Product Name

  • Name

    Pyrrole

  • EINECS 203-724-7
  • CAS No. 109-97-7
  • Article Data203
  • CAS DataBase
  • Density 0.99 g/cm3
  • Solubility 60 g/L (20 °C) in water
  • Melting Point -23 °C
  • Formula C4H5N
  • Boiling Point 129.76 °C at 760 mmHg
  • Molecular Weight 67.0904
  • Flash Point 33.333 °C
  • Transport Information UN 1993
  • Appearance colourless to brown liquid with chloroform odour
  • Safety 26-37/39-45-39-24-16
  • Risk Codes 10-20-25-41
  • Molecular Structure Molecular Structure of 109-97-7 (Pyrrole)
  • Hazard Symbols ToxicT
  • Synonyms Pyrrole(8CI);1-Aza-2,4-cyclopentadiene;Azole;Divinylenimine;Imidole;Monopyrrole;NSC 62777;Pyrrol;1H-Pyrrole;
  • PSA 15.79000
  • LogP 1.01470

Synthetic route

diethyl 2,6-dimethyl-4-(1H-pyrrol-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate
53219-31-1

diethyl 2,6-dimethyl-4-(1H-pyrrol-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate

A

pyrrole
109-97-7

pyrrole

B

2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester
1149-24-2

2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 1h; Heating;A n/a
B 100%
2,2-dimethyl-1-pyrrol-1-yl-propan-1-ol

2,2-dimethyl-1-pyrrol-1-yl-propan-1-ol

A

pyrrole
109-97-7

pyrrole

B

pivalaldehyde
630-19-3

pivalaldehyde

Conditions
ConditionsYield
With sodium methylate In tetrahydrofuran at 20℃; for 12h; Product distribution; Further Variations:; Reagents; reaction time;A n/a
B 100%
N-p-toluenesulfonylpyrrole
17639-64-4

N-p-toluenesulfonylpyrrole

pyrrole
109-97-7

pyrrole

Conditions
ConditionsYield
With potassium tert-butylate In dimethyl sulfoxide at 20℃; for 1h; Inert atmosphere; Darkness; Schlenk technique;99%
With 3,6‐di‐tert‐butyl‐9‐mesityl‐10‐phenylacridin‐10‐ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In water; acetonitrile for 20h; Irradiation;70 %Spectr.
N,N-dimethyl-1H-pyrrol-1-amine
78307-76-3

N,N-dimethyl-1H-pyrrol-1-amine

pyrrole
109-97-7

pyrrole

Conditions
ConditionsYield
at 850℃; under 0.032 - 0.073 Torr; for 0.316667h; Temperature; Pressure;99%
1-(tert-butyldimethylsilyl)-1H-pyrrole
103872-45-3

1-(tert-butyldimethylsilyl)-1H-pyrrole

pyrrole
109-97-7

pyrrole

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran for 0.0166667h; Ambient temperature; deprotection;94%
(4-methoxy-phenyl)-pyrrol-1-yl-methanol

(4-methoxy-phenyl)-pyrrol-1-yl-methanol

A

pyrrole
109-97-7

pyrrole

B

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃; for 12h; Product distribution; Further Variations:; Reagents;A n/a
B 93%
N-(1-hydroxy-1-benzyl)pyrrole
86734-19-2

N-(1-hydroxy-1-benzyl)pyrrole

A

pyrrole
109-97-7

pyrrole

B

benzaldehyde
100-52-7

benzaldehyde

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃; for 12h; Product distribution; Further Variations:; Reagents;A n/a
B 89%
1-methylthiopyrrole
108279-49-8

1-methylthiopyrrole

A

2-methylthiopyrrole
53391-61-0

2-methylthiopyrrole

B

pyrrole
109-97-7

pyrrole

Conditions
ConditionsYield
With trifluoroacetic acid for 0.5h; Ambient temperature;A 15%
B 85%
With trifluoroacetic acid for 0.5h; Product distribution; Ambient temperature;A 15%
B 85%
furan-2-yl-pyrrol-1-yl-methanol

furan-2-yl-pyrrol-1-yl-methanol

A

furfural
98-01-1

furfural

B

pyrrole
109-97-7

pyrrole

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃; for 12h; Product distribution; Further Variations:; Reagents;A 85%
B n/a
1-methyl-4-<2-(4-pyrrolyl)ethyl>pyridinium iodide
113123-61-8

1-methyl-4-<2-(4-pyrrolyl)ethyl>pyridinium iodide

A

pyrrole
109-97-7

pyrrole

B

4-ethenyl-1-methylpyridinium iodide
21351-43-9

4-ethenyl-1-methylpyridinium iodide

Conditions
ConditionsYield
With sodium hydroxide In water; acetone at 25℃; for 24h;A 84%
B n/a
cis,trans-2,5-dimethoxytetrahydrofuran
696-59-3

cis,trans-2,5-dimethoxytetrahydrofuran

pyrrole
109-97-7

pyrrole

Conditions
ConditionsYield
With iron(III) chloride heptahydrate; ammonia In water at 60℃; Paal-Knorr pyrrole synthesis;82%
piperazine
110-85-0

piperazine

A

1,4-pyrazine
290-37-9

1,4-pyrazine

B

2-Methylpyrazine
109-08-0

2-Methylpyrazine

C

2-ethylpyrazine
13925-00-3

2-ethylpyrazine

D

pyrrole
109-97-7

pyrrole

Conditions
ConditionsYield
With hydrogen; Pt(0.6 percent)-Al2O3-In2O3(2.3 percent)-Re2O7(0.5 percent) at 400℃; Product distribution; other bifunctional Pt/Al2O3 modified catalysts;A 78.7%
B n/a
C n/a
D n/a
Pt-Al2O3-In2O3-Re at 400℃; Further byproducts given;A 78.7%
B 1.6%
C 3.5%
D 0.6%
With hydrogen; Pt(0.6 percent)-Al2O3-In2O3(2.3 percent)-Re2O7(0.5 percent) at 400℃; Yields of byproduct given;A 78.7%
B n/a
C n/a
D n/a
(4-nitro-phenyl)-pyrrol-1-yl-methanol

(4-nitro-phenyl)-pyrrol-1-yl-methanol

A

pyrrole
109-97-7

pyrrole

B

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

Conditions
ConditionsYield
With sodium methylate In tetrahydrofuran at 20℃; for 12h; Product distribution; Further Variations:; Reagents;A n/a
B 77%
N2-<(E)-2-Propenyliden>glycinnitril

N2-<(E)-2-Propenyliden>glycinnitril

A

pyrrole
109-97-7

pyrrole

B

(Z)-2-butenenitrile
1190-76-7

(Z)-2-butenenitrile

C

crotononitrile
4786-20-3

crotononitrile

D

but-3-enenitrile
109-75-1

but-3-enenitrile

Conditions
ConditionsYield
at 650℃; under 0.2 Torr; Product distribution; Irradiation;A 74%
B 7%
C 8%
D 0.7%
1-phenylthiopyrrole
108279-52-3

1-phenylthiopyrrole

A

pyrrole
109-97-7

pyrrole

B

diphenyldisulfane
882-33-7

diphenyldisulfane

Conditions
ConditionsYield
With potassium hydroxide at 55℃; for 2h;A n/a
B 73%
With potassium hydroxide at 55℃; for 2h; Product distribution;A n/a
B 73%
2-methyl-1-pyrrol-1-yl-propan-1-ol
643734-28-5

2-methyl-1-pyrrol-1-yl-propan-1-ol

A

pyrrole
109-97-7

pyrrole

B

isobutyraldehyde
78-84-2

isobutyraldehyde

Conditions
ConditionsYield
With sodium methylate In tetrahydrofuran at 20℃; for 12h; Product distribution; Further Variations:; Reagents; reaction time;A n/a
B 70%
benzene
71-43-2

benzene

pyrrole
109-97-7

pyrrole

Conditions
ConditionsYield
69%
3-Pyrroline
109-96-6

3-Pyrroline

pyrrole
109-97-7

pyrrole

Conditions
ConditionsYield
With H8O20P8Pt2(4-)*4C34H72N(1+) In methanol Inert atmosphere; Irradiation;61%
4-butannitril

4-butannitril

A

pyrrole
109-97-7

pyrrole

B

(Z)-2-butenenitrile
1190-76-7

(Z)-2-butenenitrile

C

crotononitrile
4786-20-3

crotononitrile

D

acrylonitrile
107-13-1

acrylonitrile

Conditions
ConditionsYield
at 500 - 700℃; under 0.2 Torr; Product distribution; Irradiation; mol. sieve (3 Angstroem);A 59%
B n/a
C n/a
D 6%
2-pyrrole aldehyde
1003-29-8

2-pyrrole aldehyde

pyrrole
109-97-7

pyrrole

Conditions
ConditionsYield
With carbon dioxide; palladium/alumina at 145℃; under 45004.5 Torr; for 4h; Green chemistry;56.2%
With palladium diacetate In cyclohexane at 140℃; for 24h; Molecular sieve; air;58 %Chromat.
With palladium diacetate In cyclohexane at 140℃; for 24h; Molecular sieve;58 %Chromat.
acetyl chloride
75-36-5

acetyl chloride

butyryl chloride
141-75-3

butyryl chloride

(S)-3-(4-hydroxyphenyl)-2-pyrrol-1-yl-propionic acid methyl ester
116763-11-2

(S)-3-(4-hydroxyphenyl)-2-pyrrol-1-yl-propionic acid methyl ester

A

pyrrole
109-97-7

pyrrole

B

(S)-3-(4-Acetoxy-phenyl)-2-(2-butyryl-pyrrol-1-yl)-propionic acid methyl ester
501030-93-9

(S)-3-(4-Acetoxy-phenyl)-2-(2-butyryl-pyrrol-1-yl)-propionic acid methyl ester

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; triethylamine In dichloromethane; water; acetonitrileA n/a
B 55%
methyl Pyrrole-2-carboxylate
1193-62-0

methyl Pyrrole-2-carboxylate

A

pyrrole
109-97-7

pyrrole

B

pyrocoll
484-73-1

pyrocoll

Conditions
ConditionsYield
In acetonitrile at 330℃; under 97509.8 Torr; for 0.116667h; Pyrolysis;A n/a
B 55%
alpha-cedrene
469-61-4

alpha-cedrene

A

2-(N,N-dimethylaminomethyl)pyrrole
14745-84-7

2-(N,N-dimethylaminomethyl)pyrrole

B

pyrrole
109-97-7

pyrrole

C

N,N-dimethyl-1H-pyrrol-1-amine
78307-76-3

N,N-dimethyl-1H-pyrrol-1-amine

Conditions
ConditionsYield
With sodium hydroxide for 24h; Heating;A 5.5%
B 41%
C 53%
pyrrole
109-97-7

pyrrole

formaldehyd
50-00-0

formaldehyd

(1H-pyrrole-2,5-diyl)dimethanol
6249-04-3

(1H-pyrrole-2,5-diyl)dimethanol

Conditions
ConditionsYield
With potassium carbonate In water at 5℃; for 168h;100%
With sodium hydroxide for 3h; Ambient temperature;46.4%
With potassium carbonate In water at 5℃; for 168h; Inert atmosphere; Sealed flask; Darkness;32%
pyrrole
109-97-7

pyrrole

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

2-(trifluoroacetyl)pyrrole
2557-70-2

2-(trifluoroacetyl)pyrrole

Conditions
ConditionsYield
100%
With benzene
With 1H-imidazole
pyrrole
109-97-7

pyrrole

pyrrolidine
123-75-1

pyrrolidine

Conditions
ConditionsYield
With 5% Ru/MgO; hydrogen In tetrahydrofuran at 150℃; under 38002.6 Torr; for 0.7h;100%
With dichloro(μ-chloro)(μ-hydrido)bis(η-p-cymene)diruthenium(II); hydrogen In neat (no solvent) at 90℃; under 60006 Torr; for 40h;89%
With Cp*Rh(2-(2-pyridyl)phenyl)H; hydrogen In neat (no solvent) at 100℃; under 27361.8 Torr; for 48h; Catalytic behavior; Glovebox;74%
pyrrole
109-97-7

pyrrole

lithium pyrrolide
20671-52-7

lithium pyrrolide

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane for 1h; Heating;100%
With n-butyllithium In hexane at -78 - 20℃; for 4.25h; Inert atmosphere;90%
With lithium in fluessigem NH3;
pyrrole
109-97-7

pyrrole

2-(3-methylbutoxy)-1,3-benzodithiole
55315-56-5

2-(3-methylbutoxy)-1,3-benzodithiole

2,5-bis(1,3-benzodithiol-2-yl)pyrrole
58488-39-4

2,5-bis(1,3-benzodithiol-2-yl)pyrrole

Conditions
ConditionsYield
With acetic acid for 7h; Ambient temperature;100%
In acetic acid Ambient temperature;
pyrrole
109-97-7

pyrrole

bis(heptafluorobutyryl) peroxide
336-64-1

bis(heptafluorobutyryl) peroxide

2-heptafluoropropylpyrrole
118425-75-5

2-heptafluoropropylpyrrole

Conditions
ConditionsYield
In 1,1,2-Trichloro-1,2,2-trifluoroethane at -30℃; further temperature, further solvent;100%
pyrrole
109-97-7

pyrrole

triisopropylsilyl chloride
13154-24-0

triisopropylsilyl chloride

N-triisopropylsilylpyrrole
87630-35-1

N-triisopropylsilylpyrrole

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃;100%
With sodium hydride In N,N-dimethyl-formamide100%
Stage #1: pyrrole With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 1.5h;
Stage #2: triisopropylsilyl chloride In tetrahydrofuran; mineral oil at 0℃; for 1.5h;
100%
pyrrole
109-97-7

pyrrole

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

2,2'-[(4-nitrophenyl)methylene]bis(1H-pyrrole)
143859-77-2

2,2'-[(4-nitrophenyl)methylene]bis(1H-pyrrole)

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 2h;100%
With tetramethyl-tetra-3,4-pyridinoporphyrazinato copper(II) methyl sulfate In water at 20℃;98%
With hydrogenchloride In water at 20℃; for 2h;97%
pyrrole
109-97-7

pyrrole

2-(t-butyl)-1,3-benzodithiolium tetrafluoroborate

2-(t-butyl)-1,3-benzodithiolium tetrafluoroborate

2,5-Bis-(2-tert-butyl-benzo[1,3]dithiol-2-yl)-1H-pyrrole
132371-57-4

2,5-Bis-(2-tert-butyl-benzo[1,3]dithiol-2-yl)-1H-pyrrole

Conditions
ConditionsYield
With pyridine In acetonitrile for 1h;100%
pyrrole
109-97-7

pyrrole

2-phenyl-1,3-benzodithiol-2-ylium tetrafluoroborate

2-phenyl-1,3-benzodithiol-2-ylium tetrafluoroborate

2,5-Bis-(2-phenyl-benzo[1,3]dithiol-2-yl)-1H-pyrrole
132371-52-9

2,5-Bis-(2-phenyl-benzo[1,3]dithiol-2-yl)-1H-pyrrole

Conditions
ConditionsYield
With pyridine In acetonitrile for 0.166667h; Ambient temperature;100%
pyrrole
109-97-7

pyrrole

2-(4-tolyl)-1,3-benzodithiolium tetrafluoroborate

2-(4-tolyl)-1,3-benzodithiolium tetrafluoroborate

2,5-bis<2-<2-(4-tolyl)-1,3-benzodithiolyl>>pyrrole
132371-53-0

2,5-bis<2-<2-(4-tolyl)-1,3-benzodithiolyl>>pyrrole

Conditions
ConditionsYield
With pyridine In acetonitrile for 0.166667h; Ambient temperature;100%
pyrrole
109-97-7

pyrrole

2-(4-chlorophenyl)-1,3-benzodithiolium tetrafluoroborate

2-(4-chlorophenyl)-1,3-benzodithiolium tetrafluoroborate

2,5-Bis-[2-(4-chloro-phenyl)-benzo[1,3]dithiol-2-yl]-1H-pyrrole
132371-55-2

2,5-Bis-[2-(4-chloro-phenyl)-benzo[1,3]dithiol-2-yl]-1H-pyrrole

Conditions
ConditionsYield
With pyridine In acetonitrile for 0.166667h; Ambient temperature;100%
pyrrole
109-97-7

pyrrole

2-(p-methoxyphenyl)-1,3-benzodithiolylium tetrafluoroborate

2-(p-methoxyphenyl)-1,3-benzodithiolylium tetrafluoroborate

2,5-Bis-[2-(4-methoxy-phenyl)-benzo[1,3]dithiol-2-yl]-1H-pyrrole
132371-54-1

2,5-Bis-[2-(4-methoxy-phenyl)-benzo[1,3]dithiol-2-yl]-1H-pyrrole

Conditions
ConditionsYield
With pyridine In acetonitrile for 0.166667h; Ambient temperature;100%
pyrrole
109-97-7

pyrrole

2-(4-Chlorophenyl)-1,3-benzoxathiolium tetrafluoroborate
58948-38-2

2-(4-Chlorophenyl)-1,3-benzoxathiolium tetrafluoroborate

2,5-Bis-[2-(4-chloro-phenyl)-benzo[1,3]oxathiol-2-yl]-1H-pyrrole
179811-43-9

2,5-Bis-[2-(4-chloro-phenyl)-benzo[1,3]oxathiol-2-yl]-1H-pyrrole

Conditions
ConditionsYield
With pyridine In acetonitrile for 0.5h; Ambient temperature;100%
Yield given;
pyrrole
109-97-7

pyrrole

2-(4-Methoxyphenyl)-1,3-benzoxathiolium tetrafluoroborate
58948-36-0

2-(4-Methoxyphenyl)-1,3-benzoxathiolium tetrafluoroborate

2,5-bis<2-(4-methoxyphenyl)-1,3-benzoxathiolyl>pyrrole
171523-06-1

2,5-bis<2-(4-methoxyphenyl)-1,3-benzoxathiolyl>pyrrole

Conditions
ConditionsYield
With pyridine In acetonitrile for 0.5h; Ambient temperature;100%
pyrrole
109-97-7

pyrrole

2-tert-butyl-1,3-benzoxathiolium tetrefluoroborate
59045-53-3

2-tert-butyl-1,3-benzoxathiolium tetrefluoroborate

2,5-bis<2-(2-tert-butyl-1,3-benzoxathiolyl)>pyrrole
112816-67-8

2,5-bis<2-(2-tert-butyl-1,3-benzoxathiolyl)>pyrrole

Conditions
ConditionsYield
With pyridine In acetonitrile for 0.5h; Ambient temperature;100%
pyrrole
109-97-7

pyrrole

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

N-phenylsulfonylpyrrole
16851-82-4

N-phenylsulfonylpyrrole

Conditions
ConditionsYield
With potassium hydroxide; 1-butyl-3-methylimidazolium Tetrafluoroborate at 80℃; for 1h;100%
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In dichloromethane; water at 20℃; Inert atmosphere; Cooling;99%
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 18.5h;98%
pyrrole
109-97-7

pyrrole

tris(pentafluorophenyl)borate
1109-15-5

tris(pentafluorophenyl)borate

N-[tris(pentafluorophenyl)borane]-5H-pyrrole
333334-62-6

N-[tris(pentafluorophenyl)borane]-5H-pyrrole

Conditions
ConditionsYield
In dichloromethane at 20℃;100%
pyrrole
109-97-7

pyrrole

trans-Crotonaldehyde
123-73-9

trans-Crotonaldehyde

(E)-1-Pyrrol-1-yl-but-2-en-1-ol

(E)-1-Pyrrol-1-yl-but-2-en-1-ol

Conditions
ConditionsYield
Stage #1: pyrrole With n-butyllithium In tetrahydrofuran; hexane at -78℃;
Stage #2: trans-Crotonaldehyde In tetrahydrofuran; hexane
100%
pyrrole
109-97-7

pyrrole

pivalaldehyde
630-19-3

pivalaldehyde

2,2-dimethyl-1-pyrrol-1-yl-propan-1-ol

2,2-dimethyl-1-pyrrol-1-yl-propan-1-ol

Conditions
ConditionsYield
Stage #1: pyrrole With n-butyllithium In tetrahydrofuran; hexane at -78℃;
Stage #2: pivalaldehyde In tetrahydrofuran; hexane
100%
pyrrole
109-97-7

pyrrole

isobutyraldehyde
78-84-2

isobutyraldehyde

2-methyl-1-pyrrol-1-yl-propan-1-ol
643734-28-5

2-methyl-1-pyrrol-1-yl-propan-1-ol

Conditions
ConditionsYield
Stage #1: pyrrole With n-butyllithium In tetrahydrofuran; hexane at -78℃;
Stage #2: isobutyraldehyde In tetrahydrofuran; hexane
100%
pyrrole
109-97-7

pyrrole

iodobenzene
591-50-4

iodobenzene

1-phenylpyrrole
635-90-5

1-phenylpyrrole

Conditions
ConditionsYield
With caesium carbonate; copper(I) oxide; trans-N,N'-bis(pyridin-2-ylmethylene)cyclohexane-1,2-diamine In acetonitrile at 50 - 82℃; for 96h; Conversion of starting material;100%
Stage #1: pyrrole With caesium carbonate; copper(I) oxide; trans-N,N'-bis(pyridin-2-ylmethylene)cyclohexane-1,2-diamine at 100℃;
Stage #2: iodobenzene In acetonitrile at 50℃; for 96h;
100%
With copper(II) ferrite; potassium tert-butylate In N,N-dimethyl-formamide at 155℃; for 24h; Inert atmosphere;99%
pyrrole
109-97-7

pyrrole

diphenyl acetylene
501-65-5

diphenyl acetylene

1-((E)-1,2-Diphenyl-vinyl)-1H-pyrrole
81374-51-8

1-((E)-1,2-Diphenyl-vinyl)-1H-pyrrole

Conditions
ConditionsYield
phosphazene base-P4-tert-butyl In hexane; dimethyl sulfoxide at 120℃; for 24h;100%
pyrrole
109-97-7

pyrrole

chloroethylamine
689-98-5

chloroethylamine

1-(2-aminoethyl)pyrrole
29709-35-1

1-(2-aminoethyl)pyrrole

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide100%
With C4H13NO4S; sodium hydroxide100%
With sodium hydroxide; 2-acrylamido-2-methylpropanesulfonic acid In acetonitrile
pyrrole
109-97-7

pyrrole

methyl 3,3,3-trifluoropyruvate
13089-11-7

methyl 3,3,3-trifluoropyruvate

3,3,3-trifluoro-2-hydroxy-2-(1H-pyrrol-2-yl)-propionic acid methyl ester

3,3,3-trifluoro-2-hydroxy-2-(1H-pyrrol-2-yl)-propionic acid methyl ester

Conditions
ConditionsYield
at 20℃; for 0.0166667h; Friedel-Crafts reaction;100%
C24H22O6

C24H22O6

pyrrole
109-97-7

pyrrole

C40H38N4O4
936620-34-7

C40H38N4O4

Conditions
ConditionsYield
In trifluoroacetic acid at 20℃; for 0.25h;100%
pyrrole
109-97-7

pyrrole

1,4-bis<2-<2-<2-(o-formylphenoxy)ethoxy>ethoxy>ethoxy>benzene
144654-25-1

1,4-bis<2-<2-<2-(o-formylphenoxy)ethoxy>ethoxy>ethoxy>benzene

C48H54N4O8
936620-37-0

C48H54N4O8

Conditions
ConditionsYield
In trifluoroacetic acid at 20℃; for 0.25h;100%
pyrrole
109-97-7

pyrrole

2,3:5,6-di-O-isopropylidene-α-D-mannofuranosyl trichloroacetamidate
83441-62-7, 137894-65-6

2,3:5,6-di-O-isopropylidene-α-D-mannofuranosyl trichloroacetamidate

2-(1-deoxy-2,3:5,6-di-O-isopropylidene-mannfuranosyl)pyrrole

2-(1-deoxy-2,3:5,6-di-O-isopropylidene-mannfuranosyl)pyrrole

Conditions
ConditionsYield
boron trifluoride diethyl etherate In diethyl ether; dichloromethane at -50 - 18℃; for 2.33h;100%

Pyrrole Consensus Reports

Reported in EPA TSCA Inventory.

Pyrrole Specification

The IUPAC name of Pyrrole is 1H-pyrrole. With the CAS registry number 109-97-7, it is also named as 1-Aza-2,4-cyclopentadiene. The product's categories are Porphyrins; Pyrrole; Halogenated; Organohalides; Porphyrin Building Blocks; Alkoxy; Organoborons; Functional Materials; Pyrroles (for Conduting Polymer Research); Reagents for Conducting Polymer Research, and the other registry numbers are 21995-14-2; 45361-50-0. Besides, it is colourless to brown liquid with chloroform odour, which should be stored in a cool, ventilated warehouse at 0-6 °C. In addition, its molecular formula is C4H5N and molecular weight is 67.09.

The other characteristics of this product can be summarized as: (1)EINECS: 203-724-7; (2)ACD/LogP: 0.85; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): 0.845; (5)ACD/LogD (pH 7.4): 0.845; (6)ACD/BCF (pH 5.5): 2.584; (7)ACD/BCF (pH 7.4): 2.584; (8)ACD/KOC (pH 5.5): 68.671; (9)ACD/KOC (pH 7.4): 68.671; (10)#H bond acceptors: 1; (11)#H bond donors: 1; (12)#Freely Rotating Bonds: 0; (13)Index of Refraction: 1.523; (14)Molar Refractivity: 20.686 cm3; (15)Molar Volume: 67.756 cm3; (16)Surface Tension: 36.799 dyne/cm; (17)Density: 0.99 g/cm3; (18)Flash Point: 33.333 °C; (19)Melting Point: -23 °C; (20)Water solubility: 60 g/L (20 °C); (21)Enthalpy of Vaporization: 38.75 kJ/mol; (22)Boiling Point: 129.76 °C at 760 mmHg; (23)Vapour Pressure: 12.234 mmHg at 25 °C.

Preparation of Pyrrole: this chemical can be prepared by treating Furan with Ammonia in the presence of solid acid catalysts.

Uses of Pyrrole: this chemical can be used for the synthesis of drugs and spices and other fine chemicals. It can also be used as standard substance in chromatographic analysis. Additionally, it is used in organic synthesis and pharmaceutical industry. And it can react with 4-Chloro-benzoyl chloride to get 1-(4-Chloro-benzoyl)-pyrrole.



This reaction needs Et3N, DMAP and CH2Cl2 at ambient temperature. The yield is 82 %.

When you are using this chemical, please be cautious about it as the following: it is flammable, so please keep away from sources of ignition. It is also harmful by inhalation, and toxic if swallowed. Moreover, it is risk of serious damage to the eyes. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable gloves and eye/face protection to avoid contact with skin. Furthermore, in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: C1=CNC=C1
(2)InChI: InChI=1S/C4H5N/c1-2-4-5-3-1/h1-5H
(3)InChIKey: KAESVJOAVNADME-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 98mg/kg (98mg/kg)   Progress in Biochemical Pharmacology. Vol. 1, Pg. 542, 1965.
mouse LD50 subcutaneous 61mg/kg (61mg/kg)   "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969Vol. 4, Pg. 335, 1969.
rabbit LDLo intraperitoneal 150mg/kg (150mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 36, Pg. 387, 1930.
rabbit LDLo oral 147mg/kg (147mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 36, Pg. 387, 1930.
rabbit LDLo subcutaneous 250mg/kg (250mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 36, Pg. 387, 1930.

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