Pyrazine-2-carbaldehyde supplier

Name
Pyrazine-2-carbaldehyde
EINECS
CAS No. 5780-66-5
Article Data30
CAS DataBase
Density 1.235 g/cm³
Solubility
Melting Point
Formula C₅H₄N₂O
Boiling Point 192.079 °C at 760 mmHg
Molecular Weight 108.1
Flash Point 70.501 °C
Transport Information
Appearance
Safety 26-36/37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Pyrazinecarboxaldehyde(7CI,8CI,9CI);2-Formylpyrazine;2-Pyrazinecarboxaldehyde;
PSA 42.85000
LogP 0.28910

Synthetic route

: 6164-79-0
methyl pyrazine-2-carboxylate

: 5780-66-5
pyrazinecarboxaldehyde

Conditions

Conditions	Yield
Stage #1: methyl pyrazine-2-carboxylate With lithium aluminium tetrahydride In tetrahydrofuran at -78 - 72℃; for 0.333333h; Stage #2: With hydrogenchloride; water	100%
With lithium aluminium tetrahydride In tetrahydrofuran at -83℃; for 2h;	68%
With lithium aluminium tetrahydride In tetrahydrofuran at -78℃; for 1.83333h; Inert atmosphere; Schlenk technique;	53.4%

: 2-formalpyrazine

: 5780-66-5
pyrazinecarboxaldehyde

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium acetate In ethanol at 50℃; for 2h; Temperature;	96.8%

: 123-32-0
2,5-dimethyl-pyrazine

A: 77666-94-5
2,5-pyrazine-dicarboxaldehyde

B: 50866-30-3
5-methyl-2-pyrazinecarboxaldehyde

C: 5780-66-5
pyrazinecarboxaldehyde

Conditions

Conditions	Yield
With air; vanadia; molybdenum(VI) oxide In water for 2.77778E-05h; Product distribution; different ratio of V:Mo, different temperature, different time of contact;	A 10% B 21% C n/a
With air; vanadia; molybdenum(VI) oxide In water at 360℃; for 2.77778E-05h;	A 10% B 21% C n/a

...Expand

: 109-08-0
2-Methylpyrazine

: 5780-66-5
pyrazinecarboxaldehyde

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; selenium(IV) oxide In 1,4-dioxane for 3h; Heating;	11%

: 6705-33-5
pyrazin-2-ylmethanol

: 5780-66-5
pyrazinecarboxaldehyde

Conditions

Conditions	Yield
With selenium(IV) oxide In 1,4-dioxane Heating;
With manganese(IV) oxide In acetone Sonication;
With Dess-Martin periodane In dichloromethane at 20℃; for 1h;	100 mg
With 2,2'-azinobis(3-ethylbenzthiazolinesulfonate); horse-radish peroxidase; choline oxidase from Arthrobacter cholorphenolicus, mutant S101A/D250G/F253R/V355T/F357R/M359R In aq. phosphate buffer at 30℃; for 24h; pH=8; Catalytic behavior; Reagent/catalyst; Enzymatic reaction;

: 109-08-0
2-Methylpyrazine

A: 5780-66-5
pyrazinecarboxaldehyde

B carbon oxides: carbon oxides

Conditions

Conditions	Yield
β-VO(PO3)2 In gas at 400℃; Product distribution; Rate constant; selectivity of reaction, rates of partial and total oxidation;

: 98-97-5
2-pyrazylcarboxylic acid

: 5780-66-5
pyrazinecarboxaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / conc. H2SO4 / 48 h / Heating 2: 26 percent / DIBAL / CH2Cl2 View Scheme

: 67936-72-5
pyrazine carboxaldehyde diethyl acetal

: 593-56-6
N-methoxylamine hydrochloride

: 5780-66-5
pyrazinecarboxaldehyde

Conditions

Conditions	Yield
With sodium hydrogencarbonate In chloroform; Petroleum ether

: 109-08-0
2-Methylpyrazine

A: 25594-37-0
2-methylpyrazine 4-oxide

B: 31396-35-7
2-methylpyrazine 1-oxide

C: 98-97-5
2-pyrazylcarboxylic acid

D: 5780-66-5
pyrazinecarboxaldehyde

E: 874-54-4
pyrazine-2-carboxylic acid-4-oxide

F: 32046-09-6
pyrazine-2-carboxylic acid-1-oxide

Conditions

Conditions	Yield
With acetyl peroxyborate In water at 94.84℃; for 5h;	A n/a B n/a C 56.3 mol % D 4.5 mol % E n/a F n/a
With acetyl peroxyborate In water at 94.84℃; for 5h;	A n/a B n/a C 28.5 mol % D 41.2 mol % E n/a F n/a

...Expand

: 109-08-0
2-Methylpyrazine

: 64-19-7
acetic acid

A: 73763-94-7
acetate de (pyrazinyl-2) methyle

B: 5780-66-5
pyrazinecarboxaldehyde

Conditions

Conditions	Yield
With copper(l) iodide; oxygen; palladium diacetate at 120℃; for 24h; Autoclave;

...Expand

: 107-15-3
ethylenediamine

: 56-81-5
glycerol

A: 290-37-9
1,4-pyrazine

B: 109-08-0
2-Methylpyrazine

C: 123-32-0
2,5-dimethyl-pyrazine

D: 5910-89-4
2,3-dimethylpyrazine

E: 5780-66-5
pyrazinecarboxaldehyde

Conditions

Conditions	Yield
With calcined ZnO-ZnCr2O4 catalyst In water at 300 - 400℃; under 760.051 Torr;

...Expand

: 107-15-3
ethylenediamine

: 56-81-5
glycerol

A: 290-37-9
1,4-pyrazine

B: 109-08-0
2-Methylpyrazine

C: 123-32-0
2,5-dimethyl-pyrazine

D: 5910-89-4
2,3-dimethylpyrazine

E: 6705-33-5
pyrazin-2-ylmethanol

F: 108-50-9
2,6-dimethylpyrazine

G: 5780-66-5
pyrazinecarboxaldehyde

Conditions

Conditions	Yield
In water at 375℃; under 760.051 Torr; for 6h; Inert atmosphere; Flow reactor;

...Expand

: 5780-66-5
pyrazinecarboxaldehyde

: 20010-99-5
2-aminomethylpyrazine

: (E)-1-(pyrazin-2-yl)-N-(pyrazin-2-ylmethyl)methanimine

Conditions

Conditions	Yield
Stage #1: pyrazinecarboxaldehyde; 2-aminomethylpyrazine In dichloromethane for 0.0833333h; Inert atmosphere; Stage #2: With sodium sulfate In dichloromethane at 20℃; for 0.75h; Inert atmosphere; Darkness;	100%

: 50598-92-0, 132839-80-6
(E)-(2-nitrovinyl)cyclohexane

: 5780-66-5
pyrazinecarboxaldehyde

: 1175052-23-9
(S)-2-cyclohexyl-3-nitro-1-(pyrazin-2-yl)propan-1-one

Conditions

Conditions	Yield
With (5R,7R)-7-fluoro-5-isopropyl-2-(perfluorophenyl)-6,7-dihydro-5H-pyrrolo[2,1c][1,2,4]triazol-2-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In methanol at 0℃; Stetter reaction; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 75-52-5
nitromethane

: 5780-66-5
pyrazinecarboxaldehyde

: 854928-19-1
2-nitro-1-pyrazin-2-yl-ethanol

Conditions

Conditions	Yield
With triethylamine at 20℃; for 1h;	93.3%
With potassium tert-butylate In tetrahydrofuran at 0 - 5℃; for 0.25h;	64%

: 5780-66-5
pyrazinecarboxaldehyde

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1402710-03-5
tert-butyl 4-(pyrazin-2-ylmethyl)piperazine-1-carboxylate

Conditions

Conditions	Yield
With sodium triacetoxy borohydride; acetic acid In dichloromethane at 20℃; for 6.5h;	91%

: 5780-66-5
pyrazinecarboxaldehyde

: 111781-48-7
2-(difluoromethyl)pyrazine

Conditions

Conditions	Yield
With XtalFluor-E; triethylamine tris(hydrogen fluoride) In dichloromethane at 20℃;	90%
With (diethylamido)sulfur trifluoride In trichlorofluoromethane at 20℃;	39%

: 5780-66-5
pyrazinecarboxaldehyde

: 1576-35-8
toluene-4-sulfonic acid hydrazide

: 4-methyl-N'-(pyrazin-2-ylmethylene)benzenesulfonohydrazide

Conditions

Conditions	Yield
In methanol at 60℃; for 0.5h;	90%

: 3731-51-9
(2-aminomethylpyridine)

: 5780-66-5
pyrazinecarboxaldehyde

: 1084898-22-5
(2-picolyl)-(pyrazin-2-yl-methyl)amine

Conditions

Conditions	Yield
Stage #1: 2-(Aminomethyl)pyridine; pyrazinecarboxaldehyde In methanol at 25℃; for 0.5h; Stage #2: With sodium tetrahydroborate In methanol at 25℃; for 2h;	90%

: 84689-36-1
3-methoxy-2-methylquinoline

: 5780-66-5
pyrazinecarboxaldehyde

: C16H13N3O

Conditions

Conditions	Yield
With toluene-4-sulfonamide In toluene at 120℃; for 12h; Inert atmosphere;	89%

: 3033-80-5
8-methoxy-2-methylquinoline

: 5780-66-5
pyrazinecarboxaldehyde

: C16H13N3O

Conditions

Conditions	Yield
With toluene-4-sulfonamide In toluene at 120℃; for 12h; Inert atmosphere;	87%

: 870-46-2
t-butoxycarbonylhydrazine

: 5780-66-5
pyrazinecarboxaldehyde

: tert-butyl N-[(E)-pyrazin-2-ylmethyleneamino]carbamate

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 16h;	87%

: 88-14-2
2-furanoic acid

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 769-92-6
4-tert-Butylaniline

: 5780-66-5
pyrazinecarboxaldehyde

: 1417700-04-9
N-tert-butyl-2-[N-(4-tert-butylphenyl)-1-(furan-2-yl)formamido]-2-(pyrazin-2-yl)acetamide

Conditions

Conditions	Yield
Stage #1: 4-tert-Butylaniline; pyrazinecarboxaldehyde In methanol at 20℃; for 0.5h; Ugi Condensation; Inert atmosphere; Stage #2: 2-furanoic acid; tert-butylisonitrile In methanol at 20℃; Ugi Condensation; Inert atmosphere;	86%
In methanol at 20℃; for 16h; Ugi Condensation;

...Expand

: 1078-28-0
6-methoxyquinaldine

: 5780-66-5
pyrazinecarboxaldehyde

: C16H13N3O

Conditions

Conditions	Yield
With toluene-4-sulfonamide In toluene at 120℃; for 12h; Inert atmosphere;	85%

: 31835-53-7
4-methoxy-2-methyl-quinoline

: 5780-66-5
pyrazinecarboxaldehyde

: C16H13N3O

Conditions

Conditions	Yield
With toluene-4-sulfonamide In toluene at 120℃; for 12h; Inert atmosphere;	83%

: 88-14-2
2-furanoic acid

: 92-67-1
4-Aminobiphenyl

: 17329-20-3, 21872-32-2, 21872-33-3, 42412-74-8
(S)-1-isocyano-1-phenylethane

: 5780-66-5
pyrazinecarboxaldehyde

: 2-(N-{[1,1′-biphenyl]-4-yl}-1-(furan-2-yl)formamido)-N-[(1S)1-phenylethyl]-2-(pyrazin-2-yl)acetamide

Conditions

Conditions	Yield
Stage #1: 4-phenylalanine; pyrazinecarboxaldehyde In methanol at 20℃; for 0.5h; Ugi Condensation; Inert atmosphere; Stage #2: 2-furanoic acid; (S)-1-isocyano-1-phenylethane In methanol at 20℃; Ugi Condensation; Inert atmosphere;	83%

...Expand

: 873692-91-2
[2-(3-bromo-benzo[b]thiophen-2-yl)-ethyl]dimethyl-amine

: 5780-66-5
pyrazinecarboxaldehyde

: 76-05-1
trifluoroacetic acid

: 1186219-29-3
[2-(2-dimethylamino-ethyl)-benzo[b]thiophen-3-yl]-pyrazin-2-yl-methanol trifluoroacetate

Conditions

Conditions	Yield
Stage #1: [2-(3-bromo-benzo[b]thiophen-2-yl)-ethyl]dimethyl-amine With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In hexane; toluene at -78℃; Stage #2: pyrazinecarboxaldehyde In hexane; toluene at -78 - 0℃; Stage #3: trifluoroacetic acid In water; acetonitrile	82%

...Expand

: 79205-04-2
5-methoxy-2-methylquinoline

: 5780-66-5
pyrazinecarboxaldehyde

: C16H13N3O

Conditions

Conditions	Yield
With toluene-4-sulfonamide In toluene at 120℃; for 12h; Inert atmosphere;	82%

: 6-bromoquinoline-2,4-diol

: 5780-66-5
pyrazinecarboxaldehyde

: 6-bromo-3-(pyrazin-2-ylmethyl)quinoline-2,4-diol

Conditions

Conditions	Yield
With pyridine; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate at 100℃; for 4h; Knoevenagel Condensation;	82%

: 19490-87-0
7-methoxy-2-methylquinoline

: 5780-66-5
pyrazinecarboxaldehyde

: C16H13N3O

Conditions

Conditions	Yield
With toluene-4-sulfonamide In toluene at 120℃; for 12h; Inert atmosphere;	80%

: 5780-66-5
pyrazinecarboxaldehyde

: 108-59-8
malonic acid dimethyl ester

: dimethyl 2-(pyrazin-2-ylmethylene)malonate

Conditions

Conditions	Yield
With piperidine; acetic acid In toluene at 110℃; for 18h; Inert atmosphere; Schlenk technique; Sealed tube;	80%

: 1560-54-9
allyltriphenylphosphonium bromide

: 5780-66-5
pyrazinecarboxaldehyde

: 2-(buta-1,3-dien-1-yl)pyrazine

Conditions

Conditions	Yield
Stage #1: allyltriphenylphosphonium bromide In tetrahydrofuran; hexane at 0℃; for 0.25h; Inert atmosphere; Stage #2: pyrazinecarboxaldehyde In tetrahydrofuran; hexane for 1h; Inert atmosphere;	79%

: 5780-66-5
pyrazinecarboxaldehyde

: 100-46-9
benzylamine

: C12H13N3

Conditions

Conditions	Yield
With sodium cyanoborohydride; acetic acid at 100℃; for 14h; Flow reactor;	76%

: 1080061-14-8
4-[3-fluoro-4-(methylsulfanyl)phenyl]-5-(tetrahydro-2H-pyran-4-yl)pent-1-en-3-one

: 5780-66-5
pyrazinecarboxaldehyde

: 1080061-16-0
5-[3-fluoro-4-(methylsulfanyl)phenyl]-1-(pyrazin-2-yl)-6-(tetrahydro-2H-pyran-4-yl)hexane-1,4-dione

Conditions

Conditions	Yield
With 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; triethylamine In ethanol for 2h; Reflux;	75%

: 5780-66-5
pyrazinecarboxaldehyde

: 93691-18-0
1,2-di(pyrazin-2-yl)ethene-1,2-diol

Conditions

Conditions	Yield
With potassium cyanide In water at 20℃; for 1h;	73%

: 100-59-4
phenylmagnesium chloride

: 5780-66-5
pyrazinecarboxaldehyde

: 98792-43-9
(α-hydroxybenzyl)pyrazine

Conditions

Conditions	Yield
In tetrahydrofuran at -78 - 20℃; for 0.25h;	73%

: 5780-66-5
pyrazinecarboxaldehyde

: 196929-78-9
(R)-2-methylpropane-2-sulfinamide

: 1421236-66-9
(R,E)-2-methyl-N-(pyrazin-2-ylmethylene)propane-2-sulfinamide

Conditions

Conditions	Yield
With caesium carbonate In dichloromethane at 20℃; Inert atmosphere;	72%

: 101-77-9
4,4'-diamino diphenyl methane

: 5780-66-5
pyrazinecarboxaldehyde

: C22H17N7

Conditions

Conditions	Yield
In ethanol at 20℃; for 24h;	71%

: 5718-83-2
rhodanine 3-acetic acid

: 5780-66-5
pyrazinecarboxaldehyde

: [(5Z)-4-oxo-5-(pyrazin-2-ylmethylene)-2-thioxo-1,3-thiazolidin-3-yl]acetic acid

Conditions

Conditions	Yield
With sodium acetate; acetic anhydride; acetic acid for 3h; Reflux;	71%

Pyrazine-2-carbaldehyde Chemical Properties

Molecule structure of 2-Pyrazinecarboxaldehyde (CAS NO.5780-66-5):

Molecular Weight: 108.0981 g/mol
Molecular Formula: C₅H₄N₂O
Density: 1.234 g/cm³
Boiling Point: 192.1 °C at 760 mmHg
Flash Point: 70.5 °C
Index of Refraction: 1.581
Molar Refractivity: 29.18 cm³
Molar Volume: 87.5 cm³
Polarizability: 11.57×10^-24 cm³
Surface Tension: 57 dyne/cm
Enthalpy of Vaporization: 42.83 kJ/mol
Vapour Pressure: 0.498 mmHg at 25 °C
InChI: InChI=1/C5H4N2O/c8-4-5-3-6-1-2-7-5/h1-4H
InChIKey: DXBWJLDFSICTIH-UHFFFAOYAA
Product Categories of 2-Pyrazinecarboxaldehyde (CAS NO.5780-66-5): Heterocycles; Aldehydes; Pyrazines, Pyrimidines & Pyridazines; Pyrazines, Pyrimidines & Pyridazines

Pyrazine-2-carbaldehyde Safety Profile

Hazard Codes: Irritant Xi

Pyrazine-2-carbaldehyde Specification

2-Pyrazinecarboxaldehyde (CAS NO.5780-66-5) is also named as Pyrazin-2-carbaldehyd ; Pyrazine-2-carbaldehyde .

Product Name

Pyrazine-2-carbaldehyde

Synthetic route

Pyrazine-2-carbaldehyde Chemical Properties

Pyrazine-2-carbaldehyde Safety Profile

Pyrazine-2-carbaldehyde Specification

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