1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester
ribavirin
Conditions | Yield |
---|---|
With ammonia at 20℃; under 5250.53 Torr; for 20h; Temperature; Pressure; Autoclave; Green chemistry; | 99.71% |
With ammonia In methanol at 0℃; for 2.5h; Temperature; Solvent; | 97% |
With methanol; ammonia at 10 - 20℃; for 18h; Autoclave; | 92.6% |
methyl 1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxylate
ribavirin
Conditions | Yield |
---|---|
With sodium methylate; diethylamine In methanol at 80℃; for 6h; Solvent; | 95% |
With ammonia In methanol at 20℃; for 4h; | |
With ammonia In methanol for 5h; Autoclave; | 107.52 g |
With ammonia In methanol at 20℃; for 4h; |
3-cyano-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1,2,4-triazole
ribavirin
Conditions | Yield |
---|---|
With ammonium hydroxide; dihydrogen peroxide; platinum In methanol | 51.2% |
Multi-step reaction with 3 steps 1: methanol / 2 h / 25 °C 2: methanol / 1 h / 50 °C 3: pH 7.4, phosphate buffer / Ambient temperature View Scheme |
Conditions | Yield |
---|---|
With Enterobacter gergoviae CECT 875 in agar In phosphate buffer at 60℃; for 3h; pH=7.0; Enzymatic reaction; | 45% |
With potassium phosphate buffer at 60℃; for 24h; Enterobakter aerogenes AJ 1125; | |
With Geobacillus kaustophilus ATCC 8005 entrapped in agarose matrix supplemented with bentonite In aq. phosphate buffer at 60℃; for 6h; pH=7; Reagent/catalyst; Green chemistry; |
methyl 1H-1,2,4-triazole-3-carboxylate
1,2,3,5-tetraacetylribose
ribavirin
Conditions | Yield |
---|---|
With Bis(p-nitrophenyl) phosphate at 80 - 147℃; for 0.833333h; Temperature; Large scale; | 77.1% |
ribavirin benzoate
ribavirin
Conditions | Yield |
---|---|
With pyrographite In dichloromethane; acetonitrile at 60℃; for 0.333333h; | 90.16 g |
1,2,3,5-tetraacetylribose
ribavirin
Conditions | Yield |
---|---|
Stage #1: 1-trimethylsilyl-1H-1,2,4-triazole-3-carboxamide With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane at 95℃; for 5h; Stage #2: 1,2,3,5-tetraacetylribose With tin(ll) chloride In dichloromethane at 0℃; Temperature; |
Conditions | Yield |
---|---|
With 1A cells; E. coli BMT 4D In phosphate buffer at 60℃; for 30h; pH=7.5; | 70% |
With phosphate buffer; purine nucleoside phosphorylase immobilised on AP-CPG-170 In water at 60℃; for 36h; pH=7.0; | 68% |
at 60℃; catalyzation by purine nucleoside phosphorylase of Brevibacterium acetylicum ATCC 954, potassium phosphate buffered at pH 7.0; Yield given; |
(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(3-(ethoxycarbonyl)-1H-1,2,4-triazol-1-yl)tetrahydrofuran-3,4-diyl diacetate
ribavirin
Conditions | Yield |
---|---|
With ammonia In methanol at 20℃; for 48.5h; Ice-bath; | 90% |
methyl 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxylate
ribavirin
Conditions | Yield |
---|---|
With ammonia In methanol overnight; | 91.3% |
With ammonia In methanol at 20℃; for 24h; | 80% |
1-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-1H-1,2,4-triazol-3-carboxamid
ribavirin
Conditions | Yield |
---|---|
With hydrogenchloride; hydrogen; palladium In ethanol | 86% |
7-methylinosine
1,2,4-triazole-3-carboxamide
A
7-methyl-1,7-dihydro-purin-6-one
B
ribavirin
Conditions | Yield |
---|---|
With phosphate buffer; purine nucleoside phosphorylase In water at 25℃; for 48h; pH 7.4; | A n/a B 57% |
1,2,4-triazole-3-carboxamide
C11H15N5O5*HI
A
7-methylguanine
B
ribavirin
Conditions | Yield |
---|---|
With phosphate buffer; purine nucleoside phosphorylase In water at 25℃; for 48h; pH 7.4; | A n/a B 54% |
7-methylguanosine
1,2,4-triazole-3-carboxamide
A
7-methylguanine
B
ribavirin
Conditions | Yield |
---|---|
With phosphate buffer; purine nucleoside phosphorylase In water at 25℃; for 48h; pH 7.4; | A n/a B 44% |
α,β-D-ribofuranose-5-phophate disodium salt
1,2,4-triazole-3-carboxamide
ribavirin
Conditions | Yield |
---|---|
With 2-hydroxyethanethiol; manganese(ll) chloride; purine nucleoside phosphorylase In various solvent(s) at 45℃; for 1.5h; pH=7; | 100 % Chromat. |
1-(2',3'-di-O-isopropylidene-β-D-ribofuranosyl)<1,2,4>triazole-3-carboxamide
ribavirin
Conditions | Yield |
---|---|
With ion exchanger Merck I (H+) In water; acetone Ambient temperature; | 90% |
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose
methyl 1H-1,2,4-triazole-3-carboxylate
A
1-β-D-ribofuranosyl-1H-1,2,4-triazole-5-carboxamide
B
ribavirin
Conditions | Yield |
---|---|
Stage #1: 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose; methyl 1H-1,2,4-triazole-3-carboxylate With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate In acetonitrile at 130℃; for 0.0833333h; Vorbrueggen glycosylation; microwave irradiation; Stage #2: With ammonia In methanol at 50℃; for 16h; | A 17% B n/a |
methyl 1-(2,3,5-tri-O-acetyl-β-L-ribofuranosyl)-1,2,4-triazole-3-carboxylate
ribavirin
Conditions | Yield |
---|---|
In ethanol; water |
1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester
ribavirin
Conditions | Yield |
---|---|
In ethanol; water |
1-β-D-Ribofuranosyl-1H-1,2,4-triazol-3-carbonsaeure-ethylester
ribavirin
Conditions | Yield |
---|---|
With ammonia In methanol Ambient temperature; | 76% |
ethanol
methyl 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxylate
ribavirin
Conditions | Yield |
---|---|
In methanol |
methyl 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboximidate
ribavirin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: methanol / 1 h / 50 °C 2: pH 7.4, phosphate buffer / Ambient temperature View Scheme |
Amino(2,3,5-Tri-O-benzyl-D-ribofuranosylhydrazono)essigsaeure-ethylester
ribavirin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: toluene / 4 h / 100 °C 2: H2, 9.5 N ethanolic HCl / Pd / ethanol / 10 h 3: 76 percent / NH3 / methanol / Ambient temperature View Scheme | |
Multi-step reaction with 3 steps 1: toluene / 4 h / 100 °C 2: 100 percent / NH3 / methanol / 12 h / Ambient temperature 3: 86 percent / H2, 9.5 N ethanolic HCl / Pd / ethanol View Scheme |
1-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-1H-1,2,4-triazol-3-carbonsaeure-ethylester
ribavirin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H2, 9.5 N ethanolic HCl / Pd / ethanol / 10 h 2: 76 percent / NH3 / methanol / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: 100 percent / NH3 / methanol / 12 h / Ambient temperature 2: 86 percent / H2, 9.5 N ethanolic HCl / Pd / ethanol View Scheme |
Conditions | Yield |
---|---|
With aeromonas hydrophila CECT 4226 at 60℃; for 26h; pH=7; aq. phosphate buffer; Enzymatic reaction; | A n/a B 65% |
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose
ribavirin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 47 percent / (CH3)3SiOSO2CF3 / 1,2-dichloro-ethane; acetonitrile / 4 h / 4 °C 2: 91.3 percent / NH3 / methanol / overnight View Scheme |
1,2,3,5-tetra-O-acetyl-D-ribofuranose
ribavirin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tin(IV) chloride / dichloromethane / 2 h / 5 - 20 °C / Heating / reflux 2: methanol; water; sodium methylate / 3.5 h / 10 °C 3: ammonia / methanol / 4 h / 20 °C View Scheme |
trifluoroacetic acid
1-(2',3'-di-O-isopropylidene-β-D-ribofuranosyl)<1,2,4>triazole-3-carboxamide
ribavirin
Inosine
ribavirin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 136 °C 1.2: 60 - 100 °C 2.1: trifluorormethanesulfonic acid / 2 h / 135 °C / 55 Torr 3.1: ammonia / methanol / 40 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: methanesulfonic acid / 110 °C 2: Bis(p-nitrophenyl) phosphate / 2 h / 140 - 150 °C 3: methanol; ammonia / 18 h / 10 - 20 °C / Autoclave View Scheme | |
Multi-step reaction with 3 steps 1: trifluoroacetic acid / 60 - 100 °C 2: trifluorormethanesulfonic acid / 90 °C 3: ammonia / methanol / 20 °C View Scheme |
inosine
ribavirin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 55 percent / H2O / 3 h / 60 °C / phosphate buffer pH 7.0; purine nucleoside phosphorylase of Enterobacter aerogenes AJ 11125 2: Enterobacter aerogenes / 3 h / 60 °C / pH 8.0; also with further bacteria View Scheme | |
Multi-step reaction with 3 steps 1: aluminum (III) chloride / methanol / 2 h / 60 °C 2: methanol; sodium iodide / 1 h / 65 °C 3: sodium methylate; diethylamine / methanol / 6 h / 80 °C View Scheme |
acetic anhydride
ribavirin
2',3',5'-Tri-O-acetyl-1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
Conditions | Yield |
---|---|
With pyridine at 20℃; for 22h; Concentration; | 100% |
With pyridine at 20℃; | 100% |
With pyridine Ambient temperature; | 43.1 g |
2,2-dimethoxy-propane
ribavirin
1-(2',3'-di-O-isopropylidene-β-D-ribofuranosyl)<1,2,4>triazole-3-carboxamide
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In acetone at 60℃; for 3h; Concentration; Temperature; | 99% |
With toluene-4-sulfonic acid In acetone at 60℃; for 6h; | 73% |
With perchloric acid In acetone at 0℃; for 1.5h; | 58% |
With perchloric acid In acetone at 20℃; Inert atmosphere; | |
With toluene-4-sulfonic acid In acetone at 60℃; for 3h; |
divinyl adipate
ribavirin
Conditions | Yield |
---|---|
With 1-methyl-1H-imidazole; lipase acrylic resin from Candida antartica In acetone at 50℃; for 4h; | 96% |
With [bmim]BF4; Candida antarctica lipase acrylic resin In acetone at 50℃; for 12h; | 98.5 % Chromat. |
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
ribavirin
3,5-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanyl)-ribavirin
Conditions | Yield |
---|---|
With pyridine; triethylamine In N,N-dimethyl-formamide at 20℃; for 17h; | 94% |
With pyridine at 20℃; for 23.5h; | 91% |
mono-4-methoxytrityl chloride
ribavirin
5'-O-(4-methoxytrityl)ribavirin
Conditions | Yield |
---|---|
With pyridine for 48h; Ambient temperature; | 92% |
With pyridine | 68% |
With pyridine | 68% |
With pyridine | 68% |
Conditions | Yield |
---|---|
Stage #1: C10H15NO8; ribavirin In water at 4℃; Stage #2: With sodium tetrahydroborate In water at 20℃; for 1h; Stage #3: With Dowex 50 (H+) resin In water | 89% |
(2S,4S,5R,6R)-5-Acetylamino-6-formyl-2,4-dihydroxy-tetrahydro-pyran-2-carboxylic acid
ribavirin
C17H25N5O11
Conditions | Yield |
---|---|
Stage #1: (2S,4S,5R,6R)-5-Acetylamino-6-formyl-2,4-dihydroxy-tetrahydro-pyran-2-carboxylic acid; ribavirin In water at 4℃; Stage #2: With sodium tetrahydroborate In water at 20℃; for 1h; Stage #3: With Dowex 50 (H+) In water | 87% |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid; trimethyl orthoformate at 50℃; for 2h; | 87% |
acetone
ribavirin
1-(2',3'-di-O-isopropylidene-β-D-ribofuranosyl)<1,2,4>triazole-3-carboxamide
Conditions | Yield |
---|---|
Stage #1: acetone With toluene-4-sulfonic acid; orthoformic acid triethyl ester at 20℃; Stage #2: ribavirin In N,N-dimethyl-formamide at 50℃; | 85% |
ribavirin
phenylboronic acid
1-(2,3-di-O-phenylboranylidene-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide
Conditions | Yield |
---|---|
With pyridine at 20℃; for 2.08333h; Reflux; | 85% |
ribavirin
trimethyl orthoformate
1-(β-D-ribofuranosyl-2',3'-O-methoxymethylidene)-1,2,4-triazole-3-carboxamide
Conditions | Yield |
---|---|
With pyridine; toluene-4-sulfonic acid In tetrahydrofuran at 20℃; | 84% |
tert-butyldimethylsilyl chloride
ribavirin
Conditions | Yield |
---|---|
Stage #1: ribavirin With 1H-imidazole; dmap In N,N-dimethyl-formamide for 0.0833333h; Inert atmosphere; Stage #2: tert-butyldimethylsilyl chloride In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere; | 84% |
Conditions | Yield |
---|---|
In water at 20℃; for 24h; | 83% |
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In tetrahydrofuran at 60℃; for 2h; | 81.3% |
Conditions | Yield |
---|---|
In water at 20℃; for 24h; | 79% |
lauric acid
ribavirin
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 36h; | 79% |
Conditions | Yield |
---|---|
With pyridine; triethylamine In tetrahydrofuran at 30 - 50℃; for 36h; | 78% |
Conditions | Yield |
---|---|
With pyridine; triethylamine In tetrahydrofuran at 30 - 50℃; for 36h; | 78% |
Conditions | Yield |
---|---|
With pyridine; triethylamine In tetrahydrofuran at 30 - 50℃; for 36h; | 77% |
Conditions | Yield |
---|---|
With pyridine; triethylamine In tetrahydrofuran at 30 - 50℃; for 36h; | 75% |
2-acetoxy-2-methylpropanoyl chloride
ribavirin
Conditions | Yield |
---|---|
Stage #1: 2-acetoxy-2-methylpropanoyl chloride With sodium bromide In acetonitrile at 20℃; for 0.5h; Stage #2: ribavirin In acetonitrile at 70℃; for 3h; | 74.8% |
Ribavirin (36791-04-5) is a synthetic chemical not natural. It was first synthesized in 1970 (Lau, 2002—see hepcassoc.org external link below) at ICN Pharmaceuticals, Inc. (later Valeant Pharmaceuticals International) by chemist Joseph T. Witkowski, under the direction of laboratory director Roland K. Robins. This was inspired in part by discovery (in the 1960s) of antiviral activity from naturally-occurring purine-like nucleoside antibiotics like showdomycin, coformycin, and pyrazomycin. These agents had too much toxicity to be clinically useful (and the antiviral activity of them may be incidental), but they served as the starting point for pharmaceutical chemists interested in antivirals and antimetabolic chemotherapeutic agents.
In 1972 it was reported that ribavirin was active against a variety of RNA and DNA viruses in culture and in animals, without undue toxicity.Some results repoted in human trials against experimental influenza infection were mixed, however, and the FDA ultimately did not approve this indication for ribavirin use in humans, thereby causing a severe financial shock to ICN.
Though ICN was allowed in 1980 to market ribavirin,it is in inhalant form for RSV infection in children.By the time oral ribavirin was finally approved by the FDA as part of a combination treatment (with interferon) for hepatitis C in 1998, the original ICN patents on ribavirin itself had expired, and (notwithstanding subsequent patent disputes) ribavirin had become essentially a generic drug.
Ribavirin is an anti-viral drug indicated for severe RSV infection (individually), hepatitis C infection, and other viral infections. With the CAS NO. 36791-04-5, Ribavirin is Merck Sharp & Dohme Corp.'s brand name for ribavirin, a synthetic nucleoside analogue (purine analogue). The chemical name of ribavirin is 1-β-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide. Ribavirin is a white, crystalline powder. It is freely soluble in water and slightly soluble in anhydrous alcohol. The empirical formula is C8H12N4O5 and the molecular weight is 244.21.
Physical properties about Ribavirin are: (1)ACD/LogP: -1.85; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -1.85; (4)ACD/LogD (pH 7.4): -1.85; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 2.35; (8)ACD/KOC (pH 7.4): 2.35; (9)#H bond acceptors: 9; (10)#H bond donors: 5; (11)#Freely Rotating Bonds: 6; (12)Index of Refraction: 1.823; (13)Molar Refractivity: 51.088 cm3; (14)Molar Volume: 117.055 cm3; (15)Polarizability: 20.253 10-24cm3; (16)Surface Tension: 106.78099822998 dyne/cm; (17)Density: 2.086 g/cm3; (18)Flash Point: 340.728 °C; (19)Enthalpy of Vaporization: 99.283 kJ/mol; (20)Boiling Point: 639.782 °C at 760 mmHg
Uses of Ribavirin: Ribavirin is used as broad-spectrum nucleoside antiviral medicine. Ribavirin is active against a number of DNA and RNA viruses. It is a member of the nucleoside antimetabolite drugs that interfere with duplication of viral genetic material. In the U.K. and the U.S. the oral (capsule or tablet) form of ribavirin is used in the treatment of hepatitis C, in combination with pegylated interferon drugs.
When you are using this chemical, please be cautious about it as the following:
1. Avoid exposure - obtain special instruction before use;
2. Do not breathe dust;
3. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible);
4. Wear suitable gloves and eye/face protection;
5. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
You can still convert the following datas into molecular structure:
(1)InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1;
(2)InChIKey=IWUCXVSUMQZMFG-AFCXAGJDSA-N;
(3)Smilesn1([C@@H]2O[C@H](CO)[C@H]([C@H]2O)O)nc(C(N)=O)nc1
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | unreported | 1500mg/kg (1500mg/kg) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: HEMORRHAGE | Pharmaceutical Chemistry Journal Vol. 18, Pg. 667, 1984. |
mouse | LD50 | intraperitoneal | 1300mg/kg (1300mg/kg) | Journal of Medicinal Chemistry. Vol. 15, Pg. 1150, 1972. | |
mouse | LDLo | oral | 4gm/kg (4000mg/kg) | Pharmaceutical Chemistry Journal Vol. 18, Pg. 667, 1984. | |
rat | LD50 | oral | 2700mg/kg (2700mg/kg) | Pharmaceutical Chemistry Journal Vol. 18, Pg. 667, 1984. |
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