Product Name

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  • Name

    Potassium cyanide

  • EINECS 205-792-3
  • CAS No. 151-50-8
  • Article Data86
  • CAS DataBase
  • Density 1.00 g/mL at 20 °C
  • Solubility Soluble in water
  • Melting Point 634.5 °C
  • Formula KCN
  • Boiling Point 1625 °C
  • Molecular Weight 65.116
  • Flash Point 1625°C
  • Transport Information UN 1680 6.1/PG 1
  • Appearance White crystalline solid
  • Safety 7-28-29-45-60-61
  • Risk Codes 26/27/28-32-50/53
  • Molecular Structure Molecular Structure of 151-50-8 (Potassium cyanide)
  • Hazard Symbols DangerousN, VeryT+
  • Synonyms Potassiumcyanide (8CI);Cyanide of potassium;Hydrocyanic acid, potassium salt;Kalium cyanid;Potassium cyanide (K(CN));
  • PSA 23.79000
  • LogP 0.01678

Synthetic route

hydrogen cyanide
74-90-8

hydrogen cyanide

potassium ethoxide
917-58-8

potassium ethoxide

potassium cyanide
151-50-8

potassium cyanide

hydrogen cyanide
74-90-8

hydrogen cyanide

potassium cyanide
151-50-8

potassium cyanide

Conditions
ConditionsYield
With potassium hydroxide; ethanol
potassium cyanate
590-28-3

potassium cyanate

potassium cyanide
151-50-8

potassium cyanide

Conditions
ConditionsYield
at 700℃;
at 900℃;
potassium thioacyanate
333-20-0

potassium thioacyanate

sodium carbonate
497-19-8

sodium carbonate

potassium cyanide
151-50-8

potassium cyanide

9H-carbazole
86-74-8

9H-carbazole

KOH

KOH

potassium cyanide
151-50-8

potassium cyanide

Conditions
ConditionsYield
anschl. Gluehen;
anschl. Gluehen;
cyanuric acid
108-80-5

cyanuric acid

potassium

potassium

potassium cyanide
151-50-8

potassium cyanide

Conditions
ConditionsYield
Schmelzen mit viel Kalium;
N-(benzo[1,3]dioxol-5-yl-cyano-methyl)-glycin-ethyl ester

N-(benzo[1,3]dioxol-5-yl-cyano-methyl)-glycin-ethyl ester

alcoholic KOH-solution

alcoholic KOH-solution

A

N-piperonylidene-glycine

N-piperonylidene-glycine

B

potassium cyanide
151-50-8

potassium cyanide

citrazinic acid
99-11-6

citrazinic acid

potassium hydroxide

potassium hydroxide

A

potassium cyanide
151-50-8

potassium cyanide

B

oxalic acid
144-62-7

oxalic acid

Conditions
ConditionsYield
beim Schmelzen;
2,6-diethyl-5-methyl-3H-pyrimidin-4-one
859802-57-6

2,6-diethyl-5-methyl-3H-pyrimidin-4-one

potassium hydroxide

potassium hydroxide

A

ammonia
7664-41-7

ammonia

B

potassium cyanide
151-50-8

potassium cyanide

C

acetic acid
64-19-7

acetic acid

D

propionic acid
802294-64-0

propionic acid

Conditions
ConditionsYield
beim Schmelzen;
uric Acid
69-93-2

uric Acid

potassium hydroxide

potassium hydroxide

A

potassium cyanate
590-28-3

potassium cyanate

B

potassium cyanide
151-50-8

potassium cyanide

C

potassium carbonate

potassium carbonate

Conditions
ConditionsYield
im bedeckten Tiegel;
uric Acid
69-93-2

uric Acid

potassium hydroxide

potassium hydroxide

A

ammonia
7664-41-7

ammonia

B

potassium cyanide
151-50-8

potassium cyanide

C

potassium oxalate
583-52-8

potassium oxalate

D

potassium carbonate

potassium carbonate

methyl thiocyanate
556-64-9

methyl thiocyanate

alcoholic KOH-solution

alcoholic KOH-solution

A

Dimethyldisulphide
624-92-0

Dimethyldisulphide

B

ammonia
7664-41-7

ammonia

C

potassium cyanide
151-50-8

potassium cyanide

D

potassium carbonate

potassium carbonate

dipicryl-diazene
19159-68-3

dipicryl-diazene

diluted KOH-solution

diluted KOH-solution

A

potassium cyanide
151-50-8

potassium cyanide

B

2,4,6-Trinitrophenol
88-89-1

2,4,6-Trinitrophenol

C

2,2',4,4',6,6'-hexanitrohydrazobenzene
68683-32-9

2,2',4,4',6,6'-hexanitrohydrazobenzene

D

potassium nitrite

potassium nitrite

diethyl ether
60-29-7

diethyl ether

cyanogen iodide
506-78-5

cyanogen iodide

KOH

KOH

potassium cyanide
151-50-8

potassium cyanide

bromocyane
506-68-3

bromocyane

ethanol
64-17-5

ethanol

KOH

KOH

potassium cyanide
151-50-8

potassium cyanide

cyanogen iodide
506-78-5

cyanogen iodide

ethanol
64-17-5

ethanol

KOH

KOH

potassium cyanide
151-50-8

potassium cyanide

diethyl ether
60-29-7

diethyl ether

bromocyane
506-68-3

bromocyane

chloroform
67-66-3

chloroform

KOH

KOH

potassium cyanide
151-50-8

potassium cyanide

cyanogen iodide
506-78-5

cyanogen iodide

chloroform
67-66-3

chloroform

KOH

KOH

potassium cyanide
151-50-8

potassium cyanide

bromocyane
506-68-3

bromocyane

water
7732-18-5

water

KOH

KOH

potassium cyanide
151-50-8

potassium cyanide

cyanogen iodide
506-78-5

cyanogen iodide

water
7732-18-5

water

KOH

KOH

potassium cyanide
151-50-8

potassium cyanide

ethanedinitrile
460-19-5

ethanedinitrile

potassium

potassium

potassium cyanide
151-50-8

potassium cyanide

ethanedinitrile
460-19-5

ethanedinitrile

potassium carbonate

potassium carbonate

A

potassium cyanate
590-28-3

potassium cyanate

B

potassium cyanide
151-50-8

potassium cyanide

Conditions
ConditionsYield
in der Rotglut;
ethyl isothiocyanate
542-90-5

ethyl isothiocyanate

aqueous KOH-solution

aqueous KOH-solution

A

Diethyl disulfide
110-81-6

Diethyl disulfide

B

potassium cyanate
590-28-3

potassium cyanate

C

potassium cyanide
151-50-8

potassium cyanide

Conditions
ConditionsYield
at 100℃; im zugeschmolzenen Rohr;
trichloroacetonitrile
14752-58-0

trichloroacetonitrile

concentrated KOH-solution

concentrated KOH-solution

A

ammonia
7664-41-7

ammonia

B

potassium cyanide
151-50-8

potassium cyanide

Cyan-imidoameisensaeureethylester
13369-04-5

Cyan-imidoameisensaeureethylester

alcoholic potash

alcoholic potash

A

potassium cyanide
151-50-8

potassium cyanide

B

potassium fulminate

potassium fulminate

ethanedinitrile
460-19-5

ethanedinitrile

aqueous KOH-solution

aqueous KOH-solution

A

potassium cyanide
151-50-8

potassium cyanide

B

potassium fulminate

potassium fulminate

ethyl isocyanide
624-79-3

ethyl isocyanide

potassium amide

potassium amide

A

potassium cyanide
151-50-8

potassium cyanide

B

ethylamine
75-04-7

ethylamine

ethyl isocyanide
624-79-3

ethyl isocyanide

potassium amide

potassium amide

liquid.ammonia

liquid.ammonia

A

potassium cyanide
151-50-8

potassium cyanide

B

ethylamine
75-04-7

ethylamine

Conditions
ConditionsYield
at 80℃;
ethanedinitrile
460-19-5

ethanedinitrile

aqueous KOH-solution

aqueous KOH-solution

A

potassium cyanate
590-28-3

potassium cyanate

B

ammonia
7664-41-7

ammonia

C

potassium cyanide
151-50-8

potassium cyanide

D

azulminic acid

azulminic acid

Conditions
ConditionsYield
Produkt5: CO2;
ethanedinitrile
460-19-5

ethanedinitrile

K2CO3

K2CO3

A

potassium cyanate
590-28-3

potassium cyanate

B

carbon dioxide
124-38-9

carbon dioxide

C

potassium cyanide
151-50-8

potassium cyanide

D

paracyan

paracyan

Conditions
ConditionsYield
at 190 - 370℃; Produkt 5: Stickstoff;
1-bromo-octane
111-83-1

1-bromo-octane

potassium cyanide
151-50-8

potassium cyanide

nonanonitrile
2243-27-8

nonanonitrile

Conditions
ConditionsYield
Sucrose-ethyleneoxide adducts In acetonitrile at 83℃; for 24h; Product distribution; further catalysts: PEG, DB18K6; further objects of study: phase-transfer catalysis; further solvents: toluene/H2O;100%
tetraoctyl ammonium bromide In water; toluene at 90℃; for 24h; Product distribution; other phase-transfer catalysts, time;99%
tetraoctyl ammonium bromide In water; toluene at 90℃; for 24h;99%
potassium cyanide
151-50-8

potassium cyanide

acetophenone
98-86-2

acetophenone

2-hydroxy-2-phenylpropionitrile
20102-12-9

2-hydroxy-2-phenylpropionitrile

Conditions
ConditionsYield
Stage #1: potassium cyanide; acetophenone With 18-crown-6 ether In dichloromethane at 20℃; for 4h;
Stage #2: With hydrogenchloride In tetrahydrofuran; dichloromethane at 0 - 20℃; for 2h;
100%
Stage #1: potassium cyanide; acetophenone With tetrachlorosilane In acetonitrile at 60 - 70℃; for 5h;
Stage #2: With sodium hydrogencarbonate In water; acetonitrile Further stages.;
82%
With hydrogenchloride
potassium cyanide
151-50-8

potassium cyanide

1-bromomethyl-3-trifluoromethylbenzene
402-23-3

1-bromomethyl-3-trifluoromethylbenzene

3-trifluoromethylphenylacetonitrile
2338-76-3

3-trifluoromethylphenylacetonitrile

Conditions
ConditionsYield
In ethanol; water for 1.5h; Heating / reflux;100%
In dimethyl sulfoxide
3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

potassium cyanide
151-50-8

potassium cyanide

2-hydroxy-2-(pyridin-3-yl)acetonitrile
17604-74-9

2-hydroxy-2-(pyridin-3-yl)acetonitrile

Conditions
ConditionsYield
With water; acetic acid at 5 - 10℃; for 2h;100%
With hydrogenchloride
With acetic acid In water for 18h; Ambient temperature;
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

6-methoxy-2-acetylnaphthalene
3900-45-6

6-methoxy-2-acetylnaphthalene

potassium cyanide
151-50-8

potassium cyanide

2-(6-methoxy-2-naphthyl)-2-(trimethylsilyloxy)propiononitrile
107727-73-1

2-(6-methoxy-2-naphthyl)-2-(trimethylsilyloxy)propiononitrile

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 60℃; for 13.5h;100%
(+)-<(1S,2S)-1-Hydroxy-2-methyl-3-oxo-cyclopent-2-yl>-essigsaeure-γ-lacton
71629-66-8

(+)-<(1S,2S)-1-Hydroxy-2-methyl-3-oxo-cyclopent-2-yl>-essigsaeure-γ-lacton

potassium cyanide
151-50-8

potassium cyanide

(1S,2S)-6-Cyano-6-hydroxy-5-methyl-2-oxa-bicyclo<3.3.0>octan-3-on
98926-41-1

(1S,2S)-6-Cyano-6-hydroxy-5-methyl-2-oxa-bicyclo<3.3.0>octan-3-on

Conditions
ConditionsYield
In water; acetic acid at 5℃; for 20h;100%
Octanal
124-13-0

Octanal

methylamine hydrochloride
593-51-1

methylamine hydrochloride

potassium cyanide
151-50-8

potassium cyanide

2-Methylamino-nonanenitrile
112101-12-9

2-Methylamino-nonanenitrile

Conditions
ConditionsYield
With aluminum oxide In acetonitrile at 50℃; for 22h; ultrasound;100%
5-anti-Chloro-6-syn-cyanobicyclo<2.1.1>hexene
51991-03-8

5-anti-Chloro-6-syn-cyanobicyclo<2.1.1>hexene

potassium cyanide
151-50-8

potassium cyanide

endo,endo-3,5-Dicyanotricyclo<2.2.0.02.6>hexane
72431-16-4

endo,endo-3,5-Dicyanotricyclo<2.2.0.02.6>hexane

Conditions
ConditionsYield
In water; acetonitrile for 30h; Ambient temperature;100%
9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-one
841-95-2

9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-one

potassium cyanide
151-50-8

potassium cyanide

2-Amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2-carbonitrile
133308-74-4

2-Amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2-carbonitrile

Conditions
ConditionsYield
With ammonia; acetic acid In water at 40℃; for 25h; Irradiation; irrad. with ultrasound;100%
potassium cyanide
151-50-8

potassium cyanide

1-Chloromethyl-7-methoxy-1,4,4-trimethyl-isothiochroman

1-Chloromethyl-7-methoxy-1,4,4-trimethyl-isothiochroman

7-methoxy-1,4,4-trimethylisothiochroman-1-ylacetonitril
128276-86-8

7-methoxy-1,4,4-trimethylisothiochroman-1-ylacetonitril

Conditions
ConditionsYield
In ethanol; water for 3h; Heating;100%
potassium cyanide
151-50-8

potassium cyanide

benzyl bromide
100-39-0

benzyl bromide

phenylacetonitrile
140-29-4

phenylacetonitrile

Conditions
ConditionsYield
Sucrose-ethyleneoxide adducts In acetonitrile at 20℃; for 8h; Product distribution; further catalysts: PEG, DB18K6; further objects of study: phase-transfer catalysis; further solvents: toluene/H2O;100%
With water; Aliquat 336 for 2h; Ambient temperature;97%
With poly(ethylene glycol)-supported tetrabutylamminium bromide In water at 25℃; for 2h; Substitution;97%
potassium cyanide
151-50-8

potassium cyanide

aniline hydrochloride
142-04-1

aniline hydrochloride

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

2-(4-fluorophenyl)-2-(phenylamino) acetonitrile
124573-71-3

2-(4-fluorophenyl)-2-(phenylamino) acetonitrile

Conditions
ConditionsYield
In ethanol; water 1.) 1 h cooling; 2.) 20 h room temperature;100%
potassium cyanide
151-50-8

potassium cyanide

<5-(Diphenylmethylen)-1,3-cyclopentadien-1-yl>dimethylsulfonium-perchlorat

<5-(Diphenylmethylen)-1,3-cyclopentadien-1-yl>dimethylsulfonium-perchlorat

1-(Cyandiphenylmethyl)-2-(dimethylsulfonio)cyclopentadienid

1-(Cyandiphenylmethyl)-2-(dimethylsulfonio)cyclopentadienid

Conditions
ConditionsYield
In methanol at 0℃; for 0.25h;100%
potassium cyanide
151-50-8

potassium cyanide

<5-(Diphenylmethylen)-1,3-cyclopentadien-1-yl>diphenylsulfonium-perchlorat

<5-(Diphenylmethylen)-1,3-cyclopentadien-1-yl>diphenylsulfonium-perchlorat

1-(Cyandiphenylmethyl)-2-(diphenylsulfonio)cyclopentadienid

1-(Cyandiphenylmethyl)-2-(diphenylsulfonio)cyclopentadienid

Conditions
ConditionsYield
In methanol at 0℃; for 0.25h;100%
potassium cyanide
151-50-8

potassium cyanide

<5-(Diphenylmethylen)-1,3-cyclopentadien-1-yl>bis(4-methylphenyl)sulfonium-perchlorat

<5-(Diphenylmethylen)-1,3-cyclopentadien-1-yl>bis(4-methylphenyl)sulfonium-perchlorat

1--2-(cyandiphenylmethyl)cyclopentadienid

1--2-(cyandiphenylmethyl)cyclopentadienid

Conditions
ConditionsYield
In methanol at 0℃; for 0.25h;100%
potassium cyanide
151-50-8

potassium cyanide

ethyl [L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-pentenoate
104700-37-0

ethyl [L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-pentenoate

(S)-4-tert-Butoxycarbonylamino-3-cyano-pentanoic acid ethyl ester

(S)-4-tert-Butoxycarbonylamino-3-cyano-pentanoic acid ethyl ester

Conditions
ConditionsYield
With 18-crown-6 ether In acetonitrile for 24h; Ambient temperature;100%
potassium cyanide
151-50-8

potassium cyanide

2-Benzyl-3-(bromomethyl)-1,4-dimethoxynaphthalene
161363-80-0

2-Benzyl-3-(bromomethyl)-1,4-dimethoxynaphthalene

2-Benzyl-3-(cyanomethyl)-1,4-dimethoxynaphthalene
161363-81-1

2-Benzyl-3-(cyanomethyl)-1,4-dimethoxynaphthalene

Conditions
ConditionsYield
In 1,4-dioxane; water for 10h; Heating;100%
potassium cyanide
151-50-8

potassium cyanide

trans-1-iodo-2-isothiocyanatocyclohexane
60211-89-4, 63616-13-7, 93424-19-2

trans-1-iodo-2-isothiocyanatocyclohexane

2-cyano-cis-3a,4,5,6,7,7a-hexahydrobenzothiazole
77469-22-8

2-cyano-cis-3a,4,5,6,7,7a-hexahydrobenzothiazole

Conditions
ConditionsYield
With 18-crown-6 ether In chloroform; water for 92h; Heating;100%
potassium cyanide
151-50-8

potassium cyanide

4'-(chloromethyl)dispirobis<1,3>dioxole-6',1''-cyclohexane>
114200-84-9

4'-(chloromethyl)dispirobis<1,3>dioxole-6',1''-cyclohexane>

dispirobis<1,3>dioxole-6',1''-cyclohexane>-4'-acetonitrile
114200-85-0

dispirobis<1,3>dioxole-6',1''-cyclohexane>-4'-acetonitrile

Conditions
ConditionsYield
With 18-crown-6 ether In acetonitrile for 5h; Heating;100%
potassium cyanide
151-50-8

potassium cyanide

diethyl <<3-(bromomethyl)phenyl>methyl>phosphonate
120667-42-7

diethyl <<3-(bromomethyl)phenyl>methyl>phosphonate

diethyl <<3-(cyanomethyl)phenyl>methyl>phosphonate
140151-14-0

diethyl <<3-(cyanomethyl)phenyl>methyl>phosphonate

Conditions
ConditionsYield
With sodium iodide In water; acetone at 50℃; for 48h;100%
potassium cyanide
151-50-8

potassium cyanide

4-(diethoxyphosphorylmethyl)-1-bromomethyl-phenyl
108228-81-5

4-(diethoxyphosphorylmethyl)-1-bromomethyl-phenyl

diethyl <<4-(cyanomethyl)phenyl>methyl>phosphonate
135335-15-8

diethyl <<4-(cyanomethyl)phenyl>methyl>phosphonate

Conditions
ConditionsYield
With sodium iodide In water; acetone at 50℃; for 48h;100%
potassium cyanide
151-50-8

potassium cyanide

3-(2,6-Dimethylphenyl)-4-methyl-5-acetyl-2-imino-thiazolin Hydrobromid

3-(2,6-Dimethylphenyl)-4-methyl-5-acetyl-2-imino-thiazolin Hydrobromid

2-Aminocarbonylimino-3-(2,6-dimethylphenyl)-4-methyl-5-acetyl-thiazolin

2-Aminocarbonylimino-3-(2,6-dimethylphenyl)-4-methyl-5-acetyl-thiazolin

Conditions
ConditionsYield
In water100%
potassium cyanide
151-50-8

potassium cyanide

<5-(Diphenylmethylen)-1,3-cyclopentadien-1-yl>methylphenylsulfonium-perchlorat

<5-(Diphenylmethylen)-1,3-cyclopentadien-1-yl>methylphenylsulfonium-perchlorat

1-(Cyandiphenylmethyl)-2-(methylphenylsulfonio)cyclopentadienid

1-(Cyandiphenylmethyl)-2-(methylphenylsulfonio)cyclopentadienid

Conditions
ConditionsYield
In methanol at 0℃; for 0.25h;100%
potassium cyanide
151-50-8

potassium cyanide

ethyl 8,9-bis(4-methoxyphenyl)-10,10-dimethyl-5-oxotricyclo<5.2.1.02,6>deca-3,8-diene-2-carboxylate

ethyl 8,9-bis(4-methoxyphenyl)-10,10-dimethyl-5-oxotricyclo<5.2.1.02,6>deca-3,8-diene-2-carboxylate

(3aS,4R,7S,7aR)-3-Cyano-5,6-bis-(4-methoxy-phenyl)-8,8-dimethyl-1-oxo-1,2,3,4,7,7a-hexahydro-4,7-methano-indene-3a-carboxylic acid ethyl ester

(3aS,4R,7S,7aR)-3-Cyano-5,6-bis-(4-methoxy-phenyl)-8,8-dimethyl-1-oxo-1,2,3,4,7,7a-hexahydro-4,7-methano-indene-3a-carboxylic acid ethyl ester

Conditions
ConditionsYield
With ammonium chloride In water; N,N-dimethyl-formamide at 100℃; for 4.5h;100%
potassium cyanide
151-50-8

potassium cyanide

acetaldehyde
75-07-0

acetaldehyde

2-amino-1-phenylpropane
60-15-1, 156-34-3, 51-64-9, 300-62-9

2-amino-1-phenylpropane

2-<(1-methyl-2-phenylethyl)amino>propanenitrile
3535-04-4

2-<(1-methyl-2-phenylethyl)amino>propanenitrile

Conditions
ConditionsYield
With sodium hydrogensulfite In methanol; water Ambient temperature;100%
methylamine hydrochloride
593-51-1

methylamine hydrochloride

potassium cyanide
151-50-8

potassium cyanide

acetophenone
98-86-2

acetophenone

2-methylamino-2-phenyl-propionitrile
112101-15-2

2-methylamino-2-phenyl-propionitrile

Conditions
ConditionsYield
With aluminum oxide In acetonitrile at 50℃; for 24h; ultrasound;100%
potassium cyanide
151-50-8

potassium cyanide

3-methoxy-benzaldehyde
591-31-1

3-methoxy-benzaldehyde

m-methoxymandelonitrile
53313-94-3

m-methoxymandelonitrile

Conditions
ConditionsYield
Stage #1: 3-methoxy-benzaldehyde With hydrogenchloride; sodium sulfite In tetrahydrofuran; water at 20℃; for 0.166667h;
Stage #2: potassium cyanide In tetrahydrofuran; water for 0.5h;
100%
With sodium hydrogensulfite 1) H2O, 40 deg C, 0.5 h, 2) H2O, 0 deg C, 1 h; Multistep reaction;
With acetic acid In water
With hydrogenchloride; sodium sulfite In tetrahydrofuran at 20℃; for 0.5h;
formaldehyd
50-00-0

formaldehyd

potassium cyanide
151-50-8

potassium cyanide

benzyl-methyl-amine
103-67-3

benzyl-methyl-amine

(N-benzyl-N-methylamino)acetonitrile
14321-25-6

(N-benzyl-N-methylamino)acetonitrile

Conditions
ConditionsYield
With hydrogenchloride for 16h; Ambient temperature;100%
potassium cyanide
151-50-8

potassium cyanide

(1S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-6-((E)-(4S,6S)-4,6-dimethyl-oct-2-enoyloxy)-7-hydroxy-4-oxo-2,8-dioxa-bicyclo[3.2.1]octane-5-carboxylic acid

(1S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-6-((E)-(4S,6S)-4,6-dimethyl-oct-2-enoyloxy)-7-hydroxy-4-oxo-2,8-dioxa-bicyclo[3.2.1]octane-5-carboxylic acid

(1S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-4-cyano-6-((E)-(4S,6S)-4,6-dimethyl-oct-2-enoyloxy)-4,7-dihydroxy-2,8-dioxa-bicyclo[3.2.1]octane-5-carboxylic acid

(1S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-4-cyano-6-((E)-(4S,6S)-4,6-dimethyl-oct-2-enoyloxy)-4,7-dihydroxy-2,8-dioxa-bicyclo[3.2.1]octane-5-carboxylic acid

Conditions
ConditionsYield
With acetic acid In methanol; isopropyl alcohol100%
(2Z)-3-methyl-2-penten-4-ynal
52421-93-9

(2Z)-3-methyl-2-penten-4-ynal

potassium cyanide
151-50-8

potassium cyanide

(Z)-1-cyano-3-methylpent-2-en-4-yn-1-ol

(Z)-1-cyano-3-methylpent-2-en-4-yn-1-ol

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; water 30 min, 0 deg C; 2 h, 20 deg C;100%

Potassium cyanide Specification

The IUPAC name of Potassium cyanide is potassium cyanide. With the CAS registry number 151-50-8, it is also named as Hydrocyanic acid, potassium salt. The product's categories are Inorganics; ACS Grade; Essential Chemicals; Routine Reagents; Masking AgentsAnalytical Reagents for General Use; Complexometric Titration (IDRANAL); O-P, Puriss p.a. ACS; Puriss p.a. ACS; Titration; Masking Agents; O-P, Puriss p.a.; Puriss p.a., and the other registry numbers are 133708-36-8; 15745-74-1; 60195-52-0. Besides, it is white granular powder or crystals, which should be sealed in a cool and dry warehouse. In addition, its molecular formula is CKN and molecular weight is 65.12.

The other characteristics of this product can be summarized as: (1)EINECS: 205-792-3; (2)H-Bond Donor: 0; (3)H-Bond Acceptor: 2; (4)Rotatable Bond Count: 0; (5)Exact Mass: 64.966781; (6)MonoIsotopic Mass: 64.966781; (7)Topological Polar Surface Area: 23.8; (8)Heavy Atom Count: 3; (9)Complexity: 12.8; (10)Density: 1.52 g/cm3; (11)Melting point: 634.5 °C; (12)Boiling point: 1625 °C; (13)Flash Point: 1625 °C; (14)Solubility in water: 71.6 g/100 ml (25 °C).

Preparation of Potassium cyanide: this chemical can be prepared by the treatment of Hydrogen cyanide with Potassium hydroxide:
HCN + KOH → KCN + H2O

Uses of Potassium cyanide: it is widely used in organic synthesis for the preparation of nitriles and carboxylic acids. It is also used in electroplating, such as jewelry for chemical gilding and buffing. And this product has been used as a killing agent in collecting jars by entomologists. Additionally, this chemical can form water-soluble salts from gold metal in the presence of air in gold mining:
4 Au + 8 KCN + O2 + 2 H2O → 4 K[Au(CN)2] + 4 KOH

When you are using this chemical, please be cautious about it as the following: it is very toxic by inhalation, in contact with skin and if swallowed. And it would liberate very toxic gas in contact with acid. Please keep container tightly closed and do not empty into drains. After contact with skin, you should wash immediately with plenty of soap-suds. Moreover, it is very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) And this material and its container must be disposed of as hazardous waste. Please avoid release to the environment and refer to special instructions / safety data sheets.

People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: [C-]#N.[K+]
(2)InChI: InChI=1S/CN.K/c1-2;/q-1;+1
(3)InChIKey: NNFCIKHAZHQZJG-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 2200ug/kg (2.2mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 35, Pg. 316, 1936.
dog LD50 subcutaneous 6mg/kg (6mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archiv fuer Toxikologie. Vol. 21, Pg. 89, 1965.
dog LDLo intravenous 5mg/kg (5mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 209, 1973.
frog LDLo subcutaneous 60mg/kg (60mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 3, Pg. 77, 1897.
guinea pig LDLo intraarterial 5mg/kg (5mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig LDLo intraperitoneal 8mg/kg (8mg/kg)   Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 96, Pg. 202, 1927.
guinea pig LDLo intravenous 5mg/kg (5mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig LDLo subcutaneous 8mg/kg (8mg/kg)   Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 96, Pg. 202, 1927.
human LDLo oral 2857ug/kg (2.857mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 191, 1969.
man TDLo oral 13699ug/kg (13.699mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA
Journal of Toxicology, Clinical Toxicology. Vol. 25, Pg. 121, 1987.
mouse LD50 intraperitoneal 5991ug/kg (5.991mg/kg)   Pesticide Biochemistry and Physiology. Vol. 2, Pg. 95, 1972.
mouse LD50 intravenous 2600ug/kg (2.6mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Japanese Journal of Pharmacology. Vol. 3, Pg. 99, 1954.
mouse LD50 oral 8500ug/kg (8.5mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 161, Pg. 163, 1968.
mouse LD50 subcutaneous 6500ug/kg (6.5mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 54, Pg. 1057, 1958.
pigeon LD50 intramuscular 4mg/kg (4mg/kg)   Japanese Journal of Pharmacology. Vol. 3, Pg. 99, 1954.
rabbit LD50 intramuscular 3256ug/kg (3.256mg/kg)   Journal of the American College of Toxicology. Vol. 1(3), Pg. 120, 1982.
rabbit LD50 intraperitoneal 3972ug/kg (3.972mg/kg) BLOOD: OTHER CHANGES Toxicologist. Vol. 3, Pg. 64, 1983.
rabbit LD50 ocular 7870ug/kg (7.87mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Journal of Toxicology, Cutaneous and Ocular Toxicology. Vol. 2, Pg. 119, 1983.
rabbit LD50 oral 5mg/kg (5mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 209, 1973.
rabbit LD50 subcutaneous 4mg/kg (4mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Japanese Journal of Pharmacology. Vol. 3, Pg. 99, 1954.
rat LD50 intraperitoneal 4mg/kg (4mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Journal of Applied Physiology. Vol. 32, Pg. 315, 1972.
rat LD50 intravenous 3600ug/kg (3.6mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Drug Development Research. Vol. 5, Pg. 225, 1985.
rat LD50 oral 5mg/kg (5mg/kg)   Archives of Toxicology. Vol. 54, Pg. 275, 1983.
rat LD50 subcutaneous 7814ug/kg (7.814mg/kg)   Archives of Toxicology, Supplement. Vol. 14, Pg. 231, 1991.
rat LDLo intramuscular 8mg/kg (8mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 209, 1973.
women TDLo oral 100mg/kg (100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
American Journal of Emergency Medicine. Vol. 1, Pg. 94, 1983.
 

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