Product Name

  • Name

    (+)-ETHYL D-LACTATE

  • EINECS
  • CAS No. 7699-00-5
  • Article Data57
  • CAS DataBase
  • Density 1.05 g/cm3
  • Solubility
  • Melting Point
  • Formula C5H10O3
  • Boiling Point 154.5 °C at 760 mmHg
  • Molecular Weight 118.133
  • Flash Point 54.6 °C
  • Transport Information UN 1192 3/PG 3
  • Appearance
  • Safety 24-26-39
  • Risk Codes 10-37-41
  • Molecular Structure Molecular Structure of 7699-00-5 ((+)-ETHYL D-LACTATE)
  • Hazard Symbols IrritantXi
  • Synonyms Lacticacid, ethyl ester, D- (8CI);Propanoic acid, 2-hydroxy-, ethyl ester, (R)-;(+)-Ethyl 2-hydroxypropanoate;(+)-Ethyl 2-hydroxypropionate;(+)-Ethyllactate;(2R)-2-Hydroxypropanoic acid ethyl ester;(R)-(+)-Ethyl lactate;(R)-(+)-Lactic acid ethyl ester;(R)-2-Hydroxypropionic acid ethyl ester;(R)-Ethyl lactate;(R)-Lactic acid ethyl ester;D-Ethyl lactate;Ethyl(R)-2-hydroxypropanoate;Ethyl (R)-2-hydroxypropionate;Ethyl D-lactate;
  • PSA 46.53000
  • LogP -0.06970

Synthetic route

ethanol
64-17-5

ethanol

D-Lactic acid
10326-41-7

D-Lactic acid

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
With salicylaldehyde at 80℃; for 28h; Inert atmosphere; chemoselective reaction;85%
With sulfuric acid at 120℃; for 8h; Molecular sieve;25%
With hydrogenchloride
With sulfuric acid; benzene durch azeotrope Destillation;
ethanol
64-17-5

ethanol

(3R,5S,6R,9S)-3,9-Dimethyl-6-(1-methyl-1-phenyl-ethyl)-1,4-dioxa-spiro[4.5]decan-2-one
104196-77-2, 104264-83-7

(3R,5S,6R,9S)-3,9-Dimethyl-6-(1-methyl-1-phenyl-ethyl)-1,4-dioxa-spiro[4.5]decan-2-one

A

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

B

(-)-(2S,5R)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexanon
97371-54-5

(-)-(2S,5R)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexanon

Conditions
ConditionsYield
With hydrogenchloride for 2h; Heating;A 84%
B n/a
2-oxo-propionic acid ethyl ester
617-35-6

2-oxo-propionic acid ethyl ester

A

(S)-Ethyl lactate
687-47-8

(S)-Ethyl lactate

B

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
With hydrogen; cinchonidine In cyclohexane at 24.84℃; under 30003 Torr; optical yield given as %ee; enantioselective reaction;A n/a
B 76%
With D-Glucose; cliona varians In water at 25℃; for 72h; Reagent/catalyst;A 49%
B n/a
With hydrogen; cinchonine; Pt/Al2O3 In toluene at 20℃; under 15001.2 Torr; Rate constant; Product distribution; var. conc. of HCd, solvent;
ethanol
64-17-5

ethanol

D-lactide
13076-17-0

D-lactide

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
With hydrogenchloride In toluene76%
2-oxo-propionic acid ethyl ester
617-35-6

2-oxo-propionic acid ethyl ester

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
With glycerol dehydrogenase; 2-propanol-NAD(1+) potassium phosphate buffer, pH 7;61%
With Leifsonia sp. S749 cells alcohol dehydrogenase; nicotinamide adenine dinucleotide; isopropyl alcohol In phosphate buffer at 25℃; for 24h; pH=7.0;19%
With hydrogen; (R)-N-<2-hydroxy2-(1-naphthyl)ethyl>pyrrolidine; Pt/Al2O3 In acetic acid at 25℃; under 7500.6 Torr; for 2h; Product distribution; enantioselectivity; var. modifiers, also in the absence of modifiers, var. solvents, temp., pressure and time;
ethanol
64-17-5

ethanol

(R)-(+)-2-acetoxypropionic acid
18668-00-3

(R)-(+)-2-acetoxypropionic acid

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
With sulfuryl dichloride at -40 - 20℃; for 48h;58%
ethyl 2-hydroxypropionate
97-64-3, 2676-33-7

ethyl 2-hydroxypropionate

A

L-Lactic acid
79-33-4

L-Lactic acid

B

D-Lactic acid
10326-41-7

D-Lactic acid

C

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
With ammonium hydroxide at 30℃; pH=6.9;A n/a
B n/a
C 34.5%
2-nitryloxy-propionic acid ethyl ester
997-04-6

2-nitryloxy-propionic acid ethyl ester

A

(S)-Ethyl lactate
687-47-8

(S)-Ethyl lactate

B

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
With acetic acid; zinc Yield given. Yields of byproduct given. Title compound not separated from byproducts;
(R)-2-(Acetoxy)propionsaeure-ethylester
20918-92-7

(R)-2-(Acetoxy)propionsaeure-ethylester

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In ethanol for 72h; Heating; Yield given;
(1R)-2-ethoxy-1-methyl-2-oxoethyl 4-nitrobenzoate
90246-32-5

(1R)-2-ethoxy-1-methyl-2-oxoethyl 4-nitrobenzoate

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
With potassium carbonate In ethanol at 23℃; for 15h;
ethanol
64-17-5

ethanol

(R)-Methyl lactate
17392-83-5

(R)-Methyl lactate

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 30h; Heating; Yield given;
ethyl 2-hydroxypropionate
97-64-3, 2676-33-7

ethyl 2-hydroxypropionate

(R)-(1-naphthyl)-glycyl-(R)-phenylglycine
160289-70-3

(R)-(1-naphthyl)-glycyl-(R)-phenylglycine

A

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

B

(R)-((R)-2-Amino-2-naphthalen-1-yl-acetylamino)-phenyl-acetic acid; compound with (S)-2-hydroxy-propionic acid ethyl ester

(R)-((R)-2-Amino-2-naphthalen-1-yl-acetylamino)-phenyl-acetic acid; compound with (S)-2-hydroxy-propionic acid ethyl ester

C

(R)-((R)-2-Amino-2-naphthalen-1-yl-acetylamino)-phenyl-acetic acid; compound with (R)-2-hydroxy-propionic acid ethyl ester

(R)-((R)-2-Amino-2-naphthalen-1-yl-acetylamino)-phenyl-acetic acid; compound with (R)-2-hydroxy-propionic acid ethyl ester

Conditions
ConditionsYield
In methanol Ambient temperature; Yield given; Title compound not separated from byproducts;
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

water
7732-18-5

water

Ag2O

Ag2O

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
anschliessende Veresterung;
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

acetone
67-64-1

acetone

Ag2O

Ag2O

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
anschliessende Veresterung;
ethanol
64-17-5

ethanol

calcium salt of/the/ d(-)-lactic acid

calcium salt of/the/ d(-)-lactic acid

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
With sulfuric acid
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

silver nitrate

silver nitrate

diluted HNO3

diluted HNO3

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
at 50℃; anschliessende Veresterung;
ethyl iodide
75-03-6

ethyl iodide

silver salt of/the/ l-lactic acid

silver salt of/the/ l-lactic acid

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

ethyl ester of p-toluenesulfonic acid
80-40-0

ethyl ester of p-toluenesulfonic acid

sodium salt of/the/ d(-)-lactic acid

sodium salt of/the/ d(-)-lactic acid

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
With ethanol
ethanol
64-17-5

ethanol

zinc ammonium salt of/the/ d(-)-lactic acid

zinc ammonium salt of/the/ d(-)-lactic acid

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
With sulfuric acid
(S)-Ethyl lactate
687-47-8

(S)-Ethyl lactate

A

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

B

inactive lactic acid ethyl ester

inactive lactic acid ethyl ester

Conditions
ConditionsYield
durch Schweineleber-Lipase schneller gespalten;
ethanol
64-17-5

ethanol

l(-)-p-toluenesulfonyl-lactic acid ethyl ester

l(-)-p-toluenesulfonyl-lactic acid ethyl ester

A

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

B

levorotatory O-ethyllactic acid ethyl ester

levorotatory O-ethyllactic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate
(R)-2-bromo-propionic acid ; sodium salt
56985-74-1, 112449-57-7, 112529-73-4

(R)-2-bromo-propionic acid ; sodium salt

Ag2O

Ag2O

water

water

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
at 0℃; anschliessende Veresterung sowie Hydrolyse-geschwindigkeiten;
2-oxo-propionic acid ethyl ester
617-35-6

2-oxo-propionic acid ethyl ester

methanol
67-56-1

methanol

A

methyl lactate
547-64-8

methyl lactate

B

(S)-Ethyl lactate
687-47-8

(S)-Ethyl lactate

C

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
With hydrogen; chiral Ru complex at 20℃; under 25857.4 Torr; for 48h; Product distribution; Further Variations:; Catalysts; Temperatures; Solvents;
ethanol
64-17-5

ethanol

3,6-dimethyl-1,4-dioxane-2,5-dione

3,6-dimethyl-1,4-dioxane-2,5-dione

A

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

B

(S)-2-hydroxy-propionic acid (S)- 1-ethoxycarbonyl-ethyl ester
64231-47-6

(S)-2-hydroxy-propionic acid (S)- 1-ethoxycarbonyl-ethyl ester

Conditions
ConditionsYield
With Candida antarctica lipase B In tetrahydrofuran; hexane at 60℃; for 66h;A 49 % Chromat.
B 48 % Chromat.
(S)-Ethyl lactate
687-47-8

(S)-Ethyl lactate

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) Ph3P, diethyl azodicarboxylate / 2) THF, -20 deg C, 0.5 h, 2) THF, 27 h
2: K2CO3 / ethanol / 15 h / 23 °C
View Scheme
Multi-step reaction with 3 steps
1: 87 percent / pyridine / 3 h / 0 - 10 °C
2: 85 percent / dimethylsulfoxide / 12 h
3: 4-toluenesulfonic acid / ethanol / 72 h / Heating
View Scheme
ethyl (S)-2-[[(4-methylphenyl)sulfonyl]oxy]propanoate
57057-80-4

ethyl (S)-2-[[(4-methylphenyl)sulfonyl]oxy]propanoate

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / dimethylsulfoxide / 12 h
2: 4-toluenesulfonic acid / ethanol / 72 h / Heating
View Scheme
(S)-ethyl 2-(methylsulfonyloxy)propanoate
63696-99-1

(S)-ethyl 2-(methylsulfonyloxy)propanoate

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / Amberlyst A-26 NO3(1-) form / pentane / 5 h / 120 °C
2: Zn, CH3COOH
View Scheme
C18H20O3

C18H20O3

A

(S)-Ethyl lactate
687-47-8

(S)-Ethyl lactate

B

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

Conditions
ConditionsYield
With methanol; toluene-4-sulfonic acid Inert atmosphere; optical yield given as %ee;
With toluene-4-sulfonic acid In methanol Inert atmosphere; optical yield given as %ee;
2-oxo-propionic acid ethyl ester
617-35-6

2-oxo-propionic acid ethyl ester

methyl 2-oxo-2-phenylacetate
15206-55-0

methyl 2-oxo-2-phenylacetate

A

(S)-Ethyl lactate
687-47-8

(S)-Ethyl lactate

B

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

C

(S)-Methyl mandelate
21210-43-5

(S)-Methyl mandelate

D

(R)-methyl mandelate
20698-91-3

(R)-methyl mandelate

Conditions
ConditionsYield
With 5% Pt/Al2O3; hydrogen; acetic acid In toluene at 19.84℃; under 30003 Torr;
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

(R)-ethyl 2-((tert-butyldimethylsilyl)oxy)propanoate

(R)-ethyl 2-((tert-butyldimethylsilyl)oxy)propanoate

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane99%
With 1H-imidazole In dichloromethane at 0 - 20℃; for 3h;99%
With 1H-imidazole In dichloromethane at 20℃; for 4h; Inert atmosphere;96%
With 1H-imidazole In N,N-dimethyl-formamide at 25℃; Etherification;
With 1H-imidazole In dichloromethane at 0 - 20℃; for 5h;
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

3,5-dibenzyloxybenzoic acid
28917-43-3

3,5-dibenzyloxybenzoic acid

(S)-1-ethoxy-1-oxopropan-2-yl 3,5-bis(benzyloxy)benzoate

(S)-1-ethoxy-1-oxopropan-2-yl 3,5-bis(benzyloxy)benzoate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 3h; Inert atmosphere;99%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

ethyl iodide
75-03-6

ethyl iodide

ethyl (R)-2-ethoxypropanoate
869588-04-5

ethyl (R)-2-ethoxypropanoate

Conditions
ConditionsYield
With silver(l) oxide In diethyl ether at 23 - 42℃; Williamson Ether Synthesis; Reflux;98%
With silver(l) oxide
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

(2R)-propane-1,2-diol
4254-14-2

(2R)-propane-1,2-diol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether for 0.5h; Heating;97%
With sodium tetrahydroborate; aluminium trichloride
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

(S)-ethyl 2-(methylsulfonyloxy)propanoate
63696-99-1

(S)-ethyl 2-(methylsulfonyloxy)propanoate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃;95%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

6-methoxy-1-naphthoic acid
36112-61-5

6-methoxy-1-naphthoic acid

(R)-[1-ethoxy-1-carbonylpropan-2-yl]-6-methoxy-1-naphthoic acid ester

(R)-[1-ethoxy-1-carbonylpropan-2-yl]-6-methoxy-1-naphthoic acid ester

Conditions
ConditionsYield
Stage #1: 6-methoxy-1-naphthoic acid With thionyl chloride In N,N-dimethyl-formamide; toluene at 10 - 40℃; for 4h; Green chemistry;
Stage #2: (R)-Ethyl lactate With triethylamine In toluene at 10 - 20℃; for 2h; Green chemistry;
92%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

phenol
108-95-2

phenol

(R)-2-phenoxypropionic acid ethyl ester
76671-56-2

(R)-2-phenoxypropionic acid ethyl ester

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at 0 - 20℃; Mitsunobu reaction; Inert atmosphere;91%
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran Mitsunobu Displacement;
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

triisopropylsilyl chloride
13154-24-0

triisopropylsilyl chloride

ethyl (R)-2-((triisopropylsilyl)oxy)propanoate

ethyl (R)-2-((triisopropylsilyl)oxy)propanoate

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 12h; Inert atmosphere;91%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

recorcinol
108-46-3

recorcinol

diethyl (2R,2'R)-2,2'-(1,3-phenylene)bis(oxy)dipropanoate

diethyl (2R,2'R)-2,2'-(1,3-phenylene)bis(oxy)dipropanoate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at 0 - 20℃; Mitsunobu reaction; Inert atmosphere;90%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

O-diphenylmethyl 2,2,2-trichloroacetimidate
100865-93-8

O-diphenylmethyl 2,2,2-trichloroacetimidate

(R)-ethyl 2-(benzhydryloxy)propanoate

(R)-ethyl 2-(benzhydryloxy)propanoate

Conditions
ConditionsYield
In toluene at 111℃;90%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

1-naphthalenecarboxylic acid
86-55-5

1-naphthalenecarboxylic acid

(R)-[1-ethoxy-1-carbonylpropan-2-yl]-1-naphthoic acid ester

(R)-[1-ethoxy-1-carbonylpropan-2-yl]-1-naphthoic acid ester

Conditions
ConditionsYield
Stage #1: 1-naphthalenecarboxylic acid With thionyl chloride In N,N-dimethyl-formamide; toluene at 10 - 40℃; for 4h; Green chemistry;
Stage #2: (R)-Ethyl lactate With triethylamine In toluene at 10 - 20℃; for 2h; Green chemistry;
90%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

2-iodoresorcinol
41046-67-7

2-iodoresorcinol

(2R,2'R)-diethyl 2,2'-(2-iodo-1,3-phenylene)bis(oxy)dipropanoate
1226896-32-7

(2R,2'R)-diethyl 2,2'-(2-iodo-1,3-phenylene)bis(oxy)dipropanoate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at 0 - 20℃; for 6h;90%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

ethyl (S)-lactate triflate
84028-88-6

ethyl (S)-lactate triflate

R,R-dilactic acid diethyl ester
171753-75-6

R,R-dilactic acid diethyl ester

Conditions
ConditionsYield
With potassium carbonate In 1,2-dichloro-ethane; pentane at 20℃; for 24h;89%
With potassium carbonate In 1,2-dichloro-ethane; pentane at 20℃; for 48h; Inert atmosphere;20%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

N-(4-methoxybenzyl)-2-nitro-N-(prop-2-yn-1-yl)benzenesulfonamide
171414-16-7

N-(4-methoxybenzyl)-2-nitro-N-(prop-2-yn-1-yl)benzenesulfonamide

(R)-2-[(4-Methoxy-benzyl)-(2-nitro-benzenesulfonyl)-amino]-propionic acid ethyl ester

(R)-2-[(4-Methoxy-benzyl)-(2-nitro-benzenesulfonyl)-amino]-propionic acid ethyl ester

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In dichloromethane at 23℃; for 1h;87%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

1-bromo-octane
111-83-1

1-bromo-octane

(2R)-3-octylundecane-2,3-diol
103117-91-5

(2R)-3-octylundecane-2,3-diol

Conditions
ConditionsYield
With magnesium In tetrahydrofuran for 1.5h; Ambient temperature;86%
O-methylresorcine
150-19-6

O-methylresorcine

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

ethyl (R)-2-(3-methoxyphenoxy)propanoate

ethyl (R)-2-(3-methoxyphenoxy)propanoate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at 0 - 20℃; Mitsunobu reaction; Inert atmosphere;86%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

(-)-ethyl 2-<(p-tolylsulfonyl)oxy>propionate
117589-34-1

(-)-ethyl 2-<(p-tolylsulfonyl)oxy>propionate

Conditions
ConditionsYield
With triethylamine In benzene for 6h; Ambient temperature;85.1%
With pyridine Substitution;85%
Stage #1: (R)-Ethyl lactate; p-toluenesulfonyl chloride In dichloromethane at 0 - 10℃; for 0.166667h; Inert atmosphere;
Stage #2: With triethylamine In dichloromethane at 20℃; for 4h; Cooling;
85.1%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

2-(benzyloxy)-4-bromophenol

2-(benzyloxy)-4-bromophenol

(2S)-methyl 2-(2-(benzyloxy)-4-bromophenoxy)propanoate

(2S)-methyl 2-(2-(benzyloxy)-4-bromophenoxy)propanoate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 4h; Mitsunobu Displacement; Inert atmosphere;85%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

2,4-dichlorophenol
120-83-2

2,4-dichlorophenol

(R)-2-(2,4-Dichlorphenoxy)propionsaeure-ethylester
66423-06-1

(R)-2-(2,4-Dichlorphenoxy)propionsaeure-ethylester

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 16h; Mitsunobu Displacement;84%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran Mitsunobu reaction;
4-methyleneoxetan-2-one
674-82-8

4-methyleneoxetan-2-one

(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

(R)-1-ethoxy-1-oxopropan-2-yl 3-oxobutanoate
143444-49-9

(R)-1-ethoxy-1-oxopropan-2-yl 3-oxobutanoate

Conditions
ConditionsYield
With triethylamine In dichloromethane for 15h; Heating;81%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

4-nitro-benzoic acid
62-23-7

4-nitro-benzoic acid

ethyl (S)-2-((4-nitrobenzoyl)oxy)propanoate

ethyl (S)-2-((4-nitrobenzoyl)oxy)propanoate

Conditions
ConditionsYield
With PPh3-containing polystyrene non-cross-linked polymer; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 0.5h; Mitsunobu reaction;80%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

1-chloro-N-(2,6-dichlorophenyl)methanesulfonamide

1-chloro-N-(2,6-dichlorophenyl)methanesulfonamide

ethyl (2S)-2-[2,6-dichloro-N-(chloromethylsulfonyl)anilino]propanoate

ethyl (2S)-2-[2,6-dichloro-N-(chloromethylsulfonyl)anilino]propanoate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃;79%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

(R)-1-ethoxy-1-oxopropane-2-yl 4-chlorobenzoate
1259030-71-1

(R)-1-ethoxy-1-oxopropane-2-yl 4-chlorobenzoate

Conditions
ConditionsYield
With C18H20N2O4; Nb-TPP In tetrahydrofuran at 0 - 20℃; Mitsunobu reaction;76%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

4-nitro-benzoic acid
62-23-7

4-nitro-benzoic acid

(1R)-2-ethoxy-1-methyl-2-oxoethyl 4-nitrobenzoate
90246-32-5

(1R)-2-ethoxy-1-methyl-2-oxoethyl 4-nitrobenzoate

Conditions
ConditionsYield
With C18H20N2O4; Nb-TPP In tetrahydrofuran at 0 - 20℃; Mitsunobu reaction;74%
With 1-phenylphospholane-1-oxide; di-isopropyl azodicarboxylate; phenylsilane In tetrahydrofuran at 80℃; for 18h; Mitsunobu Displacement; Sealed tube;68%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

(S)-ethyl 2-(2-hydroxyphenoxy)propanoate

(S)-ethyl 2-(2-hydroxyphenoxy)propanoate

C16H22O6

C16H22O6

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In toluene at 0 - 20℃; Mitsunobu Displacement;74%
(R)-Ethyl lactate
7699-00-5

(R)-Ethyl lactate

3-(dimethylamino)benzoic acid
99-64-9

3-(dimethylamino)benzoic acid

(R)-1-ethoxy-1-oxopropan-2-yl 3-(dimethylamino)benzoate
1259030-70-0

(R)-1-ethoxy-1-oxopropan-2-yl 3-(dimethylamino)benzoate

Conditions
ConditionsYield
With C18H20N2O4; Nb-TPP In tetrahydrofuran at 0 - 20℃; Mitsunobu reaction;73%

Propanoicacid, 2-hydroxy-, ethyl ester, (2R)- Specification

The Propanoicacid, 2-hydroxy-, ethyl ester, (2R)-, with the CAS registry number 7699-00-5, has the systematic name of ethyl 2-hydroxypropanoate. It belongs to the product category of Acetyl Group. And the molecular formula of the chemical is C5H10O3.

The characteristics of Propanoicacid, 2-hydroxy-, ethyl ester, (2R)- are as followings: (1)# of Rule of 5 Violations: 0; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 18.84; (5)ACD/KOC (pH 7.4): 18.84; (6)#H bond acceptors: 3; (7)#H bond donors: 1; (8)#Freely Rotating Bonds: 4; (9)Polar Surface Area: 46.53 Å2; (10)Index of Refraction: 1.42; (11)Molar Refractivity: 28.48 cm3; (12)Molar Volume: 112.4 cm3; (13)Polarizability: 11.29×10-24cm3; (14)Surface Tension: 33.2 dyne/cm; (15)Density: 1.05 g/cm3; (16)Flash Point: 54.6 °C; (17)Enthalpy of Vaporization: 45.57 kJ/mol; (18)Boiling Point: 154.5 °C at 760 mmHg; (19)Vapour Pressure: 1.16 mmHg at 25°C.

You should be cautious while dealing with this chemical. It is a kind of flammable chemical which irritates to respiratory system. What's more, it has risk of serious damage to eyes. Therefore, you had better take the following instructions: Avoid contact with skin; Wear eye/face protection, and if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: CCOC(=O)C(C)O
(2)InChI: InChI=1/C5H10O3/c1-3-8-5(7)4(2)6/h4,6H,3H2,1-2H3
(3)InChIKey: LZCLXQDLBQLTDK-UHFFFAOYAV

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