Conditions | Yield |
---|---|
With salicylaldehyde at 80℃; for 28h; Inert atmosphere; chemoselective reaction; | 85% |
With sulfuric acid at 120℃; for 8h; Molecular sieve; | 25% |
With hydrogenchloride | |
With sulfuric acid; benzene durch azeotrope Destillation; |
ethanol
(3R,5S,6R,9S)-3,9-Dimethyl-6-(1-methyl-1-phenyl-ethyl)-1,4-dioxa-spiro[4.5]decan-2-one
A
(R)-Ethyl lactate
B
(-)-(2S,5R)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexanon
Conditions | Yield |
---|---|
With hydrogenchloride for 2h; Heating; | A 84% B n/a |
2-oxo-propionic acid ethyl ester
A
(S)-Ethyl lactate
B
(R)-Ethyl lactate
Conditions | Yield |
---|---|
With hydrogen; cinchonidine In cyclohexane at 24.84℃; under 30003 Torr; optical yield given as %ee; enantioselective reaction; | A n/a B 76% |
With D-Glucose; cliona varians In water at 25℃; for 72h; Reagent/catalyst; | A 49% B n/a |
With hydrogen; cinchonine; Pt/Al2O3 In toluene at 20℃; under 15001.2 Torr; Rate constant; Product distribution; var. conc. of HCd, solvent; |
Conditions | Yield |
---|---|
With hydrogenchloride In toluene | 76% |
Conditions | Yield |
---|---|
With glycerol dehydrogenase; 2-propanol-NAD(1+) potassium phosphate buffer, pH 7; | 61% |
With Leifsonia sp. S749 cells alcohol dehydrogenase; nicotinamide adenine dinucleotide; isopropyl alcohol In phosphate buffer at 25℃; for 24h; pH=7.0; | 19% |
With hydrogen; (R)-N-<2-hydroxy2-(1-naphthyl)ethyl>pyrrolidine; Pt/Al2O3 In acetic acid at 25℃; under 7500.6 Torr; for 2h; Product distribution; enantioselectivity; var. modifiers, also in the absence of modifiers, var. solvents, temp., pressure and time; |
Conditions | Yield |
---|---|
With sulfuryl dichloride at -40 - 20℃; for 48h; | 58% |
ethyl 2-hydroxypropionate
A
L-Lactic acid
B
D-Lactic acid
C
(R)-Ethyl lactate
Conditions | Yield |
---|---|
With ammonium hydroxide at 30℃; pH=6.9; | A n/a B n/a C 34.5% |
2-nitryloxy-propionic acid ethyl ester
A
(S)-Ethyl lactate
B
(R)-Ethyl lactate
Conditions | Yield |
---|---|
With acetic acid; zinc Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
(R)-2-(Acetoxy)propionsaeure-ethylester
(R)-Ethyl lactate
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In ethanol for 72h; Heating; Yield given; |
(1R)-2-ethoxy-1-methyl-2-oxoethyl 4-nitrobenzoate
(R)-Ethyl lactate
Conditions | Yield |
---|---|
With potassium carbonate In ethanol at 23℃; for 15h; |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid for 30h; Heating; Yield given; |
ethyl 2-hydroxypropionate
(R)-(1-naphthyl)-glycyl-(R)-phenylglycine
A
(R)-Ethyl lactate
Conditions | Yield |
---|---|
In methanol Ambient temperature; Yield given; Title compound not separated from byproducts; |
Conditions | Yield |
---|---|
anschliessende Veresterung; |
Conditions | Yield |
---|---|
anschliessende Veresterung; |
Conditions | Yield |
---|---|
With sulfuric acid |
R-(+)-2-bromopropionic acid
(R)-Ethyl lactate
Conditions | Yield |
---|---|
at 50℃; anschliessende Veresterung; |
Conditions | Yield |
---|---|
With ethanol |
Conditions | Yield |
---|---|
With sulfuric acid |
Conditions | Yield |
---|---|
durch Schweineleber-Lipase schneller gespalten; |
Conditions | Yield |
---|---|
With potassium carbonate |
(R)-2-bromo-propionic acid ; sodium salt
(R)-Ethyl lactate
Conditions | Yield |
---|---|
at 0℃; anschliessende Veresterung sowie Hydrolyse-geschwindigkeiten; |
2-oxo-propionic acid ethyl ester
methanol
A
methyl lactate
B
(S)-Ethyl lactate
C
(R)-Ethyl lactate
Conditions | Yield |
---|---|
With hydrogen; chiral Ru complex at 20℃; under 25857.4 Torr; for 48h; Product distribution; Further Variations:; Catalysts; Temperatures; Solvents; |
ethanol
A
(R)-Ethyl lactate
B
(S)-2-hydroxy-propionic acid (S)- 1-ethoxycarbonyl-ethyl ester
Conditions | Yield |
---|---|
With Candida antarctica lipase B In tetrahydrofuran; hexane at 60℃; for 66h; | A 49 % Chromat. B 48 % Chromat. |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1) Ph3P, diethyl azodicarboxylate / 2) THF, -20 deg C, 0.5 h, 2) THF, 27 h 2: K2CO3 / ethanol / 15 h / 23 °C View Scheme | |
Multi-step reaction with 3 steps 1: 87 percent / pyridine / 3 h / 0 - 10 °C 2: 85 percent / dimethylsulfoxide / 12 h 3: 4-toluenesulfonic acid / ethanol / 72 h / Heating View Scheme |
ethyl (S)-2-[[(4-methylphenyl)sulfonyl]oxy]propanoate
(R)-Ethyl lactate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 85 percent / dimethylsulfoxide / 12 h 2: 4-toluenesulfonic acid / ethanol / 72 h / Heating View Scheme |
(S)-ethyl 2-(methylsulfonyloxy)propanoate
(R)-Ethyl lactate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / Amberlyst A-26 NO3(1-) form / pentane / 5 h / 120 °C 2: Zn, CH3COOH View Scheme |
Conditions | Yield |
---|---|
With methanol; toluene-4-sulfonic acid Inert atmosphere; optical yield given as %ee; | |
With toluene-4-sulfonic acid In methanol Inert atmosphere; optical yield given as %ee; |
2-oxo-propionic acid ethyl ester
methyl 2-oxo-2-phenylacetate
A
(S)-Ethyl lactate
B
(R)-Ethyl lactate
C
(S)-Methyl mandelate
D
(R)-methyl mandelate
Conditions | Yield |
---|---|
With 5% Pt/Al2O3; hydrogen; acetic acid In toluene at 19.84℃; under 30003 Torr; |
(R)-Ethyl lactate
tert-butyldimethylsilyl chloride
Conditions | Yield |
---|---|
With 1H-imidazole In dichloromethane | 99% |
With 1H-imidazole In dichloromethane at 0 - 20℃; for 3h; | 99% |
With 1H-imidazole In dichloromethane at 20℃; for 4h; Inert atmosphere; | 96% |
With 1H-imidazole In N,N-dimethyl-formamide at 25℃; Etherification; | |
With 1H-imidazole In dichloromethane at 0 - 20℃; for 5h; |
(R)-Ethyl lactate
3,5-dibenzyloxybenzoic acid
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 3h; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With silver(l) oxide In diethyl ether at 23 - 42℃; Williamson Ether Synthesis; Reflux; | 98% |
With silver(l) oxide |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In diethyl ether for 0.5h; Heating; | 97% |
With sodium tetrahydroborate; aluminium trichloride |
(R)-Ethyl lactate
methanesulfonyl chloride
(S)-ethyl 2-(methylsulfonyloxy)propanoate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0℃; | 95% |
(R)-Ethyl lactate
6-methoxy-1-naphthoic acid
Conditions | Yield |
---|---|
Stage #1: 6-methoxy-1-naphthoic acid With thionyl chloride In N,N-dimethyl-formamide; toluene at 10 - 40℃; for 4h; Green chemistry; Stage #2: (R)-Ethyl lactate With triethylamine In toluene at 10 - 20℃; for 2h; Green chemistry; | 92% |
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at 0 - 20℃; Mitsunobu reaction; Inert atmosphere; | 91% |
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran Mitsunobu Displacement; |
(R)-Ethyl lactate
triisopropylsilyl chloride
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 12h; Inert atmosphere; | 91% |
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at 0 - 20℃; Mitsunobu reaction; Inert atmosphere; | 90% |
(R)-Ethyl lactate
O-diphenylmethyl 2,2,2-trichloroacetimidate
Conditions | Yield |
---|---|
In toluene at 111℃; | 90% |
Conditions | Yield |
---|---|
Stage #1: 1-naphthalenecarboxylic acid With thionyl chloride In N,N-dimethyl-formamide; toluene at 10 - 40℃; for 4h; Green chemistry; Stage #2: (R)-Ethyl lactate With triethylamine In toluene at 10 - 20℃; for 2h; Green chemistry; | 90% |
(R)-Ethyl lactate
2-iodoresorcinol
(2R,2'R)-diethyl 2,2'-(2-iodo-1,3-phenylene)bis(oxy)dipropanoate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at 0 - 20℃; for 6h; | 90% |
(R)-Ethyl lactate
ethyl (S)-lactate triflate
R,R-dilactic acid diethyl ester
Conditions | Yield |
---|---|
With potassium carbonate In 1,2-dichloro-ethane; pentane at 20℃; for 24h; | 89% |
With potassium carbonate In 1,2-dichloro-ethane; pentane at 20℃; for 48h; Inert atmosphere; | 20% |
(R)-Ethyl lactate
N-(4-methoxybenzyl)-2-nitro-N-(prop-2-yn-1-yl)benzenesulfonamide
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In dichloromethane at 23℃; for 1h; | 87% |
Conditions | Yield |
---|---|
With magnesium In tetrahydrofuran for 1.5h; Ambient temperature; | 86% |
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at 0 - 20℃; Mitsunobu reaction; Inert atmosphere; | 86% |
(R)-Ethyl lactate
p-toluenesulfonyl chloride
(-)-ethyl 2-<(p-tolylsulfonyl)oxy>propionate
Conditions | Yield |
---|---|
With triethylamine In benzene for 6h; Ambient temperature; | 85.1% |
With pyridine Substitution; | 85% |
Stage #1: (R)-Ethyl lactate; p-toluenesulfonyl chloride In dichloromethane at 0 - 10℃; for 0.166667h; Inert atmosphere; Stage #2: With triethylamine In dichloromethane at 20℃; for 4h; Cooling; | 85.1% |
(R)-Ethyl lactate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 4h; Mitsunobu Displacement; Inert atmosphere; | 85% |
(R)-Ethyl lactate
2,4-dichlorophenol
(R)-2-(2,4-Dichlorphenoxy)propionsaeure-ethylester
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 16h; Mitsunobu Displacement; | 84% |
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran Mitsunobu reaction; |
4-methyleneoxetan-2-one
(R)-Ethyl lactate
(R)-1-ethoxy-1-oxopropan-2-yl 3-oxobutanoate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 15h; Heating; | 81% |
Conditions | Yield |
---|---|
With PPh3-containing polystyrene non-cross-linked polymer; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 0.5h; Mitsunobu reaction; | 80% |
(R)-Ethyl lactate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; | 79% |
(R)-Ethyl lactate
para-chlorobenzoic acid
(R)-1-ethoxy-1-oxopropane-2-yl 4-chlorobenzoate
Conditions | Yield |
---|---|
With C18H20N2O4; Nb-TPP In tetrahydrofuran at 0 - 20℃; Mitsunobu reaction; | 76% |
(R)-Ethyl lactate
4-nitro-benzoic acid
(1R)-2-ethoxy-1-methyl-2-oxoethyl 4-nitrobenzoate
Conditions | Yield |
---|---|
With C18H20N2O4; Nb-TPP In tetrahydrofuran at 0 - 20℃; Mitsunobu reaction; | 74% |
With 1-phenylphospholane-1-oxide; di-isopropyl azodicarboxylate; phenylsilane In tetrahydrofuran at 80℃; for 18h; Mitsunobu Displacement; Sealed tube; | 68% |
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In toluene at 0 - 20℃; Mitsunobu Displacement; | 74% |
(R)-Ethyl lactate
3-(dimethylamino)benzoic acid
(R)-1-ethoxy-1-oxopropan-2-yl 3-(dimethylamino)benzoate
Conditions | Yield |
---|---|
With C18H20N2O4; Nb-TPP In tetrahydrofuran at 0 - 20℃; Mitsunobu reaction; | 73% |
The Propanoicacid, 2-hydroxy-, ethyl ester, (2R)-, with the CAS registry number 7699-00-5, has the systematic name of ethyl 2-hydroxypropanoate. It belongs to the product category of Acetyl Group. And the molecular formula of the chemical is C5H10O3.
The characteristics of Propanoicacid, 2-hydroxy-, ethyl ester, (2R)- are as followings: (1)# of Rule of 5 Violations: 0; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 18.84; (5)ACD/KOC (pH 7.4): 18.84; (6)#H bond acceptors: 3; (7)#H bond donors: 1; (8)#Freely Rotating Bonds: 4; (9)Polar Surface Area: 46.53 Å2; (10)Index of Refraction: 1.42; (11)Molar Refractivity: 28.48 cm3; (12)Molar Volume: 112.4 cm3; (13)Polarizability: 11.29×10-24cm3; (14)Surface Tension: 33.2 dyne/cm; (15)Density: 1.05 g/cm3; (16)Flash Point: 54.6 °C; (17)Enthalpy of Vaporization: 45.57 kJ/mol; (18)Boiling Point: 154.5 °C at 760 mmHg; (19)Vapour Pressure: 1.16 mmHg at 25°C.
You should be cautious while dealing with this chemical. It is a kind of flammable chemical which irritates to respiratory system. What's more, it has risk of serious damage to eyes. Therefore, you had better take the following instructions: Avoid contact with skin; Wear eye/face protection, and if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: CCOC(=O)C(C)O
(2)InChI: InChI=1/C5H10O3/c1-3-8-5(7)4(2)6/h4,6H,3H2,1-2H3
(3)InChIKey: LZCLXQDLBQLTDK-UHFFFAOYAV
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View