperazine

: 107-15-3
ethylenediamine

A: 110-85-0
piperazine

B: 280-57-9
1,4-diaza-bicyclo[2.2.2]octane

Conditions

Conditions	Yield
With ZSM-5 type zeolite In water at 320℃; pH=9; Temperature; pH-value;	A 54% B 46%

...Expand

: 290-37-9
1,4-pyrazine

: 110-85-0
piperazine

Conditions

Conditions	Yield
With potassium carbonate; [Ir(cod)(1-neopentyl-4-n-butyl-triazole-5-ylidene)PPh3]BF4 In isopropyl alcohol at 82℃; for 24h;	100%
With dichloro(μ-chloro)(μ-hydrido)bis(η-p-cymene)diruthenium(II); hydrogen In 1,4-dioxane at 75℃; under 37503.8 Torr; for 40h;	87%
With Cp*Rh(2-(2-pyridyl)phenyl)H; hydrogen In neat (no solvent) at 100℃; under 27361.8 Torr; for 48h; Catalytic behavior; Glovebox;	31%

: 23147-58-2, 110822-84-9, 110822-85-0
glycolaldehyde dimer

A: 110-85-0
piperazine

B: 141-43-5
ethanolamine

C: 107-15-3
ethylenediamine

Conditions

Conditions	Yield
With ammonia; hydrogen In tetrahydrofuran at 100℃; under 75007.5 Torr; for 8h; Autoclave;

...Expand

: 111-42-2
2,2'-iminobis[ethanol]

A: 110-85-0
piperazine

B: 140-31-8
aminoethylpiperazine

C: 107-15-3
ethylenediamine

Conditions

Conditions	Yield
With ammonia; hydrogen In water at 196℃; under 150015 Torr; Temperature;	A 36.7 %Chromat. B 6.7 %Chromat. C 5.1 %Chromat.

...Expand

: 141-43-5
ethanolamine

A: 110-85-0
piperazine

B: 111-41-1
2-(2-Aminoethylamino)ethanol

C: 107-15-3
ethylenediamine

D: 111-40-0
1,5-diamino-3-azapentane

Conditions

Conditions	Yield
With ammonia; hydrogen
With ammonia; hydrogen
With ammonia; hydrogen at 170℃; under 60006 Torr; for 12h; Reagent/catalyst; Flow reactor;
With ammonia at 170℃; under 60006 Torr;

...Expand

: 10430-90-7
piperazine-1-carboxylic acid

: 75-56-9, 16033-71-9
methyloxirane

A: 110-85-0
piperazine

B: 108-32-7
1,2-propylene cyclic carbonate

Conditions

Conditions	Yield
With potassium iodide at 160℃; for 10h; Reagent/catalyst;	A 97.6% B 95.3%

...Expand

: 75-21-8
oxirane

: 10430-90-7
piperazine-1-carboxylic acid

A: 110-85-0
piperazine

B: 96-49-1
[1,3]-dioxolan-2-one

Conditions

Conditions	Yield
With zinc dibromide at 160℃; for 8.5h;	A 97.7% B 94.9%

...Expand

: 17046-84-3
1,4-bis-(toluene-4-sulfonyl)-piperazine

: 110-85-0
piperazine

Conditions

Conditions	Yield
Stage #1: 1,4-bis-(toluene-4-sulfonyl)-piperazine With Na/K absorbed into silica gel In 1,2-dimethoxyethane at 60℃; Inert atmosphere; Stage #2: With water In 1,2-dimethoxyethane	76%
With sulfuric acid at 170℃;

: 107-06-2
1,2-dichloro-ethane

A: 110-85-0
piperazine

B: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

C: 111-40-0
1,5-diamino-3-azapentane

D: 112-24-3
triethylentetramine

Conditions

Conditions	Yield
With ammonium hydroxide; ethylenediamine In water at 100℃; under 18751.9 Torr;

...Expand

: 141-43-5
ethanolamine

A: 110-85-0
piperazine

B: 140-31-8
aminoethylpiperazine

C: 107-15-3
ethylenediamine

D: 111-40-0
1,5-diamino-3-azapentane

Conditions

Conditions	Yield
With ammonia; hydrogen In water at 80℃; under 26463 Torr; Temperature; Pressure;

...Expand

: 141-43-5
ethanolamine

A: 110-85-0
piperazine

B: 103-76-4
1-(2-hydroxyethyl)piperazine

C: 107-15-3
ethylenediamine

D: 111-40-0
1,5-diamino-3-azapentane

Conditions

Conditions	Yield
With ammonia; hydrogen In water at 103℃; under 26463 Torr; Temperature;

...Expand

: 3141-27-3
2,5-dibromothiophen

: C10H9BrN2S

: 110-85-0
piperazine

Conditions

Conditions	Yield
With 1-(1-methylethyl)piperazine; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,2-dimethoxyethane Inert atmosphere;	74%

: 110-85-0
piperazine

: 612-62-4
2-Chloroquinoline

: 4774-24-7
2-(piperazin-1-yl)quinoline

Conditions

Conditions	Yield
In ethylene glycol at 140℃; for 2h; Product distribution / selectivity;	100%
In ethylene glycol at 140℃; for 2h;	100%
With potassium hydroxide In toluene for 4h; Heating;	83%

: 110-85-0
piperazine

: 140-79-4
N,N'-dinitrosopiperazine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; sodium nitrite In dichloromethane at 20℃; chemoselective reaction;	100%
With sulfuric acid; silica gel; sodium nitrite In dichloromethane at 20℃; for 0.166667h;	99%
With cross-linked polyvinylpyrrolidone*N2O4; dinitrogen tetraoxide In dichloromethane at 20℃; for 0.333333h;	98%

: 110-85-0
piperazine

: 72553-83-4
1-Chlor-4-phenyl-pyridazino<4,5-d>pyridazin

: 83490-52-2
1-Piperazino-4-phenyl-pyridazino<4,5-d>pyridazin

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	100%

: 110-85-0
piperazine

: 626-48-2
6-Methyluracil

: 50-00-0
formaldehyd

: 75682-13-2
C-5,N-3-Dipiperazinomethylene-6-methyluracil

Conditions

Conditions	Yield
In ethanol; water for 24h; Ambient temperature;	100%

...Expand

: 110-85-0
piperazine

: 1635-61-6
5-chloro-2-nitroaniline

: 96103-52-5
2-nitro-5-piperazin-1-yl-phenylamine

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 120℃; for 24h;	100%
for 5h; Heating;	93%
With potassium carbonate In N,N-dimethyl acetamide at 120℃; for 21h;	84%

: 110-85-0
piperazine

: 106-94-5
propyl bromide

: 21867-64-1
1-n-propylpiperazine

Conditions

Conditions	Yield
With triethylamine In ethanol Reflux;	100%
With triethylamine In ethanol for 21h; Heating;	45%

: 110-85-0
piperazine

: 121-17-5
2-chloro-3-nitro-5-trifluoromethylbenzene

: 137918-81-1
1,4-Bis(1'-nitro-3'-(trifluoromethyl)-6'-phenyl)piperazine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 100℃; under 6000480 Torr; for 120h;	100%

: 110-85-0
piperazine

: 80100-67-0
C18H18N2O2

: 80100-68-1
2-(1-piperazinyl)-2,4,6-cycloheptatrien-1-one

Conditions

Conditions	Yield
at 110℃;	100%

: 110-85-0
piperazine

: 122-60-1
Phenyl glycidyl ether

: 40944-05-6
1-phenoxy-3-(1-piperazinyl)propan-2-ol

Conditions

Conditions	Yield
In 2,2,2-trifluoroethanol at 20℃; for 6h; regioselective reaction;	100%
In ethanol for 0.0583333h; Ring cleavage; addition; Irradiation; microwave irradiation;	84%
In methanol at 14.9℃; Rate constant; Thermodynamic data; var. temp., ΔH(excit.), ΔG(excit.), ΔS(excit), E;

: 110-85-0
piperazine

: 1027017-16-8
6,7-Difluoro-1-(2-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

: 1-o-fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid

Conditions

Conditions	Yield
In acetonitrile	100%

: 110-85-0
piperazine

: 86-98-6
4,7-dichloroquinoline

: 837-52-5
7-chloro-4-piperazinylquinoline

Conditions

Conditions	Yield
In isopropyl alcohol at 100℃; for 20h;	100%
With triethylamine at 130℃; for 4h; Inert atmosphere;	98%
With potassium carbonate In isopropyl alcohol for 36h; Reflux;	95%

: 110-85-0
piperazine

: 201230-82-2
carbon monoxide

: 98-83-9
isopropenylbenzene

: 1,4-Bis-(3-phenyl-butyl)-piperazine

Conditions

Conditions	Yield
With hydrogen; chloro(1,5-cyclooctadiene)rhodium(I) dimer In 1,4-dioxane at 80℃; under 82506.6 Torr; for 72h;	100%

...Expand

: 110-85-0
piperazine

: 10199-89-0
NBD chloride

: 139332-66-4
4-nitro-7-(piperazin-1-yl)benzo[c][1,2,5]oxadiazole

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃;	100%
at 0℃; for 0.833333h;	95%
In N,N-dimethyl-formamide at 85℃; for 4h; Inert atmosphere; Schlenk technique;	78%

: 110-85-0
piperazine

: 207857-15-6
1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

: dipiperazine-1,4-carboxamidine

Conditions

Conditions	Yield
With triethylamine In chloroform for 20h; Ambient temperature;	100%

: 110-85-0
piperazine

: 98-88-4
benzoyl chloride

: 21615-34-9
2-Methoxybenzoyl chloride

: N-(2-methoxybenzoyl)-N'-(benzoyl)iperazine

Conditions

Conditions	Yield
Stage #1: piperazine With n-butyllithium In tetrahydrofuran at 20℃; for 1h; Metallation; Stage #2: benzoyl chloride In tetrahydrofuran for 0.166667h; Acylation; Stage #3: 2-Methoxybenzoyl chloride In tetrahydrofuran for 0.166667h; Acylation;	100%

...Expand

: 110-85-0
piperazine

: 50-00-0
formaldehyd

: 153581-47-6
3-(2-isobutylthioethyl)-6-methyluracil

: 3-(2-isobutylthioethyl)-6-methyl-5-(piperazin-1-yl)methyluracil

Conditions

Conditions	Yield
In ethanol; water for 1h; Heating;	100%

...Expand

: 110-85-0
piperazine

: 50-00-0
formaldehyd

: 7417-28-9
5-hydroxy-6-methyluracil

: 5-hydroxy-6-methyl-3-(piperazin-1-yl)methyluracil

Conditions

Conditions	Yield
In ethanol; water for 1.08333h; Heating;	100%

...Expand

: 110-85-0
piperazine

: 50-00-0
formaldehyd

: 7417-28-9
5-hydroxy-6-methyluracil

: 5-hydroxy-6-methyl-1,3-bis[(piperazin-1-yl)methyl]uracil

Conditions

Conditions	Yield
In ethanol; water at 50 - 70℃; for 1.16667h;	100%

...Expand

: 110-85-0
piperazine

: 626-55-1
3-Bromopyridine

: 67980-77-2
1-(pyridin-3-yl)piperazine

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate In xylene for 4h; Buchwald coupling; Heating;	100%
With dichlorobis(tri-O-tolylphosphine)palladium; potassium tert-butylate In diethylene glycol dimethyl ether at 170℃; for 48h;	61%
With dichlorobis(tri-O-tolylphosphine)palladium; sodium t-butanolate In various solvent(s) at 169℃; for 24h;	32%

: 110-85-0
piperazine

: 33371-00-5
4-chloro-6,7,8-trimethoxy-quinazoline

: 6,7,8-trimethoxy-4-(1-piperazinyl)quinazoline

Conditions

Conditions	Yield
In isopropyl alcohol for 4h; Heating;	100%
Heating;

: 110-85-0
piperazine

: 155960-96-6
4-chloro-6,8-dimethoxyquinazoline

: 6,8-dimethoxy-4-(1-piperazinyl)quinazoline

Conditions

Conditions	Yield
In isopropyl alcohol for 4h; Heating;	100%
Heating;

: 110-85-0
piperazine

: 4203-18-3
4,6-dichloroquinoline

: 92026-62-5
6-chloro-4-(1-piperazinyl)quinoline

Conditions

Conditions	Yield
In isopropyl alcohol for 4h; Heating;	100%

: 110-85-0
piperazine

: 21617-12-9
4,8-dichloroquinoline

: 8-chloro-4-(1-piperazinyl)quinoline

Conditions

Conditions	Yield
In isopropyl alcohol for 4h; Heating;	100%

: 110-85-0
piperazine

: 7357-26-8
4-chloro-6,7-dimethoxycinnoline

: 6,7-dimethoxy-4-(1-piperazinyl)cinnoline

Conditions

Conditions	Yield
In isopropyl alcohol for 4h; Heating;	100%

: 110-85-0
piperazine

: 346-55-4
4-chloro-7-trifluoromethyl quinoline

: 4-(piperazin-1-yl)-7-(trifluoromethyl)quinoline

Conditions

Conditions	Yield
In isopropyl alcohol for 4h; Heating;	100%
With triethylamine at 80 - 140℃; for 7h;	78%
With triethylamine at 80 - 130℃; Neat (no solvent);	68%

: 110-85-0
piperazine

: 40848-53-1
1-benzyl-4-chlorophthalazine

: 1-(piperazin-1-yl)-4-benzylphthalazine

Conditions

Conditions	Yield
In isopropyl alcohol for 4h; Heating;	100%
In ethanol at 20 - 60℃;	61%
In ethanol at 60℃; for 5h;	61%

Piperazine Consensus Reports

Reported in EPA TSCA Inventory.

Piperazine Standards and Recommendations

DOT Classification: 8; Label: Corrosive

Piperazine Specification

The Piperazine, with the CAS registry number 110-85-0, is also known as 1,4-Diazacyclohexane. It belongs to the product categories of Blocks; BuildingBlocks; Organics; Heterocycles; Isotope Labelled Compounds. Its EINECS number is 203-808-3. This chemical's molecular formula is C₄H₁₀N₂ and molecular weight is 86.13. What's more, its systematic name is Piperazine. Its classification codes are: (1) Agricultural Chemical; (2)Anthelmintic; (3)Anthelmintics; (4)Anti-Infective Agents; (5)Antinematodal agents; (6)Antiparasitic Agents; (7)Drug / Therapeutic Agent; (8)Human Data; (9)Skin / Eye Irritant; (10)Unspecified / Unclassified pesticide. This chemical should be sealed and stored in a cool, ventilated and dry place. Moreover, it should be protected from oxides, heat and fire. This chemical is commonly used as a pharmaceutical intermediate. It is also used in the manufacture of plastics, resins, pesticides, brake fluid and other industrial materials.

Physical properties of Piperazine are: (1)ACD/LogP: -1.171; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -4.41; (4)ACD/LogD (pH 7.4): -3.28; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 24.06 Å²; (13)Index of Refraction: 1.424; (14)Molar Refractivity: 25.143 cm³; (15)Molar Volume: 98.521 cm³; (16)Polarizability: 9.968×10^-24cm³; (17)Surface Tension: 27.6 dyne/cm; (18)Density: 0.874 g/cm³; (19)Flash Point: 49.726 °C; (20)Enthalpy of Vaporization: 38.624 kJ/mol; (21)Boiling Point: 149.324 °C at 760 mmHg; (22)Vapour Pressure: 4.0 mmHg at 25°C.

Uses of Piperazine: it can be used to produce 1-(3-methyl-butyl)-piperazine by heating. It will need reagent triethylamine and solvent ethanol with the reaction time of 17 hours. The yield is about 62%.

Piperazine can be used to produce 1-(3-methyl-butyl)-piperazine by heating

When you are using this chemical, please be cautious about it as the following:
This chemical can cause burns. It may cause sensitisation by inhalation and skin contact. This substance is harmful to aquatic organisms as it may cause long-term adverse effects in the aquatic environment. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. You should not breathe dust. When using it, you need wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, you must seek medical advice immediately (show the label where possible). You should avoid releasing it to the environment, and you need refer to special instructions/safety data sheet.

You can still convert the following datas into molecular structure:
(1)SMILES: C1CNCCN1
(2)Std. InChI: InChI=1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2
(3)Std. InChIKey: GLUUGHFHXGJENI-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	75mg/kg (75mg/kg)	BEHAVIORAL: SLEEP GASTROINTESTINAL: NAUSEA OR VOMITING	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 478, 1969.
mouse	LC50	inhalation	5400mg/m³/2H (5400mg/m³)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: EXCITEMENT	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 15, Pg. 116, 1979.
mouse	LD50	intraperitoneal	1900mg/kg (1900mg/kg)		Progress in Biochemical Pharmacology. Vol. 1, Pg. 542, 1965.
mouse	LD50	intravenous	1180mg/kg (1180mg/kg)		Drugs in Japan Vol. 6, Pg. 635, 1982.
mouse	LD50	oral	600mg/kg (600mg/kg)		Bollettino Chimico Farmaceutico. Vol. 103, Pg. 414, 1964.
rabbit	LD50	skin	4mL/kg (4mL/kg)		Union Carbide Data Sheet. Vol. 7/16/1965,
rat	LD50	intramuscular	> 2500mg/kg (2500mg/kg)		Drugs in Japan Vol. 6, Pg. 635, 1982.
rat	LD50	intravenous	1340mg/kg (1340mg/kg)		Drugs in Japan Vol. 6, Pg. 635, 1982.
rat	LD50	oral	1900mg/kg (1900mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: EXCITEMENT	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 15, Pg. 116, 1979.
rat	LD50	subcutaneous	3700mg/kg (3700mg/kg)		Drugs in Japan Vol. 6, Pg. 635, 1982.

Product Name

1,4-Diazacyclohexane

Synthetic route

Piperazine Consensus Reports

Piperazine Standards and Recommendations

Piperazine Specification

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