Pyrrolidine, 1-ethyl- supplier

Name
N-ETHYLPYRROLIDINE
EINECS 230-840-5
CAS No. 7335-06-0
Article Data30
CAS DataBase
Density 0.845 g/cm³
Solubility
Melting Point 102-104 °C
Formula C₆H₁₃N
Boiling Point 104 °C at 760 mmHg
Molecular Weight 99.1759
Flash Point 1.6 °C
Transport Information
Appearance
Safety 26-36/37/39
Risk Codes 10-34
Molecular Structure
Hazard Symbols F,C
Synonyms N-ethyl-Tetrahydropyrrole;N-Ethylpyrrolidine;N-Ethyltetrahydropyrrole;
PSA 3.24000
LogP 1.04000

Synthetic route

: 123-75-1
pyrrolidine

: 64-17-5
ethanol

: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
With Ru on activatedcarbon cloth; activatedcarbon cloth In aq. phosphate buffer at 60℃; for 10h; pH=8.5; Time; Electrochemical reaction;	99%
rhodium hydrido (PEt3)3 complex for 6h;	74 % Chromat.

: 72332-01-5
Phenothiazine-10-carboxylic acid 4-diethylamino-butyl ester

A: 7335-06-0
1-ethylpyrrolidine

B: 92-84-2
10H-phenothiazine

Conditions

Conditions	Yield
at 200℃; for 0.5h; Yields of byproduct given;	A n/a B 89%

: 123-75-1
pyrrolidine

: 74-96-4
ethyl bromide

: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 96h;	80%
In methanol at 20℃;

: 4030-18-6
N-(acetyl)pyrrolidine

: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
With hydrogen; RhMoZn/C In di-isopropyl ether at 70 - 160℃; under 7500.75 Torr; for 16h; Conversion of starting material;	77%
With hydrogen; PtReIn/silica In di-isopropyl ether at 70 - 160℃; under 7500.75 Torr; for 16h; Conversion of starting material;	50%
With hydrogen; PtReCu/silica In di-isopropyl ether at 70 - 160℃; under 7500.75 Torr; for 16h; Conversion of starting material;	40%

: 109-99-9
tetrahydrofuran

: 75-04-7
ethylamine

: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
With aluminium oxide thorium oxide-catalyst at 300℃;
With aluminum oxide at 400℃;

: 123-75-1
pyrrolidine

: 141-78-6
ethyl acetate

: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

: 186581-53-3, 908094-01-9
diazomethane

: 120-94-5
1-Methylpyrrolidine

A: 7335-06-0
1-ethylpyrrolidine

B: 765-48-0, 802254-03-1, 802822-49-7
1,2-dimethylpyrrolidine

C: 45470-22-2
N-methyl-3-methylpyrrolidine

Conditions

Conditions	Yield
UV-Licht;

...Expand

: 120-94-5
1-Methylpyrrolidine

: 2465-56-7
methylene

A: 7335-06-0
1-ethylpyrrolidine

B: 765-48-0, 802254-03-1, 802822-49-7
1,2-dimethylpyrrolidine

C: 45470-22-2
N-methyl-3-methylpyrrolidine

...Expand

: 617-92-5
1-ethyl-1H-pyrrole

: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
With palladium at 160℃; Hydrogenation;
With acetic acid; platinum Hydrogenation;

: 2314-78-5
N-ethylsuccinimide

: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
With sulfuric acid Reduktion unter Verwendung einer Zink-Amalgam-Kathode;

: 16751-58-9
3-aminohexane

: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
Chlorierung; folgende Behandlung mit Schwefelsaeure;

: 2683-56-9
4-(N,N-diethylamino)-1-butanol

: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
With aluminum oxide; nitrogen at 280℃;
Multi-step reaction with 2 steps 1: 1) NaH / 1) toluene, heating, 3 h; 2) heating, 3 h 2: 0.5 h / 200 °C View Scheme

: 110-52-1
1,4-dibromo-butane

: 75-04-7
ethylamine

: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
With zinc(II) chloride

: 628-21-7
1,4-Diiodobutane

: 75-04-7
ethylamine

: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
With ethanol

: 110-63-4
Butane-1,4-diol

: 75-04-7
ethylamine

: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
With aluminium oxide thorium oxide-catalyst at 300℃;

: 4186-68-9
1-Ethyl-1-methylpyrrolidinium iodide

: 141-43-5
ethanolamine

A: 120-94-5
1-Methylpyrrolidine

B: 7335-06-0
1-ethylpyrrolidine

C: 2955-88-6
1-pyrrolidineethanol

D: 624-78-2
N-Ethylmethylamine

...Expand

: 110-63-4
Butane-1,4-diol

: 75-04-7
ethylamine

A: 109-99-9
tetrahydrofuran

B: 7335-06-0
1-ethylpyrrolidine

C: 39216-86-9
4-(ethylamino)butan-1-ol

Conditions

Conditions	Yield
CrZMS-5 at 300℃; for 3h;	A n/a B 59.6 % Chromat. C n/a

...Expand

: 2314-78-5
N-ethylsuccinimide

: 7664-93-9
sulfuric acid

: 7732-18-5
water

: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
at 30℃; elektrochemischen Reduktoin an einer Zink-Amalgam-Kathode;

...Expand

: 123-91-1
1,4-dioxane

: 4277-64-9
ethyl 1H-pyrrole-1-carboxylate

copper oxide-chromium oxide: copper oxide-chromium oxide

A: 120-94-5
1-Methylpyrrolidine

B: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
at 230℃; under 147102 - 220652 Torr; Hydrogenation;

...Expand

: 4277-64-9
ethyl 1H-pyrrole-1-carboxylate

: 64-17-5
ethanol

copper oxide-chromium oxide: copper oxide-chromium oxide

A: 120-94-5
1-Methylpyrrolidine

B: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
at 230℃; under 147102 - 220652 Torr; Hydrogenation;

...Expand

: 2314-78-5
N-ethylsuccinimide

: 7664-93-9
sulfuric acid

: 7732-18-5
water

A: 7335-06-0
1-ethylpyrrolidine

B: 2687-91-4
1-ethyl-2-pyrrolidinone

Conditions

Conditions	Yield
at 28℃; elektrochemischen Reduktion an einer Blei-Kathode;

...Expand

: 109-99-9
tetrahydrofuran

: 109-89-7
diethylamine

Al2O3: Al2O3

: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
at 400℃;

...Expand

: 109-99-9
tetrahydrofuran

: 7664-41-7
ammonia

: 75-04-7
ethylamine

aluminium oxide: aluminium oxide

A: 123-75-1
pyrrolidine

B: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
at 400℃;

...Expand

: 123-91-1
1,4-dioxane

: 64-17-5
ethanol

: 854852-25-8
3-hydroxy-4-nitro-butyric acid ethyl ester

copper oxide-chromium oxide: copper oxide-chromium oxide

A: 7335-06-0
1-ethylpyrrolidine

B: 2687-91-4
1-ethyl-2-pyrrolidinone

Conditions

Conditions	Yield
at 260℃; under 191232 Torr; Hydrogenation;

...Expand

: 110-61-2
butanedinitrile

: 75-04-7
ethylamine

A: 7335-06-0
1-ethylpyrrolidine

B: 617-92-5
1-ethyl-1H-pyrrole

Conditions

Conditions	Yield
With hydrogen; palladium

...Expand

: 110-63-4
Butane-1,4-diol

: 64-17-5
ethanol

: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
With ammonium hydroxide; hydrogen at 290℃; under 30003 Torr; for 4h; Autoclave;

: 13360-63-9
N-ethylbutylamine

: 7335-06-0
1-ethylpyrrolidine

Conditions

Conditions	Yield
With C31H37ClN3NiO2(1-)*Li(1+); potassium tert-butylate In dimethyl sulfoxide at 110℃; for 3h; Catalytic behavior; Sealed tube; Inert atmosphere;	20.8 %Chromat.

: 7335-06-0
1-ethylpyrrolidine

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 335215-12-8
1-((4-methoxyphenyl)sulfonyl)pyrrolidine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; decane at 80℃; for 4h; Sealed tube; chemoselective reaction;	98%

: 7335-06-0
1-ethylpyrrolidine

: 1-(2-azulenyl)-2-propyne-1-one

: 1-(2-azulenyl)-3-pyrrolidino-2-propene-1-one

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 1.5h;	96%

: 7335-06-0
1-ethylpyrrolidine

: 1,3-phenylenebis(propane-3,1-diyl) bis(4-methylbenzenesulfonate)

: 1,1'-(1,3-phenylenebis(propane-3,1-diyl))bis(1-ethylpyrrolidin-1-ium) 4-methylbenzenesulfonate

Conditions

Conditions	Yield
Stage #1: 1,3-phenylenebis(propane-3,1-diyl) bis(4-methylbenzenesulfonate) In acetonitrile for 0.0833333h; Inert atmosphere; Stage #2: 1-ethylpyrrolidine In acetonitrile at 20℃; for 1h; Inert atmosphere;	96%

: 7335-06-0
1-ethylpyrrolidine

: 16133-25-8
Pyridine-3-sulfonyl chloride

: 26103-51-5
3-(pyrrolidin-1-ylsulfonyl)pyridine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; decane at 80℃; for 4h; Sealed tube; chemoselective reaction;	95%

: 7335-06-0
1-ethylpyrrolidine

: 93-11-8
2-Naphthalenesulfonyl chloride

: 111659-88-2
1-(naphthalen-2-ylsulfonyl)pyrrolidine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; decane at 80℃; for 4h; Sealed tube; chemoselective reaction;	94%

: 7335-06-0
1-ethylpyrrolidine

: 543-27-1
isobutyl chloroformate

: C11H22ClNO2

Conditions

Conditions	Yield
In dichloromethane; toluene at 20℃;	93%

: 7335-06-0
1-ethylpyrrolidine

: 16629-19-9
thiophene-2-sulfonyl chloride

: 1-(thiophen-2-ylsulfonyl)pyrrolidine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; decane at 80℃; for 4h; Sealed tube; chemoselective reaction;	93%

: 7335-06-0
1-ethylpyrrolidine

: 824-79-3
sodium 4-methylbenzenesulfinate

: 6435-78-5
N-tosylpyrrolidine

Conditions

Conditions	Yield
With sodium sulfate In water; acetonitrile at 20℃; for 9h; Electrolysis;	92%
With tert.-butylhydroperoxide; iodine In water at 80℃; for 8h; Sealed tube;	89%

: 7335-06-0
1-ethylpyrrolidine

: 98-59-9
p-toluenesulfonyl chloride

: 6435-78-5
N-tosylpyrrolidine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; decane at 80℃; for 4h; Sealed tube; chemoselective reaction;	92%

: 7335-06-0
1-ethylpyrrolidine

: 108-23-6
isopropyl chloroformate

: C10H20ClNO2

Conditions

Conditions	Yield
In dichloromethane; toluene at 20℃;	91%

: 7335-06-0
1-ethylpyrrolidine

: 49584-26-1
p-cyanobenzenesulfonyl chloride

: 4-(pyrrolidin-1-ylsulfonyl)benzonitrile

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; decane at 80℃; for 4h; Sealed tube; chemoselective reaction;	91%

: 7335-06-0
1-ethylpyrrolidine

: 15084-51-2
4-tert-butylbenzenesulfonyl chloride

: 1-((4-(tert-butyl)phenyl)sulfonyl)pyrrolidine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; decane at 80℃; for 4h; Sealed tube; chemoselective reaction;	91%

: 7335-06-0
1-ethylpyrrolidine

: 15898-42-7
sodium 4-cyanobenzenesulfinate

: 4-(pyrrolidin-1-ylsulfonyl)benzonitrile

Conditions

Conditions	Yield
With sodium sulfate In water; acetonitrile at 20℃; for 9h; Electrolysis;	91%

: 7335-06-0
1-ethylpyrrolidine

: 98-09-9
benzenesulfonyl chloride

: 5033-22-7
1-(benzenesulfonyl)pyrrolidine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; decane at 80℃; for 4h; Catalytic behavior; Reagent/catalyst; Solvent; Sealed tube; chemoselective reaction;	90%

: 7335-06-0
1-ethylpyrrolidine

: 85-46-1
1-Naphthalenesulfonyl chloride

: 1-(naphthalen-1-ylsulfonyl)pyrrolidine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; decane at 80℃; for 4h; Sealed tube; chemoselective reaction;	90%

: 7335-06-0
1-ethylpyrrolidine

: 873-55-2
sodium benzenesulfonate

: 5033-22-7
1-(benzenesulfonyl)pyrrolidine

Conditions

Conditions	Yield
With sodium sulfate In water; acetonitrile at 20℃; for 9h; Electrolysis;	90%

: 7335-06-0
1-ethylpyrrolidine

: 98-58-8
4-bromobenzenesulfonyl chloride

: 1-((4-bromopheny 1)sulfonyl)pyrrolidine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; decane at 80℃; for 4h; Sealed tube; chemoselective reaction;	88%

: 7335-06-0
1-ethylpyrrolidine

: 98-61-3
4-iodobenzenesulfonyl chloride

: (3R)-1-[(4-iodophenyl)sulfonyl]tetrahydro-1H-3-pyrrole

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; decane at 80℃; for 4h; Sealed tube; chemoselective reaction;	88%

: 7335-06-0
1-ethylpyrrolidine

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 1-[(4-chlorophenyl)sulfonyl]-pyrrolidine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; decane at 80℃; for 4h; Sealed tube; chemoselective reaction;	86%

: 7335-06-0
1-ethylpyrrolidine

: 607-68-1
2,4-dichloroquinazoline

: 84347-15-9
2-chloro-4--quinazoline

Conditions

Conditions	Yield
In acetone for 2h; Heating;	85.5%

: 7335-06-0
1-ethylpyrrolidine

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 157187-14-9
1-((4-fluorophenyl)sulfonyl)pyrrolidine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; decane at 80℃; for 4h; Sealed tube; chemoselective reaction;	85%

: 7335-06-0
1-ethylpyrrolidine

: 1950-68-1
4-methoxybenzenesulfonyl hydrazide

: 335215-12-8
1-((4-methoxyphenyl)sulfonyl)pyrrolidine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; iodine In water at 80℃; for 8h; Green chemistry;	85%

: 7335-06-0
1-ethylpyrrolidine

: 824-80-6
sodium 4-fluorobenzenesulfinate

: 157187-14-9
1-((4-fluorophenyl)sulfonyl)pyrrolidine

Conditions

Conditions	Yield
With sodium sulfate In water; acetonitrile at 20℃; for 9h; Electrolysis;	85%

: 7335-06-0
1-ethylpyrrolidine

: 132481-85-7
3-chloro-4-(trifluoromethyl)benzenesulfonyl chloride

: 1-((3-chloro-4-(trifluoromethyl)phenyl)sulfonyl)pyrrolidine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; decane at 80℃; for 4h; Sealed tube; chemoselective reaction;	83%

: 7335-06-0
1-ethylpyrrolidine

: 10151-46-9
2-naphthylsulfonyl hydrazide

: 111659-88-2
1-(naphthalen-2-ylsulfonyl)pyrrolidine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; iodine In water at 80℃; for 8h; Green chemistry;	83%

: 7335-06-0
1-ethylpyrrolidine

: 1576-35-8
toluene-4-sulfonic acid hydrazide

: 6435-78-5
N-tosylpyrrolidine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; iodine In water at 80℃; for 8h; Green chemistry;	82%

: 7335-06-0
1-ethylpyrrolidine

: 65604-75-3
4-(tert-butyl)benzenesulfonyl hydrazide

: 1-((4-(tert-butyl)phenyl)sulfonyl)pyrrolidine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; iodine In water at 80℃; for 8h; Green chemistry;	82%

: 7335-06-0
1-ethylpyrrolidine

: 1623-93-4
4-diphenylsulfonyl chloride

: 1-([1,1'-biphenyl]-4-ylsulfonyl)pyrrolidine

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In tetrahydrofuran; decane at 80℃; for 4h; Sealed tube; chemoselective reaction;	81%

Pyrrolidine, 1-ethyl- Specification

The Pyrrolidine, 1-ethyl-, with the CAS registry number 7335-06-0, is also known as N-Ethyl-tetrahydropyrrole. Its EINECS number is 230-840-5. This chemical's molecular formula is C₆H₁₃N and molecular weight is 99.17. What's more, its systematic name is 1-Ethylpyrrolidine.

Physical properties of Pyrrolidine, 1-ethyl- are: (1)ACD/LogP: 1.29; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.8; (4)ACD/LogD (pH 7.4): -1.57; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 3.24 Å²; (13)Index of Refraction: 1.446; (14)Molar Refractivity: 31.34 cm³; (15)Molar Volume: 117.3 cm³; (16)Polarizability: 12.42×10^-24cm³; (17)Surface Tension: 26.8 dyne/cm; (18)Density: 0.845 g/cm³; (19)Flash Point: 1.6 °C; (20)Enthalpy of Vaporization: 34.31 kJ/mol; (21)Boiling Point: 104 °C at 760 mmHg; (22)Vapour Pressure: 31.4 mmHg at 25°C.

Preparation: this chemical can be prepared by phenothiazine-10-carboxylic acid 4-diethylamino-butyl ester at the temperature of 200°C. This reaction will need the reaction time of 30 min. The yield is about 89%.

Pyrrolidine, 1-ethyl- can be prepared by phenothiazine-10-carboxylic acid 4-diethylamino-butyl ester

Uses of Pyrrolidine, 1-ethyl-: it can be used to produce 2-chloro-4-[N-(4-chlorobutyl)-N-ethylamino]-quinazoline when it is heated. It will need reagent acetone with the reaction time of 2 hours. The yield is about 85.5%.

Pyrrolidine, 1-ethyl- can be used to produce 2-chloro-4-[N-(4-chlorobutyl)-N-ethylamino]-quinazoline

When you are using this chemical, please be cautious about it as the following:
It is flammable and easy to cause burn. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)SMILES: N1(CC)CCCC1
(2)Std. InChI: InChI=1S/C6H13N/c1-2-7-5-3-4-6-7/h2-6H2,1H3
(3)Std. InChIKey: ONQBOTKLCMXPOF-UHFFFAOYSA-N

Product Name

N-ETHYLPYRROLIDINE

Synthetic route

Pyrrolidine, 1-ethyl- Specification

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